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Longitudinal Study of Ocular Complications of AIDS (LSOCA)
Ocular abnormalities in patients with AIDS were first reported in 1982. The most common
finding is a non-infectious "HIV retinopathy", characterized by cotton wool spots,
intraretinal hemorrhages, and/or microaneurysms. These changes occur in approximately 50
percent of p... The Collaborative Longitudinal Evaluation of Ethnicity and Refractive Error (CLEERE) Study
The Orinda Longitudinal Study of Myopia (OLSM) was started in 1989 to investigate normal eye
growth and the development of myopia in over 1,200 school-aged children to date. Beginning in
1997, three parallel study phases are being conducted. Phase 1 investigates additional
... Preliminary Testing of New Treatment for Chronic Leg Wounds
Most chronic wounds of the leg fail to heal in a reasonable period of time. In fact, despite
considerable advances in elucidating the molecular basis of wound repair, attempts to develop
new therapies have been disappointing. In general, therapies based on recently elucidated
... A Study to Monitor Patients With Primary or Early HIV Infection
Primary HIV-1 infection is frequently identified as a nonspecific viral syndrome occurring
within 20 days to 8 weeks following a documented HIV exposure. However, symptoms vary from
person to person, and some people undergo asymptomatic seroconversion. Because of the
diffic... The Biology of HIV Transmission
Persons with early HIV infection may represent high transmission risk to their partners.
Early infection, characterized by rapid virologic replication, insufficient immunologic
control of infection, and more rapid course of disease progression, may be associated with
increa... Effectiveness of Interleukin-2 (IL-2) Plus Anti-HIV Therapy in HIV-Positive Patients
At the time of initial HIV infection, CD4 cells are susceptible to infection, and the virus
infects many T cells during the first 4 to 6 weeks. Many of these infected cells subsequently
maintain the virus in a latent state. Immune reconstitution with daily low-dose IL-2 therapy
... Long-Term Data Collection From Participants in Adult AIDS Clinical Trials
A compilation of outcomes of various antiretroviral therapies would be beneficial when
evaluating which strategies are most effective in long-term treatment of HIV-1. Using data
from present and recently completed studies, this study will collect information on therapies
an... Lipoprotein Metabolism in Normal Volunteers and Patients With High Levels of Lipoproteins
We propose to investigate human in vivo lipoprotein metabolism using either radiolabeled
apolipoproteins or nonradioactive isotopically labeled amino acids. Paired kinetic studies
using dual-labeled iodinated lipoproteins and apolipoproteins are performed in normal
volunte... Assessment of Patients With Multiple Sclerosis (MS)
The Neuroimmunology Branch (NIB) conducts research into the cause of immunologically mediated
diseases of the nervous system such as multiple sclerosis (MS). The studies in the NIB range
for studies of the natural history of MS to trials of new experimental therapies. In order
... Evaluation of Patients With Thyroid Disorders
Patients with thyroid function abnormalities (hyperthyroidism, hypothyroidism) are studied
and treated in this protocol. A limited number of patients with a personal history of signs,
symptoms or laboratory studies consistent with thyroid dysfunction or a strong family history
... Studies on Tumors of the Thyroid
The purpose of this study is to evaluate methods for preoperative diagnosis and therapy of
thyroid cancer and to screen patients for participation in other protocols. Study subjects
will include adults and children with thyroid nodules or cancer requiring diagnostic fine
n... Parasitic Infections of the Gastrointestinal Tract
The precis of this protocol is to allow the evaluation, treatment and study of patients with
a variety of gastrointestinal parasites. This protocol primarily allows evaluation and
treatment of patients with any intestinal parasite that requires a medical evaluation. The
t... Evaluation of Lipoproteins
The lipoprotein transport system is vital to the delivery of the hydrophobic fats that are
carried in the aqueous environment of the blood. The lipoprotein particles that comprise
this system are polydisperse and contain triglycerides, free and esterified cholesterol,
phos... Evaluation of the Genetics of Bipolar Disorder
Bipolar affective disorder is a severe, heritable condition affecting about one percent of
the population. The mode of inheritance is poorly understood and probably involves multiple
loci of small to moderate effect. Genetic linkage has been reported to a number of
chromo... Study of Menstrually-Regulated Mood and Behavioral Disorder
The purpose of this screening protocol is to identify a population of women who experience
menstrually-related mood or behavior difficulties and to describe the symptoms in this group
and their relationship to the menses. This will be accomplished by means of clinical
inte... Brain Study of Patients With Frontal Lobe Dementia and Parkinsonian Disorders
The Cognitive Neuroscience Section of the National Institute of Neurological Disorders and
Stroke proposes to continue its cross-sectional and longitudinal studies of cerebral
metabolism in frontal lobe dementias and atypical basal ganglia disorders. These studies
include ... Evaluation of the Causes and Disease Processes of Chronic Lung Disease
The chronic lung diseases are those disorders associated with functional and/or structural
derangement to the alveolar structures, airways, pulmonary blood vessels, pleura and/or
mediastinum. The purpose of this project is to permit the comprehensive evaluation of
patients... Immune Regulation in Ulcerative Colitis or Crohn's Disease
This natural history protocol provides for the evaluation of patients with idiopathic
inflammatory bowel disease (ulcerative colitis, Crohn's disease, IBD associated with
immunodeficiency and genetic diseases, such as chronic granulomatous disease and
Hermansky-pudlak syndr... Endocrine Studies of Healthy Children
We wish to obtain blood, urine, saliva, and stool specimens from healthy children ages 5-17
years for use in establishing the normal ranges of levels of hormones and the variations in
genes that are important for hormones to act. Such hormone values are extremely important to
... Evaluation of Salivary Gland Dysfunction
This study will evaluate patients with complaints of dry mouth to determine the cause and
severity of their salivary gland dysfunction and their possible eligibility for other NIDCR
protocols. Salivary gland secretions have antibacterial, lubricatory, remineralizing,
diges... Evaluating Genetic Risk Factors for Childhood-Onset Schizophrenia
A study of children and adolescents (current N=48) with very early onset by age 12 (COS) of
DSM-III-R defined schizophrenia with (97-M-0126) is examining the clinical, neurobiological,
early neurodevelopmental, genetic, and clinical drug response characteristics of these cases.
... Treatment of Patients With Cysticercosis With Praziquantel or Albendazole
The purpose of this protocol is to allow evaluation, treatment and follow up of patients with
cysticercosis. Cysticercosis is defined as an infection with the larvae form of T.solium and
includes infection of the brain (neurocysticercosis) that accounts for most of the
symp... Biological Markers in Attention Deficit/Hyperactivity Disorder (ADHD)
1. This protocol allows the continuing prospective longitudinal study of ADHD probands for
whom we have neurobiological measures, particularly quantitative brain MRI. The
follow-up consists of structured psychiatric interviews, and neuropsychological tests.
... Botulinum Toxin for the Treatment of Involuntary Movement Disorders
The efficacy of botulinum toxin (btx) has now been demonstrated for a variety of diseases
associated with involuntary muscle spasms or movement. The application of botulinum toxin
therapy to movement disorders requires treatment tailored to the individual patient and
speci... Cysteamine Eye Drops to Treat Corneal Crystals in Cystinosis
OBJECTIVE: The free thiol cysteamine depletes cystinotic leukocytes and other cells of
cystine, whose accumulation is considered the cause of organ damage in cystinosis. This
organ damage involves most tissues of the body. Cysteamine therapy improved growth and
stabilize... Collection of Blood From Patients With Pancytopenia
Patients with aplastic anemia, myelodysplasia, and other marrow failure syndromes have a
variety of immunologic abnormalities including lymphocyte phenotypic and lymphokine
production dysregulation. Because of their low blood counts, it has been difficult to obtain
suffici... Genetic Studies of Lysosomal Storage Disorders
There is a vast spectrum of clinical manifestations encountered in individuals with lysosomal
storage diseases. Lysosomes are organelles that are involved in the degradation of
intracellular proteins, recycled products and organelle in the cell. Lysosomal storage
disorder... Comparing Magnetic Resonance Imaging/Spectroscopy Techniques
MRI is a constantly evolving imaging modality and MR. Pulse sequences are often modified to
improve their performance. However, many of these changes have not yet been approved by the
FDA and therefore, are not considered standard of care. Some of these sequences require the
... Studying Patients With Cystic Fibrosis and Other Pulmonary and Pancreatic Disorders
This is an omnibus protocol for studying patients with cystic fibrosis and other familial
pulmonary and pancreatic disorders. The main purpose of the study is to expand knowledge of
the natural history, clinical manifestations (phenotypes) and the genetic variants
(genotyp... Host Response to Infection and Treatment in Filarial Diseases
Patients admitted on this protocol will have, or be suspected of having, one of the filarial
infections affecting humans. After routine clinical evaluation they will be studied in depth
immunologically, and their blood cells and/or serum will be collected to provide reagents
... Perimenopause-Related Mood and Behavioral Disorders
Controversy exists regarding the relevance of changes in gonadal steroids for midlife onset
depressions. In this protocol, we examine the possible role of gonadal steroids in these
disorders in two ways. First, we identify groups of both depressed and asymptomatic women
w... Resistance to Vitamin D or Parathyroid Hormone
Patients with confirmed or suspected states with resistance to vitamin D or parathyroid
hormone (PTH) will be admitted for diagnosis and treatment and for inclusion in other
protocols. These states include hypocalcemia, rickets, osteomalacia,
pseudohypoparathyroidism. Res... Study of Patients With Strongyloides Stercoralis Infection
This study is directed to patients with known or suspected Strongyloides stercoralis
infection because it is a relatively common parasitic infection, even in the United States.
It is difficult to diagnose, and efficacy of treatment is difficult to evaluate. Because
newer d... Immune Regulation in Patients With Common Variable Immunodeficiency and Related Syndromes
The purpose of this protocol is to carry out laboratory studies concerning the
immunopathogenesis of Common Variable Immunodeficiency and related primary humoral
immunodeficiency diseases.
Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Children
Driven by the hypotheses that many of the most severe neuropsychiatric disorders of childhood
onset are associated with deviations from the path of normal brain development, the
neuroanatomical substrates of which can be detected by magnetic resonance imaging, we are
acquir... Inpatient Evaluation of Adults With Schizophrenia
Schizophrenia and related psychoses are chronic brain disorders whose prognosis is often poor
and whose pathophysiology remains obscure. Neuroimaging technologies such as PET (positron
emission tomography), fMRI (functional magnetic resonance imaging), DTI (diffusion tensor
... Magnetic Resonance Imaging (MRI) to Evaluate Activity of Multiple Sclerosis (MS)
Studies performed under 89-N-0045 are designed to examine the natural history of multiple
sclerosis (MS) using MRI and immunological measures. In addition to studying the natural
history of untreated patients, the natural history of patients receiving approved
disease-modif... Human Movement Database
The purpose of this study is to develop a database of normative and adaptive control
strategies for human motion. Up to 500 volunteers will serve as subjects after they complete
a neuromusculoskeletal screening exam. Subjects will be asked to perform one or more tasks
rel... Inflammatory Responses in Normal Volunteers and Patients With Abnormal Immune Responses
Patients with abnormal regulation of inflammation and with host defense defects often have an
exaggerated or depressed inflammatory response with resultant difficulty in healing of
recurrent infections. Delayed healing can be manifested by either a delay in wound healing,
... Studies of Frontal Lobe Brain Functioning in Schizophrenia
The purpose of this work is to investigate the role of the frontal lobe, and its connections,
for cognition in health and in neuropsychiatric diseases, particularly schizophrenia.
Regional cerebral blood flow (rCBF) will be measured with oxygen-15 water positron emission
to... Brain Tissue Collection for Neuropathological Studies
The knowledge of how affected tissue deviates from normal control tissue is an integral part
of fully understanding a neurological or psychiatric disorder. The purpose of this protocol
is to establish a coordinating program with the pathology departments of the Washington, D.C.
... Clinical Trial of Leuprolide Acetate for the Treatment of PMS
This protocol is designed to accompany Clinical Protocol # 81-M-0126, The Phenomenology and
Biophysiology of Menstrually-Related Mood and Behavioral Disorders. Its original purposes
were as follows: 1) to evaluate the efficacy of the gonadotropin releasing hormone (GnRH)
... Copper Histidine Therapy for Menkes Diseases
Menkes disease is an X-linked recessive neurodegenerative disorder caused by defects in a
gene that encodes an evolutionarily conserved copper-transporting ATPase (ATP7A). Several
issues must be addressed in configuring therapeutic strategies for this disorder: (a)
affecte... Study and Treatment of Inflammatory Muscle Diseases
Polymyositis, dermatomyositis and related disorders, also known as the idiopathic
inflammatory myopathies (IIM), are an uncommon, heterogenous group of diseases. This is an
omnibus protocol designed to continue our description of this rare group of diseases, further
deline... Diagnosing and Treating Low Blood Sugar Levels
The purpose of this protocol is to continue our studies of the evaluation and treatment of
patients with fasting hypoglycemia due to diverse etiologies. Patients will be admitted to
the Clinical Research Center under this protocol and undergo supervised fasting, dynamic
te... Ovarian Follicle Function in Patients With Premature Ovarian Failure
No proven therapy to restore ovarian function and fertility is available to patients with
karyotypically normal spontaneous premature ovarian failure. We know that one-half of these
patients have primordial follicles remaining in the ovary, and these follicles can function
... Studies of Elevated Parathyroid Activity
Patients with confirmed or suspected primary hyperparathyroidism or complications therefrom
(such as postoperative hypoparathyroidism) will be admitted for diagnosis and treatment.
Patients with moderately severe primary hyperparathyroidism will be treated. The principal
d...
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