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Vaccination With Tetanus and KLH to Assess Immune Responses.

RecruitingView Trial DetailsConditions:Cancer
Prevalence of Carbohydrate Intolerance in Lean and Obese Children

RecruitingView Trial DetailsConditions:Obesity
Longitudinal Study of Ocular Complications of AIDS (LSOCA)
Ocular abnormalities in patients with AIDS were first reported in 1982. The most common finding is a non-infectious "HIV retinopathy", characterized by cotton wool spots, intraretinal hemorrhages, and/or microaneurysms. These changes occur in approximately 50 percent of p...
RecruitingView Trial DetailsConditions:HIV Infections
The Collaborative Longitudinal Evaluation of Ethnicity and Refractive Error (CLEERE) Study
The Orinda Longitudinal Study of Myopia (OLSM) was started in 1989 to investigate normal eye growth and the development of myopia in over 1,200 school-aged children to date. Beginning in 1997, three parallel study phases are being conducted. Phase 1 investigates additional ...
RecruitingView Trial DetailsConditions:Myopia
Treatments for Benign Paroxysmal Positional Vertigo (BPPV)

RecruitingView Trial DetailsConditions:Vertigo
Preliminary Testing of New Treatment for Chronic Leg Wounds
Most chronic wounds of the leg fail to heal in a reasonable period of time. In fact, despite considerable advances in elucidating the molecular basis of wound repair, attempts to develop new therapies have been disappointing. In general, therapies based on recently elucidated ...
RecruitingView Trial DetailsConditions:Varicose Ulcer
A Study to Monitor Patients With Primary or Early HIV Infection
Primary HIV-1 infection is frequently identified as a nonspecific viral syndrome occurring within 20 days to 8 weeks following a documented HIV exposure. However, symptoms vary from person to person, and some people undergo asymptomatic seroconversion. Because of the diffic...
RecruitingView Trial DetailsConditions:HIV Infections
The Biology of HIV Transmission
Persons with early HIV infection may represent high transmission risk to their partners. Early infection, characterized by rapid virologic replication, insufficient immunologic control of infection, and more rapid course of disease progression, may be associated with increa...
RecruitingView Trial DetailsConditions:HIV Infections
Effectiveness of Interleukin-2 (IL-2) Plus Anti-HIV Therapy in HIV-Positive Patients
At the time of initial HIV infection, CD4 cells are susceptible to infection, and the virus infects many T cells during the first 4 to 6 weeks. Many of these infected cells subsequently maintain the virus in a latent state. Immune reconstitution with daily low-dose IL-2 therapy ...
RecruitingView Trial DetailsConditions:HIV Infections
Long-Term Data Collection From Participants in Adult AIDS Clinical Trials
A compilation of outcomes of various antiretroviral therapies would be beneficial when evaluating which strategies are most effective in long-term treatment of HIV-1. Using data from present and recently completed studies, this study will collect information on therapies an...
RecruitingView Trial DetailsConditions:HIV Infections
Lipoprotein Metabolism in Normal Volunteers and Patients With High Levels of Lipoproteins
We propose to investigate human in vivo lipoprotein metabolism using either radiolabeled apolipoproteins or nonradioactive isotopically labeled amino acids. Paired kinetic studies using dual-labeled iodinated lipoproteins and apolipoproteins are performed in normal volunte...
RecruitingView Trial DetailsConditions:Abetalipoproteinemia
Assessment of Patients With Multiple Sclerosis (MS)
The Neuroimmunology Branch (NIB) conducts research into the cause of immunologically mediated diseases of the nervous system such as multiple sclerosis (MS). The studies in the NIB range for studies of the natural history of MS to trials of new experimental therapies. In order ...
RecruitingView Trial DetailsConditions:Herpesviridae Infection
Evaluation of Patients With Thyroid Disorders
Patients with thyroid function abnormalities (hyperthyroidism, hypothyroidism) are studied and treated in this protocol. A limited number of patients with a personal history of signs, symptoms or laboratory studies consistent with thyroid dysfunction or a strong family history ...
RecruitingView Trial DetailsConditions:Hyperthyroidism
Studies on Tumors of the Thyroid
The purpose of this study is to evaluate methods for preoperative diagnosis and therapy of thyroid cancer and to screen patients for participation in other protocols. Study subjects will include adults and children with thyroid nodules or cancer requiring diagnostic fine n...
RecruitingView Trial DetailsConditions:Neoplasm Metastasis
Parasitic Infections of the Gastrointestinal Tract
The precis of this protocol is to allow the evaluation, treatment and study of patients with a variety of gastrointestinal parasites. This protocol primarily allows evaluation and treatment of patients with any intestinal parasite that requires a medical evaluation. The t...
RecruitingView Trial DetailsConditions:Amebiasis
Evaluation of Lipoproteins
The lipoprotein transport system is vital to the delivery of the hydrophobic fats that are carried in the aqueous environment of the blood. The lipoprotein particles that comprise this system are polydisperse and contain triglycerides, free and esterified cholesterol, phos...
RecruitingView Trial DetailsConditions:Hyperlipidemia
Evaluation of the Genetics of Bipolar Disorder
Bipolar affective disorder is a severe, heritable condition affecting about one percent of the population. The mode of inheritance is poorly understood and probably involves multiple loci of small to moderate effect. Genetic linkage has been reported to a number of chromo...
RecruitingView Trial DetailsConditions:Anxiety Disorder
Study of Menstrually-Regulated Mood and Behavioral Disorder
The purpose of this screening protocol is to identify a population of women who experience menstrually-related mood or behavior difficulties and to describe the symptoms in this group and their relationship to the menses. This will be accomplished by means of clinical inte...
RecruitingView Trial DetailsConditions:Mental Disorder
Brain Study of Patients With Frontal Lobe Dementia and Parkinsonian Disorders
The Cognitive Neuroscience Section of the National Institute of Neurological Disorders and Stroke proposes to continue its cross-sectional and longitudinal studies of cerebral metabolism in frontal lobe dementias and atypical basal ganglia disorders. These studies include ...
RecruitingView Trial DetailsConditions:Alzheimer's Disease
Evaluation of the Causes and Disease Processes of Chronic Lung Disease
The chronic lung diseases are those disorders associated with functional and/or structural derangement to the alveolar structures, airways, pulmonary blood vessels, pleura and/or mediastinum. The purpose of this project is to permit the comprehensive evaluation of patients...
RecruitingView Trial DetailsConditions:Lung Disease
Immune Regulation in Ulcerative Colitis or Crohn's Disease
This natural history protocol provides for the evaluation of patients with idiopathic inflammatory bowel disease (ulcerative colitis, Crohn's disease, IBD associated with immunodeficiency and genetic diseases, such as chronic granulomatous disease and Hermansky-pudlak syndr...
RecruitingView Trial DetailsConditions:Crohn's Disease
Endocrine Studies of Healthy Children
We wish to obtain blood, urine, saliva, and stool specimens from healthy children ages 5-17 years for use in establishing the normal ranges of levels of hormones and the variations in genes that are important for hormones to act. Such hormone values are extremely important to ...
RecruitingView Trial DetailsConditions:Healthy
Evaluation of Salivary Gland Dysfunction
This study will evaluate patients with complaints of dry mouth to determine the cause and severity of their salivary gland dysfunction and their possible eligibility for other NIDCR protocols. Salivary gland secretions have antibacterial, lubricatory, remineralizing, diges...
RecruitingView Trial DetailsConditions:Sjogren's Syndrome
Evaluating Genetic Risk Factors for Childhood-Onset Schizophrenia
A study of children and adolescents (current N=48) with very early onset by age 12 (COS) of DSM-III-R defined schizophrenia with (97-M-0126) is examining the clinical, neurobiological, early neurodevelopmental, genetic, and clinical drug response characteristics of these cases. ...
RecruitingView Trial DetailsConditions:Healthy
Treatment of Patients With Cysticercosis With Praziquantel or Albendazole
The purpose of this protocol is to allow evaluation, treatment and follow up of patients with cysticercosis. Cysticercosis is defined as an infection with the larvae form of T.solium and includes infection of the brain (neurocysticercosis) that accounts for most of the symp...
RecruitingView Trial DetailsConditions:Cysticercosis
Biological Markers in Attention Deficit/Hyperactivity Disorder (ADHD)
1. This protocol allows the continuing prospective longitudinal study of ADHD probands for whom we have neurobiological measures, particularly quantitative brain MRI. The follow-up consists of structured psychiatric interviews, and neuropsychological tests. ...
RecruitingView Trial DetailsConditions:Attention Deficit and Disruptive Behavior Disorder
Botulinum Toxin for the Treatment of Involuntary Movement Disorders
The efficacy of botulinum toxin (btx) has now been demonstrated for a variety of diseases associated with involuntary muscle spasms or movement. The application of botulinum toxin therapy to movement disorders requires treatment tailored to the individual patient and speci...
RecruitingView Trial DetailsConditions:Chorea
Cysteamine Eye Drops to Treat Corneal Crystals in Cystinosis
OBJECTIVE: The free thiol cysteamine depletes cystinotic leukocytes and other cells of cystine, whose accumulation is considered the cause of organ damage in cystinosis. This organ damage involves most tissues of the body. Cysteamine therapy improved growth and stabilize...
RecruitingView Trial DetailsConditions:Cystinosis
Collection of Blood From Patients With Pancytopenia
Patients with aplastic anemia, myelodysplasia, and other marrow failure syndromes have a variety of immunologic abnormalities including lymphocyte phenotypic and lymphokine production dysregulation. Because of their low blood counts, it has been difficult to obtain suffici...
RecruitingView Trial DetailsConditions:Aplastic Anemia
Genetic Studies of Lysosomal Storage Disorders
There is a vast spectrum of clinical manifestations encountered in individuals with lysosomal storage diseases. Lysosomes are organelles that are involved in the degradation of intracellular proteins, recycled products and organelle in the cell. Lysosomal storage disorder...
RecruitingView Trial DetailsConditions:Gaucher's Disease
Comparing Magnetic Resonance Imaging/Spectroscopy Techniques
MRI is a constantly evolving imaging modality and MR. Pulse sequences are often modified to improve their performance. However, many of these changes have not yet been approved by the FDA and therefore, are not considered standard of care. Some of these sequences require the ...
RecruitingView Trial DetailsConditions:Healthy
Studying Patients With Cystic Fibrosis and Other Pulmonary and Pancreatic Disorders
This is an omnibus protocol for studying patients with cystic fibrosis and other familial pulmonary and pancreatic disorders. The main purpose of the study is to expand knowledge of the natural history, clinical manifestations (phenotypes) and the genetic variants (genotyp...
RecruitingView Trial DetailsConditions:Bronchiectasis
Host Response to Infection and Treatment in Filarial Diseases
Patients admitted on this protocol will have, or be suspected of having, one of the filarial infections affecting humans. After routine clinical evaluation they will be studied in depth immunologically, and their blood cells and/or serum will be collected to provide reagents ...
RecruitingView Trial DetailsConditions:Filariasis
Perimenopause-Related Mood and Behavioral Disorders
Controversy exists regarding the relevance of changes in gonadal steroids for midlife onset depressions. In this protocol, we examine the possible role of gonadal steroids in these disorders in two ways. First, we identify groups of both depressed and asymptomatic women w...
RecruitingView Trial DetailsConditions:Depressive Disorder
Resistance to Vitamin D or Parathyroid Hormone
Patients with confirmed or suspected states with resistance to vitamin D or parathyroid hormone (PTH) will be admitted for diagnosis and treatment and for inclusion in other protocols. These states include hypocalcemia, rickets, osteomalacia, pseudohypoparathyroidism. Res...
RecruitingView Trial DetailsConditions:Hypocalcemia
Study of Patients With Strongyloides Stercoralis Infection
This study is directed to patients with known or suspected Strongyloides stercoralis infection because it is a relatively common parasitic infection, even in the United States. It is difficult to diagnose, and efficacy of treatment is difficult to evaluate. Because newer d...
RecruitingView Trial DetailsConditions:HIV Infection
Immune Regulation in Patients With Common Variable Immunodeficiency and Related Syndromes
The purpose of this protocol is to carry out laboratory studies concerning the immunopathogenesis of Common Variable Immunodeficiency and related primary humoral immunodeficiency diseases.
RecruitingView Trial DetailsConditions:Agammaglobulinemia
Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Children
Driven by the hypotheses that many of the most severe neuropsychiatric disorders of childhood onset are associated with deviations from the path of normal brain development, the neuroanatomical substrates of which can be detected by magnetic resonance imaging, we are acquir...
RecruitingView Trial DetailsConditions:Autoimmune Disease
Inpatient Evaluation of Adults With Schizophrenia
Schizophrenia and related psychoses are chronic brain disorders whose prognosis is often poor and whose pathophysiology remains obscure. Neuroimaging technologies such as PET (positron emission tomography), fMRI (functional magnetic resonance imaging), DTI (diffusion tensor ...
RecruitingView Trial DetailsConditions:Psychotic Disorder
Magnetic Resonance Imaging (MRI) to Evaluate Activity of Multiple Sclerosis (MS)
Studies performed under 89-N-0045 are designed to examine the natural history of multiple sclerosis (MS) using MRI and immunological measures. In addition to studying the natural history of untreated patients, the natural history of patients receiving approved disease-modif...
RecruitingView Trial DetailsConditions:Multiple Sclerosis
Human Movement Database
The purpose of this study is to develop a database of normative and adaptive control strategies for human motion. Up to 500 volunteers will serve as subjects after they complete a neuromusculoskeletal screening exam. Subjects will be asked to perform one or more tasks rel...
RecruitingView Trial DetailsConditions:Healthy
Inflammatory Responses in Normal Volunteers and Patients With Abnormal Immune Responses
Patients with abnormal regulation of inflammation and with host defense defects often have an exaggerated or depressed inflammatory response with resultant difficulty in healing of recurrent infections. Delayed healing can be manifested by either a delay in wound healing, ...
RecruitingView Trial DetailsConditions:Healthy
Studies of Frontal Lobe Brain Functioning in Schizophrenia
The purpose of this work is to investigate the role of the frontal lobe, and its connections, for cognition in health and in neuropsychiatric diseases, particularly schizophrenia. Regional cerebral blood flow (rCBF) will be measured with oxygen-15 water positron emission to...
RecruitingView Trial DetailsConditions:Healthy
Brain Tissue Collection for Neuropathological Studies
The knowledge of how affected tissue deviates from normal control tissue is an integral part of fully understanding a neurological or psychiatric disorder. The purpose of this protocol is to establish a coordinating program with the pathology departments of the Washington, D.C. ...
RecruitingView Trial DetailsConditions:Bipolar Disorder
Clinical Trial of Leuprolide Acetate for the Treatment of PMS
This protocol is designed to accompany Clinical Protocol # 81-M-0126, The Phenomenology and Biophysiology of Menstrually-Related Mood and Behavioral Disorders. Its original purposes were as follows: 1) to evaluate the efficacy of the gonadotropin releasing hormone (GnRH) ...
RecruitingView Trial DetailsConditions:Depressive Disorder
Copper Histidine Therapy for Menkes Diseases
Menkes disease is an X-linked recessive neurodegenerative disorder caused by defects in a gene that encodes an evolutionarily conserved copper-transporting ATPase (ATP7A). Several issues must be addressed in configuring therapeutic strategies for this disorder: (a) affecte...
RecruitingView Trial DetailsConditions:Kinky Hair Syndrome
Study and Treatment of Inflammatory Muscle Diseases
Polymyositis, dermatomyositis and related disorders, also known as the idiopathic inflammatory myopathies (IIM), are an uncommon, heterogenous group of diseases. This is an omnibus protocol designed to continue our description of this rare group of diseases, further deline...
RecruitingView Trial DetailsConditions:Autoimmune Disease
Diagnosing and Treating Low Blood Sugar Levels
The purpose of this protocol is to continue our studies of the evaluation and treatment of patients with fasting hypoglycemia due to diverse etiologies. Patients will be admitted to the Clinical Research Center under this protocol and undergo supervised fasting, dynamic te...
RecruitingView Trial DetailsConditions:Hypoglycemia
Ovarian Follicle Function in Patients With Premature Ovarian Failure
No proven therapy to restore ovarian function and fertility is available to patients with karyotypically normal spontaneous premature ovarian failure. We know that one-half of these patients have primordial follicles remaining in the ovary, and these follicles can function ...
RecruitingView Trial DetailsConditions:Amenorrhea
Studies of Elevated Parathyroid Activity
Patients with confirmed or suspected primary hyperparathyroidism or complications therefrom (such as postoperative hypoparathyroidism) will be admitted for diagnosis and treatment. Patients with moderately severe primary hyperparathyroidism will be treated. The principal d...
RecruitingView Trial DetailsConditions:Hyperparathyroidism
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