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GST Primary GST Primary Best Strategies for Health Care Quality Im... Best Strategies for Health Care Quality Improvement - Diabetes Quality Improvement Strategies for Antibio... Kathryn McDonald, Stanford-UCSF Evidence-b... Systematic review assessing the effect of ... Quality Improvement Strategies for Antibiotics Management Kathryn McDonald, Stanford-UCSF Evidence-based Practice Center, 117 Encina Commons, Stanford, CA 94305-6019, Kathy.mcdonald@stanford.edu Systematic review assessing the effect of quality improvement strategies on appropriate prescribing of antibiotics and appropriate choice of antibiotics. Adherence Adherence Assistive Devices Assistive Devices Childhood Burn Hanson MacMillan Childhood Burn Hanson MacMillan CLSA_9 CLSA_9 Cyberabuse Cyberabuse Cognitive Behavioural Therapy for Violent ... This review included randomized trials abo... Cognitive Behavioural Therapy for Violent Men who Batter Their Partners This review included randomized trials about the effects of cognitive behavioral therapy on domestic violence. The intervention included programs based on the Duluth Model. The violence had to be committed by a male toward his female partner. The violence also had to be physical. The primary outcomes were new arrests and convictions, and new reports of violence. CABG vs PCI CABG vs PCI Quality Improvement Strategies for Prevent... Quality Improvement Strategies for Preventing Nosocomial Infections (Created 17-Feb-06) Quality Improvement Strategies for Asthma ... Quality Improvement Strategies for Asthma Control Erectile Dysfunction (Created 30-Jan-06) Erectile Dysfunction (Created 30-Jan-06) Inequality - Smoking Cessation to Reduce S... This review was the first part of a projec... Inequality - Smoking Cessation to Reduce Socio-Economic Differences This review was the first part of a project about inequality. It included randomized trials about the effect of smoking cessation interventions on reducing socio-economic differences. The studies had to report data either on persons with low socio-economic groups status or, preferably, on both low and high socio-economic groups. Diet and Physical Activity to Reduce Socio... This review was the second part in a proje... Diet and Physical Activity to Reduce Socio-Economic Differences This review was the second part in a project about inequality. It included randomized trials about the effect of interventions on reducing socio-economic differences in diet and physical activity. The studies had to report data either on persons with low socio-economic groups status or, preferably, on both low and high socio-economic groups. Workfare The data in SRS are not identical to the d... Workfare The data in SRS are not identical to the data in the published report. We used SRS only for an updated search. The review included randomized trials about the effect of welfare-to-work programs. Participants were welfare recipients. There were basically two types of programs. The educational type tried to build knowledge and skills in order to help the welfare recipients acquire jobs that could support them economically. The "work first" approach was more aimed at getting the participants quickly into a job. Exercise interventions for the management ... The objective of this systematic review wa... Exercise interventions for the management of frailty The objective of this systematic review was to examine the effectiveness of current exercise interventions on the management of frailty. A comprehensive search of Medline, Embase, Psycinfo, Cinahl, Scopus, Ageline, Eric, and SportDiscus databases was conducted and produced 1808 citations. So far we have completed 2 levels of “title and abstract” screening and we ended up with 262 articles. We have just started the full text screening. Eligibility criteria included original studies whose participants were identified as frail or prefrail with specific criteria and in which structured physical activity was included as at least one component of the intervention. Create a free account, build a dictionary with saved terms to re-use later! Public Domestic Violence - Using Cognitive Behavior Therapy Smoking Cessation to Reduce Socio-Economic Differences Diet and Physical Activity to Reduce Socio-Economic Differences Workfare Exercise Interventions for the Management of Frailty Search     Simple Advanced Refine (4 coded questions)  Any of these:   Exact Phrase: All of these: None of these: Author: Periodical: Projects: No restrictions   Libraries: Public   Select SRS Projects Show Saved Terms Select Library Show articles that do not have abstracts  Humans or Animals Humans Animals Type of Article Clinical Trial Editorial Letter Meta-Analysis Practice Guideline Randomized Controlled Trial Review Addresses Bibliography Biography Case Reports Classical Article Clinical Conference Clinical Trial, Phase I Clinical Trial, Phase II Clinical Trial, Phase III Clinical Trial, Phase IV Comment Comparative Study Consensus Development Conference Consensus Development Conference, NIH Controlled Clinical Trial Corrected and Republished Article Dictionary Directory Duplicate Publication English Abstract Evaluation Studies Festschrift Government Publications Guideline Historical Article Interview In Vitro Journal Article Lectures Legal Cases Legislation Multicenter Study News Newspaper Article Overall Patient Education Handout Periodical Index Published Erratum Retracted Publication Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. 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Retraction of Publication Scientific Integrity Review Support of Research Technical Report Twin Study Validation Studies Not a Primary Study or Review Unknown Primary Study Case Series Case Control Cohort Study Observational Study Qualitative Research CBA or ITS Registry Double Blind Controlled before after study Quasi-randomized trial Simple before after study Cluster-RCT Non-Randomized Study Report Book Book chapter Dissertation Conference procedings Secondary Research Not RCT Ages All Infant: birth-23 months All Child: 0-18 years All Adult: 19+ years Newborn: birth-1 month Infant: 1-23 months Preschool Child: 2-5 years Child: 6-12 years Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Middle Aged + Aged: 45+ years Aged: 65+ years 80 and over: 80+ years Undetermined Language English French German Italian Japanese Russian Spanish Afrikaans Albanian Unknown Arabic Armenian Azerbaijani Bosnian Bulgarian Catalan Chinese Croatian Czech Danish Dutch Esperanto Estonian Finnish Georgian Greek, Modern Hebrew Hindi Hungarian Icelandic Indonesian Kinyarwanda Korean Latin Latvian Lithuanian Macedonian Malay Malayalam Maori Multiple Languages Norwegian Persian Polish Portuguese Pushto Romanian Sanskrit Scottish gaelic Serbian Slovak Slovenian Swedish Thai Turkish Ukrainian Vietnamese Not English Not French Results(1-25 of 193) Sort By: Publication Date Relevance Took: 0.935 seconds to search 17,750,454  Action: Copy Results to new Clipboard Build Search Link Page 1 of 8 1 2 3 4 > Last >> (193 articles found) Isoluminant stimuli and red background attenuate the effects of transient spatial attention on temporal resolution. Jun 2004 Yaffa Yeshurun The effects of transient spatial attention on temporal resolution were recently studied and compared with attentional effects on spatial resolution. It was found that in contrast to the attentional enhancement of spatial resolution, transient attention impairs temporal resolution. To account for th... ( view more )ese findings a novel attentional mechanism was suggested. This attentional mechanism facilitates parvocellular neurons at the attended location, which in turn inhibit the activity of magnocellular neurons at the same location [Yeshurun & Levy, Psychol. Sci. 14 (3) (2003a) 225]. The goal of the present study was to replicate the attentional decrement in temporal resolution (Experiment 1), and perform direct tests of this 'parvo facilitation-magno inhibition' hypothesis. The employment of isoluminant stimuli (Experiments 2a and 2b) or a red background (Experiment 3) ensured that the parvo system was the main system mediating performance. Consequently, any parvo-magno inhibitory processes elicited by the attentional mechanism should only have a minor effect on performance. As predicted, these manipulations either significantly attenuated or completely eliminated the attentional decrement in temporal resolution. These findings provide direct support to the hypothesis that attention favors parvocellular over magnocellular neurons. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles On the flexibility of sustained attention and its effects on a texture segmentation task. Jan 2008 Yaffa Yeshurun,Barbara Montagna,Marisa Carrasco Previously we have shown that transient attention--the more automatic, stimulus-driven component of spatial attention--enhances spatial resolution. Specifically, transient attention improves texture segmentation at the periphery, where spatial resolution is too low, but impairs performance at centr... ( view more )al locations, where spatial resolution is already too high for the task. In the present study we investigated whether sustained attention--the more controlled component of spatial attention-can also affect texture segmentation, and if so whether its effect will be similar to that of transient attention. To that end we combined central, symbolic cues with texture displays in which the target appears at several eccentricities. We found that sustained attention can also affect texture segmentation, but unlike transient attention, sustained attention improved performance at all eccentricities. Comparing the effect of pre-cues and post-cues indicated that the benefit brought about by sustained attention is significantly greater than the effect of location uncertainty reduction. These findings indicate that sustained attention is a more flexible mechanism that can optimize performance at all eccentricities in a task where performance is constrained by spatial resolution. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles The effects of transient attention on spatial resolution and the size of the attentional cue. Jan 2008 Yaffa Yeshurun,Marisa Carrasco It has been shown that transient attention enhances spatial resolution, but is the effect of transient attention on spatial resolution modulated by the size of the attentional cue? Would a gradual increase in the size of the cue lead to a gradual decrement in spatial resolution? To test these hypot... ( view more )heses, we used a texture segmentation task in which performance depends on spatial resolution, and systematically manipulated the size of the attentional cue: A bar of different lengths (Experiment 1) or a frame of different sizes (Experiments 2-3) indicated the target region in a texture segmentation display. Observers indicated whether a target patch region (oriented line elements in a background of an orthogonal orientation), appearing at a range of eccentricities, was present in the first or the second interval. We replicated the attentional enhancement of spatial resolution found with small cues; attention improved performance at peripheral locations but impaired performance at central locations. However, there was no evidence of gradual resolution decrement with large cues. Transient attention enhanced spatial resolution at the attended location when it was attracted to that location by a small cue but did not affect resolution when it was attracted by a large cue. These results indicate that transient attention cannot adapt its operation on spatial resolution on the basis of the size of the attentional cue. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Predicting visual search performance by quantifying stimuli similarities. 2008 Tamar Avraham,Yaffa Yeshurun,Michael Lindenbaum The effect of distractor homogeneity and target-distractor similarity on visual search was previously explored under two models designed for computer vision. We extend these models here to account for internal noise and to evaluate their ability to predict human performance. In four experiments, ob... ( view more )servers searched for a horizontal target among distractors of different orientation (orientation search; Experiments 1 and 2) or a gray target among distractors of different color (color search; Experiments 3 and 4). Distractor homogeneity and target-distractor similarity were systematically manipulated. We then tested our models' ability to predict the search performance of human observers. Our models' predictions were closer to human performance than those of other prominent quantitative models. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Antifungal prophylaxis in cancer patients after chemotherapy or hematopoietic stem-cell transplantation: systematic review and meta-analysis. Dec 1, 2007 Eyal Robenshtok,Anat Gafter-Gvili,Elad Goldberg,Miriam Weinberger,Moshe Yeshurun,Leonard Leibovici,Mical Paul PURPOSE: To evaluate the effect of antifungal prophylaxis on all-cause mortality as primary outcome, invasive fungal infections (IFIs), and adverse events. Many studies have evaluated the role of antifungal prophylaxis in cancer patients, with inconsistent conclusions. METHODS: We performed a syste... ( view more )matic review and meta-analysis of randomized, controlled trials comparing systemic antifungals with placebo, no intervention, or other antifungal agents for prophylaxis in cancer patients after chemotherapy. The Cochrane Library, MEDLINE, conference proceedings, and references were searched. Two reviewers independently appraised the quality of trials and extracted data. RESULTS: Sixty-four trials met inclusion criteria. Antifungal prophylaxis decreased all-cause mortality significantly at end of follow-up compared with placebo, no treatment, or nonsystemic antifungals (relative risk [RR], 0.84; 95% CI, 0.74 to 0.95). In allogeneic hematopoietic stem-cell transplantation (HSCT) recipients, prophylaxis reduced all-cause mortality (RR, 0.62; 95% CI, 0.45 to 0.85), fungal-related mortality, and documented IFI. In acute leukemia patients, there was a significant reduction in fungal-related mortality and documented IFI, whereas the difference in mortality was only borderline significant (RR, 0.88; 95% CI, 0.74 to 1.06). Prophylaxis with itraconazole suspension reduced documented IFI when compared with fluconazole, with no difference in survival, and at the cost of more adverse events. On the basis of two studies, posaconazole prophylaxis reduced all-cause mortality (RR, 0.74; 95% CI, 0.56 to 0.98), fungal-related mortality, and IFI when compared with fluconazole. CONCLUSION: Antifungal prophylaxis decreases all-cause mortality significantly in patients after chemotherapy. Antifungal prophylaxis should be administered to patients undergoing allogeneic HSCT, and should probably be administered to high-risk acute leukemia patients. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Modern hunting behavior in the early Middle Paleolithic: faunal remains from Misliya Cave, Mount Carmel, Israel. Dec 2007 Reuven Yeshurun,Guy Bar-Oz,Mina Weinstein-Evron Understanding the behavioral adaptations and subsistence strategies of Middle Paleolithic humans is critical in the debate over the evolution and manifestations of modern human behavior. The study of faunal remains plays a central role in this context. Until now, the majority of Levantine archaeofa... ( view more )unal evidence was derived from late Middle Paleolithic sites. The discovery of faunal remains from Misliya Cave, Mount Carmel, Israel (>200 ka), allowed for detailed taphonomic and zooarchaeological analyses of these early Middle Paleolithic remains. The Misliya Cave faunal assemblage is overwhelmingly dominated by ungulate taxa. The most common prey species is the Mesopotamian fallow deer (Dama mesopotamica), followed closely by the mountain gazelle (Gazella gazella). Some aurochs (Bos primigenius) remains are also present. Small-game species are rare. The fallow deer mortality pattern is dominated by prime-aged individuals. A multivariate taphonomic analysis demonstrates (1) that the assemblage was created solely by humans occupying the cave and was primarily modified by their food-processing activities; and (2) that gazelle carcasses were transported complete to the site, while fallow deer carcasses underwent some field butchery. The new zooarchaeological data from Misliya Cave, particularly the abundance of meat-bearing limb bones displaying filleting cut marks and the acquisition of prime-age prey, demonstrate that early Middle Paleolithic people possessed developed hunting capabilities. Thus, modern large-game hunting, carcass transport, and meat-processing behaviors were already established in the Levant in the early Middle Paleolithic, more than 200 ka ago. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Nap and melatonin-induced changes in hippocampal activation and their role in verbal memory consolidation. Nov 2007 Tali Gorfine,Yaara Yeshurun,Nava Zisapel Overnight sleep contributes to memory consolidation; even a short nap improves memory performance. Such improvement has been linked to hippocampal activity during sleep. Melatonin has been shown to affect the human hippocampus and to induce 'sleep like' changes in brain activation. We therefore con... ( view more )ducted and compared two functional magnetic resonance imaging studies: the first study assessed the effect of a 2-hr mid-day nap versus an equal amount of wakefulness on a verbal memory task (unrelated word pair association); the second assessed the effect of melatonin versus placebo (both conditions without nap) on a similar task. We report that following a nap relative to wakefulness, successful retrieval-related activation in the parahippocampus is decreased. A smaller decrease is seen in wakefulness with melatonin but not placebo. In parallel, an improvement in verbal memory recall was found after a nap compared with wakefulness but not with melatonin during wakefulness compared with placebo. Our findings demonstrate effects of melatonin that resemble those of sleep on verbal memory processing in the hippocampus thus suggesting that melatonin, like sleep, can initiate offline plastic changes underlying memory consolidation; they also suggest that concomitant rest without interferences is necessary for enhanced performance. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Enhanced category tuning revealed by intracranial electroencephalograms in high-order human visual areas. Jun 6, 2007 Eran Privman,Yuval Nir,Uri Kramer,Svetlana Kipervasser,Fani Andelman,Miri Y Neufeld,Roy Mukamel,Yehezkel Yeshurun,Itzhak Fried,Rafael Malach The functional organization of human sensory cortex was studied by comparing intracranial EEG (iEEG) recordings of local field potentials in neurosurgical patients with functional magnetic resonance imaging (fMRI) obtained in healthy subjects. Using naturalistic movie stimuli, we found a tight corr... ( view more )elation between these two measures throughout the human sensory cortex. Importantly, the correlation between the iEEG and fMRI signals was site-specific, exhibiting neuroanatomically specific coupling. In several cortical sites the iEEG activity was confined strictly to one object category. This site selectivity was not limited to faces but included other object categories such as houses and tools. The selectivity of the iEEG signals to images of different object categories was remarkably higher when compared with the selectivity of the corresponding fMRI signals. A plausible interpretation of the fMRI and iEEG results concerns cortical organization in which object categories are organized in a mosaic of narrowly tuned object-selective clusters. ( view less ) View Full Abstract View Article Details   Related Articles Dynamic order-to-metastable-disorder vortex matter transition in Bi2Sr2CaCu2O8+delta. Mar 9, 2007 B Kalisky,Y Myasoedov,A Shaulov,T Tamegai,E Zeldov,Y Yeshurun Magneto-optical measurements of transient vortex states in Bi2Sr2CaCu2O8+delta show enhanced effects of metastability in prism-shaped as compared to platelet crystals including a significant shift of the second magnetization peak and qualitatively different dynamics. In contrast to platelets, where... ( view more ) dislocations are generated only at the sample edges, we propose that in prism samples the dislocations are generated dynamically in the entire sample due to distributed surface barriers. As a result, a dynamic phase transition from a Bragg glass to a metastable disordered phase may occur well below the thermodynamic transition field. ( view less ) View Full Abstract View Article Details   Related Articles Automatic, stimulus-driven attentional capture by objecthood. Feb 2007 Ruth Kimchi,Yaffa Yeshurun,Aliza Cohen-Savransky In three experiments, we investigated whether the mere organization of some elements in the visual field by Gestalt factors into a coherent unit (an object), with no abrupt onset or any other unique transient, could attract attention automatically. Participants viewed a display of nine red and gree... ( view more )n elements, one of which was the target, and had to identify the target's color. On some trials, a subset of the elements was grouped by Gestalt factors (collinearity, closure, and symmetry) into an object. The object was task-irrelevant and unpredictive of the target. Performance on trials with an object present in the display was faster than performance on trials with no object for targets in the object area (a benefit) but slower for targets in a nonobject area (a cost). These findings demonstrate that an object by itself can capture attention automatically in a stimulus-driven manner, much as exogenous cues can. ( view less ) View Full Abstract View Article Details   Related Articles Spatiotemporal vortex matter oscillations in Bi2Sr2CaCu2O8+delta crystals. Jan 5, 2007 B Kalisky,M Gitterman,B Ya Shapiro,I Shapiro,A Shaulov,T Tamegai,Y Yeshurun We observed an oscillatory behavior, both in space and time, of the induction in Bi2Sr2CaCu2O8+delta crystals exposed to a steady magnetic field. This new "flux waves" phenomenon appears near the order-disorder vortex phase transition, under specific conditions of temperature and induction gradient... ( view more ). A theoretical description of this effect is based on two coupled equations: the Landau-Khalatnikov dynamic equation for the order parameter of the vortex phase transition and the diffusion equation for the time evolution of the magnetic induction. A linear stability analysis of these equations predicts an oscillatory instability characterized by a period and wavelength in accordance with the experimental results. ( view less ) View Full Abstract View Article Details   Related Articles Combined increased and decreased skeletal uptake of F-18 FDG. Sep 2006 Elinor Goshen,Tima Davidson,Moshe Yeshurun,S Tzila Zwas Increased uptake of F-18 FDG is the general mainstay of diagnosis, because it indicates hypermetabolic foci of pathology. This case, describing a patient with relapsing lymphoma, represents the diagnostic dilemmas of both locally decreased and diffusely increased uptake in the skeleton. View Full Abstract View Article Details   Related Articles Flux-flow resistivity anisotropy in the instability regime of the a-b plane of epitaxial superconducting YBa2Cu3O7-delta thin films. Aug 11, 2006 B Kalisky,P Aronov,G Koren,A Shaulov,Y Yeshurun,R P Huebener Measurements of the nonlinear flux-flow resistivity rho and the critical vortex velocity vphi* at high voltage bias close to the instability regime predicted by Larkin and Ovchinnikov (Z. Eksp. Teor. Fiz 68, 1915 (1975) [Sov. Phys. JETP 41, 960 (1976)]) are reported along the node and antinode dire... ( view more )ctions of the d-wave order parameter in the a-b plane of epitaxial YBa2Cu3O7-delta films. In this pinning-free regime, rho and vphi* are found to be anisotropic with values in the node direction larger on average by 10% than in the antinode direction. The anisotropy of rho is almost independent of temperature and field. We attribute the observed results to the anisotropic quasiparticle distribution on the Fermi surface of YBa2Cu3O7-delta. ( view less ) View Full Abstract View Article Details   Related Articles Sleep-anticipating effects of melatonin in the human brain. May 15, 2006 Tali Gorfine,Yaniv Assaf,Yonatan Goshen-Gottstein,Yaara Yeshurun,Nava Zisapel Melatonin, the hormone produced nocturnally by the pineal gland, is an endogenous regulator of the sleep-wake cycle. The effects of melatonin on brain activities and their relation to induction of sleepiness were studied in a randomized, double-blind, placebo controlled functional magnetic resonanc... ( view more )e imaging (fMRI) study. Melatonin, but not placebo, reduced task-related activity in the rostro-medial aspect of the occipital cortex during a visual-search task and in the auditory cortex during a music task. These effects correlated with subjective measurements of fatigue. In addition, melatonin enhanced the activation in the left parahippocampus in an autobiographic memory task. Results demonstrate that melatonin modulates brain activity in a manner resembling actual sleep although subjects are fully awake. Furthermore, the fatigue inducing effect of melatonin on brain activity is essentially different from that of sleep deprivation thus revealing differences between fatigues related to the circadian sleep regulation as opposed to increased homeostatic sleep need. Our findings highlight the role of melatonin in priming sleep-associated brain activation patterns in anticipation of sleep. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Widespread functional connectivity and fMRI fluctuations in human visual cortex in the absence of visual stimulation. May 1, 2006 Yuval Nir,Uri Hasson,Ifat Levy,Yehezkel Yeshurun,Rafael Malach To what extent does the visual system's activity fluctuate when no sensory stimulation is present? Here, we studied this issue by examining spontaneous fluctuations in BOLD signal in the human visual system, while subjects were placed in complete darkness. Our results reveal widespread slow fluctua... ( view more )tions during such rest periods. In contrast to stimulus-driven activity, during darkness, functionally distinct object areas were fluctuating in unison. These fMRI fluctuations became rapidly spatially de-correlated (39% drop in correlation level, P < 0.008) during visual stimulation. Functional connectivity analysis revealed that the slow spontaneous fluctuations during rest had consistent and specific neuro-anatomical distribution which argued against purely hemodynamic noise sources. Control experiments ruled out eye closure, low luminance and mental imagery as the underlying sources of the spontaneous fluctuations. These results demonstrate that, when no stimulus is present, sensory systems manifest a robust level of slow organized fluctuation patterns. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Allogeneic hematopoietic stem-cell transplantation in AML and MDS using myeloablative versus reduced-intensity conditioning: the role of dose intensity. Feb 2006 A Shimoni,I Hardan,N Shem-Tov,M Yeshurun,R Yerushalmi,A Avigdor,I Ben-Bassat,A Nagler Allogeneic stem-cell transplantation (SCT) with both myeloablative and reduced-intensity conditioning (RIC) is an effective therapy in AML/MDS. However, the relative merits of each may differ in different settings. To define the role of dose intensity, we analyzed SCT outcomes of 112 consecutive pa... ( view more )tients with AML/MDS. A total of 45 patients met eligibility criteria for standard myeloablative conditioning and were given intravenous-busulfan (12.8 mg/kg) and cyclophosphamide (ivBuCy). A total of 67 noneligible patients were given RIC with fludarabine and intravenous-busulfan (6.4 mg/kg, FB2, n=41) or a modified myeloablative regimen with fludarabine and myeloablative doses of intravenous-busulfan (12.8 mg/kg, FB4, n=26). The overall survival (OS) at 2 years was 50, 49 and 47% after ivBuCy, FB4 and FB2, respectively (P=NS). Nonrelapse mortality was higher after ivBuCy, 22 vs 8% (P=0.05), but relapse rates were lower. Active disease at SCT was the most significant predictor of reduced survival in multivariable analysis (HR 4.5, P=0.0001). Myeloablative and RIC regimens had similar outcomes when leukemia was in remission at SCT; however, patients with active disease could only be salvaged by myeloablative conditioning. Among the latter, OS was 45% after ivBuCy but no FB2 recipient survived (P=0.02). Patients with active disease, ineligible for standard myeloablation, could tolerate modified myeloablation well; however, long-term outcome cannot be determined yet. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Arthrodesis of the tarsometatarsal joint, using type II ESF with acrylic connecting bars in four dogs. 2006 J Shanil,Y Yeshurun,R Shahar Hyperextension injury of the tarsometatarsal joint (TMTJ) is a debilitating injury and arthrodesis of this joint is often the only procedure that can result in full return to function. Most surgical procedures described for arthrodesis of the tarsometatarsal joint necessitate the use of external, s... ( view more )plint or cast, to protect the implants used from fatigue failure. This report describes the successful use of type II external fixator that spans the tarsometatarsal joint in four dogs with hyperextension injury of the tarsometatarsal joint. This technique enables the patient to bear weight on the limb immediately after surgery until bony fusion is achieved, without the need for an additional protecting splint. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles A 10-year median follow-up study after allogeneic stem cell transplantation for chronic myeloid leukemia in chronic phase from HLA-identical sibling donors. Sep 2005 M Robin,P Guardiola,A Devergie,M Yeshurun,S Shapiro,H Esperou,P Ribaud,V Rocha,E Gluckman,G Socié We report long-term outcome in 102 patients with cCML transplanted from an HLA-identical sibling donor from 1982 to 1998. The conditioning regimen was based on cyclophosphamide associated with either total body irradiation (TBI) (37 patients) or with busulfan (63 patients). Graft-versus-host diseas... ( view more )e (GvHD) prophylaxis consisted of cyclosporin and methotrexate in the majority of the patients. Fifteen year overall survival was estimated at 53% (95% confidence interval (CI), 44-65) with a plateau after 2.5 years. Long-term survival was adversely affected by: longer time from chronic myeloid leukemia (CML) diagnosis to transplantation, older age at time of transplantation and GvHD (acute grade III-IV or chronic extensive). The main cause of death was infection, related to GvHD in 69% of patients. Splenectomy also significantly increased the risk of bacterial infection. 15-year relapse was estimated at 8% (95% CI, 0.1-14). Late malignancies occurred in seven patients, four of whom had an invasive cancer. Other frequent late complications included cataracts, psychological depression, osteonecrosis and hypothyroidism. These complications were more frequent following splenectomy, TBI and in patients with chronic extensive GvHD. We conclude that allogeneic transplantation with a related donor can cure more than half of CML patients in chronic phase, although physicians should be alert to long-term complications. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles The effect of infliximab on extraintestinal manifestations of Crohn's disease. Aug 2005 Ilana Kaufman,Dan Caspi,Dror Yeshurun,Iris Dotan,Michael Yaron,Ori Elkayam OBJECTIVE: The purpose of this open pilot study was to assess prospectively the effect of infliximab on extraintestinal manifestations in patients with active Crohn's disease refractory to conventional treatment. PATIENTS AND METHODS: Twenty-two consecutive patients with Crohn's disease and one wit... ( view more )h ulcerative colitis presenting at least one of the known extraintestinal manifestations of Crohn's disease participated in the study. All the patients had Crohn's disease activity index (CAI) scores above 2. Each patient received an intravenous infusion of infliximab at a dosage of 5 mg/kg. A thorough questionnaire was used reviewing the extraintestinal manifestations of Crohn's disease such as erythema nodosum, pyoderma gangrenosum, eye lesions, arthritis or arthralgia, sacroiliitis or inflammatory back pain, hepatic disease, hematologic manifestations (megaloblastic, iron deficiency or hemolytic anemia, thrombocytosis), thrombosis, and nephrolithiasis. Musculoskeletal complaints were evaluated using the parameters intensity of pain, duration of morning stiffness (in minutes), presence of inflammatory back pain, Schober's test of the lumbar region, chest expansion, and distance from occiput to wall. The clinical assessment was performed on the day of the infusion and 2 weeks later. RESULTS: Eleven out of 23 patients had arthralgia of inflammatory nature, three others had evidence of active synovitis on physical examination, and 11 reported inflammatory back pain. Four patients suffered from protracted pyoderma gangrenosum; three had resistant aphthous stomatitis. Eleven patients had more than one extraintestinal manifestation. All four with pyoderma gangrenosum demonstrated significant improvement of their ulcers after one course of infliximab, with complete resolution of the skin lesions in three of them after repeated infusions of infliximab. Aphthous stomatitis completely responded in all patients after a single infusion. Seven out of 11 patients with arthralgia and seven out of 11 with inflammatory back pain/sacroiliitis experienced benefit after treatment with infliximab and reported at least partial clinical improvement in duration of morning stiffness, tender joint count, and visual analogue scale for pain. Only one of three patients with frank arthritis demonstrated clear improvement, and two others failed to respond to infliximab treatment. CONCLUSION: These preliminary results are encouraging and suggest a promising role of infliximab in the treatment of extraintestinal symptoms of Crohn's disease. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Prevention of prescription errors by computerized, on-line surveillance of drug order entry. Jun 2005 Arie Oliven,Irena Michalake,Daniela Zalman,Evgenia Dorman,Dan Yeshurun,Majed Odeh AIMS: The present study was undertaken to quantify the impact of computerized drug order entry system (CDOE) connected to the patients' database, on the incidence and type of prescription errors (PEs) in the medical service, and to delineate the causes for remaining errors. METHODS: Drug orders wer... ( view more )e reviewed daily by a physician-reviewer, in a department of internal medicine that used for more than 3 years a CDOE (CDOEdept), and in a similar department in which drug orders were handwritten (HWdept). PEs were divided into those not related to the individual patient (type 1 PEs), and PEs resulting from drug-laboratory, drug-disease, and drug-allergy interactions (type 2 PEs). RESULTS: Ten thousand and two hospitalization days were evaluated. The incidence of type 1 PEs was 5.21 and 1.36 per 100 hospitalization days in the HWdept and CDOEdept, respectively (p<0.0001). Type 2 PEs were more common, 7.20 and 3.02 per 100 hospitalization days in the HWdept and CDOEdept, respectively (p<0.0001), and about 75% of them were due to few drug-laboratory interactions. Most of the remaining errors in the CDOEdept were due to inadequate adjustment of drugs and doses to renal function, or failure to perform adequate changes when new laboratory results became available. CONCLUSIONS: We conclude that linking the CDOE with few, specific, laboratory results has a large impact on the prevention of PEs. Combining the CDOE with a drug-laboratory alert system is expected to further reduce the incidence of PEs. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles [Eye cosmetics--the beauty and the beast] May 2005 Oren Blumenfeld,Nir Nathansohn,Itamar Yeshurun,Isaac Ashkenazi The use of eye cosmetics is a popular practice in modern times that dates back to ancient civilizations. This practice, however, is not without hazards. The most common adverse effect of eye cosmetics is eyelid dermatitis, although an array of other adverse effects has been reported. This article r... ( view more )eviews the different types of eye cosmetics in current use, their composition and the adverse effects of both commercial and traditional products. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Hematopoietic stem-cell transplantation from unrelated donors in elderly patients (age >55 years) with hematologic malignancies: older age is no longer a contraindication when using reduced intensity conditioning. Jan 2005 A Shimoni,N Kröger,T Zabelina,F Ayuk,I Hardan,M Yeshurun,N Shem-Tov,A Avigdor,I Ben-Bassat,A R Zander,A Nagler Allogeneic stem cell transplantation (SCT) is a potentially curative approach for patients with hematological malignancies. Reduced-intensity conditioning regimens allow SCT in elderly patients; however, there are only limited data on the feasibility and outcomes of unrelated donor SCT in these pat... ( view more )ients. In this study, we analyzed, retrospectively, data of 36 patients with various hematological malignancies and median age 58 years (range, 55-66), who were given unrelated donor SCT after reduced-intensity conditioning. The preparative regimen consisted of fludarabine combined with oral busulfan (8 mg/kg, n=8), intravenous busulfan (6.4 mg/kg, n=11), treosulfan (30 g/m(2), n=5) or melphalan (100-150 mg/m(2), n=12). Patients were also given serotherapy, ATG (n=32), or alemtuzumab (n=4). The probabilities of overall survival, disease-free survival, and nonrelapse mortality at 1 year after SCT were 52, 43, and 39%, respectively. Acute graft-versus-host disease (GVHD) grade II-IV and chronic GVHD occurred in 31 and 45%, respectively. Multivariable analysis determined that survival rates were higher in patients with chemosensitive disease (HR 4.5), and patients conditioned with intravenous busulfan or treosulfan (HR 3.9). Unrelated donor SCT is feasible in elderly patients, with outcomes that are similar to younger patients. Favorable outcome was observed in patients with myeloid malignancies, and those transplanted in remission and early in the course of disease. Age alone should not be considered a contraindication to unrelated donor SCT. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Modified sutureless sclerotomies for pars plana vitrectomy. Nov 2004 Itamar Yeshurun,Tali Rock,Elisha Bartov PURPOSE: To describe a modified technique for performing sutureless sclerotomies for pars plana vitrectomy and to examine its efficacy and safety. DESIGN: Retrospective, interventional case series. METHODS: Self-sealing sclerotomies were created in 35 consecutive cases by oblique penetration of the... ( view more ) sclera with a 19G MVR blade. RESULTS: All but two (2.9%) of the sclerotomies were watertight without suturing at the end of surgery. A conjunctival bleb was observed during the first postoperative week in one case, but it resolved without intervention. CONCLUSIONS: Construction of sutureless sclerotomies by this technique is simpler and more rapid compared with previously described techniques. The resulting sclerotomies are more resistant to stretching and tearing of the tunnel's roof, they rarely need suturing, and insertion of instruments is facilitated. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Detection of pseudoperiodic patterns using partial acquisition of magnetic resonance images. Nov 2004 Oren Boiman,Sharon Peled,Yehezkel Yeshurun Improving the resolution of magnetic resonance imaging (MRI), or, alternatively, reducing the acquisition time, can be quite beneficial for many applications. The main motivation of this work is the assumption that any information that is a priori available on the target image could be used to achi... ( view more )eve this goal. In order to demonstrate this approach, we present a novel partial acquisition strategy and reconstruction algorithm, suitable for the special case of detection of pseudoperiodic patterns. Pseudoperiodic patterns are frequently encountered in the cerebral cortex due to its columnar functional organization (best exemplified by orientation columns and ocular dominance columns of the visual cortex). We present a new MRI research methodology, in which we seek an activity pattern, and a pattern-specific experiment is devised to detect it. Such specialized experiments extend the limits of conventional MRI experiments by substantially reducing the scan time. Using the fact that pseudoperiodic patterns are localized in the Fourier domain, we present an optimality criterion for partial acquisition of the MR signal and a strategy for obtaining the optimal discrete Fourier transform (DFT) coefficients. A by-product of this strategy is an optimal linear extrapolation estimate. We also present a nonlinear spectral extrapolation algorithm, based on projections onto convex sets (POCSs), used to perform the actual reconstruction. The proposed strategy was tested and analyzed on simulated signals and in MRI phantom experiments. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles A long-term follow-up of 33 patients with non-Hodgkin's lymphoma who received the BEAM high-dose intensification regimen with cytokine support only and no transplant. Oct 2004 J Ph Laporte,M Yeshurun,L Fouillard,M Labopin,C Cailliot,S Lesage,F Isnard,A Najman,N-C Gorin High-dose intensification and autologous stem-cell transplantation (ASCT) is widely used to consolidate patients with non-Hodgkin's lymphoma (NHL), who have reached a stage of minimal residual disease. However, patients with persisting marrow and/or blood involvement and those who fail peripheral b... ( view more )lood hemopoietic progenitor mobilization are excluded from ASCT. For such patients with no available graft to infuse, we developed 15 years ago, before the anti-CD20 monoclonal antibody therapeutic era, the use of the BEAM pretransplant regimen followed only by the administration of three cytokines (erythropoietin, granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor). We report here on the long-term follow-up of 33 patients treated with this approach. In all, 33 NHL patients underwent the BEAM (carmustine, VP-16, cytosine-arabinoside, melphalan) followed by the administration of the three cytokines from January 1994-2000. A backup marrow, albeit infiltrated by tumor cells, had been collected earlier and stored in all. A total of 30 patients (91%) recovered normal hematopoiesis. In total, 32 patients (97%) recovered neutrophils (>500/microl) at a median of 19 days and 30 patients (91%) recovered platelets (>20,000/microl) at a median of 26 days. Age, richness of backup graft and blood-hemoglobin level at intensification had an impact on the time for hematopoietic recovery (P=0.014, P=0.014, P=0.048). The median follow-up was 62 months. Five patients died from toxicity related to the procedure. Eight patients relapsed and died. A total of 20 patients (61%) are alive, 16 (49%) in complete remission. A 5-year disease-free survival was 52+/-9%, relapse incidence 35+/-16%, mortality due to the procedure 12+/-12% and overall survival 61+/-10%. The BEAM regimen is not myeloablative. The BEAM+3CK procedure is a feasible therapeutic option that has shown efficacy in poor risk NHL patients who were not eligible for autografting because of persisting marrow/blood tumor contamination, or poor hemopoietic progenitor harvesting. It is unclear today whether some of these patients would have cleared their marrow/peripheral blood with the additional use of anti-CD20 treatment, thereby making the classical approach (BEAM followed by the infusion of a clean autograft) feasible. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Page 1 of 8 1 2 3 4 > Last >> (193 articles found)

      
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