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GST Primary GST Primary Best Strategies for Health Care Quality Im... Best Strategies for Health Care Quality Improvement - Diabetes Quality Improvement Strategies for Antibio... Kathryn McDonald, Stanford-UCSF Evidence-b... Systematic review assessing the effect of ... Quality Improvement Strategies for Antibiotics Management Kathryn McDonald, Stanford-UCSF Evidence-based Practice Center, 117 Encina Commons, Stanford, CA 94305-6019, Kathy.mcdonald@stanford.edu Systematic review assessing the effect of quality improvement strategies on appropriate prescribing of antibiotics and appropriate choice of antibiotics. Adherence Adherence Assistive Devices Assistive Devices Childhood Burn Hanson MacMillan Childhood Burn Hanson MacMillan CLSA_9 CLSA_9 Cyberabuse Cyberabuse Cognitive Behavioural Therapy for Violent ... This review included randomized trials abo... Cognitive Behavioural Therapy for Violent Men who Batter Their Partners This review included randomized trials about the effects of cognitive behavioral therapy on domestic violence. The intervention included programs based on the Duluth Model. The violence had to be committed by a male toward his female partner. The violence also had to be physical. The primary outcomes were new arrests and convictions, and new reports of violence. CABG vs PCI CABG vs PCI Quality Improvement Strategies for Prevent... Quality Improvement Strategies for Preventing Nosocomial Infections (Created 17-Feb-06) Quality Improvement Strategies for Asthma ... Quality Improvement Strategies for Asthma Control Erectile Dysfunction (Created 30-Jan-06) Erectile Dysfunction (Created 30-Jan-06) Inequality - Smoking Cessation to Reduce S... This review was the first part of a projec... Inequality - Smoking Cessation to Reduce Socio-Economic Differences This review was the first part of a project about inequality. It included randomized trials about the effect of smoking cessation interventions on reducing socio-economic differences. The studies had to report data either on persons with low socio-economic groups status or, preferably, on both low and high socio-economic groups. Diet and Physical Activity to Reduce Socio... This review was the second part in a proje... Diet and Physical Activity to Reduce Socio-Economic Differences This review was the second part in a project about inequality. It included randomized trials about the effect of interventions on reducing socio-economic differences in diet and physical activity. The studies had to report data either on persons with low socio-economic groups status or, preferably, on both low and high socio-economic groups. Workfare The data in SRS are not identical to the d... Workfare The data in SRS are not identical to the data in the published report. We used SRS only for an updated search. The review included randomized trials about the effect of welfare-to-work programs. Participants were welfare recipients. There were basically two types of programs. The educational type tried to build knowledge and skills in order to help the welfare recipients acquire jobs that could support them economically. The "work first" approach was more aimed at getting the participants quickly into a job. Exercise interventions for the management ... The objective of this systematic review wa... Exercise interventions for the management of frailty The objective of this systematic review was to examine the effectiveness of current exercise interventions on the management of frailty. A comprehensive search of Medline, Embase, Psycinfo, Cinahl, Scopus, Ageline, Eric, and SportDiscus databases was conducted and produced 1808 citations. So far we have completed 2 levels of “title and abstract” screening and we ended up with 262 articles. We have just started the full text screening. Eligibility criteria included original studies whose participants were identified as frail or prefrail with specific criteria and in which structured physical activity was included as at least one component of the intervention. Create a free account, build a dictionary with saved terms to re-use later! Public Domestic Violence - Using Cognitive Behavior Therapy Smoking Cessation to Reduce Socio-Economic Differences Diet and Physical Activity to Reduce Socio-Economic Differences Workfare Exercise Interventions for the Management of Frailty Search     Simple Advanced Refine (4 coded questions)  Any of these:   Exact Phrase: All of these: None of these: Author: Periodical: Projects: No restrictions   Libraries: Public   Select SRS Projects Show Saved Terms Select Library Show articles that do not have abstracts  Language English French German Italian Japanese Russian Spanish Afrikaans Albanian Unknown Arabic Armenian Azerbaijani Bosnian Bulgarian Catalan Chinese Croatian Czech Danish Dutch Esperanto Estonian Finnish Georgian Greek, Modern Hebrew Hindi Hungarian Icelandic Indonesian Kinyarwanda Korean Latin Latvian Lithuanian Macedonian Malay Malayalam Maori Multiple Languages Norwegian Persian Polish Portuguese Pushto Romanian Sanskrit Scottish gaelic Serbian Slovak Slovenian Swedish Thai Turkish Ukrainian Vietnamese Not English Not French Humans or Animals Humans Animals Type of Article Clinical Trial Editorial Letter Meta-Analysis Practice Guideline Randomized Controlled Trial Review Addresses Bibliography Biography Case Reports Classical Article Clinical Conference Clinical Trial, Phase I Clinical Trial, Phase II Clinical Trial, Phase III Clinical Trial, Phase IV Comment Comparative Study Consensus Development Conference Consensus Development Conference, NIH Controlled Clinical Trial Corrected and Republished Article Dictionary Directory Duplicate Publication English Abstract Evaluation Studies Festschrift Government Publications Guideline Historical Article Interview In Vitro Journal Article Lectures Legal Cases Legislation Multicenter Study News Newspaper Article Overall Patient Education Handout Periodical Index Published Erratum Retracted Publication Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. 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Retraction of Publication Scientific Integrity Review Support of Research Technical Report Twin Study Validation Studies Not a Primary Study or Review Unknown Primary Study Case Series Case Control Cohort Study Observational Study Qualitative Research CBA or ITS Registry Double Blind Controlled before after study Quasi-randomized trial Simple before after study Cluster-RCT Non-Randomized Study Report Book Book chapter Dissertation Conference procedings Secondary Research Not RCT Ages All Infant: birth-23 months All Child: 0-18 years All Adult: 19+ years Newborn: birth-1 month Infant: 1-23 months Preschool Child: 2-5 years Child: 6-12 years Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Middle Aged + Aged: 45+ years Aged: 65+ years 80 and over: 80+ years Undetermined Results(1-25 of 19,800) Sort By: Publication Date Relevance Took: 1.712 seconds to search 17,750,454  Action: Copy Results to new Clipboard Build Search Link Page 1 of 792 1 2 3 4 > Last >> (19800 articles found) [Syndrome differentiation through drug effects in mapping the two regulatory pathways of gene networks in Shen deficiency syndrome] Jun 2006 Zi-yin Shen,Yu Chen,Jian-hua Huang OBJECTIVE: To study the regulatory pathways and rules of the gene networks in Shen deficiency syndrome. METHODS: Tissues of hypothalamus, pituitary, adrenal, lymphocyte, bone, liver and kidney were taken as samples from 4 months' and 24 months' old SD rats and rats after treatment with Epimedium fl... ( view more )avonoids (EF), differences of gene expression profile in Shen deficiency syndrome were studied repeatedly with gene chip rat expression set U230 2.0 array from Affymetrix Co. RESULTS: Gene expressions in the aged rats all decreased including neurotransmitter of gamma-aminobutyric acid (gammaGABA), gonadotropin releasing hormone (GnRH), thyrotropin-releasing hormone (TRH), thyroid stimulating hormone (TSH), growth hormone-releasing hormone receptor (GHRH), insulin-like growth factor (IGF) and binding proteins (IGFBP) in hypothalamus, pituitary and adrenal (HPA axis), cell growth-related gene, growth factor related protein, and immune regulatory genes such as interferon gamma (IFN-gamma), interleukin 4 (IL-4) and interleukin 6 (IL-6) in lymphocytes, parathyroid hormone (PTH), calcitonin, procollagen, collagen, connective tissue growth factor in bone, and oxidative phosphorylation genes such as cytochrome P450 and NADH dehydrogenase, glutamate dehydrogenase related with protein metabolism, and glucose-6-phosphatase related with glucose metabolism in liver, most of which were up-regulated after treatment with EF as well as genes related with ageing and cell cycle, such as cyclin B, metabolism related genes and proteins of sodium and chloride channel in kidney. CONCLUSION: Dysfunction of the two regulatory pathways of gene networks as nerve-endocrine-immunity and nerve-endocrine-bone metabolism exists in Shen deficiency syndrome differentiated by effects of drugs, which could be improved by strengthening Shen therapy. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles [The "shen" reaction to trauma--an experimental study] Oct 1991 Y Shen,D Y Kuang,W R Zhang An experimental study using adult Kunming male mice was designed to observe the Shen reaction to trauma (bone fracture and burn). It was shown that the mice testes of the experimental groups were degenerated and the spermatogenesis disturbed. Under the electron microscope, the granules reduction, p... ( view more )yknosis, vesicular degeneration in the plasma of gonadotrophs and hemorrhage were found. It was revealed that the pathological changes of shen by trauma were mainly attacked on the adenohypophysis-gonadal axis. According to the results of this experimental study, the shen in the hypothesis of "trauma hurts shen" should be related to testes and ovaries (gonadal organs). ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Shen instrumentation for the management of unstable thoracolumbar fractures. Jun 15, 1998 D K Ruan,G B Shen,H X Chui STUDY DESIGN: A retrospective study was carried out using Shen instrumentation, which is a modified pedicle rod sleeve spinal system, to perform reduction and fusion in patients with unstable thoracolumbar fracture. OBJECTIVES: To demonstrate that the simple, locally made pedicle rod sleeve instrum... ( view more )entation is as effective as conventional systems in the management of thoracolumbar fractures. The current results are also compared with those reported in the literature. SUMMARY OF THE BACKGROUND DATA: Many instrumentations, such as Harrington, Luque, and Dick, have been used for the management of thoracolumbar fracture in the past 2 decades. Every device has its advantages and disadvantages based on clinical practice and the biomechanical mechanism of reduction. METHODS: Between January 1991 and December 1995, 96 consecutive patients who had experienced unstable thoracolumbar fractures were treated surgically with Shen instrumentation, which consists of four components: superior pedicle screws, distraction rods, sleeves, and inferior laminar hooks. Of these 96 patients, 76 were male and 20 were female (age range, 16-68 years; mean, 37 years). Thirty patients had partial paraplegia and 38 patients had complete paraplegia, according to the Frankel classification. Injury categories were as follows: 43 burst fractures, 26 flexion-compression fractures, 22 fracture-dislocation injuries, and 5 flexion-distraction injuries. RESULTS: The average follow-up was 39 months (range, 24-60 months). Kyphotic deformity was corrected from 27.1 degrees before surgery to 4.2 degrees after surgery, translation was reduced from 30.7% to 0%, height of compressed vertebral bodies was restored from 52.3% to 96.5% of the normal height. Computed tomographic evaluation showed that the cross-canal area was restored from 48.1% before to 70.9% after surgery. Improvement of neurologic function of more than one Frankel grade occurred in 90% of patients. CONCLUSION: Based on the understanding of biomechanics and the present clinical results, Shen instrumentation is as efficacious as conventional devices available today and may serve as a cost-effective option for thoracolumbar injuries, especially in a developing country. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles [Comparison of gene expression profiles between rats of Shen deficiency syndrome and Shen-yang deficiency syndrome differentiated according to therapeutic efficacy of drugs used] Feb 2007 Zi-Yin Shen,Jian-Hua Huang,Wei-Hua Chen OBJECTIVE: To explore similarity and difference of connotation between Shen deficiency syndrome (SDS) and Shen-yang deficiency syndrome (SYDS) on the molecular level. METHODS: The senescent SD rats and corticosterone-treated rats were adopted for models of SDS and SYDS respectively, their syndrome ... ( view more )was differentiated according to the therapeutic efficacy of treatment with epimedium flavonoids (EF). The gene expression profiles of hypothalamas, pituitary, adrenal gland and lymphocytes (HPAT axis) were detected before and after EF treatment using gene chip provided by Affymetrix company. RESULTS: As compared with the young rats, the ageing rats and corticosterone-treated rats showed a significant down-regulation in highly consistent pattern, of various neurotransmitters of HPAT axis firstly, followed with that of growth and sex hormone related genes. EF could reverse the above genes expression in both models, and for SYDS model rats, it could also significantly up-regulate the gene expressions of heat shock protein, cytochrome P450 and thyroid stimulating hormone (TSH). CONCLUSION: Both SDS and SYDS model rats show connotation of Shen deficiency, and the substantial base of Shen-yang deficiency syndrome resides in the process of oxidative phosphorylation of energy metabolism accelerated by thyroid hormone. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Redescription of Steinernema longicaudum Shen & Wang (Nematoda: Steinernematidae); geographic distribution and phenotypic variation between allopatric populations. Mar 2001 S P Stock,J Heng,D J Hunt,A P Reid,X Shen,H Y Choo Steinernema longicaudum Shen & Wang is redescribed based on a comparative morphological study of specimens from the type isolate from China, and two other isolates recovered from Korea and the USA. For the first and second generation female, the location of the vulva, shape of the vulval lips, and ... ( view more )shape and length of the tail were newly observed diagnostic characters. A more detailed description of the morphology of the male spicules and gubernaculum, and the arrangement of the genital papillae is included. A description, based on scanning electron microscopy observations, of the lateral field pattern of the third-stage infective juveniles is also provided. Additionally, restriction fragment length polymorphism profiles based on the internal transcribed spacer region, and cross-breeding tests supplement the description of this species. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles [Study on the regulative rule of reinforcing shen principle on sexual precocity and senescence at the molecular level] Jun 2005 Zi-yin Shen,De-pei Cai The imbalance of Shen-yin and Shen-yang is a common pathological basis of sexual precocity and senescence. Senescence can be regarded as physiological Shen-deficiency, which is mainly the deficiency of Shen-Yang, while the essence of sexual precocity is hyperactivity of Fire due to Yin-deficiency, ... ( view more )and deficiency of Shen-Yin is the predominance in the imbalance. The process of growth, development, maturing and aging led by Shen-qi, is mainly involving the hypothalamus-pituitary-growth hormone axis and sexual gland axis. Early initiation of these two axes appears in sexual premature children, manifesting syndrome of Fire hyperactivity due to Yin-deficiency, while in senescence, the decline of the axes appears ahead of time and manifests syndrome of Yang qi consumption. It has been shown in experimental and clinical researches that significantly good effects could be obtained by applying Chinese recipe for warmly reinforcing Shen-Yang to postpone senescence and recipe for nourishing Yin and removing Fire to inhibit sexual precocity. It also been proved by determining syndrome and speculating the damaged site according to the effects of drug that the pathologic damage of sexual precocity and senescence is sited on the hypothalamus or higher center. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Measurements of the cross section for e(+)e(-) --> hadrons at center-of-mass energies from 2 to 5 GeV. Mar 11, 2002 J Z Bai,Y Ban,J G Bian,A D Chen,H F Chen,H S Chen,J C Chen,X D Chen,Y B Chen,B S Cheng,S P Chi,Y P Chu,J B Choi,X Z Cui,Y S Dai,L Y Dong,Z Z Du,W Dunwoodie,H Y Fu,L P Fu,C S Gao,S D Gu,Y N Guo,Z J Guo,S W Han,Y Han,F A Harris,J He,J T He,K L He,M He,X He,T Hong,Y K Heng,G Y Hu,H M Hu,Q H Hu,T Hu,G S Huang,X P Huang,Y Z Huang,J M Izen,X B Ji,C H Jiang,Y Jin,B D Jones,J S Kang,Z J Ke,H J Kim,S K Kim,T Y Kim,D Kong,Y F Lai,D Li,H B Li,H H Li,J Li,J C Li,P Q Li,Q J Li,R Y Li,W Li,W G Li,X N Li,X Q Li,B Liu,F Liu,Feng Liu,H M Liu,J Liu,J P Liu,T R Liu,R G Liu,Y Liu,Z X Liu,X C Lou,G R Lu,F Lu,J G Lu,Z J Lu,X L Luo,E C Ma,J M Ma,R Malchow,H S Mao,Z P Mao,X C Meng,X H Mo,J Nie,Z D Nie,S L Olsen,D Paluselli,H Park,N D Qi,X R Qi,C D Qian,J F Qiu,Y K Que,G Rong,Y Y Shao,B W Shen,D L Shen,H Shen,X Y Shen,H Y Sheng,F Shi,H Z Shi,X F Song,J Y Suh,H S Sun,L F Sun,Y Z Sun,S Q Tang,W Toki,G L Tong,G S Varner,J Wang,J Z Wang,L Wang,L S Wang,P Wang,P L Wang,S M Wang,Y Y Wang,Z Y Wang,C L Wei,N Wu,D M Xi,X M Xia,X X Xie,G F Xu,Y Xu,S T Xue,W B Yan,W G Yan,C M Yang,C Y Yang,G A Yang,H X Yang,W Yang,X F Yang,M H Ye,S W Ye,Y X Ye,C S Yu,C X Yu,G W Yu,Y Yuan,B Y Zhang,C Zhang,C C Zhang,D H Zhang,H L Zhang,H Y Zhang,J Zhang,J W Zhang,L Zhang,L S Zhang,P Zhang,Q J Zhang,S Q Zhang,X Y Zhang,Y Y Zhang,Z P Zhang,D X Zhao,H W Zhao,Jiawei Zhao,J W Zhao,M Zhao,P P Zhao,W R Zhao,Y B Zhao,Z G Zhao,J P Zheng,L S Zheng,Z P Zheng,B Q Zhou,G M Zhou,L Zhou,K J Zhu,Q M Zhu,Y C Zhu,Y S Zhu,Z A Zhu,B A Zhuang,B S Zou,BES Collaboration We report values of R = sigma(e(+)e(-)-->hadrons)/sigma(e(+)e(-)-->mu(+)mu(-)) for 85 center-of-mass energies between 2 and 5 GeV measured with the upgraded Beijing Spectrometer at the Beijing Electron-Positron Collider. View Full Abstract View Article Details View Coded Data Related Articles Observation of Y(2175) in J/psi --> etaphif0 (980). Mar 14, 2008 M Ablikim,J Z Bai,Y Bai,Y Ban,X Cai,H F Chen,H S Chen,H X Chen,J C Chen,Jin Chen,X D Chen,Y B Chen,Y P Chu,Y S Dai,Z Y Deng,S X Du,J Fang,C D Fu,C S Gao,Y N Gao,S D Gu,Y T Gu,Y N Guo,Z J Guo,F A Harris,K L He,M He,Y K Heng,J Hou,H M Hu,T Hu,G S Huang,X T Huang,Y P Huang,X B Ji,X S Jiang,J B Jiao,D P Jin,S Jin,Y F Lai,H B Li,J Li,R Y Li,W D Li,W G Li,X L Li,X N Li,X Q Li,Y F Liang,H B Liao,B J Liu,C X Liu,Fang Liu,Feng Liu,H H Liu,H M Liu,J B Liu,J P Liu,H B Liu,J Liu,Q Liu,R G Liu,S Liu,Z A Liu,F Lu,G R Lu,J G Lu,C L Luo,F C Ma,H L Ma,L L Ma,Q M Ma,M Q A Malik,Z P Mao,X H Mo,J Nie,S L Olsen,R G Ping,N D Qi,H Qin,J F Qiu,G Rong,X D Ruan,L Y Shan,L Shang,C P Shen,D L Shen,X Y Shen,H Y Sheng,H S Sun,S S Sun,Y Z Sun,Z J Sun,X Tang,J P Tian,G L Tong,G S Varner,X Wan,L Wang,L L Wang,L S Wang,P Wang,P L Wang,W F Wang,Y F Wang,Z Wang,Z Y Wang,C L Wei,D H Wei,Y Weng,N Wu,X M Xia,X X Xie,G F Xu,X P Xu,Y Xu,M L Yan,H X Yang,M Yang,Y X Yang,M H Ye,Y X Ye,C X Yu,G W Yu,C Z Yuan,Y Yuan,S L Zang,Y Zeng,B X Zhang,B Y Zhang,C C Zhang,D H Zhang,H Q Zhang,H Y Zhang,J W Zhang,J Y Zhang,X Y Zhang,Y Y Zhang,Z X Zhang,Z P Zhang,D X Zhao,J W Zhao,M G Zhao,P P Zhao,Z G Zhao,H Q Zheng,J P Zheng,Z P Zheng,B Zhong L Zhou,K J Zhu,Q M Zhu,X W Zhu,Y C Zhu,Y S Zhu,Z A Zhu,Z L Zhu,B A Zhuang,B S Zou,BES Collaboration The decays of J/psi --> etaphif(0)(980)[eta --> gammagamma, phi --> K(+) K(-), f(0)(980) --> pi(+)pi(-)] are analyzed using a sample of 5.8 x 10(7) J/psi events collected with the BESII detector at the Beijing Electron-Positron Collider. A structure at around 2.18 GeV/c(2) with about 5 sigma signif... ( view more )icance is observed in the phif(0)(980) invariant mass spectrum. A fit with a Breit-Wigner function gives the peak mass and width of m = 2.186+/-0.010(stat)+/-0.006(syst) GeV/c(2) and Gamma = 0.065+/-0.023(stat)+/-0.017(syst) GeV/c(2), respectively, which are consistent with those of Y(2175), observed by the BABAR Collaboration in the initial-state radiation process e(+)e(-) --> gamma(ISR) phif(0)(980). The production branching ratio is determined to be Br(J/psi --> etaY(2175))Br(Y(2175)- -> phif(0)(980))Br(f(0)(980) --> pi(+)pi(-)) = [3.23+/-0.75(stat)+/-0.73(syst)] x 10(-4), assuming that the Y(2175) is a 1(--) state. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Measurement of psi2S radiative decays. Jul 6, 2007 M Ablikim,J Z Bai,Y Ban,X Cai,H F Chen,H S Chen,H X Chen,J C Chen,Jin Chen,Y B Chen,Y P Chu,Y S Dai,L Y Diao,Z Y Deng,Q F Dong,S X Du,J Fang,S S Fang,C D Fu,C S Gao,Y N Gao,S D Gu,Y T Gu,Y N Guo,Z J Guo,F A Harris,K L He,M He,Y K Heng,J Hou,H M Hu,J H Hu,T Hu,G S Huang,X T Huang,X B Ji,X S Jiang,X Y Jiang,J B Jiao,D P Jin,S Jin,Y F Lai,G Li,H B Li,J Li,R Y Li,S M Li,W D Li,W G Li,X L Li,X N Li,X Q Li,Y F Liang,H B Liao,B J Liu,C X Liu,F Liu,Fang Liu,H H Liu,H M Liu,J Liu,J B Liu,J P Liu,Jian Liu Q Liu,R G Liu,Z A Liu,Y C Lou,F Lu,G R Lu,J G Lu,C L Luo,F C Ma,H L Ma,L L Ma,Q M Ma,Z P Mao,X H Mo,J Nie,S L Olsen,R G Ping,N D Qi,H Qin,J F Qiu,Z Y Ren,G Rong,X D Ruan,L Y Shan,L Shang,C P Shen,D L Shen,X Y Shen,H Y Sheng,H S Sun,S S Sun,Y Z Sun,Z J Sun,X Tang,G L Tong,G S Varner,D Y Wang,L Wang,L L Wang,L S Wang,M Wang,P Wang,P L Wang,Y F Wang,Z Wang,Z Y Wang,Zheng Wang,C L Wei,D H Wei,Y Weng,N Wu,X M Xia,X X Xie,G F Xu,X P Xu,Y Xu,M L Yan,H X Yang,Y X Yang,M H Ye,Y X Ye,G W Yu,C Z Yuan,Y Yuan,S L Zang,Y Zeng,B X Zhang,B Y Zhang,C C Zhang,D H Zhang,H Q Zhang,H Y Zhang,J W Zhang,J Y Zhang,S H Zhang,X Y Zhang,Yiyun Zhang,Z X Zhang,Z P Zhang,D X Zhao,J W Zhao,M G Zhao,P P Zhao,W R Zhao,Z G Zhao,H Q Zheng,J P Zheng,Z P Zheng,L Zhou,K J Zhu,Q M Zhu,Y C Zhu,Y S Zhu,Z A Zhu,B A Zhuang,X A Zhuang,B S Zou,BES Collaboration Using 14 x 10(6) psi(2S) events accumulated at the BESII detector, we report first measurements of branching fractions or upper limits for psi(2S) decays into gammapp, gamma2(pi+pi-), gammaKS0K+pi-+c.c., gammaK+K-pi+pi-, gammaK*0K-pi++c.c., gammaK*0K*0, gammapi+pi-pp, gamma2(K+K-), gamma3(pi+pi-), ... ( view more )and gamma2(pi+pi-)K+K- with the invariant mass of hadrons below 2.9 GeV/c2. We also report branching fractions of psi(2S) decays into 2(pi+pi-)pi0, omegapi+pi-, omegaf2(1270), b1+/-pi-/+, and pi02(pi+pi-)K+K-. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Endoscope-assisted supraorbital keyhole approach for the resection of benign tumors of the sellar region. 2007 Xuesheng Zheng,Weiguo Liu,Xiaofeng Yang,Jiangbiao Gong,Fang Shen,Gang Shen,Hong Shen,Xiujue Zheng,Weiming Fu The objective of the study was to evaluate the effectiveness of the supraorbital "keyhole" approach with endoscope assistance in surgical treatment of benign tumors around the sellar region. Thirty-five patients, including 19 pituitary tumors, 11 craniopharyngiomas and five tuberculum sellae mening... ( view more )iomas, were enrolled in this study. The tumors were resected through an endoscope-assisted supraorbital keyhole approach via a small skin incision within the eyebrow. Complete removal of the sellar region tumors was achieved in all 35 cases by endoscope-assisted supraorbital keyhole approach. Mean length of hospital stay after surgery was 10.2 days (range 5 - 17). There was no patient with evidence of residual or recurrent tumor during the follow-up period. There was no infection, bleeding, further vision impairment, oculomotor nerve injury or other cranial nerve injury symptom owing to surgery. Though some patients suffered from insipidus, hyperprolactinemia, subcutaneous edema or other postoperative complications, they eventually recovered with or without drug administration. The supraorbital "keyhole" approach with endoscopic assistance in the surgical treatment of benign tumors around the sellar region is an ideal pattern. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Search for invisible decays of eta and eta' in J/psi --> phi eta and phi eta'. Nov 17, 2006 M Ablikim,J Z Bai,Y Ban,J G Bian,X Cai,H F Chen,H S Chen,H X Chen,J C Chen,Jin Chen,Y B Chen,S P Chi,Y P Chu,X Z Cui,Y S Dai,L Y Diao,Z Y Deng,Q F Dong,S X Du,J Fang,S S Fang,C D Fu,C S Gao,Y N Gao,S D Gu,Y T Gu,Y N Guo,Y Q Guo,Z J Guo,F A Harris,K L He,M He,Y K Heng,H M Hu,T Hu,G S Huang,X T Huang,X B Ji,X S Jiang,X Y Jiang,J B Jiao,D P Jin,S Jin,Yi Jin,Y F Lai,G Li,H B Li,H H Li,J Li,R Y Li,S M Li,W D Li,W G Li,X L Li,X N Li,X Q Li,Y L Li,Y F Liang,H B Liao,B J Liu,C X Liu,F Liu,Fang Liu,H H Liu,H M Liu,J Liu,J B Liu,J P Liu,Q Liu,R G Liu,Z A Liu,Y C Lou,F Lu,G R Lu,J G Lu,C L Luo,F C Ma,H L Ma,L L Ma,Q M Ma,X B Ma,Z P Mao,X H Mo,J Nie,S L Olsen,H P Peng,R G Ping,N D Qi,H Qin,J F Qiu,Z Y Ren,G Rong,L Y Shan,L Shang,C P Shen,D L Shen,X Y Shen,H Y Sheng,H S Sun,J F Sun,S S Sun,Y Z Sun,Z J Sun,Z Q Tan,X Tang,G L Tong,G S Varner,D Y Wang,L Wang,L L Wang,L S Wang,M Wang,P Wang,P L Wang,W F Wang,Y F Wang,Z Wang,Z Y Wang,Zhe Wang,Zheng Wang,C L Wei,D H Wei,N Wu,X M Xia,X X Xie,G F Xu,X P Xu,Y Xu,M L Yan,H X Yang,Y X Yang,M H Ye,Y X Ye,Z Y Yi,G W Yu,C Z Yuan,J M Yuan,Y Yuan,S L Zang,Y Zeng,Yu Zeng,B X Zhang,B Y Zhang,C C Zhang,D H Zhang,H Q Zhang,H Y Zhang,J W Zhang,J Y Zhang,S H Zhang,X M Zhang,X Y Zhang,Yiyun Zhang,Z P Zhang,D X Zhao,J W Zhao,M G Zhao,P P Zhao,W R Zhao,Z G Zhao,H Q Zheng,J P Zheng,Z P Zheng,L Zhou,N F Zhou,K J Zhu,Q M Zhu,Y C Zhu,Y S Zhu,Yingchun Zhu,Z A Zhu,B A Zhuang,X A Zhuang,B S Zou,BES Collaboration Using a data sample of 58 x 10(6) J/psi decays collected with the Beijing Spectrometer II detector at the Beijing Electron Positron Collider, searches for invisible decays of eta and eta' in J/psi to phi eta and phi eta' are performed. The phi signals, which are reconstructed in K+K- final states, ... ( view more )are used to tag the eta and eta' decays. No signals are found for the invisible decays of either eta or eta', and upper limits at the 90% confidence level are determined to be 1.65 x 10(-3) for the ratio B(eta-->invisible)/B(eta --> gamma gamma) and 6.69 x 10(-2) for B(eta' --> invisible)/B(eta' --> gammagamma). These are the first searches for eta and eta' decays into invisible final states. ( view less ) View Full Abstract View Article Details   Related Articles The study recurrent tuberculosis and exogenous reinfection, Shanghai, China. Nov 2006 Guomiao Shen,Zhen Xue,Xin Shen,Bin Sun,Xiaohong Gui,Mei Shen,Jian Mei,Qian Gao Of 52 patients with recurrent tuberculosis in Shanghai, People's Republic of China, 32 (61.5%) had isolates in which genotype patterns of Mycobacterium tuberculosis differed between first and second episodes. This result indicates that exogenous reinfection is common in an area with a high incidenc... ( view more )e of tuberculosis. ( view less ) View Full Abstract View Article Details   Related Articles Liver targeting and the delayed drug release of the nanoparticles of adriamycin polybutylcyanoacrylate in mice. Aug 5, 2006 Liang-fang Shen,Yang-de Zhang,Hai-ju Shen,Shan Zeng,Xin Wang,Cheng Wang,Yuan Le,Hong Shen BACKGROUND: Liver targeting drug delivery systems can improve the curative effects and relieve the cytotoxicity of the chemotherapy drugs in the treatment of liver diseases. Nanoparticles carrying therapeutic drugs are currently under hot investigation with great clinical significance. This study w... ( view more )as aimed to investigate the different tissue distribution of the adriamycin polybutylcyanoacrylate nanoparticle (ADM-PBCA-NP) in the mice body after an injection via lateral tail vein, and to study the liver targeting effects of ADM-PBCA-NP in different diameters on normal mice liver. METHODS: One hundred and eighty Kunming mice were randomly divided into 6 groups with 30 mice in each group (5 treatment groups of ADM-PBCA-NP in the different diameter ranges, non-conjugated free adriamycin injection was employed as the control group). A single dose of either conjugated or free adriamycin equaled 2 mg/kg of body weight was delivered via the tail vein. Five mice in each trail were sacrificed at 5, 15, 30 minutes, 1, 5 and 12 hours postinjection, respectively. The adriamycin concentrations in the respectively collected liver, kidney, spleen, heart, lung and plasma were demonstrated using a high performance liquid chromatography with fluorescence detector. RESULTS: Compared with the control group, adriamycin was hardly detected in the heart muscle of the treatment groups (P < 0.05). The nanoparticle-conjugated adriamycin was cleaned up quickly from the kidney tissue. The adriamycin concentrations of the mice liver and spleen in the experimental groups were significantly higher than that in the control group, except for the group with the nanoparticles diameters of (22.3 +/- 6.2) nm (P < 0.05). The ADM-PBCA-NP in (101.0 +/- 20.3) nm diameter had the highest liver distribution, and the second highest adriamycin distribution in liver was the group of (143.0 +/- 23.5) nm diameter (P < 0.05). Moreover, adriamycin was released slowly in the liver during the detection period in the experimental groups. ADM-PBCA-NP in (22.3 +/- 6.2) nm diameter was not distributed in the tissue of the liver, kidney, heart, spleen, and lung. CONCLUSIONS: ADM-PBCA-NP in 100 - 150 nm diameter range has the best liver targeting with a characteristic of slow medicine release. It also decreases the medicine distribution in the heart, kidney and lung. In the treatment of liver cancer, the polybutylcyanoacrylate nanoparticles system has a good liver targeting ability, which increases the anticancer activity and markedly decreases the toxicity of adriamycin. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Observation of a near-threshold enhancement in the omega(phi) mass spectrum from the doubly OZI-suppressed decay J/psi-->gamma(omega)phi. Apr 28, 2006 M Ablikim,J Z Bai,Y Ban,J G Bian,X Cai,H F Chen,H S Chen,H X Chen,J C Chen,Jin Chen,Y B Chen,S P Chi,Y P Chu,X Z Cui,Y S Dai,L Y Diao,Z Y Deng,Q F Dong,S X Du,J Fang,S S Fang,C D Fu,C S Gao,Y N Gao,S D Gu,Y T Gu,Y N Guo,Y Q Guo,Z J Guo,F A Harris,K L He,M He,Y K Heng,H M Hu,T Hu,G S Huang,X T Huang,X B Ji,X S Jiang,X Y Jiang,J B Jiao,D P Jin,S Jin,Yi Jin,Y F Lai,G Li,H B Li,H H Li,J Li,R Y Li,S M Li,W D Li,W G Li,X L Li,X N Li,X Q Li,Y L Li,Y F Liang,H B Liao,B J Liu,C X Liu,F Liu,Fang Liu,H H Liu,H M Liu,J Liu,J B Liu,J P Liu,Q Liu,R G Liu,Z A Liu,Y C Lou,F Lu,G R Lu,J G Lu,C L Luo,F C Ma,H L Ma,L L Ma,Q M Ma,X B Ma,Z P Mao,X H Mo,J Nie,S L Olsen,H P Peng,R G Ping,N D Qi,H Qin,J F Qiu,Z Y Ren,G Rong,L Y Shan,L Shang,C P Shen,D L Shen,X Y Shen,H Y Sheng,H S Sun,J F Sun,S S Sun,Y Z Sun,Z J Sun,Z Q Tan,X Tang,G L Tong,G S Varner,D Y Wang,L Wang,L L Wang,L S Wang,M Wang,P Wang,P L Wang,W F Wang,Y F Wang,Z Wang,Z Y Wang,Zhe Wang,Zheng Wang,C L Wei,D H Wei,N Wu,X M Xia,X X Xie,G F Xu,X P Xu,Y Xu,M L Yan,H X Yang,Y X Yang,M H Ye,Y X Ye,Z Y Yi,G W Yu,C Z Yuan,J M Yuan,Y Yuan,S L Zang,Y Zeng,Yu Zeng,B X Zhang,B Y Zhang,C C Zhang,D H Zhang,H Q Zhang,H Y Zhang,J W Zhang,J Y Zhang,S H Zhang,X M Zhang,X Y Zhang,Yiyun Zhang,Z P Zhang,D X Zhao,J W Zhao,M G Zhao,P P Zhao,W R Zhao,Z G Zhao,H Q Zheng,J P Zheng,Z P Zheng,L Zhou,N F Zhou,K J Zhu,Q M Zhu,Y C Zhu,Y S Zhu,Yingchun Zhu,Z A Zhu,B A Zhuang,X A Zhuang,B S Zou,BES Collaboration An enhancement near threshold is observed in the omega(phi) invariant mass spectrum from the doubly Okubo-Zweig-Iizuka-suppressed decays of J/psi-->gamma(omega)phi, based on a sample of 5.8 x 10(7) J/psi events collected with the BESII detector. A partial wave analysis shows that this enhancement f... ( view more )avors JP=0+, and its mass and width are M=1812(+19)(-26)(stat)+/-18(syst) MeV/c2 and Gamma=105+/-20(stat)+/-28(syst) MeV/c2. The product branching fraction is determined to be B(J/psi-->gammaX)B(X-->omega(phi))=[2.61+/-0.27(stat)+/-0.65(syst)]x10(-4). ( view less ) View Full Abstract View Article Details View Coded Data Related Articles [Primary drug-resistance is the main cause of drug-resistant tuberculosis] Feb 2006 Jian Mei,Zhen Xue,Xin Shen,Guo-miao Shen,Xiao-hong Gui,Mei Shen,Qian Gao OBJECTIVE: To investigate the main cause of drug-resistant tuberculosis. METHODS: Clinic isolates of Mycobacterium tuberculosis from 1996 to 2004 in Shanghai were analyzed and the proportion of isolates from new cases (the proxy of primary drug-resistance) and retreatment cases (the proxy of acquir... ( view more )ed drug-resistance) were calculated. Mycobacterial interspersed repetitive units (MIRU) genotyping was performed and analyzed on pairs of isolates of Mycobacterium tuberculosis from 16 recurrent patients with drug-resistant tuberculosis. RESULTS: Of all 8 120 isolates of Mycobacterium tuberculosis from new cases, 707 isolates (8.7%) were drug resistant. Of all 610 isolates from retreatment cases, 150 isolates (24.6%) were drug resistant. Primary drug resistance accounted for 82.5% (707/857) of all drug resistant isolates. Based on the MIRU genotypes, 13 of all 16 recurrent drug-resistant patients were reinfected with new drug-resistant strain of Mycobacterium tuberculosis. CONCLUSION: Primary drug-resistance is the main cause of drug-resistant tuberculosis. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles [Study on the cause of tuberculosis recurrence by Mycobacterium tuberculosis genotyping method] Feb 2006 Guo-miao Shen,Zhen Xue,Xin Shen,Xiao-hong Gui,Yi-feng Wang,Bin Sun,Mei Shen,Jian Mei,Qian Gao OBJECTIVE: To study the contribution of exogenous reinfeciton to tuberculosis recurrence. METHODS: Mycobacterium tuberculosis isolates from patients who had experienced 2 successive tuberculosis episodes during the years from January 1999 to March 2004 were genotyped by mycobacterial interspersed r... ( view more )epetitive units (MIRU) method. The cause of tuberculosis recurrence was determined by comparing the MIRU pattern of Mycobacterium tuberculosis isolates responsible for different tuberculosis episodes from patients. RESULTS: Of 37 qualified patients with recurrent tuberculosis, the isolates from 25 patients in their two tuberculosis episodes showed different MIRU patterns, indicating that 68% recurrent patients were due to exogenous reinfection. The exogenous reinfection rate decreased with the age from 3/3 (under 30 years) to 73% (11/15, 30 to 60 years) and 58% (11/19, over 60 years). The frequency of exogenous reinfection increased with the tuberculosis recurrent interval. Within 6 months, the exogenous reinfection accounted for 58% (7/12) of all the recurrence, while for the time more than one year, the percentage increased to 79% (11/14). CONCLUSIONS: Exogenous reinfection was a major cause of tuberculosis recurrence in Shanghai. MIRU genotyping method is useful to study the cause of tuberculosis recurrence. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles [Study on the molecular epidemiology of Myobacterium tuberculosis in Shanghai] Sep 2005 Jian Mei,Xin Shen,Jia Zha,Bin Sun,Mei Shen,Guo-miao Shen,Qian Gao OBJECTIVE: To explore the molecular-epidemiology of Mycobacterium tuberculosis in Shanghai. METHODS: Drug-resistant and drug-susceptible strains of M. tuberculosis were randomly selected from the bank of M. tuberculosis of Shanghai Municipal Center for Disease Control and Prevention and were genoty... ( view more )ped by mycobacterial interspersed repetitive units(MIRU) and Spoligotyping methods. The genotyping results were analyzed and combined with epidemiological data. RESULTS: The Spoligotyping results demonstrated that 89 % (81/91) of the strains belonged to the Beijing genotype. Of the patients who had received BCG-vaccination,88.5% (54/61) infected with strains of Beijing genotype and 90.0% (27/30) of the patients were not BCG-vaccinated. However, the difference was not statistically significant. Drug-resistant rate from those strains of Beijing genotype was 45.7 (37/81), lower than that of non-Beijing genotype (60.0% ,6/10). Again,the difference was not statistically significant. The MIRU results showed that 62.6 % (57/91) were strains of clusters. CONCLUSION: The Beijing genotype of M. tuberculosis were found to be the dominant strains in Shanghai. The associations between Beijing genotype strains and BCG vaccination or drug-resistant were not found. Results from cluster analysis suggested that some cases might belong to the newly developed cases. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Nucleocapsid protein of SARS coronavirus tightly binds to human cyclophilin A. Aug 27, 2004 Cheng Luo,Haibin Luo,Suxin Zheng,Chunshan Gui,Liduo Yue,Changying Yu,Tao Sun,Peilan He,Jing Chen,Jianhua Shen,Xiaomin Luo,Yixue Li,Hong Liu,Donglu Bai,Jingkang Shen,Yiming Yang,Fangqiu Li,Jianping Zuo,Rolf Hilgenfeld,Gang Pei,Kaixian Chen,Xu Shen,Hualiang Jiang Severe acute respiratory syndrome coronavirus (SARS-CoV) is responsible for SARS infection. Nucleocapsid protein (NP) of SARS-CoV (SARS_NP) functions in enveloping the entire genomic RNA and interacts with viron structural proteins, thus playing important roles in the process of virus particle asse... ( view more )mbly and release. Protein-protein interaction analysis using bioinformatics tools indicated that SARS_NP may bind to human cyclophilin A (hCypA), and surface plasmon resonance (SPR) technology revealed this binding with the equilibrium dissociation constant ranging from 6 to 160nM. The probable binding sites of these two proteins were detected by modeling the three-dimensional structure of the SARS_NP-hCypA complex, from which the important interaction residue pairs between the proteins were deduced. Mutagenesis experiments were carried out for validating the binding model, whose correctness was assessed by the observed effects on the binding affinities between the proteins. The reliability of the binding sites derived by the molecular modeling was confirmed by the fact that the computationally predicted values of the relative free energies of the binding for SARS_NP (or hCypA) mutants to the wild-type hCypA (or SARS_NP) are in good agreement with the data determined by SPR. Such presently observed SARS_NP-hCypA interaction model might provide a new hint for facilitating the understanding of another possible SARS-CoV infection pathway against human cell. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Conformational flexibility of beta-secretase: molecular dynamics simulation and essential dynamics analysis. Jun 2004 Bin Xiong,Xiao-Qin Huang,Ling-Ling Shen,Jian-Hua Shen,Xiao-Min Luo,Xu Shen,Hua-Liang Jiang,Kai-Xian Chen AIM: Based on the structural analysis to reveal the mechanism of ligand binding to beta-secretase and the specificity of each binding sub-site. METHODS: Molecular dynamics was used to simulate on the ligand free beta-secretase and ligand bound beta-secretase. The trajectories were analyzed using th... ( view more )e essential dynamics, and the significant conformational change was illustrated employing the DynDom program. RESULTS: The essential dynamics and DynDom analyses clearly showed that the beta-secretase experienced a large conformational change upon the substrate or inhibitor binding. The flap structure adopted a swing motion, gradually covering the active site to facilitate the ligand binding process. Residues Ser86 and Ile87 served as the hinge point. Inhibitor-enzyme interaction analysis revealed that residues at P2, P1, and P1' positions of the inhibitor were very important for the binding, and residues at P2' and P3' positions may be modified to improve the binding specificity. S3 subsite of the enzyme still had space to modify the inhibitors in increasing the binding affinity. CONCLUSION: The information presented here is valuable and could be used to identify small molecular inhibitors of beta-secretase. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles [Epidemiology and drug resistance of the pathogenic microbes in the complicated infection of hematological malignancies] Jun 2004 Yang Shen,Jun Shen,Yu Chen,Xiao-Ying Zeng,Jun-Min Li,Yu-Xing Ni,Zhi-Xiang Shen OBJECTIVE: To investigate the epidemiological characteristics and drug resistance profile of the infection in patients with hematological malignancies. METHODS: All the microbe strains isolated from the department of hematology in Ruijin hospital between 1998 and 2002 were collected for the assessm... ( view more )ent of antimicrobial susceptibility and the results were analysed by WHONET5 software. RESULTS: Out of the 536 strains isolated in the department of hematology, 230 (42.9%) were Gram positive and 301 (56.2%) Gram negative organisms. The first 6 strains of Gram (-) microbes in frequent order were Pseudomonas aeruginosa, Klebsiella pneumoniae, Enterobacter cloacae, Escheriahia coli, Alinetobacter Baumannii and Stenotrophomonas (xantho) maltophi. The extended spectrum beta-lactamase (ESBLs) producing rates of Escheriahia coli and Klebsiella pneumoniae were 27.3% and 33.3%, respectively. Methylcillin resistant coagulase negative staphylococcus (MRCNS) was the most prevalent Gram (+) bacteria in the complicated infection patients with hematological malignancies, which accounted for 88.5%. Carbapenems were most sensitive for all of the gram negative bacteria, with a drug resistance rate of 11.4 (5.0% approximately 15.8%) of imipenem. For ESBLs strains, carbapenems and cefapime were the best choice, with the resistance rate of 46.4% approximately 94.4% and 50.0% approximately 75.9%, respectively. The drug resistance rate of Alinetobacter Baumannii was 25.0% approximately 41.3% for the third generation cephalosporin, 22.7% for the fourth generation cephalosporin and 12.7% for imipenem. Pseudomonas aeruginosa was resistant to carbapenems, with a resistance rate of 12.7% of imipenem; however, it was more sensitive to the third generation cephalosporin. CONCLUSION: Antibiotics should be rationally administrated with more considerations to the characteristics of epidemiology and drug resistance profile of the microbes in the given department of hematology. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Ultra-high-efficiency strong cation exchange LC/RPLC/MS/MS for high dynamic range characterization of the human plasma proteome. Feb 15, 2004 Yufeng Shen,Jon M Jacobs,David G Camp,Ruihua Fang,Ronald J Moore,Richard D Smith,Wenzhong Xiao,Ronald W Davis,Ronald G Tompkins High-efficiency nanoscale reversed-phase liquid chromatography (chromatographic peak capacities of approximately 1000: Shen, Y.; Zhao, R.; Berger, S. J.; Anderson, G. A.; Rodriguez, N.; Smith, R. D. Anal. Chem. 2002, 74, 4235. Shen, Y.; Moore, R. J.; Zhao, R.; Blonder, J.; Auberry, D. L.; Masselon,... ( view more ) C.; Pasa-Tolic, L.; Hixson, K. K.; Auberry, K. J.; Smith, R. D. Anal. Chem. 2003, 75, 3596.) and strong cation exchange LC was used to obtain ultra-high-efficiency separations (combined chromatographic peak capacities of >10(4)) in conjunction with tandem mass spectrometry (MS/MS) for characterization of the human plasma proteome. Using conservative SEQUEST peptide identification criteria (i.e., without considering chymotryptic or elastic peptides) and peptide LC normalized elution time constraints, the separation quality enabled the identification of proteins over a dynamic range of greater than 8 orders of magnitude in relative abundance using ion trap MS/MS instrumentation. Between 800 and 1682 human proteins were identified, depending on the criteria used for identification, from a total of 365 microg of human plasma. The analyses identified relatively low-level (approximately pg/mL) proteins (e.g., cytokines) coexisting with high-abundance proteins (e.g., mg/mL-level serum albumin). ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Virtual screening on natural products for discovering active compounds and target information. Nov 2003 Jianhua Shen,Xiaoying Xu,Feng Cheng,Hong Liu,Xiaomin Luo,Jingkang Shen,Kaixian Chen,Weimin Zhao,Xu Shen,Hualiang Jiang Natural products, containing inherently large-scale structural diversity than synthetic compounds, have been the major resources of bioactive agents and will continually play as protagonists for discovering new drugs. However, how to access this diverse chemical space efficiently and effectively is... ( view more ) an exciting challenge for medicinal chemists and pharmacologists. While virtual screening, which has shown a great promise in drug discovery, will play an important role in digging out lead (active) compounds from natural products. This review focuses on the strategy of virtual screening based on molecular docking and, with successful examples from our laboratory, illustrates the efficiency of virtual screening in discovering active compounds from natural products. On the other hand, the sequencing of the human genome and numerous pathogen genomes has resulted in an unprecedented opportunity for discovering potential new drug targets. Chemogenomics has appeared as a new technology to initiate target discovery by using active compounds as probes to characterize proteome functions. Natural products are the ideal probes for such research. Binding affinity fingerprint is a powerful chemogenomic descriptor to characterize both small molecules and pharmacologically relevant proteins. Therefore, this review also discusses binding affinity fingerprint strategy for identifying target information from the genomic data by using natural products as the probes. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Observation of a near-threshold enhancement in the pp mass spectrum from radiative J/psi-->gammapp decays. Jul 11, 2003 J Z Bai,Y Ban,J G Bian,X Cai,J F Chang,H F Chen,H S Chen,J Chen,Jie Chen,J C Chen,Y B Chen,S P Chi,Y P Chu,X Z Cui,Y M Dai,Y S Dai,L Y Dong,S X Du,Z Z Du,W Dunwoodie,J Fang,S S Fang,C D Fu,H Y Fu,L P Fu,C S Gao,M L Gao,Y N Gao,M Y Gong,W X Gong,S D Gu,Y N Guo,Y Q Guo,Z J Guo,S W Han,F A Harris,J He,K L He,M He,X He,Y K Heng,T Hong,H M Hu,T Hu,G S Huang,L Huang,X P Huang,J M Izen,X B Ji,C H Jiang,X S Jiang,D P Jin,S Jin,Y Jin,B D Jones,Z J Ke,D Kong,Y F Lai,F Li,G Li,H H Li,J Li,J C Li,K Li,Q J Li,R B Li,R Y Li,W Li,W G Li,X Q Li,X S Li,C F Liu,C X Liu,Fang Liu,F Liu,H M Liu,J B Liu,J P Liu,R G Liu,Y Liu,Z A Liu,Z X Liu,X C Lou,G R Lu,F Lu,H J Lu,J G Lu,Z J Lu,X L Luo,E C Ma,F C Ma,J M Ma,R Malchow,Z P Mao,X C Meng,X H Mo,J Nie,Z D Nie,S L Olsen,D Paluselli,H P Peng,N D Qi,C D Qian,J F Qiu,G Rong,D L Shen,H Shen,X Y Shen,H Y Sheng,F Shi,L W Song,H S Sun,S S Sun,Y Z Sun,Z J Sun,S Q Tang,X Tang,D Tian,Y R Tian,W Toki,G L Tong,G S Varner,J Wang,J Z Wang,L Wang,L S Wang,M Wang,Meng Wang,P Wang,P L Wang,W F Wang,Y F Wang,Zhe Wang,Z Wang,Zheng Wang,Z Y Wang,C L Wei,N Wu,X M Xia,X X Xie,G F Xu,Y Xu,S T Xue,M L Yan,W B Yan,G A Yang,H X Yang,J Yang,S D Yang,M H Ye,Y X Ye,J Ying,C S Yu,G W Yu,C Z Yuan,J M Yuan,Y Yuan,Q Yue,S L Zang,Y Zeng,B X Zhang,B Y Zhang,C C Zhang,D H Zhang,H Y Zhang,J Zhang,J M Zhang,J W Zhang,L S Zhang,Q J Zhang,S Q Zhang,X Y Zhang,Y J Zhang,Yiyun Zhang,Y Y Zhang,Z P Zhang,D X Zhao,Jiawei Zhao,J W Zhao,P P Zhao,W R Zhao,Y B Zhao,Z G Zhao,J P Zheng,L S Zheng,Z P Zheng,X C Zhong,B Q Zhou,G M Zhou,L Zhou,N F Zhou,K J Zhu,Q M Zhu,Yingchun Zhu,Y C Zhu,Y S Zhu,Z A Zhu,B A Zhuang,B S Zou,BES Collaboration We observe a narrow enhancement near 2m(p) in the invariant mass spectrum of pp pairs from radiative J/psi-->gammapp decays. No similar structure is seen in J/psi-->pi(0)pp decays. The results are based on an analysis of a 58 x 10(6) event sample of J/psi decays accumulated with the BESII detector ... ( view more )at the Beijing electron-positron collider. The enhancement can be fit with either an S- or P-wave Breit-Wigner resonance function. In the case of the S-wave fit, the peak mass is below 2m(p) at M=1859(+3)(-10) (stat)+5-25(syst) MeV/c(2) and the total width is Gamma<30 MeV/c(2) at the 90% confidence level. These mass and width values are not consistent with the properties of any known particle. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Identification of an epitope of SARS-coronavirus nucleocapsid protein. Jun 2003 Ying Lin,Xu Shen,Rui Fu Yang,Yi Xue Li,Yong Yong Ji,You Yu He,Mu De Shi,Wei Lu,Tie Liu Shi,Jin Wang,Hong Xia Wang,Hua Liang Jiang,Jian Hua Shen,You Hua Xie,Yuan Wang,Gang Pei,Bei Fen Shen,Jia Rui Wu,Bing Sun The nucleocapsid (N) protein of severe acute respiratory syndrome-coronavirus (SARS-CoV) is a major virion structural protein. In this study, two epitopes (N1 and N2) of the N protein of SARS-CoV were predicted by bioinformatics analysis. After immunization with two peptides, the peptides-specific ... ( view more )antibodies were isolated from the immunized rabbits. The further experiments demonstrated that N1 peptide-induced polyclonal antibodies had a high affinity to bind to E. coli expressed N protein of SARS-CoV. Furthermore, it was confirmed that N1 peptide-specific IgG antibodies were detectable in the sera of severe acute respiratory syndrome (SARS) patients. The results indicated that an epitope of the N protein has been identified and N protein specific Abs were produced by peptide immunization, which will be usefull for the study of SARS-CoV. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Reactive oxygen species and antioxidants in apoptosis of esophageal cancer cells induced by As2O3. Apr 2003 Zhong-Ying Shen,Wen-Ying Shen,Ming-Hua Chen,Jian Shen,Yi Zeng To explore the relationship between the reactive oxygen species (ROS) and apoptosis in esophageal carcinoma cells (SHEE85) induced by arsenic trioxide (As2O3), we focused on changes of apoptosis, ROS, and antioxidants. Apoptosis of SHEE85 was confirmed by means of DNA fragmentation stained by Hoech... ( view more )st 33342, Sub-G1 cells scored by flow cytometry and ultrastructure of cells by electron microscopy. To evaluate the level of ROS, the chemiluminescent method was used for measuring the production of superoxide anion (O(-)*2). Lipid peroxide (malondialdehyde, MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were measured respectively by the photometry method. In the cells treated with As2O3 at a concentration of 5.0 micromol/l for 2-24 h, the content of cellular O(-)*2 and MDA was increased, but SOD and GSH-Px were significantly lower in the process of apoptosis in SHEE85. As2O3 at concentration of 0.5 micromol/l did not cause cell apoptosis but promoted cell proliferation. These results suggest that As2O3 at a high dosage (5 micromol/l) causes cell apoptosis and at a low dosage (0.5 micromol/l) causes cell proliferation. The essential mechanisms of cell apoptosis induced by As2O3 may be related to the increase of ROS and decrease of anti-oxidation. ROS and antioxidants participate in the apoptotic pathway of esophageal carcinoma cells. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Page 1 of 792 1 2 3 4 > Last >> (19800 articles found)

      
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