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GST Primary GST Primary Best Strategies for Health Care Quality Im... Best Strategies for Health Care Quality Improvement - Diabetes Quality Improvement Strategies for Antibio... Kathryn McDonald, Stanford-UCSF Evidence-b... Systematic review assessing the effect of ... Quality Improvement Strategies for Antibiotics Management Kathryn McDonald, Stanford-UCSF Evidence-based Practice Center, 117 Encina Commons, Stanford, CA 94305-6019, Kathy.mcdonald@stanford.edu Systematic review assessing the effect of quality improvement strategies on appropriate prescribing of antibiotics and appropriate choice of antibiotics. Adherence Adherence Assistive Devices Assistive Devices Childhood Burn Hanson MacMillan Childhood Burn Hanson MacMillan CLSA_9 CLSA_9 Cyberabuse Cyberabuse Cognitive Behavioural Therapy for Violent ... This review included randomized trials abo... Cognitive Behavioural Therapy for Violent Men who Batter Their Partners This review included randomized trials about the effects of cognitive behavioral therapy on domestic violence. The intervention included programs based on the Duluth Model. The violence had to be committed by a male toward his female partner. The violence also had to be physical. The primary outcomes were new arrests and convictions, and new reports of violence. CABG vs PCI CABG vs PCI Quality Improvement Strategies for Prevent... Quality Improvement Strategies for Preventing Nosocomial Infections (Created 17-Feb-06) Quality Improvement Strategies for Asthma ... Quality Improvement Strategies for Asthma Control Erectile Dysfunction (Created 30-Jan-06) Erectile Dysfunction (Created 30-Jan-06) Inequality - Smoking Cessation to Reduce S... This review was the first part of a projec... Inequality - Smoking Cessation to Reduce Socio-Economic Differences This review was the first part of a project about inequality. It included randomized trials about the effect of smoking cessation interventions on reducing socio-economic differences. The studies had to report data either on persons with low socio-economic groups status or, preferably, on both low and high socio-economic groups. Diet and Physical Activity to Reduce Socio... This review was the second part in a proje... Diet and Physical Activity to Reduce Socio-Economic Differences This review was the second part in a project about inequality. It included randomized trials about the effect of interventions on reducing socio-economic differences in diet and physical activity. The studies had to report data either on persons with low socio-economic groups status or, preferably, on both low and high socio-economic groups. Workfare The data in SRS are not identical to the d... Workfare The data in SRS are not identical to the data in the published report. We used SRS only for an updated search. The review included randomized trials about the effect of welfare-to-work programs. Participants were welfare recipients. There were basically two types of programs. The educational type tried to build knowledge and skills in order to help the welfare recipients acquire jobs that could support them economically. The "work first" approach was more aimed at getting the participants quickly into a job. Exercise interventions for the management ... The objective of this systematic review wa... Exercise interventions for the management of frailty The objective of this systematic review was to examine the effectiveness of current exercise interventions on the management of frailty. A comprehensive search of Medline, Embase, Psycinfo, Cinahl, Scopus, Ageline, Eric, and SportDiscus databases was conducted and produced 1808 citations. So far we have completed 2 levels of “title and abstract” screening and we ended up with 262 articles. We have just started the full text screening. Eligibility criteria included original studies whose participants were identified as frail or prefrail with specific criteria and in which structured physical activity was included as at least one component of the intervention. Create a free account, build a dictionary with saved terms to re-use later! Public Domestic Violence - Using Cognitive Behavior Therapy Smoking Cessation to Reduce Socio-Economic Differences Diet and Physical Activity to Reduce Socio-Economic Differences Workfare Exercise Interventions for the Management of Frailty Search     Simple Advanced Refine (3 coded questions)  Any of these:   Exact Phrase: All of these: None of these: Author: Periodical: Projects: No restrictions   Libraries: Public   Select SRS Projects Show Saved Terms Select Library Show articles that do not have abstracts  Humans or Animals Humans Animals Type of Article Clinical Trial Editorial Letter Meta-Analysis Practice Guideline Randomized Controlled Trial Review Addresses Bibliography Biography Case Reports Classical Article Clinical Conference Clinical Trial, Phase I Clinical Trial, Phase II Clinical Trial, Phase III Clinical Trial, Phase IV Comment Comparative Study Consensus Development Conference Consensus Development Conference, NIH Controlled Clinical Trial Corrected and Republished Article Dictionary Directory Duplicate Publication English Abstract Evaluation Studies Festschrift Government Publications Guideline Historical Article Interview In Vitro Journal Article Lectures Legal Cases Legislation Multicenter Study News Newspaper Article Overall Patient Education Handout Periodical Index Published Erratum Retracted Publication Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. 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Retraction of Publication Scientific Integrity Review Support of Research Technical Report Twin Study Validation Studies Not a Primary Study or Review Unknown Primary Study Case Series Case Control Cohort Study Observational Study Qualitative Research CBA or ITS Registry Double Blind Controlled before after study Quasi-randomized trial Simple before after study Cluster-RCT Non-Randomized Study Report Book Book chapter Dissertation Conference procedings Secondary Research Not RCT Ages All Infant: birth-23 months All Child: 0-18 years All Adult: 19+ years Newborn: birth-1 month Infant: 1-23 months Preschool Child: 2-5 years Child: 6-12 years Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Middle Aged + Aged: 45+ years Aged: 65+ years 80 and over: 80+ years Undetermined Results(1-25 of 454) Sort By: Publication Date Relevance Took: 1.054 seconds to search 17,750,454  Action: Copy Results to new Clipboard Build Search Link Page 1 of 19 1 2 3 4 > Last >> (454 articles found) Insecticidal activity of the plant Phyllanthus amarus against Tribolium castaneum. Oct 2003 Shalini Khanna,C N Srivastava,M M Srivastava,Shalini Srivastava The plant Phyllanthus amarus is used as folk medicine since the year 1800 and has been established for its important medicinal properties particularly for liver ailments. The present communication explores the insecticidal activity of ethanolic extract of aerial and root parts of this plant against... ( view more ) stored grain pest Tribolium castaneum. LC 50 values of ethanolic aerial part were 895.77, 473.91, 279.89 and 260.85 microg/cm2, while 512.62, 376.96, 248.88 and 209.79 microg/cm2 for ethanolic root part at the exposure of 3, 5, 7, 9 and 11 days respectively. Ethanolic root extract possessed significant insecticidal activity against T. castaneum. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Assessment of microbial diversity in effluent treatment plants by culture dependent and culture independent approaches. Oct 2008 Asha Rani,Shalini Porwal,Rakesh Sharma,Atya Kapley,Hemant J Purohit,Vipin Chandra Kalia Microbial community structure of two distinct effluent treatment plants (ETPs) of pesticide and pharmaceutical industries was assessed and defined by (i) culture dependent and culture independent approaches on the basis of 16S rRNA gene sequencing, (ii) diversity index analysis - operational taxono... ( view more )mic units (OTUs). A total of 38 and 44 bacterial OTUs having 85-99% similarity with the closest match in the database were detected among pharmaceutical and pesticide sludge samples, respectively. Fifty percent of the OTUs were related to uncultured bacteria. These OTUs had a Shannon diversity index value of 2.09-2.33 for culturables and in the range of 3.25-3.38 for unculturables. The high species evenness values of 0.86 and 0.95 indicated the vastness of microbial diversity retrieved by these approaches. The dominant cultured bacteria indicative of microbial diversity in functional ETPs were Alcaligenes, Bacillus and Pseudomonas. Brevundimonas, Citrobacter, Pandoraea and Stenotrophomonas were specific to pesticide ETP and Agrobacterium, Brevibacterium, Micrococcus, Microbacterium, Paracoccus and Rhodococcus were specific to pharmaceutical ETP. These microbes can thus be maintained and exploited for efficient functioning and maintenance of ETPs. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Endometrial resection mandates reliable contraception thereafter - a case report of placenta increta following endometrial ablation. Jun 2008 Shalini Patni,Abdel Malwa Elgarib,H Soleymani Majd,Gareth J Edwards,M A Ashraf Placenta increta complicated pregnancy in a woman with a history of endometrial resection. Placentation in women with prior endometrial ablation carries a high risk for placenta accreta, increta and percreta. Contraceptive measures must be implemented after endometrial ablation and pursued until pr... ( view more )oven menopause, even in women who develop amenorrhoea postoperatively. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Effect of seabuckthorn leaf extracts on circulating energy fuels, lipid peroxidation and antioxidant parameters in rats during exposure to cold, hypoxia and restraint (C-H-R) stress and post stress recovery. Jun 2008 Shalini Saggu,Ratan Kumar The present study was carried out to study mechanism of adaptogenic activity of seabuckthorn leaf extract, administered orally in rats both in single and five doses at a dose of 100mg/kg body weight 30min prior to C-H-R exposure. The efficacy of the extract was studied on circulating energy fuels, ... ( view more )lipid peroxidation and anti-oxidant parameters in rats on attaining the T(rec) 23 degrees C during C-H-R exposure and after recovery (T(rec) 37 degrees C) from C-H-R induced hypothermia. Single dose treatment in rats restricted rise in blood malondialdehyde (MDA) levels and decrease in glutathione (GSH) and catalase (CAT) levels. Both single and five doses also restricted the rise in serum free fatty acids (FFA) and lactate dehydrogenase (LDH) levels on attaining T(rec) 23 degrees C during C-H-R exposure, suggesting more efficient utilization of FFA for energy production and better maintained cell membrane permeability. This suggested that the adaptogenic activity of the extract might be due to its anti-oxidative activity, maintained blood glucose levels, better utilization of FFA and improved cell membrane permeability. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Modeling motor connectivity using TMS/PET and structural equation modeling. Jun 1, 2008 Angela R Laird,Jacob M Robbins,Karl Li,Larry R Price,Matthew D Cykowski,Shalini Narayana,Robert W Laird,Crystal Franklin,Peter T Fox Structural equation modeling (SEM) was applied to positron emission tomographic (PET) images acquired during transcranial magnetic stimulation (TMS) of the primary motor cortex (M1(hand)). TMS was applied across a range of intensities, and responses both at the stimulation site and remotely connect... ( view more )ed brain regions covaried with stimulus intensity. Regions of interest (ROIs) were identified through an activation likelihood estimation (ALE) meta-analysis of TMS studies. That these ROIs represented the network engaged by motor planning and execution was confirmed by an ALE meta-analysis of finger movement studies. Rather than postulate connections in the form of an a priori model (confirmatory approach), effective connectivity models were developed using a model-generating strategy based on improving tentatively specified models. This strategy exploited the experimentally imposed causal relations: (1) that response variations were caused by stimulation variations, (2) that stimulation was unidirectionally applied to the M1(hand) region, and (3) that remote effects must be caused, either directly or indirectly, by the M1(hand) excitation. The path model thus derived exhibited an exceptional level of goodness (chi(2)=22.150, df=38, P=0.981, TLI=1.0). The regions and connections derived were in good agreement with the known anatomy of the human and primate motor system. The model-generating SEM strategy thus proved highly effective and successfully identified a complex set of causal relationships of motor connectivity. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Gene therapy to prevent occlusion of venous bypass grafts. Jun 2008 Shalini Bhardwaj,Himadri Roy,Seppo Ylä-Herttuala Revascularization with vein grafts is standard surgical therapy for occlusive arterial diseases. Autologous saphenous vein grafts are important conduits for repairing blocked coronary arteries and are used in the majority of vein graft procedures. Up to 50% of saphenous vein grafts will be occluded... ( view more ) during the first decade after surgery. Vein graft occlusion occurs as a result of neointimal hyperplasia, which takes place in response to hemodynamic changes and vessel wall injury, and is characterized by the migration and proliferation of vascular smooth muscle cells. Intimal hyperplasia is further complicated by the concomitant development of atherosclerosis and thrombosis. In the absence of effective pharmacological interventions for the treatment and prevention of occlusive vein graft disease, gene therapy has emerged as a potential therapeutic alternative. Gene therapy could improve vein graft patency by reducing early thrombosis, neointimal hyperplasia and atherosclerosis. In this review we will summarize the emerging applications of gene therapy as a therapeutic tool in occlusive vein graft disease. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Semilobar holoprosencephaly in seckel syndrome. May 2008 Rakesh Kumar,Manoj Rawal,Shalini Agarwal,Geeta Gathwala Seckel syndrome is a rare genetic disorder with autosomal recessive inheritance. It is associated with many CNS anomalies along with involvement of other systems. We present a case of Seckel syndrome with semilobar holoprosencephaly as associated CNS anomaly, which to the best of our knowledge has ... ( view more )not been reported earlier. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Influenza and the vocal performer: update on prevention and treatment. May 2008 Michiel J Bové,Shalini Kansal,Clark A Rosen SUMMARY: Upper respiratory tract infections (URIs) are a major cause of morbidity among vocal arts professionals, both from their acute impairment of the vocal mechanism and their predisposing influence for the development of serious vocal sequelae. In this review, we present some of the salient fe... ( view more )atures of currently available treatments effective against influenza, the virus family responsible for the most serious form of URI. At present, these include an inactivated vaccine and four antiviral drugs, each approved in the United States and many other countries for the prevention and treatment of influenza. A live attenuated vaccine is also available, and other vaccines and antiviral drugs are under development. This review details the current options available for treating both influenza and noninfluenza related URIs in the professional voice user. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles The genome of the model beetle and pest Tribolium castaneum. Apr 24, 2008 Tribolium Genome Sequencing Consortium ,Stephen Richards,Richard A Gibbs,George M Weinstock,Susan J Brown,Robin Denell,Richard W Beeman,Richard Gibbs,Richard W Beeman,Susan J Brown,Gregor Bucher,Markus Friedrich,Cornelis J P Grimmelikhuijzen,Martin Klingler,Marce Lorenzen,Stephen Richards,Siegfried Roth,Reinhard Schröder,Diethard Tautz,Evgeny M Zdobnov,Donna Muzny,Richard A Gibbs,George M Weinstock,Tony Attaway,Stephanie Bell,Christian J Buhay,Mimi N Chandrabose,Dean Chavez,Kerstin P Clerk-Blankenburg,Andrew Cree,Marvin Dao,Clay Davis,Joseph Chacko,Huyen Dinh,Shannon Dugan-Rocha,Gerald Fowler,Toni T Garner,Jeffrey Garnes,Andreas Gnirke,Alica Hawes,Judith Hernandez,Sandra Hines,Michael Holder,Jennifer Hume,Shalini N Jhangiani,Vandita Joshi,Ziad Mohid Khan,LaRonda Jackson,Christie Kovar,Andrea Kowis,Sandra Lee,Lora R Lewis,Jon Margolis,Margaret Morgan,Lynne V Nazareth,Ngoc Nguyen,Geoffrey Okwuonu,David Parker,Stephen Richards,San-Juana Ruiz,Jireh Santibanez,Joël Savard,Steven E Scherer,Brian Schneider,Erica Sodergren,Diethard Tautz,Selina Vattahil,Donna Villasana,Courtney S White,Rita Wright,Yoonseong Park,Richard W Beeman,Jeff Lord,Brenda Oppert,Marce Lorenzen,Susan Brown,Liangjiang Wang,Joël Savard,Diethard Tautz,Stephen Richards,George Weinstock,Richard A Gibbs,Yue Liu,Kim Worley,George Weinstock,Christine G Elsik,Justin T Reese,Eran Elhaik,Giddy Landan,Dan Graur,Peter Arensburger,Peter Atkinson,Richard W Beeman,Jim Beidler,Susan J Brown,Jeffery P Demuth,Douglas W Drury,Yu-Zhou Du,Haruhiko Fujiwara,Marce Lorenzen,Vincenza Maselli,Mizuko Osanai,Yoonseong Park,Hugh M Robertson,Zhijian Tu,Jian-jun Wang,Suzhi Wang,Stephen Richards,Henry Song,Lan Zhang,Erica Sodergren,Doreen Werner,Mario Stanke,Burkhard Morgenstern,Victor Solovyev,Peter Kosarev,Garth Brown,Hsiu-Chuan Chen,Olga Ermolaeva,Wratko Hlavina,Yuri Kapustin,Boris Kiryutin,Paul Kitts,Donna Maglott,Kim Pruitt,Victor Sapojnikov,Alexandre Souvorov,Aaron J Mackey,Robert M Waterhouse,Stefan Wyder,Evgeny M Zdobnov,Evgeny M Zdobnov,Stefan Wyder,Evgenia V Kriventseva,Tatsuhiko Kadowaki,Peer Bork,Manuel Aranda,Riyue Bao,Anke Beermann,Nicola Berns,Renata Bolognesi,François Bonneton,Daniel Bopp,Susan J Brown,Gregor Bucher,Thomas Butts,Arnaud Chaumot,Robin E Denell,David E K Ferrier,Markus Friedrich,Cassondra M Gordon,Marek Jindra,Martin Klingler,Que Lan,H Michael G Lattorff,Vincent Laudet,Cornelia von Levetsow,Zhenyi Liu,Rebekka Lutz,Jeremy A Lynch,Rodrigo Nunes da Fonseca,Nico Posnien,Rolf Reuter,Siegfried Roth,Joël Savard,Johannes B Schinko,Christian Schmitt,Michael Schoppmeier,Reinhard Schröder,Teresa D Shippy,Franck Simonnet,Henrique Marques-Souza,Diethard Tautz,Yoshinori Tomoyasu,Jochen Trauner,Maurijn Van der Zee,Michel Vervoort,Nadine Wittkopp,Ernst A Wimmer,Xiaoyun Yang,Andrew K Jones,David B Sattelle,Paul R Ebert,David Nelson,Jeffrey G Scott,Richard W Beeman,Subbaratnam Muthukrishnan,Karl J Kramer,Yasuyuki Arakane,Richard W Beeman,Qingsong Zhu,David Hogenkamp,Radhika Dixit,Brenda Oppert,Haobo Jiang,Zhen Zou,Jeremy Marshall,Elena Elpidina,Konstantin Vinokurov,Cris Oppert,Zhen Zou,Jay Evans,Zhiqiang Lu,Picheng Zhao,Niranji Sumathipala,Boran Altincicek,Andreas Vilcinskas,Michael Williams,Dan Hultmark,Charles Hetru,Haobo Jiang,Cornelis J P Grimmelikhuijzen,Frank Hauser,Giuseppe Cazzamali,Michael Williamson,Yoonseong Park,Bin Li,Yoshiaki Tanaka,Reinhard Predel,Susanne Neupert,Joachim Schachtner,Peter Verleyen,Florian Raible,Peer Bork,Markus Friedrich,Kimberly K O Walden,Hugh M Robertson,Sergio Angeli,Sylvain Forêt,Gregor Bucher,Stefan Schuetz,Ryszard Maleszka,Ernst A Wimmer,Richard W Beeman,Marce Lorenzen,Yoshinori Tomoyasu,Sherry C Miller,Daniela Grossmann,Gregor Bucher Tribolium castaneum is a member of the most species-rich eukaryotic order, a powerful model organism for the study of generalized insect development, and an important pest of stored agricultural products. We describe its genome sequence here. This omnivorous beetle has evolved the ability to intera... ( view more )ct with a diverse chemical environment, as shown by large expansions in odorant and gustatory receptors, as well as P450 and other detoxification enzymes. Development in Tribolium is more representative of other insects than is Drosophila, a fact reflected in gene content and function. For example, Tribolium has retained more ancestral genes involved in cell-cell communication than Drosophila, some being expressed in the growth zone crucial for axial elongation in short-germ development. Systemic RNA interference in T. castaneum functions differently from that in Caenorhabditis elegans, but nevertheless offers similar power for the elucidation of gene function and identification of targets for selective insect control. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Recommendations on risk-based strategies for detection and characterization of antibodies against biotechnology products. Apr 20, 2008 Eugen Koren,Holly W Smith,Elizabeth Shores,Gopi Shankar,Deborah Finco-Kent,Bonita Rup,Yu-Chen Barrett,Viswanath Devanarayan,Boris Gorovits,Shalini Gupta,Thomas Parish,Valerie Quarmby,Michael Moxness,Steven J Swanson,Gary Taniguchi,Linda A Zuckerman,Christopher C Stebbins,Anthony Mire-Sluis The appropriate evaluation of the immunogenicity of biopharmaceuticals is of major importance for their successful development and licensure. Antibodies elicited by these products in many cases cause no detectable clinical effects in humans. However, antibodies to some therapeutic proteins have bee... ( view more )n shown to cause a variety of clinical consequences ranging from relatively mild to serious adverse events. In addition, antibodies can affect drug efficacy. In non-clinical studies, anti-drug antibodies (ADA) can complicate interpretation of the toxicity, pharmacokinetic (PK) and pharmacodynamic (PD) data. Therefore, it is important to develop testing strategies that provide valid assessments of antibody responses in both non-clinical and clinical studies. This document provides recommendations for antibody testing strategies stemming from the experience of contributing authors. The recommendations are intended to foster a more unified approach to antibody testing across the biopharmaceutical industry. The strategies proposed are also expected to contribute to better understanding of antibody responses and to further advance immunogenicity evaluation. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Regulating the geological sequestration of CO2. Apr 15, 2008 Elizabeth J Wilson,M Granger Morgan,Jay Apt,Mark Bonner,Christopher Bunting,Jenny Gode,R Stuart Haszeldine,Carlo C Jaeger,David W Keith,Sean T Mccoy,Melisa F Pollak,David M Reiner,Edward S Rubin,Asbjørn Torvanger,Christina Ulardic,Shalini P Vajjhala,David G Victor,Iain W Wright Governments worldwide should provide incentives for initial large-scale GS projects to help build the knowledge base for a mature, internationally harmonized GS regulatory framework. Health, safety, and environmental risks of these early projects can be managed through modifications of existing reg... ( view more )ulations in the EU, Australia, Canada, and the U.S. An institutional mechanism, such as the proposed Federal Carbon Sequestration Commission in the U.S., should gather data from these early projects and combine them with factors such as GS industrial organization and climate regime requirements to create an efficient and adaptive regulatory framework suited to large-scale deployment. Mechanisms to structure long-term liability and fund long-term postclosure care must be developed, most likely at the national level, to equitably balance the risks and benefits of this important climate change mitigation technology. We need to do this right. During the initial field experiences, a single major accident, resulting from inadequate regulatory oversight, anywhere in the world, could seriously endanger the future viability of GS. That, in turn, could make it next to impossible to achieve the needed dramatic global reductions in CO2 emissions over the next several decades. We also need to do it quickly. Emissions are going up, the climate is changing, and impacts are growing. The need for safe and effective CO2 capture with deep GS is urgent. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Removal of hazardous dye congored from waste material. Apr 15, 2008 Rajeev Jain,Shalini Sikarwar The present paper is aimed to investigate and develop cheap adsorption methods for color removal from wastewater using waste material sawdust as adsorbent. Sawdust, a biosorbent, was successfully utilized in removing a water soluble azo dye, congored from wastewater. The paper incorporates effect o... ( view more )f pH, temperature, amount of adsorbent, contact time, concentration of adsorbate, particle size on adsorption. Specific rate constants of the processes were calculated by kinetic measurements and a first order adsorption kinetics was observed in each case. Langmuir and Freundlich adsorption isotherm models were then applied to calculate thermodynamics parameters as well as to suggest the plausible mechanism of the ongoing adsorption processes. In order to observe the quality of wastewater COD measurements were also carried out before and after the treatments. A significant decrease in the COD values was observed, which clearly indicates that adsorption method offer good potential to remove congored from wastewater. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Chromosomal imbalances in oral squamous cell carcinoma: examination of 31 cell lines and review of the literature. Apr 2008 Christa Lese Martin,Shalini C Reshmi,Thomas Ried,William Gottberg,John W Wilson,Jaya K Reddy,Poornima Khanna,Jonas T Johnson,Eugene N Myers,Susanne M Gollin Classical and molecular cytogenetic analysis, including fluorescence in situ hybridization (FISH) and chromosomal comparative genomic hybridization (CGH), were used to examine genetic changes involved in the development and/or progression of oral squamous cell carcinoma (OSCC). Of 31 OSCC cell line... ( view more )s studied, more than one-third expressed clonal structural abnormalities involving chromosomes 3, 7, 8, 9, and 11. Eleven OSCC cell lines were evaluated using CGH to identify novel genome-wide gains, losses, or amplifications. By CGH, more than half of the cell lines showed loss of 3p, gain of 3q, 8q, and 20q. Further, molecular cytogenetic analyses by FISH of primary tumors showed that the karyotypes of cell lines derived from those tumors correlated with specific gains and losses in the tumors from which they were derived. The most frequent nonrandom aberration identified by both karyotype and CGH analyses was amplification of chromosomal band 11q13 in the form of a homogeneously staining region. Our data suggest that loss of 9p and 11q13 amplification may be of prognostic benefit in the management of OSCC, which is consistent with the literature. The results of this study validate the relationship between these OSCC cell lines and the tumors from which they were derived. The results also emphasize the usefulness of these cell lines as in vitro experimental models and provide important genetic information on these OSCC cell lines that were recently reported in this journal. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Safety, efficacy, and immune reconstitution after rituximab therapy in pediatric patients with chronic or refractory hematologic autoimmune cytopenias. Apr 2008 Aarati Rao,Michael Kelly,Mark Musselman,Jagadeesh Ramadas,David Wilson,William Grossman,Shalini Shenoy BACKGROUND: Autoimmune hematologic cytopenias in children often require therapeutic intervention. We report a prospective pediatric multicenter trial of rituximab for refractory or steroid-dependent patients. METHODS: Four doses of rituximab (375 mg/m(2)/dose) were administered weekly. Patients wit... ( view more )hout response after three doses were offered dose escalation to 750 mg/m(2)/dose/week x 3. Safety, efficacy, and immunologic tests were evaluated after therapy. RESULTS: Twenty-nine of 30 children (2-18 years) with thrombocytopenia (21), hemolytic anemia (6), Evans syndrome (2), and neutropenia (1) received at least four doses of rituximab. One developed anaphylaxis with the first dose. One patient was subsequently diagnosed with monosomy 7 myelodysplasia. Of 28 remaining patients, 9 received dose escalation. Responders discontinued other therapy following rituximab. The overall response rate was 72% with median follow-up of 18 months. Complete remission was observed in 14 (50%); all received four doses of rituximab. Partial remission (PR) was observed in six (22%); five had received dose escalation. Of four relapses, 4-24 months after therapy, two were retreated with rituximab and achieved second remission. No major infections were encountered. Circulating B-cells were depleted by 1 month and normalized by 1 year. IgM, Ig A, and IgG levels decreased 6, 9, and 12 months after therapy, respectively, but remained near normal range. Tetanus toxoid antibody titers remained detectable. CONCLUSIONS: Rituximab was well tolerated, and induced sustained remissions in children with refractory immune cytopenias. Dose escalation and re-treatment after relapse elicited additional responses. Rituximab therapy should be considered prior to potential interventions with higher toxicity. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Comparison of symptom burden among patients referred to palliative care with hematologic malignancies versus those with solid tumors. Apr 2008 Nada A Fadul,Badi El Osta,Shalini Dalal,Valerie A Poulter,Eduardo Bruera BACKGROUND: Patients with hematologic malignancies have reduced and later access to palliative care services (APCS) than do those with solid tumors. It is unclear whether these patients develop a high symptom burden at the end of life that requires special palliative care interventions. The purpose... ( view more )s of this retrospective study were to determine whether symptoms are less severe in patients with hematologic than in those with solid malignancies on APCS and whether symptom severity is associated with early APCS. METHODS: We studied the records of consecutive patients with hematologic and solid malignancies at their first palliative care consultation (PC1). We collected information about demographics, cancer type, date of PC1, and the interval from PC1 to death (PC1-D). We reviewed the charts for the Edmonton Symptoms Assessment System (ESAS) and presence of delirium. RESULTS: We included 250 patients (125 with each type of malignancy). Median pain and drowsiness were 4 (3-5) and 7 (5-10) among hematologic compared to 5 (4-6, p=0.043) and 5 (3-6, p=0.0008) among patients with solid malignancies, respectively. Delirium was detected in 51 of 125 (41%) hematologic versus 20 of 125 (16%) solid (p=0.0001). Median PC1-D was 13 days for hematologic versus 46 days for solid (p=0.0001). There was no correlation between PC1-D and pain (r= -0.117, p=0.4 for hematologic and r=0.09, p=0.37 for solid), dyspnea (r= -0.02, p=0.85 for hematologic and r=0.09, p=0.42 for solid) or the Symptom Distress Score (r= -0.047, p=0.72 for hematologic and r= -0.093, p=0.32 for solid). CONCLUSIONS: Hematologic patients had increased delirium and drowsiness and later APCS The overall symptom severity was similar in both groups of patients and did not correlate with early APCS. Future prospective studies are needed to better define APCS patterns in this group. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Effect of topical mitomycin C on corneal endothelium. Apr 2008 Anita Panda,Jacob Pe'er,Anand Aggarwal,Hrishikesh Das,Abhiyan Kumar,Shalini Mohan PURPOSE: To evaluate patients with ocular surface squamous neoplasia (OSSN) on treatment with topical mitomycin C (MMC) with regard to changes in corneal thickness and endothelial count. DESIGN: Prospective, nonrandomized, interventional series. METHODS: In this prospective evaluation, 25 patients ... ( view more )with OSSN with different clock hours of involvement (range, one to eight), age varying from 19 to 76 years, were treated with topical MMC 0.04% in a cyclic manner. Preoperative corneal thickness measurement and endothelial cell density were obtained, and the tests were repeated after one, three, and six months of complete resolution. The fellow eyes of the same patients served as controls. RESULTS: Mean +/- standard deviation (SD) pachymetry and endothelial cell counts before and after instillation were 504.48 +/- 5.45 microm and 2325.76 +/- 192.52 cells/mm2 and 503.52 +/- 5.75 microm and 2297.60 +/- 192.08 cells/mm2, respectively, suggesting no significant difference in the above two parameters. Similarly, in the fellow control eyes, mean +/- SD pachymetry and endothelial cell counts before and after instillation were 502.80 +/- 4.34 microm and 2326.72 +/- 191.93 cells/mm2 and 504.64 +/- 5.19 microm and 2313.60 +/- 192.03 cells/mm2, respectively. CONCLUSIONS: Topical 0.04% MMC drops do not significantly affect the corneal endothelium. However, its judicious use and long-term follow-up are mandatory. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Highly active iridium(I) complexes for catalytic hydrogen isotope exchange. Mar 7, 2008 Jack A Brown,Stephanie Irvine,Alan R Kennedy,William J Kerr,Shalini Andersson,Göran N Nilsson Practically convenient methods have been developed for the preparation of new iridium complexes, possessing bulky N-heterocyclic carbene and phosphine ligands; these routinely handled complexes are highly active catalysts within directed hydrogen isotope exchange processes. View Full Abstract View Article Details View Coded Data Related Articles The moderating role of negative affect on objective verbal memory performance and subjective memory complaints in healthy older adults. Mar 2008 Moira C Dux,John L Woodard,John E Calamari,Michael Messina,Shalini Arora,Heather Chik,Noelle Pontarelli Subjective memory complaints (SMCs) are part of the diagnostic criteria for Mild Cognitive Impairment (MCI), yet little is known about their etiology. In some previous studies, no direct relation has been found between SMCs and objective memory performance, yet significant correlations have been id... ( view more )entified between SMCs and psychological factors such as depression and anxiety. In the current study, we examined whether negative affect moderated the relation between objective memory functioning and SMCs in a sample of healthy, non-demented participants aged 65 and older. As predicted, several negative affect measures moderated the relationship between objective cognitive functioning and SMCs. In the absence of objective memory impairment as indexed by the Rey Auditory Verbal Learning Test (RAVLT) and the Dementia Rating Scale-2nd Edition (DRS-2), higher levels of negative affect were associated with increased levels of SMCs. Moreover, a lower order negative affect factor, anxiety sensitivity, significantly moderated the relation between objective memory functioning and SMCs, after controlling for higher order measures of general negative affectivity. Findings suggest that negative affect, particularly anxiety sensitivity, distorts the subjective appraisal of one's own memory, such that people high on negative affect factors report more episodes of forgetting, even in the absence of objective cognitive impairments. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Mutagenicity of nitrated polycyclic aromatic hydrocarbons: a QSAR investigation. Mar 2008 Jyoti Singh,Shalini Singh,Basheerulla Shaik,Omar Deeb,Neena Sohani,Vijay K Agrawal,Padmakar V Khadikar Quantitative structure-activity relationship studies were performed to describe and predict the mutagenic activity of a set of 48 nitrated polycyclic aromatic hydrocarbons. From a larger pool of molecular descriptors (topological indices) we arrived at much a smaller set consisting of three correla... ( view more )ting parameters. Such a variable selection is made using ncss software in that successive regressions were attempted using maximum-R(2) method. The results are critically discussed using a variety of statistical parameters. Our results have shown that connectivity and shape type indices together with the distance-based Wiener index (W) play a dominating role in modelling of mutagenicity (logTA100). The predictive ability of the models is discussed on the basis of cross-validated parameters. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles The effect of probiotic dahi containing Lactobacillus acidophilus and Lactobacillus casei on gastropathic consequences in diabetic rats. Mar 2008 Hariom Yadav,Shalini Jain,P R Sinha In the present study, the effects of oral administration of probiotic dahi containing Lactobacillus acidophilus and Lactobacillus casei on gastropathic consequences in streptozotocin-induced diabetic rats were evaluated, and effects were compared with skim milk- and control dahi-fed groups. The fee... ( view more )ding of probiotic dahi did not change the blood glucose levels in chronic hyperglycemic conditions. The rate of charcoal transit was significantly higher in probiotic dahi-fed animals than in those of the diabetic control group (P < .05). Moreover, the oral administration of probiotic dahi significantly increased counts of lactobacilli adherent to epithelial walls and free in the lumen of the small and large intestine, while decreasing attached as well as free coliform counts (P < .05). In addition, probiotic dahi reversed the decrease in total lactobacilli and increase in total coliforms in fecal samples of diabetic animals. It was also shown that oral ingestion of probiotic dahi reduced the oxidative stress marker thiobarbituric acid-reactive species in intestinal tissues and glycosylation of hemoglobin (P < .05). All the effects were predominantly higher in the probiotic dahi-fed group than the skim milk- and control dahi-fed groups. The results indicate that probiotic dahi may be used as a therapeutic regimen to diminish the gastropathic consequences of diabetes. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Neuroleptic malignant syndrome variant in a patient receiving donepezil and olanzapine. Mar 2008 Tanya C Warwick,Venkata Moningi,Prasuna Jami,Kristy Lucas,Ogochukwu Molokwu,Shalini Moningi BACKGROUND: A 78-year-old man with a 22-year history of schizoaffective disorder and a 5-year history of dementia presented to the emergency department with a 5-day history of fatigue, progressive weakness, confusion and lethargy, and a 1-day history of severe muscle stiffness. For the past 10 year... ( view more )s the patient had been treated with olanzapine for an unspecified psychiatric illness, without adverse effects. One week before presentation the patient was started on donepezil to treat mild dementia. INVESTIGATIONS: Physical examination, serum and urine laboratory evaluation, lumbar puncture, brain CT scan, brain MRI, electroencephalogram, chest X-ray, and electrocardiogram. DIAGNOSIS: A variant of neuroleptic malignant syndrome secondary to drug interaction. MANAGEMENT: Discontinuation of donepezil and olanzapine, aggressive intravenous hydration, intravenous dantrolene, and bromocriptine via a nasogastric tube. The patient was also administered intravenous antibiotics for aspiration pneumonia, and carbidopa-levodopa for residual parkinsonian features. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Characteristics and outcomes of injury-related ED visits among older adults. Mar 2008 Mary W Carter,Shalini Gupta OBJECTIVES: The objectives of this study were to examine the epidemiology of injury among older adults treated in emergency departments (EDs) and to explore the effect of advanced age and nursing home residence on associated outcomes. METHODS: A secondary data analysis of a nationally representativ... ( view more )e sample from the National Hospital Ambulatory Care Survey was conducted using available sampling weights and data from the US Census Bureau. Weighted multivariate logistic regression was used to explore factors associated with injury outcomes, including hospitalization and receipt of potentially inappropriate medications. RESULTS: Nearly 21 million injury-related ED patient visits were made by older adults during the study period. Nearly 10% of episodes were identified as adverse events, which increased hospitalization risk 3-fold. Potentially inappropriate medications were provided during nearly 12% of encounters. CONCLUSIONS: Injury reductions among elders could be achieved by reducing adverse events, whereas quality could be improved by reducing potentially inappropriate medication use in the ED. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Comparative QSAR study on para-substituted aromatic sulphonamides as CAII inhibitors: information versus topological (distance-based and connectivity) indices. Mar 2008 Jyoti Singh,Basheerulla Shaik,Shalini Singh,Vijay K Agrawal,Padmakar V Khadikar,Omar Deeb,Claudiu T Supuran Comparative quantitative structure-activity relationship studies on para-substituted aromatic sulphonamides carbonic anhydrase II (CAII) inhibitors are reported in this paper. The study is made utilizing (i) information indices along; (ii) distance-based and connectivity indices and (iii) combinati... ( view more )on of information, distance-based and connectivity type topological indices. The study has shown that distance-based and connectivity type indices are superior for modelling, monitoring and estimating CAII inhibition. The results are critically discussed using a variety of statistical parameters. Our results show that starting from the mono-parametric regression itself, our results are superior: Furthermore, our methodology allowed carrying out much higher-parametric regressions, yielding a nine-parametric model with R2 as high as 0.8375. The eight-parametric regression, gave R2= 0.8343. As there is not much difference, we have considered the eight-parametric regression the best. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Subcutaneous phaeohyphomycosis caused by Wallemia sebi in an immunocompetent host. Mar 2008 Josep Guarro,Harish C Gugnani,Neelam Sood,Rashmi Batra,Emilio Mayayo,Josepa Gené,Shalini Kakkar We report a case of subcutaneous phaeohyphomycosis due to Wallemia sebi in a 43-year-old-female, the first case reported since 1950. The lesion presented as a nonhealing ulcer on the dorsum of the left foot. Diagnosis was based on histological demonstration of the fungus and its recovery in culture. View Full Abstract View Article Details View Coded Data Related Articles Neuropathology of a 4-month-old infant born to a woman with phenylketonuria. Mar 2008 Richard Koch,Shalini Verma,Floyd H Gilles We evaluated the brain of a 4-month-old male infant whose mother had inadequately controlled maternal phenylketonuria (MPKU). At autopsy his brain was normally developed but underweight. We found ventriculomegaly, hypoplastic cerebral white matter, and delay of myelination in late myelinating tract... ( view more )s without white matter astrocytosis and without chronic lesions in any gray matter structure. We compared the development of the infant's white matter tracts with published data on infant myelination. Congenital heart disease complicated the case. Abnormalities in developmental white matter may account for neurological abnormalities in infants with MPKU. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Page 1 of 19 1 2 3 4 > Last >> (454 articles found)

      
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