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GST Primary GST Primary Best Strategies for Health Care Quality Im... Best Strategies for Health Care Quality Improvement - Diabetes Quality Improvement Strategies for Antibio... Kathryn McDonald, Stanford-UCSF Evidence-b... Systematic review assessing the effect of ... Quality Improvement Strategies for Antibiotics Management Kathryn McDonald, Stanford-UCSF Evidence-based Practice Center, 117 Encina Commons, Stanford, CA 94305-6019, Kathy.mcdonald@stanford.edu Systematic review assessing the effect of quality improvement strategies on appropriate prescribing of antibiotics and appropriate choice of antibiotics. Adherence Adherence Assistive Devices Assistive Devices Childhood Burn Hanson MacMillan Childhood Burn Hanson MacMillan CLSA_9 CLSA_9 Cyberabuse Cyberabuse Cognitive Behavioural Therapy for Violent ... This review included randomized trials abo... Cognitive Behavioural Therapy for Violent Men who Batter Their Partners This review included randomized trials about the effects of cognitive behavioral therapy on domestic violence. The intervention included programs based on the Duluth Model. The violence had to be committed by a male toward his female partner. The violence also had to be physical. The primary outcomes were new arrests and convictions, and new reports of violence. CABG vs PCI CABG vs PCI Quality Improvement Strategies for Prevent... Quality Improvement Strategies for Preventing Nosocomial Infections (Created 17-Feb-06) Quality Improvement Strategies for Asthma ... Quality Improvement Strategies for Asthma Control Erectile Dysfunction (Created 30-Jan-06) Erectile Dysfunction (Created 30-Jan-06) Inequality - Smoking Cessation to Reduce S... This review was the first part of a projec... Inequality - Smoking Cessation to Reduce Socio-Economic Differences This review was the first part of a project about inequality. It included randomized trials about the effect of smoking cessation interventions on reducing socio-economic differences. The studies had to report data either on persons with low socio-economic groups status or, preferably, on both low and high socio-economic groups. Diet and Physical Activity to Reduce Socio... This review was the second part in a proje... Diet and Physical Activity to Reduce Socio-Economic Differences This review was the second part in a project about inequality. It included randomized trials about the effect of interventions on reducing socio-economic differences in diet and physical activity. The studies had to report data either on persons with low socio-economic groups status or, preferably, on both low and high socio-economic groups. Workfare The data in SRS are not identical to the d... Workfare The data in SRS are not identical to the data in the published report. We used SRS only for an updated search. The review included randomized trials about the effect of welfare-to-work programs. Participants were welfare recipients. There were basically two types of programs. The educational type tried to build knowledge and skills in order to help the welfare recipients acquire jobs that could support them economically. The "work first" approach was more aimed at getting the participants quickly into a job. Exercise interventions for the management ... The objective of this systematic review wa... Exercise interventions for the management of frailty The objective of this systematic review was to examine the effectiveness of current exercise interventions on the management of frailty. A comprehensive search of Medline, Embase, Psycinfo, Cinahl, Scopus, Ageline, Eric, and SportDiscus databases was conducted and produced 1808 citations. So far we have completed 2 levels of “title and abstract” screening and we ended up with 262 articles. We have just started the full text screening. Eligibility criteria included original studies whose participants were identified as frail or prefrail with specific criteria and in which structured physical activity was included as at least one component of the intervention. Create a free account, build a dictionary with saved terms to re-use later! Public Domestic Violence - Using Cognitive Behavior Therapy Smoking Cessation to Reduce Socio-Economic Differences Diet and Physical Activity to Reduce Socio-Economic Differences Workfare Exercise Interventions for the Management of Frailty Search     Simple Advanced Refine (4 coded questions)  Any of these:   Exact Phrase: All of these: None of these: Author: Periodical: Projects: No restrictions   Libraries: Public   Select SRS Projects Show Saved Terms Select Library Show articles that do not have abstracts  Humans or Animals Humans Animals Type of Article Clinical Trial Editorial Letter Meta-Analysis Practice Guideline Randomized Controlled Trial Review Addresses Bibliography Biography Case Reports Classical Article Clinical Conference Clinical Trial, Phase I Clinical Trial, Phase II Clinical Trial, Phase III Clinical Trial, Phase IV Comment Comparative Study Consensus Development Conference Consensus Development Conference, NIH Controlled Clinical Trial Corrected and Republished Article Dictionary Directory Duplicate Publication English Abstract Evaluation Studies Festschrift Government Publications Guideline Historical Article Interview In Vitro Journal Article Lectures Legal Cases Legislation Multicenter Study News Newspaper Article Overall Patient Education Handout Periodical Index Published Erratum Retracted Publication Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. 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Retraction of Publication Scientific Integrity Review Support of Research Technical Report Twin Study Validation Studies Not a Primary Study or Review Unknown Primary Study Case Series Case Control Cohort Study Observational Study Qualitative Research CBA or ITS Registry Double Blind Controlled before after study Quasi-randomized trial Simple before after study Cluster-RCT Non-Randomized Study Report Book Book chapter Dissertation Conference procedings Secondary Research Not RCT Ages All Infant: birth-23 months All Child: 0-18 years All Adult: 19+ years Newborn: birth-1 month Infant: 1-23 months Preschool Child: 2-5 years Child: 6-12 years Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Middle Aged + Aged: 45+ years Aged: 65+ years 80 and over: 80+ years Undetermined Language English French German Italian Japanese Russian Spanish Afrikaans Albanian Unknown Arabic Armenian Azerbaijani Bosnian Bulgarian Catalan Chinese Croatian Czech Danish Dutch Esperanto Estonian Finnish Georgian Greek, Modern Hebrew Hindi Hungarian Icelandic Indonesian Kinyarwanda Korean Latin Latvian Lithuanian Macedonian Malay Malayalam Maori Multiple Languages Norwegian Persian Polish Portuguese Pushto Romanian Sanskrit Scottish gaelic Serbian Slovak Slovenian Swedish Thai Turkish Ukrainian Vietnamese Not English Not French Results(1-25 of 266) Sort By: Publication Date Relevance Took: 1.191 seconds to search 17,750,454  Action: Copy Results to new Clipboard Build Search Link Page 1 of 11 1 2 3 4 > Last >> (266 articles found) Accuracy of consultations performed by infectious diseases trainees and factors associated with adherence to them. Nov 2007 Oguz Resat Sipahi,Meltem Tasbakan,Husnu Pullukcu,Bilgin Arda,Tansu Yamazhan,Serpil Mizrakci,Sebnem Senol,Sabri Atalay,Demet Koseli,Guray Arsu,Sebnem Calik,Hilal Sipahi,Cagri Buke,Sercan Ulusoy OBJECTIVES: Infectious diseases (ID) trainees should be familiar with duties relevant to consultation practice. In this study we aimed to analyze the ID trainee night/weekend shift consultation process in terms of consultant characteristics, types of recommendations, and compliance with recommendat... ( view more )ions. METHODS: All consultations performed by ID trainees on the night shift and at the weekends between 10 June and 10 August 2004 were recorded prospectively on standardized forms. Infectious diseases specialists assessed the appropriateness of recommendations the day after each consultation. Recommendations were considered complied with if they were carried out within 72 hours of the consultation. RESULTS: Of 440 consultations, 163 were for a clinically diagnosed infection (without specific antibiotic request) and 79 were for treatment continuation. Overall, 152 consultations were for requesting specific antibiotic(s), and 327 antibiotics were recommended or approved in 270 consultations. Eight of these recommendations were inappropriate. Overall compliance to ID recommendations was 75.3% (418/555). In univariate analysis, the compliance rate to non-treatment recommendations (microbiologic cultures, radiology, biochemistry, etc.) was found to be lower than the rate of compliance to antibiotic recommendations (186/308 vs. 232/247, p<0.05). In addition, compliance to recommendations made by the first-year trainees was lower than to the recommendations made by the other trainees. In logistic regression analysis only recommendations including antibiotic treatment was associated with higher compliance (p=0.0001, odds ratio=10.2, 95% CI=5.7-18.3). CONCLUSIONS: ID trainees are capable of evaluating patients and recommending appropriate antibiotics. Methodologies to improve the compliance to non-treatment-based recommendations and optimizing antibiotic selection seem to be necessary. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Adrenal axis functions in patients with familial Mediterranean fever. Jul 2006 Tansu Sav,Sav Tansu,Omer Ozbakir,Ozbakir Omer,Fahrettin Kelestimur,Kelestimur Fahrettin,Sebnem Gursoy,Gursoy Sebnem,Mevlut Baskol,Baskol Mevlut,Mustafa Kula,Kula Mustafa,Munis Dundar,Dundar Munis Objective: Familial Mediterranean fever (FMF) is a hereditary disease characterized by recurrent attacks of fever with peritonitis, arthritis, pleuritis or erysipelas-like rash. It is unclear what effects of FMF itself on endocrine system and hormones are. None of the FMF patients without amyloidos... ( view more )is have been reported to have any endocrine disorders, except those who developed colchicine-induced diabetes insipidus. There is a large body of evidence to show that cytokines (IL-1, IL-6 and TNF-alpha) activate the hypothalamic-pituitary-adrenal (HPA) axis. We have designated this study to investigate the HPA axis in FMF patients without amyloidosis. Methods: Twenty-one patients with FMF were included. ACTH stimulation test was performed on the healthy subjects and during attack period in the patients. In the patient group, same test was repeated during remission period. Results: Peak cortisol levels were significantly higher in the attack period than those in the remission period of patients (p<0.05). Conclusion: The cytokines play a role on the activation of the HPA axis; we thought the axis would be affected in this disease. The response of cortisol to 250 mug ACTH was significant in attack period when compared with remission period. This result reveals that HPA axis is more activated in an FMF attack. Previous studies suggest that the adrenal hormones increase in acute inflammatory events, and eventually, the changes on these hormones are related to TNF and IL-6 levels. During the FMF attack, HPA axis may be stimulated by cytokines. It seems that HPA axis is regulated normally in FMF patients. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Comparison of the effects of pulsed dye laser, pulsed dye laser + salicylic acid, and clobetasole propionate + salicylic acid on psoriatic plaques. Jan 2006 Turna Ilknur,Sevgi Akarsu,Sebnem Aktan,Sebnem Ozkan BACKGROUND: Studies show that pulsed dye laser (PDL) has some clinical benefits on psoriasis with a low clearance rate. In addition, it has been suggested that applying keratolytics before treatment might be helpful in PDL therapy. Topical corticosteroids remain the most commonly prescribed agents ... ( view more )for psoriasis. OBJECTIVE: This study was designed to compare the efficacy of the PDL treatment with that of PDL treatment after salicylic acid on psoriatic plaques. The other goal of this study was to compare the efficacy of the PDL treatment with that of clobetasol propionate treatment. METHODS: Twenty-two patients with chronic, stable psoriatic plaques that involved less than 20% of their body were included in the study. Three similar-appearing psoriasis plaques in these patients were selected. Whereas the first plaque received only PDL, the second plaque received PDL after salicylic acid, and the third plaque received clobetasol propionate ointment and salicylic acid. Evaluation of the study plaques was carried out by the modified Psoriasis Area and Severity Index (mPASI) score and by measuring the area of the plaques. RESULTS: Of the 21 patients, 19 completed the study. Although the decrease in mPASI scores was determined to be maximum for clobetasol propionate + salicylic acid-treated plaques and minimum for only PDL-treated plaques, the decrease was statistically significant in all groups when compared with baseline (p < .003). At the 3- and 6-week evaluations, there was a statistically significant difference between clobetasol propionate + salicylic acid-treated plaques and the two PDL-treated plaques (p < .003); however, the difference observed at the 9-, 12-, and 15-week evaluations was statistically significant only between clobetasol propionate + salicylic acid-treated plaques and PDL-treated plaques (p < .003). When the baseline and 15-week evaluations were compared, there was no statistically significant increase in the mean lesion areas of clobetasol propionate + salicylic acid-treated psoriatic plaques (p > .003), but there was a statistically significant increase in the mean lesion areas of two PDL-treated psoriatic plaques (p < .003). CONCLUSION: The results of this study showed that the effect of PDL could be increased when salicylic acid was added to treatment, although there was no statistically significant difference between both treatment protocols. However, clobetasol propionate + salicylic acid treatment is more effective than both PDL and PDL + salicylic acid treatment. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Quantification of female pattern hair loss: a study in a Turkish population. 2007 Jul-Aug Sebnem Aktan,Sevgi Akarsu,Turna Ilknur,Melda Demirta?o?lu,Sebnem Ozkan Studies dealing with the relationship between the clinical staging of female pattern hair loss (FPHL) and quantitative measurements of hair parameters are limited. This study was performed to quantify Turkish women's hair characteristics in FPHL, to assess the relationship between clinical presenta... ( view more )tions of FPHL with hair density and anagen hair ratio and to compare the differences in hair parameters between FPHL and normal women, using epiluminescence microscopy combined with digital image analysis (Trichoscan). Hair density and anagen hair ratio measurements of 39 patients with FPHL were evaluated according to clinical stages and compared with those of 31 healthy volunteers. The results of digital image analysis were compared with the results of visual counting using the photomacrographs of the same images. Mid-scalp hair density and anagen ratio of the patients were detected to be significantly lower than those of the controls. The visual counting detected significant differences among the hair densities of all groups including controls, Ludwig I, and Ludwig II/III groups, while digital image analysis revealed a significant difference only between controls and Ludwig II/III groups. Thus digital image analysis was found to underestimate hair density, and the amount of underestimation demonstrated a positive correlation with hair density. In conclusion, diminished hair density seems to be the main sign in the clinical diagnosis of hair loss, although digital image analysis was found to be less competent than visual counting in detecting hair density. Thus, the increase in hair density in the assessment of various treatment modality effects may be underestimated by digital image analysis. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Comparison of three different approaches in the treatment of chronic low back pain. Jul 2008 Sebnem Kolda? Do?an,Birkan Sonel Tur,Ye?im Kurtai?,Mesut Birol Atay Our aim is to investigate the effects of three therapeutic approaches in the chronic low back pain on pain, spinal mobility, disability, psychological state, and aerobic capacity. Sixty patients with chronic low back pain were randomized to three groups: group 1, aerobic exercise + home exercise; g... ( view more )roup 2, physical therapy (hot pack, ultrasound, TENS) + home exercise; group 3, home exercise only. Spinal mobility, pain severity, disability, and psychological disturbance of the patients were assessed before and after the treatment and at 1-month follow-up. Aerobic capacities of the patients were measured before and after treatment. All of the groups showed similar decrease in pain after the treatment and at 1-month follow-up, and there was no significant difference between the groups. In group 2, a significant decrease in Beck Depression Inventory scores was observed with treatment. At 1-month follow-up, group 1 and 2 showed significant decreases in General Health Assessment Questionnaire scores. In group 2, there was also a significant improvement in Roland Morris Disability scores. There were similar improvements in exercise test duration and the MET levels in all the three groups. All of the three therapeutic approaches were found to be effective in diminishing pain and thus increasing aerobic capacity in patients with chronic low back pain. On the other hand, physical therapy + home exercise was found to be more effective regarding disability and psychological disturbance. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Rapid analysis of fungal cultures and dried figs for secondary metabolites by LC/TOF-MS. Jun 9, 2008 Hamide Z Senyuva,John Gilbert,Sebnem Oztürko?lu A liquid chromatography-time-of-flight mass spectrometry (LC/TOF-MS) method has been developed for profiling fungal metabolites. The performance of the procedure in terms of mass accuracy, selectivity (specificity) and repeatability was established by spiking aflatoxins, ochratoxins, trichothecenes... ( view more ) and other metabolites into blank growth media. After extracting, and carrying out LC/TOF-MS analysis, the standards were correctly identified by searching a specially constructed database of 465 secondary metabolites. To demonstrate the viability of this approach 11 toxigenic and four non-toxigenic fungi from reference collections were grown on various media, for 7-14 days. The method was also applied to two toxigenic fungi, A. flavus (200-138) and A. parasiticus (2999-465) grown on gamma radiation sterilised dried figs, for 7-14 days. The fungal hyphae plus a portion of growth media or portions of dried figs were solvent extracted and analysed by LC/TOF-MS using a rapid resolution microbore LC column. Data processing based on cluster analysis, showed that electrospray ionization (ESI)-TOF-MS could be used to unequivocally identify metabolites in crude extracts. Using the elemental metabolite database, it was demonstrated that from culture collection isolates, anticipated metabolites. The speed and simplicity of the method has meant that levels of these metabolites could be monitored daily in sterilised figs. Over a 14-day period, levels of aflatoxins and kojic acid maximised at 5-6 days, whilst levels of 5-methoxysterigmatocystin remained relatively constant. In addition to the known metabolites expected to be produced by these fungi, roquefortine A, fumagillin, fumigaclavine B, malformins (peptides), aspergillic acid, nigragillin, terrein, terrestric acid and penicillic acid were also identified. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Comparison of different classifier algorithms on the automated detection of obstructive sleep apnea syndrome. Jun 2008 Kemal Polat,Sebnem Yosunkaya,Salih Güne? In this paper, we have compared the classifier algorithms including C4.5 decision tree, le artificial neural network (ANN), artificial immune recognition system (AIRS), and adaptive neuro-fuzzy inference system (ANFIS) in the diagnosis of obstructive sleep apnea syndrome (OSAS), which is an importa... ( view more )nt disease that affects both the right and the left cardiac ventricle. The goal of this study was to find the best classifier model on the diagnosis of OSAS. The clinical features were obtained from Polysomnography device as a diagnostic tool for obstructive sleep apnea in patients clinically suspected of suffering this disease in this study. The clinical features are arousals index, apneahypopnea index (AHI), SaO2 minimum value in stage of rapid eye movement, and percent sleep time in stage of SaO2 intervals bigger than 89%. In our experiments, a total of 83 patients (58 with a positive OSAS (AHI>5) and 25 with a negative OSAS such that normal subjects) were examined. The decision support systems can help to physicians in the diagnosing of any disorder or disease using clues obtained from signal or images taken from subject having any disorder. In order to compare the used classifier algorithms, the mean square error, classification accuracy, area under the receiver operating characteristics curve (AUC), and sensitivity and specificity analysis have been used. The obtained AUC values of C4.5 decision tree, ANN, AIRS, and ANFIS classifiers are 0.971, 0.96, 0.96, and 0.922, respectively. These results have shown that the best classifier system is C4.5 decision tree classifier on the diagnosis of obstructive sleep apnea syndrome. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Prevalence of migraine diagnosis using ID Migraine among university students in southern Turkey. Jun 2008 Sebnem Bicakci,Nafiz Bozdemir,Fahri Over,Esra Saatci,Yakup Sarica In this prospective study, we aimed to determine the prevalence of migraine and non-migraine headaches using a questionnaire, including ID Migrainetrade mark, for university students. The study was designed cross-sectionally and a questionnaire consisting of 43 questions was applied to 1,256 studen... ( view more )ts. The questionnaire consisted of questions related to demographic, social, curriculum, housing and headache characteristics of the subjects. Three-item screening questions of the ID Migrainetrade mark test were included at the end of the questionnaire aimed at migraine diagnosis. The mean age of 1,256 students (529 females and 727 males) enrolled in this study was 21.9 +/- 2.1 years (17-31 years). Migraine-type headache was detected in 265 subjects (21.9%) based on the ID Migrainetrade mark evaluation. Of these, 145 (54.7%) were female and 120 (45.3%) were male (female/male ratio: 1.2/1). Non-migraine-type headache was identified in 864 subjects, with 357 females and 507 males. As a conclusion, ID Migrainetrade mark screening test might be practical and beneficial when a face-to-face interview is not possible or to pre-determine the subjects for a face-to-face interview for migraine diagnosis in larger populations. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Hydrophobically modified low molecular weight chitosans as efficient and nontoxic gene delivery vectors. May 2008 Xin Zhang,Sebnem Ercelen,Guy Duportail,Emmanuel Schaub,Vladimir Tikhonov,Alexander Slita,Vladimir Zarubaev,Valery Babak,Yves Mély BACKGROUND: Chitosan derivatives are potential candidates for gene delivery because they are biocompatible and low toxic. However, their use has been limited by their moderate transfection efficiency and the rather large sizes of DNA complexes with high molecular weight chitosans. To circumvent the... ( view more )se limitations, we used low molecular weight (approximately 5 kDa) chitosans grafted at 3 and 18 mol% with N-/2(3)-(dodec-2-enyl)succinoyl groups (HM-LMW-ch) that exhibit surfactant-like properties. METHODS: The physico-chemical properties of complexes of DNA with the two HM-LMW-ch derivatives and the nonmodified LMW-ch were compared by electrophoresis, dynamic light scattering, fluorescence spectroscopy and fluorescence correlation spectroscopy. Moreover, their transfection efficiencies and cytotoxicity were evaluated and their intracellular trafficking was monitored by confocal microscopy. Finally, their ability to deliver genes in mice kidneys after systemic administration was investigated. RESULTS: Complexes with HM(3%)-LMW-ch, but not with HM(18%)-LMW-ch and LMW-ch, efficiently delivered genes in mice kidneys. HM(3%)-LMW-ch formed small positively charged particles that were resistant to DNases and nucleases and marginally interact with serum components. Moreover, these particles were efficiently internalized in cells and low toxic. By contrast, HM(18%)-LMW-ch formed large and weakly charged aggregates with DNA that were highly susceptible to DNases and nucleases. CONCLUSIONS: HM(3%)-LMW-ch appears to be a promising nonviral vector with low cytotoxicity and efficient transfection properties. Copyright (c) 2008 John Wiley & Sons, Ltd. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles The value of admission glycosylated hemoglobin level in patients with acute myocardial infarction. May 2008 Mahmut Cakmak,Nazmiye Cakmak,Sebnem Cetemen,Halil Tanriverdi,Yavuz Enc,Onder Teskin,I Dogu Kilic BACKGROUND: Glycosylated hemoglobin (HbA1c) level on admission is a prognostic factor for mortality in patients with and without diabetes after myocardial infarction. In the present study, the authors examined the relationship between admission HbA1c level and myocardial perfusion abnormalities in ... ( view more )patients with acute myocardial infarction. METHODS: One hundred consecutive patients with acute myocardial infarction who were treated with thrombolytic therapy were included in the present prospective study. Blood glucose and HbA1c levels of all patients were measured within 3 h of admission. Patients were divided into three groups according to HbA1c level: 4.5% to 6.4% (n=25), 6.5% to 8.5% (n=28) and higher than 8.5% (n=47). All patients then underwent exercise thallium-201 imaging and coronary angiography to determine ischemic scores and the number of diseased coronary arteries four weeks after admission. RESULTS: Seven patients died within the four-week follow-up period. There was a significant relationship between admission HbA1c level and mortality (P=0.009). Furthermore, there was a significant relationship between HbA1c level and total ischemic scores in patients with acute myocardial infarction (r=0.482; P=0.001). Ischemic scores increased as HbA1c levels increased in patients with acute myocardial infarction. CONCLUSIONS: The results demonstrated that admission plasma glucose and HbA1c levels are prognostic factors associated with mortality after acute myocardial infarction. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Inhibition of IL-1beta transcription by peptides derived from the hCMV IE2 transactivator. May 2008 James A Listman,JoAnne E Race,Nancy Walker-Kopp,Sebnem Unlu,Philip E Auron The immediate early (IE) proteins of human cytomegalovirus (hCMV) have diverse roles in directing viral and host cell transcription. Among these is the ability of IE2 to induce transcription of the IL1B gene that codes for IL-1beta in monocytes. This function is partially explained by interaction b... ( view more )etween IE2 and the host cell transcription factor Spi-1/PU.1 (Spi-1). We now show that maximal IE2 function also depends on productive interactions localizing to two C/EBP sites on the IL1B promoter suggesting either bi- or tri-molecular interactions between IE2, Spi-1 and C/EBPbeta at two different locations on the promoter. The IE2 interaction region on Spi-1 was previously mapped to the DNA-binding ETS domain and overlaps the region of Spi-1 that interacts with the transcription factor C/EBPbeta, a factor known to be critical for the induction of IL1B in response to Toll/IL-1 receptor (TIR) family signal transduction. The Spi-1 interacting region of IE2 maps to amino acids 315-328, a sequence that also interacts with the bZIP domain of C/EBPbeta. An expression vector coding for amino acids 291-364 of IE2 can suppress LPS induction of a co-transfected IL1B enhancer-promoter fragment in a monocyte cell line. This inhibition is likely the result of competition between Spi-1 and C/EBPbeta, thus blunting gene induction. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Biomechanical properties of human hair with different parameters. May 2008 Berivan Erik,Hasan Havitcioglu,Sebnem Aktan,Nuriye Karakus BACKGROUND/PURPOSE: Investigations on the mechanical properties of human hair are inadequate. This research explores the break force of anagen hair by forming criteria according to the diameter of hair, gender, age, strain, use of drugs and hair dyes and how these criteria affect the mechanical res... ( view more )istance of hair. METHODS: The resistances of anagen hair of 120 volunteers were investigated in our biomechanics laboratory. The relationship between the value of break force of hair and hair diameter, gender, age, strain, use of drugs and hair dyes was examined. Tensile tests were applied to each hair with a 50 N load cell device. RESULTS: The statistical evaluation demonstrated a significant difference between the break forces of hairs with different hair diameters. The hairs with a diameter of 51 mum and above had a significantly higher break force than those of 50 mum and below (P=0.000). An insignificant correlation was observed between break force and strain (P=0.554, r=-0.055) whereas the correlation between diameter and strain was statistically significant (P=0.000, r=0.361). CONCLUSION: The break force of hairs did not show any significant dependency on age, presence of hair dyes, gender and usage of drugs. Yet, a statistically significant difference was observed between the break forces of hairs when compared according to their diameters and strain. More research on the mechanical properties of human hair consistent with biological properties like protein structure, alpha keratin fibers and microfibril-matrix composite behaviors would guide dermatologists for diagnostic symptoms. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Isolated myelosarcoma development in an adolescent chronic myeloid leukemia patient with t(9;22)(q34;q11.2), +8, +14, +21, and der(1)(p36). Apr 1, 2008 Hale Oren,Sebnem Yilmaz,Zeynep Sercan,Fatih Demircio?lu,Erdinç Yüksel,Gülersu Irken Additional chromosomal abnormalities are found in 5-20% of patients during chronic phase of chronic myeloid leukemia and in 60-80% preceding or accompanying blast crisis. These abnormalities are important in disease progression and, because they may occur before hematological and clinical symptoms,... ( view more ) can be taken as a prognostic indicator. An adolescent with chronic myeloid leukemia initially presented with extreme thrombocytosis, increased megakaryopoiesis with dysmorphic features, and focal myelofibrosis in bone marrow examinations and then developed isolated myelosarcoma 1 year after onset, with t(9;22)(q34;q11.2), +8, +14, +21, and der(1)(p36). ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Multidisciplinary approach in the treatment of subgingivally fractured anterior teeth. Apr 2008 Sebnem Begüm Türker,Kemal Naci Köse With the advances in adhesive technology, dentists have gained great popularity with their esthetics treatment options. The enamel and partially dentin adhesive systems have proved their potential effect. This study presents the multidisciplinary approach in the treatment of subgingivally fractured... ( view more ) anterior teeth. Empress II crowns were cemented entirely on the prepared root portion of a left maxillary lateral incisor and canine after orthodontic eruption. The clinical results after 2 years were successful. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Moxifloxacin versus ampicillin + gentamicin in the therapy of experimental Listeria monocytogenes meningitis. Mar 2008 Oguz Resat Sipahi,Tuncer Turhan,Husnu Pullukcu,Sebnem Calik,Meltem Tasbakan,Hilal Sipahi,Bilgin Arda,Tansu Yamazhan,Sercan Ulusoy OBJECTIVES: This study aimed to compare the antibacterial activity of moxifloxacin and ampicillin + gentamicin in the treatment of Listeria monocytogenes meningitis in a rabbit meningitis model. METHODS: Meningitis was induced by direct inoculation of a clinical strain isolated from an immunocompro... ( view more )mised patient (10(7) cfu/mL) into the cisterna magna of New Zealand rabbits. After 16 h of incubation, rabbits were separated into four groups: moxifloxacin (M), ampicillin + gentamicin (A), ampicillin + gentamicin 2 (A2) and control (C). Group M received 20 mg/kg moxifloxacin at the end of the incubation time and 5 h later by intravenous (i.v.) route. Group A received ampicillin (30 mg/kg/h) and gentamicin (2.5 mg/kg/h) by i.v. route with continuous infusion for 8 h in 36 mL of 0.9% NaCl, group A2 received the same dosage of gentamicin and ampicillin in two different 36 mL 0.9% NaCl solutions and group C did not receive any treatment. Cerebrospinal fluid (CSF) samples (0.1-0.25 mL) were obtained 16 and 24 h after induction of meningitis. RESULTS: At the end of the 16 h of incubation, CSF bacterial counts were similar in all groups (P > 0.05). At the final stage of the study (24 h after induction of meningitis), bacterial counts in all treatment groups were significantly lower than the control group (P < 0.05). When the three treatment groups were compared, bacterial counts were found to be similar (P > 0.05). CONCLUSIONS: These data suggest that antibacterial activity of moxifloxacin is similar to ampicillin + gentamicin in the treatment of experimental L. monocytogenes meningitis of rabbits. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Recurrent headache and MRI findings in systemic lupus erythematosus. Mar 2008 Sebnem Bicakci,Suleyman Ozbek,Kenan Bicakci,Kezban Aslan,Banu Kara,Yakup Sarica BACKGROUND: Headache in patients with systemic lupus eryhtematosus (SLE) is considered a common neurological finding, although the relationship is unclear. Another obscure point is the relationship between headache and neuroradiologic findings in these patients. AIM: In this study, we aimed to eval... ( view more )uate the correlation between headache characteristics and intracranial lesions in SLE patients. METHODS AND RESULTS: Forty-eight SLE patients were chosen from those referred to our clinic depending on the American Collage of Rheumatology (ACR) criteria at the same time or after the diagnosis of SLE. Headache classification was done regarding the ICD-II criteria in the patients. Headache severity was assessed by visual analog scale (VAS), and subjects with VAS > or = 4 were included in the study. Patients were divided into two groups according to magnetic resonance imaging (MRI) findings: abnormal MRI (lesion positive) and normal MRI (lesion negative). On MRI, intracranial lesions were detected in 37.5% (n = 18) of the patients, and no lesion was found in 62.5% (n = 30). Headache characteristics were as tension type in 54.1% (n = 26) and migraine like in 39.6% (n = 19) of all patients. Imaging findings were mostly as periventricular and subcortical focal lesions, ranging from 3-22 mm in diameter. A significant correlation was found between abnormal MRI findings with advanced age and prolonged disease duration (p = 0.018, p = 0.016). CONCLUSIONS: As a conclusion, a detailed neurologic evaluation and radiologic investigation, if necessary, should be performed in SLE patients with prolonged disease and advanced age, regardless of headache characteristics. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Protein kinase C inhibition in the treatment of mania: a double-blind, placebo-controlled trial of tamoxifen. Mar 2008 Ay?egül Yildiz,Sebnem Guleryuz,Donna Pauler Ankerst,Dost Ongür,Perry F Renshaw CONTEXT: Findings that protein kinase C (PKC) activity may be altered in mania, and that both lithium carbonate and valproate sodium inhibit PKC-associated signaling in brain tissue, encourage development of PKC inhibitors as candidate antimanic agents. OBJECTIVE: To perform a controlled test of an... ( view more )timanic efficacy of the centrally active PKC inhibitor tamoxifen citrate. DESIGN: Three-week, randomized, double-blind, placebo-controlled, parallel-arms trial. SETTING: A university medical center inpatient psychiatric unit in Izmir, Turkey. PATIENTS: Sixty-six patients aged 18 to 60 years, diagnosed as having DSM-IV bipolar I disorder on the basis of the Structured Clinical Interview for DSM-IV, currently in a manic or mixed state, with or without psychotic features, with initial scores on the Young Mania Rating Scale (YMRS) greater than 20. INTERVENTION: Treatment with tamoxifen or identical placebo tablets for up to 3 weeks. Adjunctive lorazepam was allowed up to 5 mg/d. MAIN OUTCOME MEASURES: Primary: change in YMRS scores; secondary: change in Clinical Global Impressions-Mania scores, weekly ratings of depression and psychosis, and adjunctive use of lorazepam. RESULTS: The 21-day trial was completed by 29 of 35 subjects randomized to receive tamoxifen (83%) and 21 of 31 given placebo (68%) (P = .25). Intent-to-treat analysis of available measures on all 66 subjects indicated that tamoxifen treatment yielded mean decreases in scores on the YMRS and Clinical Global Impressions-Mania of 5.84 and 0.73 point per week, respectively, compared with mean increases of 1.50 and 0.10 point per week, respectively, with placebo; both drug-placebo contrasts differed significantly (P < .001). CONCLUSIONS: Tamoxifen demonstrated antimanic properties and was remarkably well tolerated. The findings encourage further clarification of the role of PKC in the pathophysiologic mechanism of bipolar I disorder and development of novel anti-PKC agents as potential antimanic or mood-stabilizing agents. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00411203 and isrctn.org Identifier: ISRCTN97160532. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Epidemiologic and Clinical Characteristics of HIV/AIDS Patients in Turkey, Where the Prevalence Is the Lowest in the Region. Mar 2008 Aysel Celikbas,Onder Ergonul,Nurcan Baykam,Sebnem Eren,Harika Esener,Mustafa Eroglu,Basak Dokuzoguz The authors describe the epidemiologic and clinical characteristics of 97 human immunodeficiency virus (HIV)-infected patients, who were followed between 1993 and 2006. Seventy-two percent of the patients were male, and median age at diagnosis was 36 years (range, 13-71 years). The mean years of su... ( view more )rvival was 3, and maximum length of life after diagnosis was 9 years. The most common professions were truck drivers, workers, and housewives. Forty-six percent of the males had a history of working abroad. Heterosexual intercourse was the most common (84%) route of transmission. Seventy-four percent of the women acquired infection from their husbands. In Turkey, less educated or uneducated and poor men are the primary target of the HIV infection usually by sexual contact with foreign women. Considering the low education status of the patients, appropriate education programs should be developed to prevent the dissemination of HIV infection. Because a significant number of patients were diagnosed at very late stages, the physicians and other health care workers should be educated on the clinical pictures of HIV/AIDS. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Etanercept for therapy-resistant macrophage activation syndrome. Feb 2008 Balahan Makay,Sebnem Yilmaz,Zeynep Türkyilmaz,Nurettin Unal,Hale Oren,Erbil Unsal Macrophage activation syndrome (MAS) is a severe, potentially fatal complication of childhood rheumatic diseases, especially systemic onset juvenile idiopathic arthritis (SoJIA). We report a 4-year-old girl with probable SoJIA who presented with MAS. She did not respond to pulse methyl prednisolone... ( view more ) and Cyclosporine A (CsA). She also failed to respond to intravenous immunoglobulin (IVIG) therapy. Etanercept was started, based on the observation of increased serum levels of tumor necrosis factor-alpha (TNF-alpha) in patients with MAS. Her condition improved following etanercept, suggesting that etanercept might have a therapeutic role in resistant MAS. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles The effects of food protector biphenyl on sister chromatid exchange, chromosome aberrations, and micronucleus in human lymphocytes. 2008 Eyyüp Rencüzo?ullari,Sebnem Parlak,Hasan Basri Ila The aim of this study was to determine the possible genotoxic effects of biphenyl (E230), which is used as an antimicrobial agent in food by using sister chromatid exchanges (SCEs), chromosome aberrations (CAs), and micronucleus (MN) tests in human peripheral lymphocytes. The human peripheral lymph... ( view more )ocytes were treated with four concentrations of biphenyl (10, 30, 50, and 70 microg/mL) for 24- and 48-h treatment periods. In the present study, biphenyl significantly increased the frequency of SCEs, CAs, and the frequency of MN when compared with both untreated control and solvent (dimethyl sulfoxide) control. The inductions of these abnormalities were in a dose-dependent manner. Biphenyl was capable to induce the structural CAs instead of numerical CAs. Biphenyl also showed a cytotoxic effect by decreasing the replication index at the highest two concentrations for 48 h and nuclear division index at the highest two concentrations for the 24- and 48-h treatment periods. However, biphenyl did not affect the mitotic index (MI). ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Chorioangiomatosis presenting with severe anemia and heart failure in a newborn. 2008 Esra Arun Ozer,Nuray Duman,Abdullah Kumral,Sebnem Yilmaz,Hale Oren,Mustafa Kir,Erdener Ozer,Hasan Ozkan Although chorioangiomas are the most common placental tumors, multiple chorioangiomas (or chorioangiomatosis) are extremely rare. We report a female newborn at 37 weeks of gestation presenting with severe anemia, thrombocytopenia, heart failure, and intrauterine growth retardation. The pathological... ( view more ) examination of the placenta revealed chorioangiomatosis explaining the pathophysiology of the symptoms presented. The patient was treated successfully with erythrocyte and thrombocyte transfusions and was discharged after full recovery. We conclude that evaluating placental lesions may be of great value in explaining severe problems during the fetal and the neonatal period and thus prevents performing unnecessary clinical investigations. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Long-term antibacterial effects and physical properties of a chlorhexidine-containing glass ionomer cement. 2008 L Sebnem Türkün,Murat Türkün,Fahinur Ertu?rul,Mustafa Ate?,Stefan Brugger STATEMENT OF THE PROBLEM: Many regions in the world do not have electricity, water, or access to dental facilities that allows the treatment of caries with dental handpieces and rotary burs. For restorative techniques used in these regions, an antibacterial self-adherent glass ionomer material woul... ( view more )d contribute considerably. PURPOSE: This study aimed to test if chlorhexidine diacetate (Fluka BioChemika, Buchs, Switzerland)- or chlorhexidine digluconate (Sigma-Aldrich, Steinheim, Germany)-added ChemFil Superior glass ionomer cement (Dentsply DeTrey, Konstanz, Germany) had any long-term antibacterial effect against certain oral bacteria and to test the new formulation's physical properties. MATERIALS AND METHODS: ChemFil Superior was used as a control. Chlorhexidine diacetate (powder) was added to the powder and chlorhexidine digluconate (liquid) was mixed with the powder in order to obtain 0.5, 1.25, and 2.5% concentrations of the respective groups. Setting time, compressive strength, and acid erosion were tested according to ISO 9917-1. Working time, hardness, diametral tensile strength, and biaxial flexural strength were also determined. Long-term antimicrobial activity against S. mutans, L. acidophilus, and C. albicans were tested with the agar diffusion method. Analysis of variance (ANOVA) was used for comparison (p < 0.05). RESULTS: Regarding the immediate antibacterial effect for S. mutans, all the tested groups showed inhibitions of the strain compared with the control group (p < 0.05), with larger zones for the higher concentration groups and all the diacetates. For L. acidophilus, all the groups were effective compared with the control, but the greatest antibacterial effect was observed with the 2.5% diacetate group. The 2.5% group of chlorhexidine diacetate showed antibacterial activity up to 90 days against S. mutans and up to 60 days against L. acidophilus. The working and setting time, acid erosion test, diametral tensile strength, and biaxial flexural strength of the tested groups were not different from the control ChemFil group. However, the 1.25 and 2.5% groups of chlorhexidine diacetate had significantly lower compressive strengths than the control group. Lower hardness values were obtained with the 0.5 and 2.5% chlorhexidine digluconate groups in comparison with the control group. CLINICAL SIGNIFICANCE: The results of this in vitro investigation demonstrated that chlorhexidine diacetate or digluconate added to the ChemFil Superior glass ionomer material can exhibit long-term antibacterial effects against S. mutans and L. acidophilus without compromising the physical properties of the material. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Skin and soft tissue complications in pediatric leukemia patients with and without central venous catheters. Jan 2008 Fatih Demircio?lu,Sebnem Ylmaz,Hale Oren,Ali Aykan Ozgüven,Gülersu Irken We aimed to retrospectively evaluate the skin and soft tissue complications secondary to procedures in acute leukemia patients with and without catheters. Eighty-seven acute leukemia patients (75 acute lymphoblastic leukemia, 12 acute myeloid leukemia ) were included. There were 30 patients with 37... ( view more ) catheter use (6 port, 31 Hickman catheter) and 57 patients without catheter. In patients with catheters, skin and soft tissue complications were seen in 20 (66%) children. The most frequent complication was cellulitis (55%). In the patients without catheter, skin and soft tissue complications were seen in 37 (65%) patients. Cellulitis (37.8%) and extravasation (37.8%) were the most frequent causes. When the frequency of skin and soft tissue complications in patients with and without catheters were compared with each other, there was statistically no significant difference (P=0.792). The duration of chemotherapy was significantly longer in patients who developed skin and soft tissue complications with or without catheters when compared with the duration of the therapy in patients without any skin and soft tissue complications (259.2+/-36.3 and 218.3+/-58.3 d, respectively; P<0.0001). In pediatric leukemia patients, with or without catheters, skin and soft tissue complications are common and these complications may prolong the duration of chemotherapy. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Simvastatin may improve myocardial perfusion abnormality in slow coronary flow. 2008 Mahmut Cakmak,Halil Tanriverdi,Nazmiye Cakmak,Harun Evrengul,Sebnem Cetemen,Omur Kuru BACKGROUND: The slow coronary flow (SCF) phenomenon is a coronary microvascular disorder characterized by the delayed passage of contrast in the absence of obstructive epicardial coronary disease. Recent studies showed the possible role of endothelial dysfunction, diffuse atherosclerosis and inflam... ( view more )mation in the pathogenesis of this phenomenon. We aimed to investigate the effect of statin on myocardial perfusion in patients with SCF. METHODS AND RESULTS: The study population consisted of 97 patients with SCF. Coronary flow patterns of the cases are determined by thrombolysis in myocardial infarction (TIMI) frame count method. Single-photon emission computed tomographic myocardial perfusion imaging studies and lipid parameters of the patients were obtained before and after 6 months of simvastatin treatment period. During the study, daily single dose of 40 mg simvastatin has been given to each subject. We found a significant positive correlation between mean TIMI frame count and basal reversibility score (r = 0.84, p = 0.0001). In addition, analysis of the reversibility scores demonstrates that simvastatin treatment has significantly improved the myocardial perfusion abnormality at the end of the follow-up period. CONCLUSION: Present findings allow us to conclude that simvastatin improved myocardial perfusion in patients with SCF. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Cell adhesion and synaptogenesis. Dec 25, 2007 Gong Chen,Xia Wu,Sebnem Tuncdemir Synapses are inter-neuronal connections that are fundamental working units in neural networks. How synapses are molecularly constructed is a fascinating question, which attracted scientistso attention for many decades. Neuromuscular junction, a field pioneered by Te-Pei FENG and many others, has be... ( view more )en an excellent model for studying synaptogenesis and paved the way for our understanding of the synapse formation in the central nervous system. Recent studies shed new light on the molecular mechanisms of central synapse formation by discovering a group of cell adhesion molecules exerting potent synaptogenic effects. This review will focus on those cell adhesion molecules which can induce central synapse formation when expressed in non-neuronal cells. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Page 1 of 11 1 2 3 4 > Last >> (266 articles found)

      
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