| Create a free account, build a dictionary with saved terms to re-use later! |
(4 coded questions)  |
Show articles that do not have abstracts
|
| Ages | | All Infant: birth-23 months All Child: 0-18 years All Adult: 19+ years Newborn: birth-1 month Infant: 1-23 months Preschool Child: 2-5 years Child: 6-12 years Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Middle Aged + Aged: 45+ years Aged: 65+ years 80 and over: 80+ years Undetermined
| | | Type of Article | | Clinical Trial Editorial Letter Meta-Analysis Practice Guideline Randomized Controlled Trial Review Addresses Bibliography Biography Case Reports Classical Article Clinical Conference Clinical Trial, Phase I Clinical Trial, Phase II Clinical Trial, Phase III Clinical Trial, Phase IV Comment Comparative Study Consensus Development Conference Consensus Development Conference, NIH Controlled Clinical Trial Corrected and Republished Article Dictionary Directory Duplicate Publication English Abstract Evaluation Studies Festschrift Government Publications Guideline Historical Article Interview In Vitro Journal Article Lectures Legal Cases Legislation Multicenter Study News Newspaper Article Overall Patient Education Handout Periodical Index Published Erratum Retracted Publication Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Retraction of Publication Scientific Integrity Review Support of Research Technical Report Twin Study Validation Studies Not a Primary Study or Review Unknown Primary Study Case Series Case Control Cohort Study Observational Study Qualitative Research CBA or ITS Registry Double Blind Controlled before after study Quasi-randomized trial Simple before after study Cluster-RCT Non-Randomized Study Report Book Book chapter Dissertation Conference procedings Secondary Research Not RCT
| | | Humans or Animals | | Humans Animals
| | | Language | | English French German Italian Japanese Russian Spanish Afrikaans Albanian Unknown Arabic Armenian Azerbaijani Bosnian Bulgarian Catalan Chinese Croatian Czech Danish Dutch Esperanto Estonian Finnish Georgian Greek, Modern Hebrew Hindi Hungarian Icelandic Indonesian Kinyarwanda Korean Latin Latvian Lithuanian Macedonian Malay Malayalam Maori Multiple Languages Norwegian Persian Polish Portuguese Pushto Romanian Sanskrit Scottish gaelic Serbian Slovak Slovenian Swedish Thai Turkish Ukrainian Vietnamese Not English Not French
| |
|
(1-25 of 3,316) |
Sort By:
|
Took: 0.794 seconds to search 17,750,454 |
Aguirre-Molina, Marilyn, Molina, Carlos W., and Ruth Enid, Ed This collection of papers includes 6 parts. Part 1, "Latino Populations in the United States," includes: (1) "Latino Health Policy: Beyond Demographic Determinism" (Angelo Falcon, Marilyn Aguirre-Molina, and Carlos W. Molina); (2) "Latino Health Status" (Olivia Carter-Pokras and Ruth Enid Zambrana)... ( view more ); and (3) "Latino Access To Health Care: The Role of Insurance, Managed Care, and Institutional Barriers" (J. Emilio Carrillo, Fernando M. Trevino, Joseph R. Betancourt, and Alberto Coustasse). Part 2, "Latino Life Stages and Health," includes: (4) "The Early Years: The Health of Children and Youth" (Glenn Flores and Ruth Enid Zambrana); (5) "The Reproductive Years: The Health of Latinas" (Aida L. Giachello); (6) "The Later Years: The Health of Elderly Latinos" (Valentine M. Villa and Fernando M. Torres-Gil); and (7) "Latino Mental Health and Treatment in the United States" (William A. Vega and Margarita Alegria). Part 3, "Patterns of Chronic Diseases among Latinos," includes: (8) "The Impact of Cancer on Latino Populations" (Amelie G. Ramirez and Lucina Suarez); (9) "Cardiovascular Disease" (Eliseo Perez-Stable, Teresa Juarbe, and Gina Moreno-John); (10) "Diabetes" (Jose Alejandro Luchsinger); and (11) "Gender, Context, and HIV Prevention among Latinos" (Hortensia Amaro, Rodolfo R. Vega, and Dellanira Valencia). Part 4, "Occupational Health and the Latino Workforce," includes: (12) "Occupational Health among Latino Workers in the Urban Setting" (Rafael Moure-Eraso and George Friedman-Jimenez) and (13) "Health and Occupational Risks of Latinos Living in Rural America" (Kathryn Azevedo and Hilda Ochoa Bogue). Part 5, "Alcohol, Tobacco, and Other Drug Use among Latinos," includes: (14) "Alcohol Use and Alcohol-Related Problems among Latinos in the United States" (Raul Caetano and Frank Hector Galvan); (15) "Tobacco Use among Latinos" (Gerardo Marin); and (16) "Latino Drug Use: Scope, Risk Factors, and Reduction Strategies" (Andres G. Gil and William A. Vega). Part 6, "A New Health Agenda," offers (17) "Latino Health Policy: A Look To the Future" (Marilyn Aguirre-Molina, Angelo Falcon, and Carlos W. Molina). (Papers contain references.) (SM) ( view less ) Marilyn L Slovak,Gordon W Dewald The inaugural meeting of the International Working Group on MDS cytogenetics convened 22-23 October 2007 in Chicago, IL. Under the sponsorship of the Myelodysplastic Syndromes Foundation, the group was organized to address the substantial need for worldwide standardized cytogenetic testing for MDS ... ( view more )in clinical practice and research. Eighteen cytogeneticists from 10 countries attended the first working group meeting. Representatives from France and Austria were unable to attend the Chicago meeting. Marilyn L. Slovak, PhD (City of Hope, USA) served as Working Group Chair and Gordon Dewald, PhD (Mayo Clinic, USA), served as Working Group Advisor and Co-Chair. Other members in attendance included: Mette Andersen, Rigshospitalet, Denmark; Lynda Campbell, St. Vincent's Hospital Melbourne, Australia; Athena Cherry, Stanford University, USA; Kathy Chun, North York General Hospital, Canada; Mike Griffiths, West Midlands Regional Genetics Lab, UK; Detlef Haase, Georg-August-Universität, Germany; Claudia Haferlach, MLL Münchner Leukämielabor GmbH, Germany; Anne Hagemeijer, University of Leuven, Belgium; Barbara Hildebrandt, Institut für Humangenetik & Anthropologie Dupsilonsseldorf, Germany; Douglas Horsman, BC Cancer Agency, Canada; M. Anwar Iqbal, University of Rochester, USA; Suresh Jhanwar, Memorial Sloan-Kettering Cancer Center, USA; Bertil Johansson, University Hospital, Sweden; Michelle LeBeau, University of Chicago, USA; Kazuma Ohyashiki, Tokyo Medical University, Japan; Francesc Solé, Hospital del Mar, Spain. The focus of the working group was to establish the natural history and clinical significance of cytogenetic anomalies associated with the myelodysplastic syndromes (MDS), and to incorporate cytogenetic testing into the development of new treatments to cure MDS. Three specific goals were discussed in an effort to rapidly improve the care of patients with MDS. The first goal was how to educate physicians on the appropriate use of cost effective cytogenetic testing for their patients with MDS. The second goal discussed was how best this working group could assist pharmaceutical companies with the use of appropriate cytogenetic testing in their evaluation of new drugs. The final goal discussed was how to advance cytogenetic research into the origin, progression and clinical significance of genetic anomalies associated with MDS. ( view less ) Marilyn H Oermann,Elizabeth A Galvin,Judith A Floyd,Janna C RoopResearch is of little value to clinical practice if the findings are not appropriately integrated into that practice. While publishing the results of research is essential for translating findings into practice, Marilyn Oermann and colleagues suggest that work is not done until the findings are dis... ( view more )seminated for use by clinicians and others who need the research results to guide their practice ( view less ) Karlene M Kerfoot,Marilyn CoxClarian Health Partners is a system that includes Methodist Hospital of Indiana, Indiana University Hospital, and Riley Hospital for Children. The nurses of Clarian Health Partners are the recipients of many national awards for their leadership and innovations in critical care. Nurse leaders at Cla... ( view more )rian have developed and implemented a unique framework for professional development based on the synergy model. In this article, the Chief Nurse Executive for the System, Dr. Karlene Kerfoot, and Marilyn Cox, the Senior Vice President for Nursing and Patient Care at Riley Hospital for Children, describe their vision of and strategies for a new approach to mentoring professional nursing staff. ( view less ) Marilyn Ford-Gilboe,Judith Wuest,Marilyn Merritt-Gray Children's health is a key factor in women's decisions to leave abusive partners, yet how these families promote their health after leaving is poorly understood. In this feminist grounded theory study, the authors conducted repeat interviews with 40 single-parent families that had left abusive part... ( view more )ners/fathers and analyzed the data using constant comparative methods. Findings reveal the central problem faced by families is intrusion, unwanted interference in everyday life that stems from abuse and its fallout. Over time, families promote their health through the basic social process of strengthening capacity to limit intrusion via four subprocesses: providing, regenerating family, renewing self, and rebuilding security. Depending on the degree of intrusion, the focus strengthening capacity shifts between practical goals of surviving and more proactive efforts directed toward positioning for the future. This theory adds to our knowledge of the long-term consequences of IPV for families and provides direction for practice and policy. ( view less ) Judith Wuest,Marilyn Ford-Gilboe,Marilyn Merritt-Gray,Helene Berman Like other single-parent families, those consisting of mothers and their children who leave abusive partners/fathers are broadly viewed a deficient, high-risk structures in which children are susceptible to multiple problems. The mechanisms of strength and vulnerability in these families are poorly... ( view more ) understood, and, consequently, their health promotion processes remain virtually unexplored. In a feminist grounded theory study of health promotion processes of single-parent families after leaving abusive partners/fathers, the authors discovered intrusion to be the basic social problem as families strive to promote health in the aftermath of abuse. The authors discuss the complex nature of intrusion, demonstrating how health is socially determined, and the challenges of health promotion in terms of the issues and dilemmas faced by study families and consider implications for health promotion knowledge and practice. ( view less ) Marilyn J HockenberryWe are pleased to publish this special issue on pediatric oncology nursing. The articles in this issue provide readers with the most current clinical updates on the treatment and care of children and youth with childhood cancer. We thank Dr. Marilyn Hockenberry and the authors for their contributio... ( view more )ns to the pediatric nursing literature. ( view less ) Judith Wuest,Marilyn Merritt-Gray,Helene Berman,Marilyn Ford-Gilboe Emphasis in health policy has shifted from curative intervention to prevention and health promotion through personal responsibility for lifestyle choices and, most recently, to the social determination of health. These shifts draw attention to and legitimize women's health research that moves beyon... ( view more )d biomedical, epidemiological, and subjective knowledge to question previously unquestioned societal norms and structures that influence women's health. The challenge is to avoid relying solely on population-based studies that support relationships between social determinants and indicators of women's health and to find ways to illuminate the processes by which social determinants interact with the health of specific groups of women. Without such research, our knowledge of how social factors that underpin women's health interact will be faceless and will not address the interplay of health and social policy within women's lives. One research method that may be useful for exploring the interplay between such policies and women's health is grounded theory. Grounded theory is a widely used approach in women's health research. The goal of grounded theory is the discovery of dominant social and structural processes that account for most of the variation in behavior in a particular situation. Despite the usefulness of this method for capturing the interaction between social conditions and women's health experiences, many grounded theory researchers restrict themselves to women's subjective experiences as a source of data for theory development. Consequently, the resultant theory's capacity to illuminate the effects of the social determinants of health is limited. The purpose of this article is to discuss how the grounded theory method can be used in a participatory way to theoretically sample structural conditions at many levels. Using examples from completed and ongoing women's health research where data have and have not been collected primarily from women themselves, we outline the benefits and process for using grounded theory to influence health and public policy in women's health. ( view less ) George Garratty,Marilyn J Telen,Lawrence D Petz Blood group antigens (BGAs) can act as functional molecules but also can evoke autoantibodies and alloantibodies, causing autoimmune hemolytic anemia, hemolytic disease of the newborn and hemolytic transfusion reactions. In Section I, Dr. Marilyn Telen discusses physiologic and pathologic functions... ( view more ) of RBC BGA-bearing molecules. She reviews some associations of BGAs with RBC membrane integrity and hemolytic anemia; association of BGAs with enzymatic and transport functions; and adhesion molecules expressed by RBCs, especially with reference to their pathophysiological role in sickle cell disease. In Section II, Dr. Lawrence Petz discusses the problems of providing blood for patients who have RBC autoantibodies. He provides an algorithm for excluding the presence of "hidden" alloantibodies, when all units appear to be incompatible due to the autoantibody. He emphasizes that clinicians should be aware of these approaches and not accept "the least incompatible unit." In Section III, Dr. George Garratty describes two processes, in development, that produce RBCs that result in RBCs that can be described as "universal" donor or "stealth" RBCs. The first process involves changing group A, B, or AB RBCs into group O RBCs by removing the immunospecific sugars responsible for A and B specificity by using specific enzymes. The second process involves covering all BGAs on the RBC surface using polyethylene glycol (PEG). Results of in vitro and in vivo studies on these modified RBCs are discussed. ( view less ) Jimerson, Shane R. and Wilson, Marilyn This volume of the journal for the California Association of School Psychologists provides current information on a broad array of topics related to the work of school psychologists. The articles contribute important information on contemporary issues in the field, such as using a strength-based pe... ( view more )rspective when assessing students, student support teams focusing on empirically supported interventions and data-based decision making, and a study examining the efficacy of a cognitive behavioral counseling group for elementary students with behavioral problems. Articles in this issue include: (1) "The California School Psychologist as a Catalyst for Change" (Shane R. Jimerson; Marilyn Wilson); (2) "Integrating Strength-Based Perspectives in Psychoeducational Evaluations" (Sabrina Rhee; Michael J. Furlong; Joseph A. Turner; Itamar Harari); (3) "Problem Solving Student Support Teams" (Kristin M. Powers); (4) "An Introduction to Cultural Issues Relevant to Assessment with Native American Youth" (Jill D. Saxton); (5) "Effectiveness of a Cognitive Behavioral Group Intervention for Elementary Aged Students" (A. Terry Richardson); (6) "A Synthesis of Grade Retention Research: Looking Backward and Moving Forward" (Shane R. Jimerson); and (7) "Primary Prevention of School-Based Violence: A Developmental Risk and Resilience Model for School Psychologists" (Rebecca Bell). (Contains 302 references.) (JDM) ( view less ) Judith Wuest,Marilyn J Hodgins,Jean Malcolm,Marilyn Merritt-Gray,Patricia SeamanThe social expectation that women will care for family members persists despite evidence that many women have difficult or abusive past relationships with their parents and partners. Little is known about how past relationship influences the health of women caring for adult family members. On the b... ( view more )asis of earlier grounded theory research, we tested the theory that past relationship and obligation predict health outcomes and health promotion in 236 women caregivers of adult family members. Structural equation modeling demonstrated support for the theory, with 56% of the variance in health outcomes and 11% of the variance in health promotion accounted for by the model. ( view less ) Minerva Smith Buerk,Naomi Marilyn Kanof,Wilma Fowler Bergfeld,Antoinette Foote Hood BACKGROUND: Women leaders in dermatology opened doors that allowed many men and women to follow in their footsteps. Their achievements have included presidencies of national and state medical organizations, teaching, and research. They changed the specialty through words and leadership. OBJECTIVE: ... ( view more )This study highlights four women who significantly influenced American dermatology. METHODS: We selected four female leaders in American dermatology, one of whom is deceased. For the other physicians, a questionnaire was sent to two and a telephone interview was conducted with one. Other responses were garnered through an autobiography, a self-recorded interview, and journal articles. RESULTS: Brief biographies with career highlights are presented for Minerva Smith Buerk, MD, founder of the Women's Dermatologic Society; Naomi Marilyn Kanof, MD, the first female editor of The Journal of Investigative Dermatology; Wilma Fowler Bergfeld, MD, the first female president of the American Academy of Dermatology; and Antoinette Foote Hood, MD, the first female executive director of the American Board of Dermatology. ( view less ) Pamela S Hinds,Christina Baggott,Joetta DeSwarte-Wallace,Marilyn Dodd,Joan Haase,Marilyn Hockenberry,Casey Hooke,Patsy McGuire Cullen,Ida Moore,Lona Roll,Kathy Ruccione PURPOSE/OBJECTIVES: To provide a brief description of the historic role of nursing and nursing research in the culture of previous pediatric oncology cooperative groups and compare the research language used in cooperative groups with the language used in nursing research. DATA SOURCES: Published e... ( view more )mpirical, clinical, and methodologic reports. DATA SYNTHESIS: The culture and language of nursing research differ from those of medical research and the pediatric oncology cooperative group, the Children's Oncology Group (COG). Different approaches exist to integrate nursing research priorities into the priorities of COG, including freestanding protocols, companion protocols, and research objectives included in therapeutic protocols. CONCLUSIONS: Full integration of nursing research into COG is feasible but dependent on recognition of cultural and language differences among researchers. Integration will be demonstrated by the number of concepts and protocols contributed to or developed by active nurses in COG. IMPLICATIONS FOR NURSING: Significant advances exist for nurses conducting research in COG. These research efforts are facilitated by a familiarity with the science language used by other disciplines in COG and an understanding of COG's research processes. Increased interdisciplinary scientific collaborations involving nurses in COG particularly benefit pediatric patients with cancer. ( view less ) Judith Wuest,Marilyn Merritt-Gray,Marilyn Ford-GilboeAlthough concern for their children's well-being is pivotal in mothers' decisions to leave abusive partners, rarely is lone-parent family life after leaving framed as beneficial for family members' emotional health. In this feminist grounded theory study of family health promotion in the aftermath ... ( view more )of intimate partner violence, we learned that families strengthen their emotional health by purposefully replacing previously destructive patterns of interaction with predictable, supportive ways of getting along in a process called regenerating family. These findings add to our knowledge of family development and how families promote their health when they have experienced intimate partner violence. ( view less ) Kim Nagel,Marilyn Eves,Linda Waterhouse,Cheryl Alyman,Susan Posgate,Janet Jamieson,Victoria Metzger,Marilyn Wright The purpose of this project was to obtain input from the families of survivors of childhood cancer regarding their needs surrounding the "coming off treatment" (COT) period. A questionnaire was developed to record their needs, their wishes, and their satisfaction surrounding this period of time. Cl... ( view more )oser examination of the time surrounding COT was undertaken in an attempt to enhance this area of service for patients and families in our clinic setting. Establishing a structured protocol is likely to alleviate some of the anxiety that surrounds this time for families and help us to provide better continuity of care. After identifying a cohort of patients and families, the reason for the survey was explained and they were asked to complete the questionnaire before they left the clinic setting. At the completion of the study, 82% of the cohort had been approached, and 100% of this group had completed the survey (n = 41). Less than 50% of participants felt they had had a formal "coming off treatment" review but, of that same group, 89% were satisfied with the process. Participants identified areas of importance and health care professionals who they would like involved in the COT process. After reviewing the responses to the questionnaires, the decision was made to proceed in preparing a COT protocol. ( view less ) Judith Wuest,Marilyn Ford-Gilboe,Marilyn Merritt-Gray,Shannon Lemire Women's health is frequently influenced by social and structural factors, largely beyond women's control, and often entrenched in public policy. Although health is acknowledged to be socially determined, the ways that social conditions affect health are rarely explicated. Grounded theory is a usefu... ( view more )l method for discovering how structural conditions influence patterns of behavior. We used grounded theory to generate a theoretical understanding of how justice system policy and services related to child custody influence health promotion processes of women and their children after leaving abusive male partners/fathers. In two diverse Canadian provinces, we interviewed single mothers who had left abusive partners as well as frontline workers and policymakers in the justice system. We identified the key dimensions of policy and services that influence the ways in which women and their children promote their health in the context of varying levels of ongoing intrusion as information, eligibility, accessibility, timeliness, human resources, safety, and diversity. In this article, the interplay between theses policy and service dimensions and women's health promotion after leaving abusive partners is discussed and suggestions are made for strengthening "healthy" custody policy. ( view less ) Betty A Poitra,Shirley Marion,Marilyn Dionne,Esther Wilkie,Paul Dauphinais,Marma Wilkie-Pepion,John T Martsolf,Marilyn G Klug,Larry Burd Fetal alcohol syndrome (FAS) is a common cause of birth defects and neuropsychiatric impairment. Identification of affected people is crucial for early entry into intervention programs and for the development of prevalence estimates. The objective of this project was to determine if screening for F... ( view more )AS in a community elementary school-based setting was feasible, to estimate prevalence in the screened population, and to determine if a screening program for FAS can be implemented using available personnel from the community.The FAS Screen was used to screen kindergarten students enrolled in a school system. Students with scores on the FAS Screen above the cutoff for a positive screen (20) were referred to one of several diagnostic clinics for evaluation.Over a 9-year period, 1384 students were screened and 69 (5%) had a positive screen (20 or above). These 69 children were then seen in a genetics/dysmorphology diagnostic clinic and 7 (10%) were found to have FAS (n=6) or partial FAS (n=1). The prevalence of affected children (FAS and partial FAS) was 1 per 198 students or 4.3 per 1000.The FAS Screen was completed annually by school staff, teachers, social workers, and psychologists. The test has acceptable epidemiologic performance characteristics in a community setting. The screening takes about 8-10 min. The procedure was well accepted in the community. This screening strategy was inexpensive to implement (less than US8.00 dollars per student), and can be easily included with the other screens completed at kindergarten entry. ( view less ) Jean-Pierre Couty,Anne-Marie Crain,Sylvie Gerbaud,Marilyne Labasque,Carmen Marchiol,Didier Fradelizi,Sarah Boudaly,Catherine Guettier,Marco Vignuzzi,Sylvie van der Werf,Nicolas Escriou,Mireille Viguier Hepatocellular carcinoma is a deadly cancer with growing incidence for which immunotherapy is one of the most promising therapeutic approach. Peptide-based vaccines designed to induce strong, sustained CD8(+) T cell responses are effective in animal models and cancer patients. We demonstrated the e... ( view more )fficacy of curative peptide-based immunisation against a unique epitope of SV40 tumour antigen, through the induction of a strong CD8(+) T cell-specific response, in our liver tumour model. However, as in human clinical trials, most tumour antigen epitopes did not induce a therapeutic effect, despite inducing strong CD8(+) T cell responses. We therefore modified the tumour environment to enhance peptide-based vaccine efficacy by delivering mengovirus (MV)-derived RNA autoreplicating sequences (MV-RNA replicons) into the liver. The injection of replication-competent RNA replicons into the liver converted partial tumour regression into tumour eradication, whereas non-replicating RNA had no such effect. Replicating RNA replicon injection induced local recruitment of innate immunity effectors (NK and NKT) to the tumour and did not affect specific CD8(+) T cell populations or other myelolymphoid subsets. The local delivery of such RNA replicons into tumour stroma is therefore a promising strategy complementary to the use of peripheral peptide-based vaccines for treating liver tumours. ( view less ) Scott M Schlauder,Thora S Steffensen,Michael Morgan,Douglas G Letson,Warren J Pledger,Le Ma,Marilyn M Bui The primitive neuroectodermal tumor (PNET)/Ewing family of tumors (EFT) and desmoplastic small round cell tumor (DSRCT) portend a grave prognosis. Ongoing research in similar neurocrest-derived neoplasms has implicated both the muscarinic acetylcholine receptor (mAChR) and nicotinic acetylcholine r... ( view more )eceptor (nAChR) in the pathogenesis of these neoplasms. Acetylcholine has been reported to impart a modulatory effect on chemotaxis and proliferation, an effect ameliorated by anticholinergic drugs. The aim of our study is to characterize the pattern of expression of mAChR and nAChR in PNET/EFT and DSRCT, in hopes of discovering a potential target for therapeutic improvements. We examined 34 cases of PNET/EFT and 2 DSRCT retrospectively by immunohistochemical studies. We found that AChRs are overexpressed in a significant number of PNET/EFT and DSRCT. The Western blot analysis of 3 human Ewing sarcoma cell lines confirms the presence of AChRs. Future studies are planned to confirm these results as well as to investigate their potential therapeutic implications. ( view less ) Jacqueline M Bourgeois,Kim Nagel,Erin Pearce,Marilyn Wright,Ronald D Barr,Mark A Tarnopolsky BACKGROUND: Corticosteroids are an important component of the treatment of acute lymphoblastic leukemia (ALL), with known significantly negative effects on bone and muscle. Creatine monohydrate (CrM) supplementation may be an adjunctive therapeutic strategy to attenuate some of these adverse effect... ( view more )s. PROCEDURE: Nine children with ALL in the maintenance phase of treatment on the Dana-Farber Cancer Institute (DFCI) protocol 2000-2001 were treated with CrM (0.1 g/kg/day) for two sequential periods of 16 weeks (16 weeks treat > 6 weeks wash-out > 16 weeks treat). A cohort of children (N = 50) who were receiving the same chemotherapy at the same time served as natural history controls. Measurements included height, weight, body mass index (BMI), and lumbar spine bone mineral density (LS-BMD), whole body bone mineral content (WB-BMC), fat-free mass (FFM), and percent body fat (%BF) using dual-energy X-ray absorptiometry. RESULTS: Despite the long course of corticosteroid treatment for ALL, children showed significant increases in height, LS-BMD, WB-BMC and FFM over approximately 38 weeks (P < 0.05) during the study. There was an increase in BMI over time, but children taking CrM had a reduction, while the natural history group showed an increase in % BF (P < 0.05 for interaction). CONCLUSIONS: Children with ALL treated with corticosteroids as part of a maintenance protocol of chemotherapy showed an increase in % BF that was attenuated by CrM supplementation. ( view less ) Cheri Cloninger,Marilyn Felton,Bonnie Paul,Yasuko Hirakawa,Stan MetzenbergAlkaline lysis of Escherichia coli is usually the method of choice for plasmid preparation, but ''ghost bands" of denatured supercoiled DNA can result if the pH is too high or the period of lysis is too long. By replacing the usual sodium hydroxide lysis solution with an arginine buffer prepared in... ( view more ) the range of pH 11.4 to 12.0, we were able to stabilize the pH during lysis and obtain plasmid that is suitably pure for restriction digestion and DNA sequencing. ( view less ) Yan Peng,Raheela Ashfaq,Gene Ewing,A Marilyn Leitch,Kyle H Molberg We report 3 cases of sentinel lymph nodes (SLNs) containing benign glandular inclusions (BGIs) in patients with breast carcinoma that were initially misdiagnosed as metastatic carcinoma.The first case had an SLN with glandular elements adjacent to a squamous inclusion cyst, the second had an SLN wi... ( view more )th a single complex gland showing apocrine features, and the third had 2 SLNs, each containing rare glands lined by bland columnar cells and surrounded by thin, fibrous bands. All glandular elements were distinctly different from the corresponding invasive carcinoma. Immunostains for myoepithelial markers revealed smooth muscle myosin reactivity and scattered p63+ nuclei, indicating the presence of myoepithelial cells. Based on morphologic and immunohistochemical findings, a diagnosis of BGIs was established.Our case series report indicates that comparison with the morphologic features of primary breast carcinoma and using immunohistochemical analysis for myoepithelial markers are important ancillary tools in distinguishing BGIs from metastatic carcinoma. ( view less ) Marilyn NicoudThe health regimen was a medical genre developed in Western Europe as of the 13th century and is one of the main sources attesting the interest that professionals working on health devoted to the dangers incurred in eating. This medical genre, part of an ancient tradition, was well known by the eli... ( view more )tes of the time. The surviving texts reveal themselves to be extremely attentive to contemporary food consumption and provided their readers with the necessary recommendations in order to enable them to take care of their health. ( view less ) Emerson R da Silva,Peter D Sly,Marilyn U de Pereira,Leonardo A Pinto,Marcus H Jones,Paulo M Pitrez,Renato T Stein Non-atopic asthma is the predominant phenotype in non-affluent parts of Latin America. We recently reported that infestation with Ascaris lumbricoides increased the risk of non-atopic asthma in less affluent areas of Brazil but the mechanism is unclear. The present study was conducted to determine ... ( view more )whether helminth infestation is associated with heightened bronchial responsiveness (BHR), a common finding in asthma. A random sample of 50 asthmatic and 50 non-asthmatic controls (mean age 10.1 years) were selected from a larger cohort (n = 1,011) without knowledge of their helminth infestation status. Three stool samples were collected from each child on different days and each sample was analyzed by the Kato-Katz method for quantitative determination of helminth eggs. Bronchial provocation tests were performed with inhaled 4.5% hypertonic saline using the ISAAC Phase II standardized protocol. There was no difference between the prevalence of positive BHR in the asthmatics (20.4%) compared with the controls (14.6%) (P = 1.0). Helminth infestation was detected in 24.0% of children, with A. lumbricoides being the most common. Children with high load infestation (>/=100 eggs/g) were five times more likely to have BHR than children with low load or no infestation. Despite the small sample size the results of the present study suggest that the link between high load helminth infestation and non-atopic asthma may be mediated via heightened bronchial responsiveness, possibly due to an inflammatory response to the pulmonary phase of the helminth life cycle. Pediatr Pulmonol. 2008; 43:662-665. (c) 2008 Wiley-Liss, Inc. ( view less ) Janet L Heitgerd,Andrew L Dent,Kimberlee A Elmore,Brian Kaplan,James B Holt,Marilyn M Metzler,Koren Melfi,Jennifer M Stanley,Keisher Highsmith,Norma Kanarek,Karen Frederickson ComerAn Internet mapping application is being introduced in conjunction with the release of the second version of the Community Health Status Indicators (CHSI) Report. The CHSI Geographic Information Systems (GIS) Analyst is an easy-to-use Web-based mapping application that provides new opportunities fo... ( view more )r the visualization, exploration, and understanding of the indicators. Indicators can be mapped and compared visually to other areas, including peer counties and neighboring counties. The Web site is accessible from a link on the CHSI Report Web site or directly from an Internet Web browser. In this paper, we discuss the conceptualization and implementation of this public health mapping application. ( view less )
|
|
|