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GST Primary GST Primary Best Strategies for Health Care Quality Im... Best Strategies for Health Care Quality Improvement - Diabetes Quality Improvement Strategies for Antibio... Kathryn McDonald, Stanford-UCSF Evidence-b... Systematic review assessing the effect of ... Quality Improvement Strategies for Antibiotics Management Kathryn McDonald, Stanford-UCSF Evidence-based Practice Center, 117 Encina Commons, Stanford, CA 94305-6019, Kathy.mcdonald@stanford.edu Systematic review assessing the effect of quality improvement strategies on appropriate prescribing of antibiotics and appropriate choice of antibiotics. Adherence Adherence Assistive Devices Assistive Devices Childhood Burn Hanson MacMillan Childhood Burn Hanson MacMillan CLSA_9 CLSA_9 Cyberabuse Cyberabuse Cognitive Behavioural Therapy for Violent ... This review included randomized trials abo... Cognitive Behavioural Therapy for Violent Men who Batter Their Partners This review included randomized trials about the effects of cognitive behavioral therapy on domestic violence. The intervention included programs based on the Duluth Model. The violence had to be committed by a male toward his female partner. The violence also had to be physical. The primary outcomes were new arrests and convictions, and new reports of violence. CABG vs PCI CABG vs PCI Quality Improvement Strategies for Prevent... Quality Improvement Strategies for Preventing Nosocomial Infections (Created 17-Feb-06) Quality Improvement Strategies for Asthma ... Quality Improvement Strategies for Asthma Control Erectile Dysfunction (Created 30-Jan-06) Erectile Dysfunction (Created 30-Jan-06) Inequality - Smoking Cessation to Reduce S... This review was the first part of a projec... Inequality - Smoking Cessation to Reduce Socio-Economic Differences This review was the first part of a project about inequality. It included randomized trials about the effect of smoking cessation interventions on reducing socio-economic differences. The studies had to report data either on persons with low socio-economic groups status or, preferably, on both low and high socio-economic groups. Diet and Physical Activity to Reduce Socio... This review was the second part in a proje... Diet and Physical Activity to Reduce Socio-Economic Differences This review was the second part in a project about inequality. It included randomized trials about the effect of interventions on reducing socio-economic differences in diet and physical activity. The studies had to report data either on persons with low socio-economic groups status or, preferably, on both low and high socio-economic groups. Workfare The data in SRS are not identical to the d... Workfare The data in SRS are not identical to the data in the published report. We used SRS only for an updated search. The review included randomized trials about the effect of welfare-to-work programs. Participants were welfare recipients. There were basically two types of programs. The educational type tried to build knowledge and skills in order to help the welfare recipients acquire jobs that could support them economically. The "work first" approach was more aimed at getting the participants quickly into a job. Exercise interventions for the management ... The objective of this systematic review wa... Exercise interventions for the management of frailty The objective of this systematic review was to examine the effectiveness of current exercise interventions on the management of frailty. A comprehensive search of Medline, Embase, Psycinfo, Cinahl, Scopus, Ageline, Eric, and SportDiscus databases was conducted and produced 1808 citations. So far we have completed 2 levels of “title and abstract” screening and we ended up with 262 articles. We have just started the full text screening. Eligibility criteria included original studies whose participants were identified as frail or prefrail with specific criteria and in which structured physical activity was included as at least one component of the intervention. Create a free account, build a dictionary with saved terms to re-use later! Public Domestic Violence - Using Cognitive Behavior Therapy Smoking Cessation to Reduce Socio-Economic Differences Diet and Physical Activity to Reduce Socio-Economic Differences Workfare Exercise Interventions for the Management of Frailty Search     Simple Advanced Refine (4 coded questions)  Any of these:   Exact Phrase: All of these: None of these: Author: Periodical: Projects: No restrictions   Libraries: Public   Select SRS Projects Show Saved Terms Select Library Show articles that do not have abstracts  Humans or Animals Humans Animals Type of Article Clinical Trial Editorial Letter Meta-Analysis Practice Guideline Randomized Controlled Trial Review Addresses Bibliography Biography Case Reports Classical Article Clinical Conference Clinical Trial, Phase I Clinical Trial, Phase II Clinical Trial, Phase III Clinical Trial, Phase IV Comment Comparative Study Consensus Development Conference Consensus Development Conference, NIH Controlled Clinical Trial Corrected and Republished Article Dictionary Directory Duplicate Publication English Abstract Evaluation Studies Festschrift Government Publications Guideline Historical Article Interview In Vitro Journal Article Lectures Legal Cases Legislation Multicenter Study News Newspaper Article Overall Patient Education Handout Periodical Index Published Erratum Retracted Publication Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. 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Retraction of Publication Scientific Integrity Review Support of Research Technical Report Twin Study Validation Studies Not a Primary Study or Review Unknown Primary Study Case Series Case Control Cohort Study Observational Study Qualitative Research CBA or ITS Registry Double Blind Controlled before after study Quasi-randomized trial Simple before after study Cluster-RCT Non-Randomized Study Report Book Book chapter Dissertation Conference procedings Secondary Research Not RCT Ages All Infant: birth-23 months All Child: 0-18 years All Adult: 19+ years Newborn: birth-1 month Infant: 1-23 months Preschool Child: 2-5 years Child: 6-12 years Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Middle Aged + Aged: 45+ years Aged: 65+ years 80 and over: 80+ years Undetermined Language English French German Italian Japanese Russian Spanish Afrikaans Albanian Unknown Arabic Armenian Azerbaijani Bosnian Bulgarian Catalan Chinese Croatian Czech Danish Dutch Esperanto Estonian Finnish Georgian Greek, Modern Hebrew Hindi Hungarian Icelandic Indonesian Kinyarwanda Korean Latin Latvian Lithuanian Macedonian Malay Malayalam Maori Multiple Languages Norwegian Persian Polish Portuguese Pushto Romanian Sanskrit Scottish gaelic Serbian Slovak Slovenian Swedish Thai Turkish Ukrainian Vietnamese Not English Not French Results(1-25 of 504) Sort By: Publication Date Relevance Took: 0.426 seconds to search 17,750,454  Action: Copy Results to new Clipboard Build Search Link Page 1 of 21 1 2 3 4 > Last >> (504 articles found) Homofermentative lactic acid bacteria of a traditional cheese, Comlek peyniri from Cappadocia region. Feb 2005 Cisem Bulut,Hatice Gunes,Burcu Okuklu,Sebnem Harsa,Sevda Kilic,Hatice Sevgi Coban,Ali Fazil Yenidunya Comlek peyniri is a typical artisanal cheese in Central Anatolia. This type of cheese was made by using the indigenous lactic acid bacteria (LAB) flora of cow or ewes' milk. Majority of the samples were taken from fresh cheese because the aim was to isolate homofermentative LAB. Initially 661 micro... ( view more )bial isolates were obtained from 17 cheese samples. Only 107 were found to be homofermentative LAB. These isolates were selected and identified by using both phenotypic and molecular methods. Phenotypic identification included curd formation from skim milk, catalase test, Gram staining and light microscopy, growth at different temperatures and salt concentrations, arginine hydrolysis, gas production from glucose, and carbohydrate fermentation. Molecular identification was based on the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) of the 16S rRNA gene-ITS (internally transcribed spacer) region. By combining the phenotypic and molecular identification results, isolates belonging to each of the following genera were determined at species or subspecies level: 54 Lactococcus lactis subsp. lactis, 21 Enterococcus faecium, 3 Ec. faecalis, 2 Ec. durans, 10 Ec. sp., 15 Lactobacillus paracasei subsp. paracasei, and 2 Lb. casei strains. Technological characterisation was also performed by culturing each of the strains in UHT skim milk, and by monitoring pH change and lactic acid production at certain time intervals through the 24 h incubation. Results of the technological characterisation indicated that 33% of the isolates (35 strains) were capable of lowering the pH of UHT milk below 5.3 after 6 h incubation at 30 degrees C. Thirty four of these strains were Lc. lactis subsp. lactis, and only one was an Ec. faecium strain. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles A hydatid cyst of the interventricular septum diagnosed incidentally by multislice computed tomography. Aug 2008 M Timur Selcuk,Hatice Selcuk,Omac Tufekcioglu,Kazim Baser,Nilgun Isiksalan Ozbulbul,Levent Birincioglu,Sule Korkmaz Cardiac involvement of the hydatid disease is uncommon. In this report a case of 54-year-old patient with a hydatid cyst in the interventricular septum was presented. The cyst was detected incidentally by cardiac multislice computed tomography and transthoracic echocardiographic appearances of the ... ( view more )cyst raised the suspicion of cardiac echinococcosis. The patient was referred to surgery immediately for the removal of the cyst in order to prevent the potentially life threatening complications. The postoperative period was uneventful and she was discharged on albendazole therapy. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Carpal tunnel syndrome in postmenopausal women. Jul 15, 2008 Yuksel Kaplan,Semiha G Kurt,Hatice Karaer OBJECTIVE: Hormonal changes that accompany menopause have a significant impact on the nervous and other physiological systems. Our objective was to evaluate the relationship between carpal tunnel syndrome (CTS) and the clinical features of menopause in postmenopausal women, in comparison to age-mat... ( view more )ched healthy controls. METHODS: Overall, 6230 women were seen during the study period. Of these, 5587 were not eligible because they were premenopausal or perimenopausal. 537 women did not meet the criteria used in the study for a diagnosis of idiopathic CTS and were excluded. Finally, one hundred and six patients with CTS and 115 controls were examined. The presence of CTS was confirmed both clinically and electrophysiologically. Socio-demographic variables and reproductive histories were evaluated via a structured interview. RESULTS: In comparison to healthy controls, patients with CTS showed a significantly greater number of pregnancies and an earlier age at menopause. Regarding the type of menopause, patients and controls showed similar frequencies for natural versus surgical menopause. The frequency of natural menopause was significantly higher than that of surgical menopause in both groups. CONCLUSION: Our results suggest that age at menopause may be a significant factor in the development of CTS. Pregnancy-related hormonal changes may have long-term effects that increase the incidence of CTS in postmenopausal women. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Dietary breads: myth or reality? Jul 2008 Banu Mesci,Aytekin Oguz,Hatice Gul Sagun,Mehmet Uzunlulu,Elmas Biberci Keskin,Damla Coksert AIMS: To assess the differences in acute effects of whole wheat bread, wheat bran bread and rye bread--perceived as dietary (Low caloric!) breads--on glucose and insulin levels in patients with type 2 diabetes, as compared to white wheat bread. METHODS: One hundred twenty one type 2 diabetic patien... ( view more )ts were randomized into three groups as whole wheat, wheat bran and rye bread groups. Each group ate 100 g of bread with water with in 10 min. Blood glucose measurements were made at every 30 min in 2 h. Insulin was measured at fasting and at the second hour in the patients who do not use insulin. The same processes were repeated on the following day, with white wheat bread for each group. RESULTS: No significant difference was found in either glycemic or insulinemic effects between four types of breads when compared to each other (p=0.093 for glycemic effect and p=0.297 for insulinemic effect). CONCLUSION: Three different bread types consumed as an alternative to white bread in Turkey, increase blood glucose levels of diabetic patients similar to white bread. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Multiparametric analysis of preoperative lymphatic mapping with the use of combined deep plus superficial radiotracer injection technique in early breast cancer. Jun 2008 Fuat Dede,Bahadir M Gulluoglu,Tunc Ones,Zeynep Farsakoglu,Billur Calskan,Hatice Mems,Yusuf T Erdl,Sabahat Inanr,Handan Kaya,Halil T Turoglu OBJECTIVES: According to literature, combined tracer injection techniques seem to be the more powerful choice to eliminate technical and patient-related limitations. In this study, we analysed the quantitative performance parameters of combined deep plus superficial radiotracer injection and their ... ( view more )correlation with a set of clinical, pathological and technical factors. METHODS: One hundred and sixteen women who underwent preoperative sentinel lymph node (SLN) mapping were studied prospectively. All patients received the simultaneous deep and superficial injection of 99mTc-nanocolloid. Mapping success rate, mean number of SLNs per patient and radiotracer uptake of SLNs were determined. The possible effects of age, tumour stage, laterality and location, type and time of previous biopsy, and SLN status on the quantitative parameters were analysed. RESULTS: Axillary SLNs were visualized in all cases. Mean number of axillary SLNs was 2.15 and advanced age (>50) significantly decreased the number of SLNs. Radiotracer uptake of SLNs was also significantly decreased by advanced age and a shorter time interval between biopsy and mapping (<10 days). Extra-axillary SLN visualization rates for medial, lateral and periareolar injection sites were 32%, 16% and 8%. Although SLN gamma probe counts were significantly higher in the single-day protocol, the 2-day protocol gave better contrast values which was also an important parameter in lesion detection. CONCLUSION: The combined radiotracer injection technique successfully demonstrated axillary and extra-axillary SLNs. Advanced age and previous biopsy time can lower the accuracy and reliability of SLN biopsy. Although periareolar injection gave the best results for the axilla, it was still insensitive for extra-axillary SLNs in spite of deep injection. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Effects of individual factors on adolescent obesity: study in Turkey. Jun 2008 Ayla Güven,Hatice Odaci,Ilker Tolga Ozgen,Yüksel Bek BACKGROUND: The aim of the present study was to investigate the effects of sociodemographic and lifestyle variables, eating habits, adolescent weight perception and weight changes on obesity in Turkish adolescents. METHODS: A total of 87 normal weight and 78 obese participants were included in the ... ( view more )study. They were selected from adolescents who had no other health problems beside obesity. Underweight and overweight adolescents were excluded. Estimation of prevalence of overweight and obesity were based on cut-off points of the International Obesity Task Force (excess of the 85th and 95th percentiles, respectively). The prevalence of underweight was defined as the percentage of adolescents below the fifth percentiles of the US adolescents' age- and gender-specific body mass index. A structured questionnaire that included sociodemographic and lifestyle variables, eating habits, weight questions about adolescents' weight perception and weight changes was administered to the participants. RESULTS: In the obese group, the level of the mothers' and fathers' education was lower than in the normal group (P = 0.006; P = 0.001, respectively). Obese adolescents had fewer obese people in their family (P = 0.001). There were statistically significant correlations between groups for fathers' occupation, joining in cultural activities, physical exercise, feeling about body shape and food preference (P = 0.014; P = 0.001; P = 0.003; P = 0.001; P = 0.001, respectively). Increase in weight was larger in the obese group (P= 0.001) and those who wanted to loose weight but failed (P = 0.001). CONCLUSIONS: There are associations between obesity and level of mothers' and fathers' education, number of obese people in family, fathers' occupation, joining in cultural activities, physical exercise and food preference in Turkish adolescents. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles The effect of stapes mobility on hearing outcome and which procedure to choose in fixed stapes in children tympanosclerosis. Jun 2008 Zeynep Kizilkaya,Hatice Emir,Kursat Ceylan,Hakan Gocmen,Erdal Samim OBJECTIVES: Our objective was to evaluate the features of tympanosclerosis in children and to determine the effect of stapes mobility and the type of one-stage operation on hearing outcomes. MATERIALS AND METHODS: Fifty-one children who were performed different types of single-stage otologic surger... ( view more )y for tympanosclerosis between January 1997 and December 2006 were retrospectively chart reviewed. The children were divided into two groups according to the mobility of ossicular chain, especially the stapes. Stapes fixed group was also evaluated in detail according to the type of surgery that was performed. Patients who had previous ventilation tube insertion, tympanic membrane parasynthesis or any other otologic surgery were excluded from the study. Improvement of the hearing by at least 10dB and air-bone gap less than 20dB were accepted as success criteria after 24 months of follow-up period. RESULTS: The air conduction levels, and the air-bone gap values of both groups were improved significantly after the single-stage operations. Pure tone averages pre- and postoperatively for stapes mobile group were 45.55+/-15.96 and 34.50+/-16.64dB (p=0.002); and in stapes fixed group these were respectively 43.97+/-13.45 and 33.16+/-12.14dB (p<0.001). When pre- and postoperative air-bone gap levels were evaluated it was seen that in both groups they were improved more than 10dB, from 34.10+/-11.37 to 23.05+/-12.32dB (p=0.002) in stapes mobile group and from 35.29+/-11.65 to 24.48+/-12.50dB (p<0.001) in stapes fixed group. In stapes fixed group air-bone gap was less than 20dB in 11 of 23 (47.8%) patients who had mobilization and 3 of 8 (37.5%) patients who had small fenestra stapedotomy operations. Although it was not statistically significant, gain was more than 10dB only in 2 of 8 (25.0%) patients in the stapedotomy group but 14 of 23 (60.9%) patients in mobilization group (p=0.698 for ABG and p=0.220 for gain). The change in the bone conduction levels were improved 0.75dB in group 1 and got worse 0.52dB in group 2 and this was not statistically significant (p=0.239). CONCLUSIONS: In this study about children, the status of stapes and the place of tympanosclerotic mass had no significant negative effect on hearing improvement. You can perform mobilization in one-stage if you are experienced and have to prefer second-stage surgery if stapes is fixed and stapedectomy is needed. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Isolated traumatic gallbladder rupture: US findings and the role of repeat US in diagnosis. Jun 2008 Hatice Ozturkmen Akay,Senem Senturk,M Kemal Cigdem,Aylin H Bayrak,Erdal Ozdemir We represent the US findings of isolated gallbladder rupture caused by blunt abdominal trauma in a 13-year-old boy. At the initial US examination, although a pericholecystic fluid collection was observed, the mildly collapsed gallbladder was regarded as a contracted gallbladder. Even though the pat... ( view more )ient was haemodynamically stable, repeat US examination after 24 h revealed gallbladder perforation. In haemodynamically stable trauma patients repeated US examinations can be useful and are strongly recommended. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Relationship of Admission QRS Duration and Changes in QRS Duration With Myocardial Reperfusion in Patients With Acute ST Segment Elevation Myocardial Infarction (STEMI) Treated With Fibrinolytic Therapy. Jun 2008 Fehmi Kacmaz,Orhan Maden,Savas Aksuyek,Cagin Ureyen,Omer Alyan,Ali Riza Erbay,Hatice Selcuk,Vasfi Ulusoy,Yucel Balbay,Erdogan Ilkay Background Although ischemia induced QRS complex changes have been described previously, their relationship with impaired reperfusion, which is known to be associated with poor clinical outcomes, is not clear. Methods and Results To investigate the relationship of QRS duration changes with myocardi... ( view more )al reperfusion, we studied 165 acute myocardial infarction (MI) patients who were administered fibrinolytic therapy for reperfusion. For each patient, 12-lead electrocardiogram (ECG) with a paper speed of 50 mm/s was recorded on admission and repeated at the 60(th) and 90(th) min following fibrinolytic therapy. Based on the myocardial blush grades obtained from a control coronary angiography, patients were divided into reperfusion (grades 2, 3) and impaired reperfusion (grades 0, 1) groups. We detected impaired reperfusion in 74 patients. The patients in the impaired reperfusion group were older, more often diabetic, and had longer pain-to-needle intervals. They also had significantly longer QRS durations at admission compared to reperfusion group patients (91+/-11 vs 79+/-11 ms, p<0.001). Reperfusion group patients showed significantly greater resolution in QRS duration at the 90(th) min post fibrinolysis ECG (18+/-5 vs 5+/-4 ms, p<0.001). In regression analysis, the pain-to-needle time (odds ratio (OR): 0.55, 95% confidence interval (CI) 0.35-0.88, p=0.012), QRS duration on admission (OR: 0.80, 95% CI 0.67-0.97, p=0.021), and change in QRS duration at the post fibrinolysis 90(th) min ECG (OR: 2.43, 95% CI, 1.29-4.60, p=0.006) were determined as independent predictors of adequate reperfusion. Conclusion The present study, for the first time, has shown that admission QRS duration and post fibrinolysis 90(th) min QRS duration changes are related to tissue reperfusion in fibrinolytic administered acute MI patients. (Circ J 2008; 72: 873 - 879). ( view less ) View Full Abstract View Article Details View Coded Data Related Articles A new approach to chromosomal abnormalities in sperm from patients with oligoasthenoteratozoospermia: detection of double aneuploidy in addition to single aneuploidy and diploidy by five-color fluorescence in situ hybridization using one probe set. Jun 2008 Hatice Gul Durakbasi-Dursun,Ayse Gul Zamani,Ruhusen Kutlu,Hüseyin Görkemli,Muhterem Bahce,Aynur Acar OBJECTIVE: To determine the frequencies of disomy, nullisomy, total aneuploidy, and diploidy in the sperms of infertile men. DESIGN: A controlled prospective study. SETTING: Assisted reproductive technology (ART)/IVF Unit and Department of Medical Biology and Genetics, Meram Medical Faculty, Konya,... ( view more ) Turkey. PATIENT(S): Infertile men with oligoasthenoteratozoospermia (OAT) and normal fertile donors. INTERVENTION(S): After slide preparation from semen samples, sperm nuclei were analyzed for chromosomes 13, 18, 21, X, and Y by five-color fluorescence in situ hybridization. MAIN OUTCOME MEASURE(S): The sperm aneuploidy (disomy and nullisomy) and diploidy rates were determined according to the number of signals detected for each probe in infertile and fertile men. RESULTS: Patients with OAT had a significantly higher incidence of disomy (except chromosome 18 and XX disomy), nullisomy (except chromosome 18), and diploidy than normal fertile controls. In addition to double disomy, double nullisomy and disomy+nullisomy were observed in patients with OAT, but none of these were seen in controls. CONCLUSION(S): In this study patients with OAT had an increased rate of sperm aneuploidy and diploidy. This finding suggest that patients with OAT may be at an increased risk of producing aneuploid and triploid offsprings. For this reason, it may be very important to perform the sperm fluorescence in situ hybridization in patients with OAT. Thus, a more informative genetic counseling might be given to couples with male factor infertility who are at an increased risk of having aneuploid offsprings and triploid conceptions before intracytoplasmic sperm injection (ICSI). ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Effects of bisphenol A on the embryonic development of sea urchin (Paracentrotus lividus). Jun 2008 Cakal Arslan Ozlem,Parlak Hatice Bisphenol A (BPA), is one of the most important industrial chemicals synthesized for diverse applications. In this study, tests for embryotoxic and spermiotoxic effects of BPA were utilized in the sperms and embryos of the sea urchin Paracentrotus lividus. The sperm and eggs of sea urchins were exp... ( view more )osed to increasing concentrations of BPA (300-3500 microg/L) under static conditions. The endpoints were successful sperm fertilization, larval malformations, developmental arrest, and embryonic/larval mortality. BPA concentration (300 microg/L) had spermiotoxic and embryotoxic effects on this species. A dose-response related reduction was observed in fertilization success and significant increases in the number of larvae with skeleton malformations at the pluteus stage when the sperms were exposed BPA. The embryotoxicity of BPA is concentration-dependent and significant growth reduction at the early life stages and an increase in larval malformations as skeleton deformities at the pluteus stage were observed. It can be concluded that BPA adversely affects the reproduction and embryonic developmental stages of the P. lividus and this is of great ecological importance due to the hazard at the population level. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Serotonin transporter gene polymorphisms and sertraline response in major depression patients. Jun 2008 Ozlem Dogan,Nevzat Yuksel,Mehmet Ali Ergun,Akin Yilmaz,Mustafa N Ilhan,Hatice Ersin Karslioglu,Aysegul Koc,Adnan Menevse Major depression (MD) has a complex multifactorial etiology with genetic and environmental factors contributing to the disorder. As with all antidepressant treatments, there is variability in drug response due to heredity, generally focusing on genetic polymorphism of the drug-metabolizing transpor... ( view more )ter genes. The serotonin transporter (5-HTT) gene is a particularly important candidate for genetic involvement in MD disorders owing to its key role in the regulation of serotonergic transmission and is therefore considered to be an interesting candidate in the mechanism of antidepressant drugs. In this study, we have focused on the associations between genetic polymorphisms in two regions of the 5-HTT gene (5-HTTLPR and VNTR) related to sertraline responses. Our sample consisted of 64 unrelated Turkish subjects who strictly met DSM-IV and CGI scores. There was no significant difference between the frequency of the SS, LS, LL, 9/10, 10/10, 9/12, 10/12, and 12/12 genotypes and responses to sertraline. However, the number of patients can be increased and different drugs can be studied in order to find a specific pharmacogenetic relation. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Interaction between startle and voluntary reactions in humans. Jun 2008 Josep Valls-Solé,Hatice Kumru,Markus Kofler The startle reaction (SR) is usually understood as an involuntary reaction to an unexpected sensory input. However, there is evidence that the mechanisms involved in the SR contribute also to the execution of actions that we consider voluntary. We need to exert a fine control of the motor output, w... ( view more )hich usually involves inhibition of the reflex reaction but it may also imply letting the SR manifest, shaped in accordance with our willed actions. The latter occurs mainly with relatively simple ballistic movements but it has also been shown to occur in complex movements. In this review, we describe arguments published in the literature in favour of the contribution of subcortical motor tracts involved in the generation of the SR to the execution of voluntary movements. Some of these studies have brought insight on the mechanisms accounting for motor preparation and execution of voluntary movements. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Horseshoe lung associated with rare bilateral variant of scimitar syndrome: demonstration by 64-slice MDCT angiography. May 2008 Hatice Ozturkmen Akay,Mehmet Kervancioglu,Hasan Nazaroglu,Selahattin Katar,Cihan Akgul Ozmen,Ilhan Kilinc,Senem Senturk Scimitar syndrome with bilateral abnormal venous drainage and horseshoe lung is extremely rare. These rare complex anomalies were diagnosed in a 5-year-old boy by 64-slice multidetector CT (MDCT). This technique provides high-quality visualization of vascular, bronchial and parenchymal structures i... ( view more )n a single session, such that no further invasive techniques are required. One obvious disadvantage of MDCT is the radiation exposure, especially in paediatric patients. The use of a single phase of contrast material administration reduces radiation exposure. The workstation platforms of MDCT systems allow multiplanar 2-D and 3-D postprocessing. As a result, various complex pathologies, such as that discussed here, can be diagnosed following a single imaging session with a certain precision. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Isokinetic evaluation of knee extensor/flexor muscle strength in patients with hypermobility syndrome. May 2008 Nilay Sahin,Akin Baskent,Hatice Ugurlu,Ender Berker Benign joint hypermobility syndrome (BJHS) is a syndrome with musculoskeletal pain originating from the increased laxity of the joints and the ligaments. The study was to compare the isokinetic strength of knee extensor/flexor muscles of BJHS patients with healthy controls. Forty patients diagnosed... ( view more ) as having BJHS with Brighton criteria and 45 years of age, height and weight-matched healthy controls were recruited for the study. Isokinetic testing was performed with isokinetic dynamometry of Biodex System 3Pro and measurements were recorded at knee extension/flexion pattern concentrically at 60, 180, and 240 degrees /s angular velocities. The study group was also evaluated for functional impairment and pain by HAQ and VAS respectively. Knee extensor muscle strength was significantly lower in the patient group compared with the controls. It was hypothesized that the muscle weakness in the study group was related to lengthening of the quadriceps muscle and pain-related inactivity as well as joint instability and proprioception defect. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Invasive squamous cell carcinoma of the conjunctiva first misdiagnosed as a pterygium: a clinicopathologic case report. May 2008 Ertugrul Mirza,Koray Gumus,Cem Evereklioglu,Hatice Arda,Ayse Oner,Ozlem Canoz,Sarper Karakucuk PURPOSE: To describe the clinical findings of a patient who initially underwent surgery for a pterygium and who was finally diagnosed with invasive squamous cell carcinoma, and to determine the necessity and importance of pathologic investigation in all cases of a presumed pterygium. METHODS: A cas... ( view more )e report. RESULTS: A 63-year-old man was referred for severe pain, redness, and purulent secretion in his right eye. A year earlier, he had undergone excision of a pterygium in his right eye by a bare sclera technique without any adjunctive antimetabolite in a private eye clinic. Furthermore, 6 months after this operation, he had undergone autologous conjunctival graft surgery because of dehiscence of the surgical site. His visual acuity was only light perception in the right eye. Slitlamp biomicroscopy showed severe nasal corneoscleral melting, purulent secretion, conjunctival hyperemia, corneal edema, hypopyon, intracamaral hemorrhage, and lid swelling. Ultrasonography showed a right hypoechoic mass invading the nasal part of the globe and a totally detached retina. Orbital magnetic resonance imaging showed a large (2 cm in diameter), irregular, lobulated mass invading the globe in the medial part of the right orbit. Results of a biopsy were consistent with squamous cell carcinoma. Because of the extensive intraocular involvement at the time of the diagnosis, subtotal orbital exenteration was performed. CONCLUSIONS: All pterygia should be evaluated meticulously with regard to possible underlying causes, such as carcinoma in situ or squamous cell carcinoma, and all excised lesions should also be evaluated pathologically to prevent such serious adverse outcomes that are mentioned in this case report. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles CYP1A1, GSTM1, and GSTT1 polymorphisms, smoking, and lung cancer risk in a pooled analysis among Asian populations. May 2008 Kyoung-Mu Lee,Daehee Kang,Margie L Clapper,Magnus Ingelman-Sundberg,Masko Ono-Kihara,Chikako Kiyohara,Shen Min,Qing Lan,Loic Le Marchand,Pinpin Lin,Maria Li Lung,Hatice Pinarbasi,Paola Pisani,Petcharin Srivatanakul,Adeline Seow,Haruhiko Sugimura,Shinkan Tokudome,Jun Yokota,Emanuela Taioli To evaluate the roles of CYP1A1 polymorphisms [Ile 462Val and T 6235C (MspI)] and deletion of GSTM1 and GSTT1 in lung cancer development in Asian populations, a pooled analysis was conducted on 13 existing studies included in Genetic Susceptibility to Environmental Carcinogenesis database. This poo... ( view more )led analysis included 1,971 cases and 2,130 controls. Lung cancer risk was estimated as odds ratios (OR) and 95% confidence intervals (95% CI) using unconditional logistic regression model adjusting for age, sex, and pack-year. The CYP1A1 6235C variant was associated with squamous cell lung cancer (TC versus TT: OR, 1.42; 95% CI, 0.96-2.09; CC versus TT: OR, 1.97; 95% CI, 1.26-3.07; P trend = 0.003). In haplotype analysis, 462Val-6235T and Ile-C haplotypes were associated with lung cancer risk with reference to the Ile-T haplotype (OR, 3.41; 95% CI, 1.78-6.53 and OR, 1.39; 95% CI, 1.12-1.71, respectively). The GSTM1-null genotype increased squamous cell lung cancer risk (OR, 1.36; 95% CI, 1.05-1.77). When the interaction was evaluated with smoking, increasing trend of lung cancer risk as pack-year increased was stronger among those with the CYP1A1 6235 TC/CC genotype compared with those with TT genotype (P interaction = 0.001) and with the GSTM1-null genotype compared with the present type (Pinteraction = 0.08, when no genotype effect with no exposure was assumed). These results suggest that genetic polymorphisms in CYP1A1 and GSTM1 are associated with lung cancer risk in Asian populations. However, further investigation is warranted considering the relatively small sample size when subgroup analyses were done and the lack of environmental exposure data other than smoking. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Exaggerated auditory startle responses in patients with spinal cord injury. May 2008 Hatice Kumru,Joan Vidal,Markus Kofler,Jesus Benito,Alejandro Garcia,Josep Valls-Solé OBJECTIVE: Central nervous system reorganization following spinal cord injury (SCI) may cause functional changes in the motor tracts in patients in whom increased auditory startle responses (ASRs) have been previously reported. We hypothesized that if increased ASRs in patients with incomplete SCI ... ( view more )were due to compensatory mechanisms, these changes would be related to severity and/or localization of the lesion. METHODS: We examined ASR characteristics in 29 SCI patients and 14 age-matched healthy volunteers. Fourteen patients had incomplete and 15 complete SCI; 10 patients had cervical and 19 thoracolumbar SCI. Five auditory stimuli were applied binaurally to subjects in a sitting position, with a 5-min interstimulus interval. Surface electromyographic recordings were obtained from orbicularis oculi (OOc), sternocleidomastoid (SCM), biceps brachii (BB), and tibialis anterior (TA) muscles. RESULTS: ASR probability was significantly higher and area-under-the-curve was significantly larger in SCM and BB in patients than in controls. ASR latency was significantly shorter in SCM and BB in patients with cervical than in those with thoracolumbar SCI (p < 0.02), but there were no statistically significant differences between complete and incomplete SCI (p > 0.1). Time span since onset correlated significantly with ASR area in OOc, SCM and BB (p < 0.05). CONCLUSION: The capability of the adult central nervous system to reorganize its circuits over time for improved functionality following injury is probably the key to understanding the increased ASRs in patients with SCI. The exaggeration of the startle reflex is potentially important since it may be useful for augmenting voluntary movement in the clinical rehabilitation of patients with SCI. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles A primary tracheal carcinoid tumor masquerading as chronic obstructive pulmonary disease. May 2008 Bahadir T Uskul,Hatice Turker,Ibrahim S Dincer,Alkin Melikoglu,Oktay Tasolar,Canan Tahaoglu Primary tumors of the trachea are rare and can be missed because of the paucity of symptoms and findings and the difficulty in detecting them with chest radiographs. A 31-year-old male patient was admitted with complaints of shortness of breath, coughing, phlegm, and blood in the sputum. He stated ... ( view more )that he was being treated for chronic obstructive pulmonary disease. Fiberoptic bronchoscopy revealed a vegetative mass with a wide base on the posterolateral wall of the distal one-third of the trachea. Postoperative histopathological examination revealed a typical carcinoid tumor. In patients with an unexplained cough, dyspnea, infrequent hemoptysis, and normal pulmonary imaging findings, tracheal carcinoma should be suspected. In such cases, early thoracic computed tomography and bronchoscopic examination can provide a rapid diagnosis and treatment options and prevent a false diagnosis. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles The effect of 2 different concentrations of rectal ketamine on its premedicant features in children. May 2008 Murat M Sayin,Arzu Mercan,Hatice Ture,Ozge Koner,Selami Sozubir,Bora Aykac OBJECTIVE: To investigate whether changing concentration and volume of ketamine for rectal premedication would change the premedication and recovery characteristics. METHODS: A prospective, randomized, clinical study was designed in Yeditepe University Hospital, Istanbul, Turkey in 2006-2007. The s... ( view more )tudy group included children weighing 10-20 kg, American Society of Anesthesiologists grade I, scheduled for inguinal hernia repair or circumcision under general anesthesia with orotracheal intubation and caudal blockade. Children were rectally premedicated with 10 mg.kg-1 ketamine 5% in group K, and 2.5% in the Group K1/2, 45 minutes before anesthesia. Anesthesia was induced and maintained by inhalation. Sedation scores at 15 minutes intervals in the preinduction area, parental separation scores, induction and recovery characteristics, time to discharge and a questionnaire at 24th postoperative hour were recorded. RESULTS: One hundred children were randomized into 2 groups of 50. Thirty minutes 1.2 versus 0.48, p=0.018 and 45 minutes 2.24 versus 1.8, p=0.027 following premedication group K1/2 had significantly lower mean sedation scores than group K. Separation, induction quality scores, induction duration, secretion scores either during induction or postoperative period, and recovery characteristics were all comparable in both groups. CONCLUSION: Although adequate sedation was obtained for most of the children in both groups, rectal premedication with 5% ketamine resulted in higher levels of sedation appearing earlier than that of 2.5% ketamine, while change of volume and concentration had no effect on recovery characteristics. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Effect of melatonin on testicular ischemia/reperfusion injury in rats: is this effect related to the proinflammatory cytokines? May 2008 Zehra Kurcer,Elif Oguz,Hatice Ozbilge,Fusun Baba,Nurten Aksoy,Necla Celik OBJECTIVE: To determine whether the protective effect of melatonin in testicular ischemia/reperfusion (IR) injury is mediated by the proinflammatory molecules. DESIGN: Experimental study. SETTING: University pharmacology laboratory. ANIMAL(S): Fifty-six 8-week-old male Wistar albino rats. INTERVENT... ( view more )ION(S): Left testicular artery and vein was occluded for 1 hour, followed by 3 hours or 24 hours of reperfusion. Melatonin (10 mg/kg IP) or vehicle (1% ethanol in saline) was given 10 minutes before ischemia. MAIN OUTCOME MEASURE(S): Malondialdehyde (MDA), protein carbonyl (PC) content, myeloperoxidase (MPO) activity, and proinflammatory cytokines TNF-alpha, IL-1beta, and IL-6 were examined in testicular tissue after 3 hours of reperfusion. Histologic examination was made after 24 hours of reperfusion. RESULT(S): The MDA, PC, and MPO levels in testicular tissue increased significantly after IR, but the proinflammatory cytokine levels did not change. Melatonin treatment decreased lipid and protein oxidation and ameloriated histopathologic alterations induced by IR without any change in proinflammatory cytokine levels. CONCLUSION(S): The protective effect of melatonin on IR-induced testiculary injury is related to its antioxidant properties but not to proinflammatory cytokines. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Nursing students' expectations from tutors in PBL and effects of tutors' behaviour on nursing students. May 2008 Samiye Mete,Hatice Yildirim Sari AIM: This study aimed to determine what nursing students expect from tutors in PBL sessions and how tutors' behaviour affects students. METHOD: It was performed in Dokuz Eylul University School of Nursing. The study sample included 21 students. They were assigned to one of three groups. Each group ... ( view more )included seven students. Focus group interviews were conducted in a quiet classroom. One researcher conducted interviews and the other observed the interviews and took notes. The interviews were semi-structured. Each interview lasted for 75-90 min and was audio recorded. Data obtained were transcribed verbatim soon after each interview and analyzed using a qualitative content analysis approach. Data were coded by two researchers separately and then compared. Following coding, themes and the main themes were determined. FINDINGS: At the end of data analyses, individual tutor characteristics were classified under seven headings: individual characteristics, asking question, expertise, giving information, group dynamics, giving feedback and evaluation. CONCLUSION: Students clearly report that tutors behaviour affected their motivation and success in the PBL. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Technetium-99m HMPAO brain SPECT in autistic children and their families. Apr 15, 2008 Berna Degirmenci,Süha Miral,Gamze Capa Kaya,Leyla Iyilikçi,Gulhan Arslan,Ay?en Baykara,Ismail Evren,Hatice Durak The purpose of the study was to investigate perfusion patterns in autistic children (AC) and their families. Ten AC (9 boys, 1 girl; mean age: 6.9+/-1.7 years) with autistic disorder defined by DSM-III-R criteria, five age-matched children (3 boys, 2 girls) as a control group, and the immediate fam... ( view more )ily members of eight AC (8 mothers, 8 fathers, 7 siblings; mean ages: 39+/-4 years, 36+/-5 years and 13+/-5 years, respectively) were included in the study. Age- and sex-matched control groups for both the parents and the siblings were also included in the study. Brain perfusion images were obtained 1 h after the intravenous injection of an adjusted dose of Tc-99m HMPAO to children and the adults. Visual and semiquantitative evaluations were performed. Hypoperfusion was seen in the right posterior parietal cortex in three AC, in bilateral parietal cortex in one AC, bilateral frontal cortex in two AC, left parietal and temporal cortex in one AC, and right parietal and temporal cortex in one AC. Asymmetric perfusion was observed in the caudate nucleus in four AC. In semiquantitative analyses, statistically significant hypoperfusion was found in the right inferior and superior frontal, left superior frontal, right parietal, right mesial temporal and right caudate nucleus. In parents of AC, significant hypoperfusion was noted in the right parietal and bilateral inferior frontal cortex. In siblings of AC, perfusion in the right frontal cortex, right nucleus caudate and left parietal cortex was significantly decreased. This preliminary study suggests the existence of regional brain perfusion alterations in frontal, temporal, and parietal cortex and in caudate nucleus in AC and in their first-degree family members. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Various root abnormalities. Report of three cases. Apr 2008 Ahmet Arslan,Emre Ozel,Hatice Altundal Disturbances during morphodifferentiation of tooth germs are rare in the permanent dentition. Reasons for abnormalities are: trauma (fighting, falling, any sport activity) occurring during the eruption; mechanical blockage of the path of eruption by neoplasms; cysts; supernumerary teeth; therapeuti... ( view more )c irradiation of the area; and orthodontic treatment. Abnormalities are classified as dilaceration, extra root formation, double root formation, concrescence, rizomegali and hypercementozis. In this article, three different root abnormalities are presented. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Bone mineral density and bone turnover in patients with psoriatic arthritis. Apr 2008 Pinar Borman,Seçil Babao?lu,Gune? Gur,Sezin Bingol,Hatice Bodur Psoriasis is a common inflammatory skin disease, and conflicting data have been published about osteoporosis and bone turnover markers in patients with psoriatic arthritis. The aim of this study was to assess bone mineral density (BMD) and bone turnover markers in psoriatic patients with and withou... ( view more )t peripheral arthritis and to investigate the relationship between clinical parameters and markers of bone turnover. Forty-seven patients (24 women, 23 men) with psoriasis were included to the study. Demographic data and clinical characteristics were recorded. Erythrocyte sedimentation rate and C-reactive protein were assessed as disease activity parameters. BMD was determined for lumbar spine and total hip by dual X-ray absorptiometry (DXA). Serum Ca, P, alkalen phosphatase (ALP), and serum type I collagen cross-linked C telopeptide (CTX) were measured as bone turnover markers in all patients. The patients were divided into two groups according to their peripheral arthritis status. The clinical and laboratory variables, as well as bone mass status of the groups, were compared with each other. Eighteen patients had peripheral arthritis. All the female patients were premenopausal. None of the patients had radiologically assessed axial involvement. There was no significant difference between the BMD levels of psoriatic patients with and without arthropathy. One patient (5%) had osteoporosis, and nine (50%) patients had osteopenia in arthritic group, while eight (27.5%) patients had osteopenia in patients without arthritis. Serum CTX, ALP, Ca, and P levels were not significantly different in arthritic than in non-arthritic patients (p > 0.05). In patients with psoriatic arthritis, the duration of arthritis was negatively correlated with BMD values of lumbar spine and total femur and serum CTX levels, suggesting an association of increased demineralization with the duration of joint disease. In conclusion, psoriatic patients with peripheral arthritis with longer duration of joint disease may be at a risk for osteoporosis, which can require preventative treatment efforts. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Page 1 of 21 1 2 3 4 > Last >> (504 articles found)

      
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