Medical and Societal information from the Research Community	Number of Articles: 17,750,454 Number of Contributors: 57 Number of Queries: 12,901,669
	Save this page:  Send this page	Login  or Create a Free Account

GST Primary GST Primary Best Strategies for Health Care Quality Im... Best Strategies for Health Care Quality Improvement - Diabetes Quality Improvement Strategies for Antibio... Kathryn McDonald, Stanford-UCSF Evidence-b... Systematic review assessing the effect of ... Quality Improvement Strategies for Antibiotics Management Kathryn McDonald, Stanford-UCSF Evidence-based Practice Center, 117 Encina Commons, Stanford, CA 94305-6019, Kathy.mcdonald@stanford.edu Systematic review assessing the effect of quality improvement strategies on appropriate prescribing of antibiotics and appropriate choice of antibiotics. Adherence Adherence Assistive Devices Assistive Devices Childhood Burn Hanson MacMillan Childhood Burn Hanson MacMillan CLSA_9 CLSA_9 Cyberabuse Cyberabuse Cognitive Behavioural Therapy for Violent ... This review included randomized trials abo... Cognitive Behavioural Therapy for Violent Men who Batter Their Partners This review included randomized trials about the effects of cognitive behavioral therapy on domestic violence. The intervention included programs based on the Duluth Model. The violence had to be committed by a male toward his female partner. The violence also had to be physical. The primary outcomes were new arrests and convictions, and new reports of violence. CABG vs PCI CABG vs PCI Quality Improvement Strategies for Prevent... Quality Improvement Strategies for Preventing Nosocomial Infections (Created 17-Feb-06) Quality Improvement Strategies for Asthma ... Quality Improvement Strategies for Asthma Control Erectile Dysfunction (Created 30-Jan-06) Erectile Dysfunction (Created 30-Jan-06) Inequality - Smoking Cessation to Reduce S... This review was the first part of a projec... Inequality - Smoking Cessation to Reduce Socio-Economic Differences This review was the first part of a project about inequality. It included randomized trials about the effect of smoking cessation interventions on reducing socio-economic differences. The studies had to report data either on persons with low socio-economic groups status or, preferably, on both low and high socio-economic groups. Diet and Physical Activity to Reduce Socio... This review was the second part in a proje... Diet and Physical Activity to Reduce Socio-Economic Differences This review was the second part in a project about inequality. It included randomized trials about the effect of interventions on reducing socio-economic differences in diet and physical activity. The studies had to report data either on persons with low socio-economic groups status or, preferably, on both low and high socio-economic groups. Workfare The data in SRS are not identical to the d... Workfare The data in SRS are not identical to the data in the published report. We used SRS only for an updated search. The review included randomized trials about the effect of welfare-to-work programs. Participants were welfare recipients. There were basically two types of programs. The educational type tried to build knowledge and skills in order to help the welfare recipients acquire jobs that could support them economically. The "work first" approach was more aimed at getting the participants quickly into a job. Exercise interventions for the management ... The objective of this systematic review wa... Exercise interventions for the management of frailty The objective of this systematic review was to examine the effectiveness of current exercise interventions on the management of frailty. A comprehensive search of Medline, Embase, Psycinfo, Cinahl, Scopus, Ageline, Eric, and SportDiscus databases was conducted and produced 1808 citations. So far we have completed 2 levels of “title and abstract” screening and we ended up with 262 articles. We have just started the full text screening. Eligibility criteria included original studies whose participants were identified as frail or prefrail with specific criteria and in which structured physical activity was included as at least one component of the intervention. Create a free account, build a dictionary with saved terms to re-use later! Public Domestic Violence - Using Cognitive Behavior Therapy Smoking Cessation to Reduce Socio-Economic Differences Diet and Physical Activity to Reduce Socio-Economic Differences Workfare Exercise Interventions for the Management of Frailty Search     Simple Advanced Refine (4 coded questions)  Any of these:   Exact Phrase: All of these: None of these: Author: Periodical: Projects: No restrictions   Libraries: Public   Select SRS Projects Show Saved Terms Select Library Show articles that do not have abstracts  Type of Article Clinical Trial Editorial Letter Meta-Analysis Practice Guideline Randomized Controlled Trial Review Addresses Bibliography Biography Case Reports Classical Article Clinical Conference Clinical Trial, Phase I Clinical Trial, Phase II Clinical Trial, Phase III Clinical Trial, Phase IV Comment Comparative Study Consensus Development Conference Consensus Development Conference, NIH Controlled Clinical Trial Corrected and Republished Article Dictionary Directory Duplicate Publication English Abstract Evaluation Studies Festschrift Government Publications Guideline Historical Article Interview In Vitro Journal Article Lectures Legal Cases Legislation Multicenter Study News Newspaper Article Overall Patient Education Handout Periodical Index Published Erratum Retracted Publication Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Retraction of Publication Scientific Integrity Review Support of Research Technical Report Twin Study Validation Studies Not a Primary Study or Review Unknown Primary Study Case Series Case Control Cohort Study Observational Study Qualitative Research CBA or ITS Registry Double Blind Controlled before after study Quasi-randomized trial Simple before after study Cluster-RCT Non-Randomized Study Report Book Book chapter Dissertation Conference procedings Secondary Research Not RCT Humans or Animals Humans Animals Ages All Infant: birth-23 months All Child: 0-18 years All Adult: 19+ years Newborn: birth-1 month Infant: 1-23 months Preschool Child: 2-5 years Child: 6-12 years Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Middle Aged + Aged: 45+ years Aged: 65+ years 80 and over: 80+ years Undetermined Language English French German Italian Japanese Russian Spanish Afrikaans Albanian Unknown Arabic Armenian Azerbaijani Bosnian Bulgarian Catalan Chinese Croatian Czech Danish Dutch Esperanto Estonian Finnish Georgian Greek, Modern Hebrew Hindi Hungarian Icelandic Indonesian Kinyarwanda Korean Latin Latvian Lithuanian Macedonian Malay Malayalam Maori Multiple Languages Norwegian Persian Polish Portuguese Pushto Romanian Sanskrit Scottish gaelic Serbian Slovak Slovenian Swedish Thai Turkish Ukrainian Vietnamese Not English Not French Results(1-25 of 2,031) Sort By: Publication Date Relevance Took: 0.864 seconds to search 17,750,454  Action: Copy Results to new Clipboard Build Search Link Page 1 of 82 1 2 3 4 > Last >> (2031 articles found) A comparative study of calibration transfer methods for determination of gasoline quality parameters in three different near infrared spectrometers. Mar 17, 2008 Claudete Fernandes Pereira,Maria Fernanda Pimentel,Roberto Kawakami Harrop Galvão,Fernanda Araújo Honorato,Luiz Stragevitch,Marcelo Nascimento Martins This work presents a comparative study of calibration transfer among three near infrared spectrometers for determination of naphthenes and RON (Research Octane Number) in gasoline. Seven transfer methods are compared: direct standardization (DS), piecewise direct standardization (PDS), orthogonal s... ( view more )ignal correction (OSC), reverse standardization (RS), piecewise reverse standardization (PRS), slope and bias correction (SBC) and model updating (MU). Two pre-treatment procedures, namely standard normal variate (SNV) and multiplicative scatter correction (MSC), are also investigated. The choice of an appropriate number of transfer samples for each technique, as well as the effect of window size in PDS/PRS and OSC components, are discussed. A broad set of gasoline samples representative of the Northeastern states of Brazil is employed in the investigation. The results show that the use of calibration transfer yields prediction errors comparable to those obtained with complete recalibration of the secondary instrument. Overall, the results point to RS as the best method for the analytical problem under consideration. When storage and/or physical transportation of transfer samples are impractical, MU is more appropriate. The comprehensive investigation carried out in the present work will be of value for practitioners involved in networks of fuel monitoring. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Early and 24-hour bond strength and degree of conversion of etch-and-rinse and self-etch adhesives. Feb 2008 Fernanda Tranchesi Sadek,Fernanda Calabró Calheiros,Paulo Eduardo Capel Cardoso,Yoshio Kawano,Franklin Tay,Marco Ferrari PURPOSE: To evaluate early and 24-hour microtensile bond strength (microTBS) and the degree of conversion (DC) of one representative adhesive system from each of the four current bonding approaches. METHODS: 40 human molars were sectioned occluso-gingivally into two halves. Resin composite was bond... ( view more )ed incrementally to flat, mid-coronal dentin, using the adhesives Adper Scotchbond MP (MP); Adper Scotchbond 2 (SB); Clearfil SE Bond (SE); and Adper Prompt L-Pop (LP) according to the respective manufacturer's instructions (n = 10). One half was immediately sectioned into sticks and subjected to muTBS test. As the sectioning process took approximately 1 hour, the results were designated as 1-hour bond strengths. The other half was stored in distilled water at 37 degrees C for 24 hours before being sectioned and tested. The DC of these systems was measured using Fourier Transform-Raman spectroscopy in three periods: immediately, 1 and 24 hours after polymerization. Data were analyzed with ANOVA and Tukey's tests. RESULTS: There were no significant differences between the 1-hour and 24-hour bond strengths (P > 0.05), or among the DC measured immediately, 1 hour and 24 hours after polymerization (P > 0.05). However, significant differences were observed among adhesives (P < 0.05). microTBS values obtained, in MPa (1 hour/24 hour), were: SB (48.6 + 1.3/48.4 + 3.5) = SE (51.9 + 4.7/53.3 +/- 2.9) > MP (35.3 +/- 10.9/38.6 + 6.7) > LP (25.5 + 1.1/26.0 + 1.5). The DC, in percentage (immediately/1 hour/24 hour), were: SE (81/82/87) > MP (79/77/81) > SB (60/63/65) > LP (39/37/42). ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Polymerization stress related to radiant exposure and its effect on microleakage of composite restorations. Dec 2007 Fernanda Calabró Calheiros,Fernanda Tranchesi Sadek,Leticia Cristina Cidreira Boaro,Roberto Ruggiero Braga OBJECTIVES: Verify the influence of radiant exposure (dose) on polymerization stress and microleakage of composite restorations using two adhesive systems. METHODS: An experimental composite (1BisGMA:1TEGDMA, 75wt.% filler) was subjected to 3, 6, 12 or 24J/cm(2) under 500mW/cm(2). Stress was measur... ( view more )ed in 1-mm height specimens placed between two glass rods (Ø=5mm) attached to a testing machine. Microleakage was assessed in cylindrical restorations (Ø=5mm, h=2mm) with enamel margins, using Adper Single Bond 2 (SB) or Adper Prompt (PR). After storage, specimens were subjected to dye penetration (50% AgNO(3)) and sectioned twice, perpendicularly. Microleakage of the 8tooth/composite interfaces was recorded in millimeters. KHN was measured at both surfaces of cylindrical specimens (Ø=5mm, 1 or 2mm height). ANOVA/Tukey test were used (alpha=0.05). KHN top and bottom were compared using paired t-tests. RESULTS: Stress increased significantly with dose (3J/cm(2): 1.4+/-0.3(c); 6J/cm(2): 4.3+/-0.5(b); 12J/cm(2): 9.3+/-0.6(a); 24J/cm(2): 9.9+/-0.7(a), in MPa). For both average and maximum microleakage, interactions were not statistically significant (p>0.05). Tooth average microleakage was influenced by the adhesive system (SB ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Antiphospholipid antibodies in HIV-positive patients. Nov 2007 Liliana Galrão,Carlos Brites,Maria Luíza Atta,Ajax Atta,Isabella Lima,Fernanda Gonzalez,Fernanda Magalhães,Mittermayer Santiago Antiphospholipid (aPL) antibodies classically have been associated with thrombotic phenomena and abortion in patients with autoimmune diseases. The objective of the present work was to evaluate the frequency of such antibodies in patients infected with HIV and study its association with the presenc... ( view more )e of clinical manifestations of antiphospholipid syndrome (APS). Using a transversal study, a population of patients diagnosed with HIV, identified through an enzyme-linked immunosorbent assay (ELISA) test and confirmed by Western blotting, aged above 17 years old, was investigated. Through a standard questionnaire, the presence of APS manifestations was investigated, as well as the frequency of rheumatic manifestations. Antibodies against beta2 glycoprotein I (anti-beta2 GPI) and anticardiolipin (aCL) IgA, IgG, and IgM were investigated by the ELISA method using commercial kits (QUANTA Lite, INOVA Diagnostics). Ninety patients were studied, 47 (52.2%) male and 43 (47.8%) female. Clinical manifestations of APS were detected in 12 patients (13.3%) of the studied population, whereas arthralgia was the most common rheumatic manifestation (38.9%). Of the 90 patients, 40 (44.4%) were reactive for at least one type of aPL antibody (aCL and/or anti-beta2 GPI). The frequency of aCL was 17.8%, from which 15 (16.7%) had aCL IgG, 3 (3.3%) IgM, and 1 (1.1%) IgA. The frequency of the anti-beta2 GPI antibody was 33.3%, from which 29 (32.2%) were positive for isotype IgA, 4 (4.4%) isotype IgM, and 1 (1.1%) isotype IgG. No association was observed between immunoreactivity for aPL antibodies in general or each isotype in particular and the presence of APS manifestation. In the present study, it was possible to observe a relatively high frequency of aPL antibodies, particularly for isotype IgA anti-beta2 GPI in HIV. However, there was no association to APS manifestations, suggesting that such antibodies had no etiopathogenic role in these complications in patients with such retroviral infection. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Isolation of transcripts over-expressed in human pathogen Trichophyton rubrum during growth in keratin. Oct 2007 Fernanda C A Maranhão,Fernanda G Paião,Nilce M Martinez-Rossi Trichophyton rubrum is a cosmopolitan and anthropophilic fungus able to invade keratinized tissue, causing infection in human skin and nails. This work evaluated the changes in the extracellular pH during its growth in keratin (after 6, 12, 24, 48, 72h and 7 days) at initial pH 5.0. We observed a g... ( view more )radual increase of basal pH under keratin exposure when compared to glucose condition. Also, we identified 576T. rubrum transcripts differentially expressed by subtractive suppression hybridization (SSH) using conidia cultivated for 72h in keratin as tester, and cultivated in glucose as driver. The over-expression of 238 transcripts obtained under keratin condition was confirmed by macro-array dot-blot, revealing 28 unigenes. Putative proteins encoded by these genes showed similarity to fungi proteins involved in basic metabolism, growth and virulence, i.e., transporters ABC-MDR, MFS and ATPase of copper, NIMA interactive protein, Gag-Pol polyprotein, virulence factors serine-protease subtilisin and metalloprotease, cytochrome P450, GlcN-6-phosphate deaminase and Hsp30. The upregulation of T. rubrum genes encoding subtilisin, metalloprotease and Gag-Pol polyprotein was also validated by northern blot. The results of this study provide the first insight into genes differentially expressed during T. rubrum grown in keratin that may be involved in fungal pathogenesis. ( view less ) View Full Abstract View Article Details   Related Articles [Vestibular rehabilitation in patients with relapsing-remitting multiple sclerosis] Jun 2007 Karina Pavan,Bruna E M Marangoni,Kizi B Schmidt,Fernanda A Cobe,Gabriela S Matuti,Lúcia K Nishino,Rodrigo B Thomaz,Maria Fernanda Mendes,Sérgio Lianza,Charles Peter Tilbery Multiple sclerosis (MS) is a demyelinating, inflammatory illness, that attack the white matter of the central nervous system, and abnormal vestibular sensations (vertigo, disequilibrium) are frequent. The vestibular rehabilitation (VR) is determined by mechanisms of adaptations, neural substitution... ( view more )s and compensations. This study evaluated the improvement of the central or peripheral vertigo in patients with relapsing-remitting MS submitted to the VR (exercises of Cawthorne-Cooksey), through the scale of Berg and Dizziness Handicap Inventory (DHI). In this sample of 4 cases the VR, carried through in a period of 2 months, demonstrated the improvement in 3 patients according to the Berg scale and in 2 patients considering that of the DHI. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles In situ expression of mononuclear cell markers and interleukin-2 receptor in renal allograft biopsies of acute rejection and borderline cases. 2007 Fernanda M D Rodrigues,Maria Fernanda C de Carvalho,Marcos R Franchi,Celene M C Gandin,Rosa M Viero The correct diagnosis of renal allograft rejection may be difficult using only clinical and/or histopathological criteria. Immunological assays should be considered in order to evaluate the phenotype of inflammatory infiltrate in renal allograft biopsies. Immunohistochemical studies were performed ... ( view more )to detect mononuclear cells, CD4 and CD8 T lymphocytes, B lymphocytes, macrophages, null cells, and positive cells for interleukin-2 receptors. A total of 41 allograft biopsies classified into three groups were studied: acute cellular rejection (28 biopsies/22 patients), borderline (7 biopsies/5 patients) and control (6 biopsies/6 patients). In the rejection group (RG), increased cellularity was found mainly at the tubulo-interstitial level. Expression of CD8 positive cells was higher in RG when compared to borderline (BG) and control (CG) groups, respectively (0.9 vs. 0.0 vs. 0.35 cells/mm2; p < 0.001). Expression of macrophages was not statistically significant among the three groups (RG = 0.6 vs. BG = 0.2 vs. CG = 0.0 cells/mm2; p < 0.02). In the BG, CD4 + cells predominated (BG = 0.2 vs. RG = 0.05 vs. CG = 0.0 cells/mm2; p < 0.05). Clinically these patients were treated as cases of acute rejection. The numbers and different types of infiltrating cells did not correlate with patient's clinical outcome. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Lipodermatosclerosis in patients with diffuse connective tissue diseases. Jul 2006 Fernanda Dias Gonzalez,Fernanda Pedreira Magalhães,Alice Pontes Vilas Boas Freitas,Humberto Castro Lima Filho,Mittermayer B Santiago Lipodermatosclerosis (LDS) is a clinical condition characterized by the appearance of hardened, painful, and hyperchromic plaques on the legs. We describe three patients with diffuse connective tissue diseases (DCTD) who developed this clinical condition. The first one was a systemic lupus erythema... ( view more )tosus patient with secondary antiphospholipid syndrome; the second patient had a superposition of DCTD (rheumatoid arthritis, Sjögren's syndrome, morphea); and the last one had been diagnosed with CREST 10 years earlier but had more recently developed primary biliary cirrhosis. Although its etiopathogenesis is unknown, LDS has been frequently seen in association with venous insufficiency. Its recognition by professionals who deal with DCTD is very relevant since it is characterized by thickening of the skin, similar to scleroderma. Its identification can avoid the inadvertent use of medications such as penicillamine and immunosuppressants, which have potentially serious side effects. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles The complete nucleotide sequence and genomic organization of Citrus Leprosis associated Virus, Cytoplasmatic type (CiLV-C). Jun 2006 Renata C Pascon,João Paulo Kitajima,Michèle C Breton,Laura Assumpção,Christian Greggio,Almir S Zanca,Vagner Katsumi Okura,Marcos C Alegria,Maria E Camargo,Giovana G C Silva,Jussara C Cardozo,Marcelo A Vallim,Sulamita F Franco,Vitor H Silva,Hamilton Jordão,Fernanda Oliveira,Poliana F Giachetto,Fernanda Ferrari,Carlos I Aguilar-Vildoso,Fabrício J B Franchiscini,José M F Silva,Paulo Arruda,Jesus A Ferro,Fernando Reinach,Ana Cláudia Rasera da Silva The Citrus leprosis disease (CiL) is associated to a virus (CiLV) transmitted by Brevipalpus spp. mites (Acari: Tenuipalpidae). CiL is endemic in Brazil and its recently spreading to Central America represents a threat to citrus industry in the USA. Electron microscopy images show two forms of CiLV... ( view more ): a rare nuclear form, characterized by rod-shaped naked particle (CiLV-N) and a common cytoplasmic form (CiLV-C) associated with bacilliform-enveloped particle and cytoplasmic viroplasm. Due to this morphological feature, CiLV-C has been treated as Rhabdovirus-like. In this paper we present the complete nucleotide sequence and genomic organization of CiLV-C. It is a bipartite virus with sequence similarity to ssRNA positive plant virus. RNA1 encodes a putative replicase polyprotein and an ORF with no known function. RNA2 encodes 4 ORFs. pl5, p24 and p61 have no significant similarity to any known proteins and p32 encodes a protein with similarity to a viral movement protein. The CiLV-C sequences are associated with typical symptoms of CiL by RT-PCR. Phylogenetic analysis suggests that CiLV-C is probably a member of a new family of plant virus evolutionarily related to Tobamovirus. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Overactive bladder: prevalence and implications in Brazil. Jun 2006 Claudio Teloken,Fernanda Caraver,Fernanda A Weber,Patrick E Teloken,João F Moraes,Paulo R Sogari,Túlio M Graziottin OBJECTIVES: To assess overactive bladder (OAB) prevalence, associated factors and implications in a young population. METHODS: An independent population-based study was carried out. A self-applicative questionnaire covering urinary symptoms, coping strategies, quality of life and treatment seeking ... ( view more )behavior was developed. RESULTS: A total of 848 subjects between 15 and 55 years completed the questionnaire. The overall prevalence of OAB was 18.9%. Women were significantly more affected than men (p = 0.001). All age groups were equally affected (p = 0.152). Subjects with OAB reported significant impairment on household chores (p = 0.009), physical activities (p = 0.016), sleep (p < 0.001), work (p < 0.001), social life (p < 0.001) and sexual life (p < 0.001). In addition, OAB individuals present higher prevalence of depression (p = 0.036), anxiety (p < 0.001), shame (p < 0.001) and tiredness (p < 0.001) OAB was independently associated to sexual life impairment (OR = 3.36, 95% CI=1.20-9.39). Only 27.5% of OAB subjects sought for medical counseling. CONCLUSIONS: OAB is a highly prevalent condition, even in such a young population. It affects both genders, yet it is more frequently observed in women. OAB is an important health condition, with serious impact on quality of life and sexual function. A large percentual of individuals remain unrecognized, under treated and consequently suffer for long periods of time. ( view less ) View Full Abstract View Article Details   Related Articles Inversions of chromosomes 2 and 6 in mantle cell lymphoma. Cytogenetic, FISH, and molecular studies. Jun 2006 Estela Pedrazzini,Roxana Cerretini,María Fernanda Noriega,Marina Narbaitz,María Fernanda Palacios,Pedro Negri,Raquel Bengió,Irma Slavutsky Inversions are infrequent events in hematological malignancies. We here report the cytogenetic, fluorescence in situ hybridization (FISH), and molecular studies of 2 patients diagnosed with mantle cell lymphoma (MCL) that showed inversions of chromosomes 2 and 6 as part of complex karyotypes. Both ... ( view more )patients showed a cytogenetically identical inv(6)(p23q11) detected as a secondary aberration. In addition, both patients had a derivative chromosome 2 which originated by partial deletion of the short arm and a pericentric inversion with different breakpoints on the long arm: der(2)del(2)(p21)inv(2)(p21q11) and der(2)del(2)(p21)inv(2)(p21q13), respectively. The presence of t(11;14)(q13;q32) was confirmed by interphase FISH and by molecular study. Residual normal cells were found in both cases. The patients showed a different clinical evolution with a poor outcome for one case and a favorable course of the disease for the other one. The review of the literature in MCL showed a total of 9 inversions affecting different chromosomes. Considering that inversions are very infrequent events in MCL, our findings could be important for detecting genes potentially involved in development and/or progression of this aggressive non-Hodgkin lymphoma subtype. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles [Leisure activities for the elderly during hospitalization] Jun 2006 Fernanda Freire Jannuzzi,Fernanda Aparecida Cintra This study intended to: 1. Identify the leisure activities available in the hospital and those in which the elderly participate; 2. Relate elderly hospitalization with their participation in leisure activities; 3. Assess the factors that motivate and inhibit elderly participation in leisure activit... ( view more )ies. This is a descriptive/exploratory study carried out with one hundred hospitalized elderly patients. Available leisure activities were television and magazines. Most participants (99%) said they participate in leisure activities such as family/ friends conversations and visits. Involvement in leisure activities decreases with associated diseases and increases with hospitalization time. Leisure was motivated by the elderly's personal characteristics, the reduction of the hospitalization's negative effects, and the benefits it brings to the health. Its limitation was associated to intrinsic aspects of the elderly and to the institutional context. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Structure of chorismate synthase from Mycobacterium tuberculosis. May 2006 Marcio V B Dias,Júlio C Borges,Fernanda Ely,José H Pereira,Fernanda Canduri,Carlos H I Ramos,Jeverson Frazzon,Mário S Palma,Luis A Basso,Diógenes S Santos,Walter F de Azevedo In bacteria, fungi, plants, and apicomplexan parasites, the aromatics compounds, such as aromatics amino acids, are synthesized through seven enzymes from the shikimate pathway, which are absent in mammals. The absence of this pathway in mammals make them potential targets for development of new th... ( view more )erapy against infectious diseases, such as tuberculosis, which is the world's second commonest cause of death from infectious disease. The last enzyme of shikimate pathway is the chorismate synthase (CS), which is responsible for conversion of the 5-enolpyruvylshikimate-3-phosphate to chorismate. Here, we report the crystallographic structure of CS from Mycobacterium tuberculosis (MtCS) at 2.65 A resolution. The MtCS structure is similar to other CS structures, presenting beta-alpha-beta sandwich structural topology, in which each monomer of MtCS consists of a central helical core. The MtCS can be described as a tetramer formed by a dimer of dimers. However, analytical ultracentrifugation studies suggest the MtCS is a dimer with a more asymmetric shape than observed on the crystallographic dimer and the existence of a low equilibrium between dimer and tetramer. Our results suggest that the MtCS oligomerization is concentration dependent and some conformational changes must be involved on that event. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Blood oxidative stress markers in Gaucher disease patients. Feb 2006 Fernanda M Roversi,Luciano C Galdieri,Bruno H C Grego,Fernanda G Souza,Cecília Micheletti,Ana Maria Martins,Vânia D'Almeida BACKGROUND: Gaucher disease (GD) is the most common glycosphingolipidosis resulting in accumulation of glucoceramide. The most effective treatment for this disease is enzyme replacement therapy (ERT) which involves recombinant enzyme infusion. Enzymatic deficiency in GD patients may induce a cascad... ( view more )e of events culminating in secondary effects such as the production of reactive oxygen species (ROS). We investigated the relationship between ROS and GD by analyzing blood oxidative stress markers in GD patients submitted to ERT at different stages during the treatment. METHODS: Blood were collected before and just after enzyme infusion. Red blood cell catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD) and total glutathione (tGSH), and plasma thiobarbituric acid reactive substances (TBARS) were assayed by spectrophotometry. Homocysteine concentrations and related polymorphisms were also studied. Control individuals matched for sex and age were also analyzed. RESULTS: Concentrations of homocysteine and TBARS, and GPx enzyme activity were not different in ERT-treated GD patients. CAT activity was higher while SOD was lower in patients compared to controls. No variations in any of these parameters were found before and just after ERT. Regarding tGSH, a significant increase was observed in GD patients after infusion. Genotypic frequencies studied did not differ from controls or other Brazilian samples. CONCLUSION: ERT-treated GD patients show an improvement in antioxidant capacity, which is further increased just after recombinant enzyme infusion. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Ureteral stenosis secondary to granulomatous vasculitis. Dec 2005 Alice Pontes Vilas Boas Freitas,Humberto Castro Lima Filho,Fernanda Gonzalez,Fernanda Magalhães,Manoel Juncal Pazos,Celso Rubens Vieira E Silva,Mittermayer B Santiago Vasculitic syndromes are a group of disorders characterized by inflammation of the blood vessels. They include polyarteritis nodosa (PAN), Churg-Strauss syndrome (CS), and Wegener granulomatosis (WG) that differ on type, size, and location of the involved vessels. We report a rare case of granuloma... ( view more )tous vasculitis leading to ureteral stenosis in the absence of other systemic manifestations of the disease. The patient was a 56-year-old woman who began to complain of left lumbar pain, nocturia, and dysuria. Computed tomography scan demonstrated a large abdominal mass with ureteral compression. A tissue specimen obtained by laparotomy revealed the presence of a chronic inflammatory process with fibrosis, granulomatous reaction, extravascular eosinophilia, and prominent vasculitis. She was put on corticosteroids and azathioprine with a decrease of the tumoral mass. This incompletely classified vasculitis was an unexpected cause of the abdominal mass. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Low serum testosterone levels are associated with positive surgical margins in radical retropubic prostatectomy: hypogonadism represents bad prognosis in prostate cancer. Dec 2005 Claudio Teloken,Carlos Teodósio Da Ros,Fernanda Caraver,Fernanda A Weber,Ana P Cavalheiro,Tulio Meyer Graziottin PURPOSE: It has been reported that more aggressive prostate cancer (PC) can be associated with low serum testosterone levels. The relationship between serum androgens and PC is still not completely understood. In this study we examined the association of prognostic factors in men who underwent radi... ( view more )cal retropubic (RRP) prostatectomy with low or normal total testosterone. MATERIALS AND METHODS: We retrospectively evaluated 64 consecutive patients with localized PC treated with RRP between July 2002 and November 2003. PC was diagnosed by transrectal ultrasonography guided biopsy performed for either a suspicious digital rectal examination or serum prostate specific antigen greater than 4.0 ng/ml. Gleason score was determined in prostatic biopsies. Pathological TNM staging (1997), capsular perforation, seminal vesicle involvement and surgical margin status were determined in all surgical specimens. The threshold for serum total testosterone was 270 ng/dl. In all analyses p <0.05 was considered statistically significant. RESULTS: There were no statistically significant differences among prostate specific antigen, Gleason score (biopsy or specimen), pathological stage, capsular perforation and seminal vesicle involvement. However, patients with low total testosterone had increased positive surgical margins (p = 0.026). CONCLUSIONS: Patients with low total testosterone more frequently present with positive surgical margins in RRP specimens. The true association between low testosterone and poor clinical outcome in the long term needs validation in large prospective studies. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles [Motor function evaluation in merosin-deficient congenital muscular dystrophy children] Jun 2005 Fernanda M Rocco,Fernanda H Gianini Luz,Alexsander Junquera Rossato,Antônio Carlos Fernandes,Acary S B Oliveira,Javier Toledano Betetas,Edmar Zanoteli Congenital muscular dystrophy (CMD) is a heterogeneous group of disorders characterized by early onset of hypotonia and weakness. Almost 50% of the cases are caused by primary deficiency of a protein named merosin (MD), and present a homogenous phenotype with a severe motor and respiratory involvem... ( view more )ent. Eleven children with clinical and histological diagnosis of CMD-MD, aged of 3 to 15 years, were studied using the manual muscle testing (Medical Research Council), goniometric analysis, motor ability and day life activities (Barthel index) scales, with the objective to characterize the main motor function limitations. The muscular groups most affected were cervical flexors, paravertebral and proximal portions of limbs. The muscular groups of upper limbs were as affected as the lower limbs, and the extensors were more affected than the flexors groups. All children had severe muscular retractions on the hip, knee and elbow. Other frequent deformities were scoliosis and equinus-varum feet. No children presented the motor ability to walk, stand up and crawl; and all of them were classified as dependents or semi-dependents in the day life activities scale. Our findings confirm the severe and diffuse involvement of skeletal muscle in CMD-MD patients, producing serious motor limitations and deformities. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Antispasmodic activity of fractions and cynaropicrin from Cynara scolymus on guinea-pig ileum. May 2005 Fernanda Emendörfer,Fabiane Emendörfer,Fernanda Bellato,Vânia Floriani Noldin,Valdir Cechinel-Filho,Rosendo Augusto Yunes,Franco Delle Monache,Alcíbia Maia Cardozo This study describes the antispasmodic activity of some fractions and cynaropicrin, a sesquiterpene lactone from Cynara scolymus, cultivated in Brazil, against guinea-pig ileum contracted by acetylcholine. The dichloromethane fraction showed the most promising biological effects, with an IC(50) of ... ( view more )0.93 (0.49-1.77) mg/ml. Its main active component, the sesquiterpene lactone cynaropicrin, exhibited potent activity, with IC(50) of 0.065 (0.049-0.086) mg/ml, being about 14-fold more active than dichloromethane fraction and having similar potency to that of papaverine, a well-known antispasmodic agent. The results confirm the popular use of artichoke for the treatment of gastrointestinal disturbances, and encourage new studies on this compound, in order to obtain new antispasmodic agents. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Evaluation of the relaxant action of some Brazilian medicinal plants in isolated guinea-pig ileum and rat duodenum. 2005 Fernanda Emendörfer,Fabiane Emendörfer,Fernanda Bellato,Vânia F Noldin,Rivaldo Niero,Valdir Cechinel-Filho,Alcibia Maia Cardozo PURPOSE: The present study aimed to evaluate the possible antispasmodic activity in vitro of methanolic extracts (ME) of six Brazilian medicinal plants. METHODS: The extracts were evaluated on isolated guinea-pig ileum and rat duodenum preparations. RESULTS: Rubus imperialis, Maytenus robusta, Ipom... ( view more )oea pes caprae and Epidendrum mosenii did not inhibit the contractile response elicited by acetylcholine on guinea-pig ileum. On the other hand, ME from Calophyllum brasiliense and Cynara scolymus exhibited significant inhibitory activity for the contractile response elicited by acetylcholine on guinea-pig ileum and on rat duodenum in a noncompetitive and concentration-dependent manner. CONCLUSIONS: The current study suggests that, of the six medicinal plants evaluated, only the ME of Calophyllum brasiliense and Cynara scolymus show probable antispasmodic activity, confirming and justifying their use in folk medicine for the treatment of intestinal disorders. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Crystallization and preliminary X-ray crystallographic analysis of chorismate synthase from Mycobacterium tuberculosis. Nov 2004 Marcio Viniciusbertacine Dias,Fernanda Ely,Fernanda Canduri,José Henrique Pereira,Jeverson Frazzon,Luiz Augusto Basso,Mário Sérgio Palma,Walter Filgueira de Azevedo,Diógenes Santiago Santos The enzymes of the shikimate pathway are potential targets for the development of new therapies because they are essential for bacteria but absent from mammals. The last step in this pathway is performed by chorismate synthase (CS), which catalyzes the conversion of 5-enolpyruvylshikimate-3-phospha... ( view more )te to chorismate. Optimization of crystallization trials allowed the crystallization of homogeneous recombinant CS from Mycobacterium tuberculosis (MtCS). The crystals of MtCS belong to space group P6(4)22 (or P6(2)22) and diffract to 2.8 A resolution, with unit-cell parameters a = b = 129.7, c = 156.8 A. There are two molecules in the asymmetric unit. Molecular-replacement trials were not successful. Heavy-atom derivative screening is in progress. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Polymerization contraction stress of low-shrinkage composites and its correlation with microleakage in class V restorations. Jul 2004 Fernanda Calabró Calheiros,Fernanda Tranchesi Sadek,Roberto Ruggiero Braga,Paulo Eduardo Capel Cardoso OBJECTIVE: The aim of this study was to compare the behavior of two new, low-shrinkage hybrid composites (Aelite LS and Inten-S) with a microfilled (Heliomolar) and a hybrid composite (Filtek Z250), in terms of polymerization contraction stress and microleakage. METHODS: Maximum contraction stress ... ( view more )after 10 min was recorded in a "tensilometer", using a C-factor (C) of 2.5 and energy density of 26 J/cm(2). For the microleakage test, cylindrical cavities with enamel margins prepared in bovine incisors (4 mm diameter, 1.5 mm depth, C = 2.5) were restored in bulk, applying the same energy density used in the contraction stress test. After immersion in 0.5% methylene blue for 4 h, specimens were sectioned twice, perpendicularly, and the highest dye penetration score was recorded. Contraction stress results were analyzed by one-way ANOVA/Tukey's test and microleakage was analyzed by Kruskal-Wallis test. Regression analysis between the two variables was also performed. RESULTS: Aelite LS showed significantly higher stress than the other composites tested. Inten-S and Filtek Z250 had similar stress levels, statistically higher than Heliomolar. In the microleakage test, a significant difference was observed between Aelite LS and Heliomolar only. Regression analysis showed a good linear correlation between the two variables (R2(adjusted) = 0.811). CONCLUSIONS: The low-shrinkage materials exhibited contraction stress values similar or higher than the hybrid composite. A direct relationship between contraction stress values and microleakage for the composites evaluated was verified. SIGNIFICANCE: The low-shrinkage composites tested did not seem to represent an improvement in terms of reducing contraction stress or microleakage. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles [Non-invasive mechanical ventilation (NIMV) for Chronic Obstructive Pulmonary Disease (COPD): complications and outcome] Nov 2003 Susana Clemente,Ana Oliveira,Fernanda Paula,Cristina Santos,Carvalheira Santos,Helena Pinto,Fernanda Oliveira,Pontes Mata Monitoring the complications during NIMV plays an important role to obtain a favourable outcome. In order to evaluate the correlation between the unsuccess of NIMV and occurrences of complications on COPD inpatients with major acidemic respiratory failure (pH<7,30), we analysed 28 admissions in sta... ( view more )ges III (79%) and IIB (7%), majority males (79%) with an average age of 73 years-old, presenting comorbidities in 82%. Respiratory infection was the main cause for inpatient. Overall success was 82% (Group1) and unsuccess was verified on the others (Group2). The general complications were recorded in all of the Group2, against 26% from Group1. NIMV related complications appeared on all of the unsuccessful group in opposition to 41% verified on Group1, being the mask discomfort the most frequent one (43%). We concluded in this study that the presence of complications was predictive for failure (p<0,05). ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Different sensitivity of Ca(2+)-ATPase and cholinesterase to pure and commercial pesticides in nervous ganglia of Phyllocaulis soleiformis (Mollusca). Jun 2003 Rosane Souza da Silva,Giana de Paula Cognato,Fernanda Cenci Vuaden,Maria Fernanda S Rezende,Flávia Valladão Thiesen,Maria da Graça Fauth,Maurício Reis Bogo,Carla Denise Bonan,Renato Dutra Dias We measured the effects in vitro of pure and commercial pesticides on Ca(2+)-activated ATPase and cholinesterase (ChE) activities in the nervous system of the slug Phyllocaulis soleiformis. The pesticides used in this study included carbamate and organophosphates, which acts as reversible and irrev... ( view more )ersible anticholinesterases, respectively. Both enzymes were insensitive to pure carbofuran (1 mM), glyphosate (1 mM) and malathion (120 microM). However, the carbamate carbofuran, in the commercial formulation Furandan 350S, inhibited ATPase and ChE activities. The organophosphate glyphosate used in the commercial preparation of Gliz 480CS inhibited ATPase activity and increased cholinesterase activity. These effects are likely due to the action of adjuvant substances of the chemical formulation. The commercial formulation (Malatol 500CE) did not alter enzymes activities. Our results suggest that cholinesterase present in the slug nervous tissue has a different behavior to those identified in vertebrate nervous tissue, since it was insensitive to pure compounds, known as anticholinesterases in vertebrates. Considering the insensitivity of the Ca(2+)-activated ATPase, we suggested that the purinergic neurotransmission and other roles of ATP might not be affected by the pure pesticides tested. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Analytical curve or standard addition method: how to elect and design--a strategy applied to copper determination in sugarcane spirits using AAS. Nov 2002 Fernanda Araujo Honorato,Ricardo Saldanha Honorato,Maria Fernanda Pimentel,Mario Cesar Ugulino Araujo In most instrumental analysis, the analyte concentration is usually obtained the by Analytical Curve Method (ACM) or Standard Addition Method (SAM). Thus, it is important for the analyst to select the most appropriate method, to seek the best conditions of analysis, and to provide parameters of ana... ( view more )lytical performance. A strategy to do so is proposed in this paper in conjunction with MATLAB software to implement it. The proposed strategy was applied to copper determination by atomic absorption spectrometry in Brazilian sugarcane spirits termed 'Cachaça' and SAM was chosen as the most appropriate method. To select the best experimental design for SAM, the influence of some factors, such as the number of standard additions and concentration levels, the location of the levels and the average concentration of the standard additions were demonstrated. The design with six standard additions, four concentration levels located near the inferior and superior levels and the average concentration of the standard additions closer to zero yielded SAM with an adequate compromise between precision, cost and time of analysis. The uniform distribution of concentration levels, usually used in routine analysis, is not a good design regarding precision. On the other hand, it is adequate when the linear range is unknown. Generally, the proposed strategy can be applied to different instrumental techniques and samples, which aim to improve their analytical performance. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Patient classification system: a proposal to complement the instrument by Fugulin et al. 2007 Sep-Oct Fernanda dos Santos,Noemi Marisa Brunet Rogenski,Cleide Maria Caetano Baptista,Fernanda Maria Togeiro Fugulin Analysis of patient classification instruments available in the literature shows that many significant aspects related to the assistance to patients with wounds are not approached, evidencing the importance to elaborate criteria to assess these patients. This study proposes the development of new o... ( view more )f areas of care to complement the Fugulin et al. instrument, validated by the Federal Nursing Council (COFEN). The construction of new areas to evaluate wounds was based on a bibliographic search on the operational models of the Patient Classification System (PCS), as well as on several instruments of wound classification. New areas of care were established, as follows: tissue impairment, number of dressing changes and time taken to their preparation. Values were also redefined indicating the patient's assistance category. The complementation of the Fugulin et al. instrument, proposed here, favors the application of this instrument in a more diversified group of patients since it adds a relevant assistance aspect, as the dressing issue. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Page 1 of 82 1 2 3 4 > Last >> (2031 articles found)

      
 ESRNexus is provided as a service by TrialStat Corporation. ESRNexus is a registered trademark of TrialStat Corporation. Copyright 2008. View a list of all articles here