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GST Primary GST Primary Best Strategies for Health Care Quality Im... Best Strategies for Health Care Quality Improvement - Diabetes Quality Improvement Strategies for Antibio... Kathryn McDonald, Stanford-UCSF Evidence-b... Systematic review assessing the effect of ... Quality Improvement Strategies for Antibiotics Management Kathryn McDonald, Stanford-UCSF Evidence-based Practice Center, 117 Encina Commons, Stanford, CA 94305-6019, Kathy.mcdonald@stanford.edu Systematic review assessing the effect of quality improvement strategies on appropriate prescribing of antibiotics and appropriate choice of antibiotics. Adherence Adherence Assistive Devices Assistive Devices Childhood Burn Hanson MacMillan Childhood Burn Hanson MacMillan CLSA_9 CLSA_9 Cyberabuse Cyberabuse Cognitive Behavioural Therapy for Violent ... This review included randomized trials abo... Cognitive Behavioural Therapy for Violent Men who Batter Their Partners This review included randomized trials about the effects of cognitive behavioral therapy on domestic violence. The intervention included programs based on the Duluth Model. The violence had to be committed by a male toward his female partner. The violence also had to be physical. The primary outcomes were new arrests and convictions, and new reports of violence. CABG vs PCI CABG vs PCI Quality Improvement Strategies for Prevent... Quality Improvement Strategies for Preventing Nosocomial Infections (Created 17-Feb-06) Quality Improvement Strategies for Asthma ... Quality Improvement Strategies for Asthma Control Erectile Dysfunction (Created 30-Jan-06) Erectile Dysfunction (Created 30-Jan-06) Inequality - Smoking Cessation to Reduce S... This review was the first part of a projec... Inequality - Smoking Cessation to Reduce Socio-Economic Differences This review was the first part of a project about inequality. It included randomized trials about the effect of smoking cessation interventions on reducing socio-economic differences. The studies had to report data either on persons with low socio-economic groups status or, preferably, on both low and high socio-economic groups. Diet and Physical Activity to Reduce Socio... This review was the second part in a proje... Diet and Physical Activity to Reduce Socio-Economic Differences This review was the second part in a project about inequality. It included randomized trials about the effect of interventions on reducing socio-economic differences in diet and physical activity. The studies had to report data either on persons with low socio-economic groups status or, preferably, on both low and high socio-economic groups. Workfare The data in SRS are not identical to the d... Workfare The data in SRS are not identical to the data in the published report. We used SRS only for an updated search. The review included randomized trials about the effect of welfare-to-work programs. Participants were welfare recipients. There were basically two types of programs. The educational type tried to build knowledge and skills in order to help the welfare recipients acquire jobs that could support them economically. The "work first" approach was more aimed at getting the participants quickly into a job. Exercise interventions for the management ... The objective of this systematic review wa... Exercise interventions for the management of frailty The objective of this systematic review was to examine the effectiveness of current exercise interventions on the management of frailty. A comprehensive search of Medline, Embase, Psycinfo, Cinahl, Scopus, Ageline, Eric, and SportDiscus databases was conducted and produced 1808 citations. So far we have completed 2 levels of “title and abstract” screening and we ended up with 262 articles. We have just started the full text screening. Eligibility criteria included original studies whose participants were identified as frail or prefrail with specific criteria and in which structured physical activity was included as at least one component of the intervention. Create a free account, build a dictionary with saved terms to re-use later! Public Domestic Violence - Using Cognitive Behavior Therapy Smoking Cessation to Reduce Socio-Economic Differences Diet and Physical Activity to Reduce Socio-Economic Differences Workfare Exercise Interventions for the Management of Frailty Search     Simple Advanced Refine (4 coded questions)  Any of these:   Exact Phrase: All of these: None of these: Author: Periodical: Projects: No restrictions   Libraries: Public   Select SRS Projects Show Saved Terms Select Library Show articles that do not have abstracts  Humans or Animals Humans Animals Type of Article Clinical Trial Editorial Letter Meta-Analysis Practice Guideline Randomized Controlled Trial Review Addresses Bibliography Biography Case Reports Classical Article Clinical Conference Clinical Trial, Phase I Clinical Trial, Phase II Clinical Trial, Phase III Clinical Trial, Phase IV Comment Comparative Study Consensus Development Conference Consensus Development Conference, NIH Controlled Clinical Trial Corrected and Republished Article Dictionary Directory Duplicate Publication English Abstract Evaluation Studies Festschrift Government Publications Guideline Historical Article Interview In Vitro Journal Article Lectures Legal Cases Legislation Multicenter Study News Newspaper Article Overall Patient Education Handout Periodical Index Published Erratum Retracted Publication Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. 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Retraction of Publication Scientific Integrity Review Support of Research Technical Report Twin Study Validation Studies Not a Primary Study or Review Unknown Primary Study Case Series Case Control Cohort Study Observational Study Qualitative Research CBA or ITS Registry Double Blind Controlled before after study Quasi-randomized trial Simple before after study Cluster-RCT Non-Randomized Study Report Book Book chapter Dissertation Conference procedings Secondary Research Not RCT Ages All Infant: birth-23 months All Child: 0-18 years All Adult: 19+ years Newborn: birth-1 month Infant: 1-23 months Preschool Child: 2-5 years Child: 6-12 years Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Middle Aged + Aged: 45+ years Aged: 65+ years 80 and over: 80+ years Undetermined Language English French German Italian Japanese Russian Spanish Afrikaans Albanian Unknown Arabic Armenian Azerbaijani Bosnian Bulgarian Catalan Chinese Croatian Czech Danish Dutch Esperanto Estonian Finnish Georgian Greek, Modern Hebrew Hindi Hungarian Icelandic Indonesian Kinyarwanda Korean Latin Latvian Lithuanian Macedonian Malay Malayalam Maori Multiple Languages Norwegian Persian Polish Portuguese Pushto Romanian Sanskrit Scottish gaelic Serbian Slovak Slovenian Swedish Thai Turkish Ukrainian Vietnamese Not English Not French Results(1-25 of 382) Sort By: Publication Date Relevance Took: 0.869 seconds to search 17,750,454  Action: Copy Results to new Clipboard Build Search Link Page 1 of 16 1 2 3 4 > Last >> (382 articles found) Glucagon like peptide-2 induces intestinal restitution through VEGF release from subepithelial myofibroblasts. Jan 14, 2008 Kerem Bulut,Christian Pennartz,Peter Felderbauer,Juris J Meier,Matthias Banasch,Daniel Bulut,Frank Schmitz,Wolfgang E Schmidt,Peter Hoffmann Glucagon like peptide-2 (GLP-2) exerts intestinotrophic actions, but the underlying mechanisms are still a matter of debate. Recent studies demonstrated the expression of the GLP-2 receptor on fibroblasts located in the subepithelial tissue, where it might induce the release of growth factors such ... ( view more )as keratinocyte growth factor (KGF) or vascular endothelial growth factor (VEGF). Therefore, in the present studies we sought to elucidate the downstream mechanisms involved in improved intestinal adaptation by GLP-2. Human colonic fibroblasts (CCD-18Co), human colonic cancer cells (Caco-2 cells) and rat ileum IEC-18 cells were used. GLP-2 receptor mRNA expression was determined using real time RT-PCR. Conditioned media from CCD-18Co cells were obtained following incubation with GLP-2 (50-250 nM) for 24 h. Cell viability was assessed by a 3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyl-tetrazolium bromide (MTT)-assay, and wound healing was determined with an established migration-assay. Transforming Growth Factor beta (TGF-beta), VEGF and KGF mRNA levels were determined by RT-PCR. Protein levels of VEGF and TGF-beta in CCD-18Co cells following GLP-2 stimulation were determined using ELISA. Neutralizing TGF-beta and VEGF-A antibodies were utilized to assess the role of TGF-beta and VEGF-A in the process of wound healing. GLP-2 receptor expression was detected in CCD-18Co cells. Conditioned media from CCD-18Co cells dose-dependently induced proliferation in Caco-2 cells, but not in IEC-18 cells. Conditioned media also enhanced cell migration in IEC-18 cells (P<0.01), while migration was even inhibited in Caco-2 cells (P<0.0012). GLP-2 significantly stimulated mRNA expression of VEGF and TGF-beta, but not of KGF in CCD-18Co. The migratory effects of GLP-2 were completely abolished in the presence of TGF-beta and VEGF-A antibodies. GLP-2 exerts differential effects on the epithelium of the small intestine and the colon. Thus, in small intestinal cells GLP-2 stimulates wound repair, whereas no such effects were observed in colonic cells. The mechanisms underlying GLP-2 induced intestinal wound repair seem to involve the secretion of VEGF and, subsequently, TGF-beta from subepithelial fibroblasts, whereas KGF appeared to be less important. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Extracorporeal shock wave treatment for defective nonunion of the radius: a rabbit model. Aug 2006 O Bulut,M Eroglu,H Ozturk,G Tezeren,S Bulut,E Koptagel PURPOSE: To investigate the effect of extracorporeal shock wave treatment (ESWT) on bony union using volume analysis of the callus mass by computed tomography and histology. METHODS: Both radii of 13 rabbits were osteotomised and a defective bony nonunion created by placing a polyethylene pad betwe... ( view more )en the osteotomy site for 40 days. Nonunion was confirmed by radiography using Lane-Sandhu criteria. ESWT (14 kW, 0.46 mJ/mm(2), 1000 shock waves) was applied to the right radius of the rabbits. The left radius served as a control. Five rabbits were killed 4 weeks after ESWT (group 1) and 8 after 6 weeks (group 2). Volume analysis of the callus mass was performed using computed tomography and the bone healing process was assessed by histology. RESULTS: In group 1, callus volume on the treated side was invariably greater than that on the control side; the difference being statistically significant (p=0.032). In group 2, the callus volume of the treated side was greater than that of the control side, except in rabbits 4 and 9. Only after excluding the findings from the latter did the difference attain statistical significance (p=0.020). Histology confirmed that the bone-healing process was faster in the treated side. CONCLUSION: ESWT enhanced the bone-healing process by increasing both volume and speed of callus formation. ( view less ) View Full Abstract View Article Details   Related Articles Expression of caspase-3, p53 and Bcl-2 in generalized aggressive periodontitis. 2006 Sule Bulut,Hilal Uslu,B Handan Ozdemir,Omer Engin Bulut BACKGROUND: Apoptosis, or programmed cell death is a form of physiological cell death. It is increased or decreased in the presence of infection, inflammation or tissue remodelling. Previous studies suggest that apoptosis is involved in the pathogenesis of inflammatory periodontal disease. The aim ... ( view more )of the present study was to investigate the clinical features and known indicators of apoptosis (p53, Bcl-2, Caspase-3) in patients with generalized aggressive periodontitis (GAP) METHODS: Eight patients with GAP, who had sites with probing depths (PD) > 5 mm, and 10 periodontally-healthy persons were included in the study. Clinical examinations and PD were performed, and the plaque index and gingival index were recorded. Gingival tissues biopsies were obtained from active site of each patient and from healthy individuals. The expression of caspase-3, Bcl-2, and p53 was evaluated by immunohistochemistry RESULTS: There were no significant differences between GAP and control group with respect to levels of caspase-3 and p53 expression (P > 0.05). Contrary, the frequency of grade 3 expression of Bcl-2 was higher in GAP group than the control group. CONCLUSION: The higher frequency of Bcl-2 expression in GAP group indicates and delayed apoptosis can lead to increasing resident inflammatory cells in periodontal tissues and resulting in progressive periodontal destruction. ( view less ) View Full Abstract View Article Details   Related Articles Analysis of proliferative activity in oral gingival epithelium in immunosuppressive medication induced gingival overgrowth. 2006 Sule Bulut,Hilal Uslu,B Handan Ozdemir,Omer Engin Bulut BACKGROUND: Drug-induced gingival overgrowth is a frequent adverse effect associated principally with administration of the immunosuppressive drug cyclosporin A and also certain antiepileptic and antihypertensive drugs. It is characterized by a marked increase in the thickness of the epithelial lay... ( view more )er and accumulation of excessive amounts of connective tissue. The mechanism by which the drugs cause gingival overgrowth is not yet understood. The purpose of this study was to compare proliferative activity of normal human gingiva and in cyclosporine A-induced gingival overgrowth. METHODS: Gingival samples were collected from 12 generally healthy individuals and 22 Cyclosporin A-medicated renal transplant recipients. Expression of proliferating cell nuclear antigen was evaluated in formalin-fixed, paraffin-embedded gingival samples using an immunoperoxidase technique and a monoclonal antibody for this antigen. RESULTS: There were differences between the Cyclosporin A group and control group in regard to proliferating cell nuclear antigen and epithelial thickness. In addition, the degree of stromal inflammation was higher in the Cyclosporin A group when compared with the control group. CONCLUSION: The results suggest that the increased epithelial thickness observed in Cyclosporin A-induced gingival overgrowth is associated with increased proliferative activity in keratinocytes. ( view less ) View Full Abstract View Article Details   Related Articles Comparison of the diagnosis of plain radiography ultrasonography and magnetic resonance imaging in early diagnosis of acute osteomyelitis experimentally formed on rabbits. Oct 2005 Fikret Ta?,Siddik Oguz,Okay Bulut,Sema Bulut,A Oktay I?ik PURPOSE: We have compared the sensitivities of MRI, US and radiography which are some of the radiologic modalities used in the early diagnosis of acute osteomyelitis. MATERIALS AND METHODS: After 1 week care and research on 20 New Zealand rabbits (average weight: 2.5 kg) in animal laboratory, study... ( view more ) was begun. Six rabbits died after anesthesia and surgical procedure. There were 14 rabbits remaining and 10 of them formed the study group. Four of them were used as the control group. Fresh mouse feces was inoculated into the bone marrow of 20 tibia under general anesthesia and during the following 15 days, MRI, US and radiographic researches were made everyday. RESULTS: According to the results that we got at the end of the 15-day period, MRI was found as the most sensitive method in describing early diagnosis of infection in the bone marrow and also in showing the extension of the infection to the soft tissue. Although US showed the findings later than MRI, it was determined that its sensitivity was less than but near MRI's in detecting subperiosteal fluid in short term period. Radiographic research gives acute osteomyelitis diagnosis latest, so it was determined as the modality that has the lowest sensitivity. CONCLUSION: MRI which is one of the radiologic modalities among other diagnostic radiologic modalities that can be used in early diagnosis of acute osteomyelitis, has the highest sensitivity. Ultrasonography is the second most sensitive modality. Radiographic analysis has the least sensitivity among other modalities. As a result, first MRI then US and after that plain radiography should be used for the early diagnosis of acute osteomyelitis. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Effect of cyclosporin A on apoptosis and expression of p53 and bcl-2 proteins in the gingiva of renal transplant patients. May 2005 Sule Bulut,B Handan Ozdemir,Emine Elif Alaaddino?lu,Füsun Bahar Oduncuo?lu,Omer Engin Bulut,Beyhan Demirhan BACKGROUND: Gingival overgrowth (GO) is a common side effect of cyclosporin A (CsA) therapy, but the exact mechanism for this is unknown. Apoptosis plays an important role in the maintenance of tissue homeostasis and mediators of this process may be involved in the pathogenesis of drug-induced GO. ... ( view more )This study compared p53 expression, bcl-2 expression, and apoptosis in gingival samples from CsA-treated renal transplant recipients to findings in controls with gingivitis. METHODS: Twenty-two kidney recipients with CsA-induced GO and 15 systemically healthy subjects with gingivitis were included in the study. The 15 systemically and periodontally healthy volunteer control group were immunohistochemically analyzed for grades of p53 and bcl-2 expression, and were processed using terminal TdT-mediated dUTP-biotin nick-end labeling (TUNEL) technique to identify and grade levels of apoptosis. RESULTS: There were no differences between the CsA group and the control group with respect to grades of p53 and bcl-2 expression (P >0.05 for both). However, the CsA group showed a lower apoptosis grade than the control group (P <0.05). None of the clinical parameters was significantly correlated with any of the immunohistochemical findings for p53 or bcl-2 (P >0.05 for all). Similarly, grade of apoptosis was not correlated with any of the clinical parameters (P >0.05). There was a significant positive correlation between serum CsA level and level of bcl-2 expression, but serum CsA was not significantly correlated with level of apoptosis or level of p53 expression. CONCLUSION: The results indicate that the pathogenesis of CsA-induced GO might involve inhibition of apoptosis, and overexpression of bcl-2 in the setting of high serum CsA. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Arthroscopic-assisted surgical treatment for developmental dislocation of the hip. May 2005 Okay Bulut,Hayati Oztürk,Gündüz Tezeren,Sema Bulut PURPOSE: Treatment of developmental dislocation of the hip (DDH) includes surgical management in older children or in those who cannot be treated conservatively. However, complication rates of surgical treatment are quite high. The purpose of this report is to introduce our new surgical technique t... ( view more )hat can eliminate existing pathologic changes in DDH. TYPE OF STUDY: A small case series. METHODS: We performed arthroscopic-assisted surgical treatment in 4 hips of 4 female children who had DDH and no previous treatment. Their ages ranged from 11 to 14 months. Closed reduction under general anesthesia was tried just before the surgical intervention, but it failed in all of them. Tightness of the iliopsoas tendon was released followed by dissection of capsular adhesions using an anterolateral mini-incision. Excision of the hypertrophic ligamentum teres, transverse acetabular ligament, and pulvinar tissue was carried out using a double-portal arthroscopic procedure. We performed percutaneus adductor tenotomies in 2 cases. A spica cast and abduction splint were used for 12 to 17 weeks postoperatively. The follow-up of the patients was a minimum of 1 year. Although a 1-year follow-up period is adequate to evaluate the short-term results, it has been considered that there is a need for further studies that include long-term follow-up. We used the acetabular index and Shenton's line for preoperative and postoperative radiologic evaluation. Also, the cases were evaluated postoperatively in respect to range of motion restriction and the leg length discrepancy. RESULTS: The mean follow-up was 13.7 months (range, 12 to 16 months). Acetabular index measurements of the cases in the preoperative/postoperative periods were as follows: in the first case, 34 degrees/27 degrees; in the second case, 35 degrees/22 degrees; in the third case, 52 degrees/39 degrees; and in the fourth case, 40 degrees/28 degrees. Hip joint restriction and leg length discrepancy were not observed postoperatively. CONCLUSIONS: All the intra-articular structures (hypertrophic ligamentum teres, transverse acetabular ligament, and pulvinar tissue) in the acetabulum that impede the reduction of the femoral head have been eliminated by using the arthroscopic technique. The arthroscopic-assisted surgical treatment of DDH is successful in the short-term follow-up period. LEVEL OF EVIDENCE: Level IV, Case Series. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Apoptosis in cyclosporin A-induced gingival overgrowth: a histological study. Feb 2005 Emine Elif Alaaddinoglu,Gülten Karabay,Sule Bulut,Füsun Bahar Oduncuoglu,Handan Ozdemir,Omer Engin Bulut,Turan Colak BACKGROUND: Cyclosporin A (CsA) is known to induce gingival overgrowth. Apoptosis plays a critical role in the regulation of inflammation and the host immune response. The aim of this study was to investigate apoptosis in CsA-induced gingival enlargement using electron microscopy examination of ker... ( view more )atinocytes. METHODS: Gingiva specimens were collected from 12 CsA-treated renal transplant patients with gingival overgrowth and eight healthy controls with gingivitis. Clinical findings (probing depth, gingival index, and plaque index) were compared in the two groups. Histological and ultrastructural features of the specimens were also compared, and extent of keratinocyte apoptosis was scored on a three-tier scale: 0 = no apoptotic cells; 1 = one or two apoptotic cells; 2 = more than two cells. RESULTS: There were no significant differences between groups with respect to gingiva-related clinical findings or extent of keratinocyte apoptosis. CONCLUSIONS: The results indicate that the extent of keratinocyte apoptosis in the gingiva of kidney recipients with CsA-induced gingival overgrowth is similar to that observed in inflamed gingiva of healthy individuals. Further studies on apoptosis of different cell types in the presence of CsA should clarify this agent's role in the pathogenesis of drug-induced gingival enlargement. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Immunohistochemical study of cyclosporin-induced gingival overgrowth in renal transplant recipients. Dec 2004 Omer Engin Bulut,Lale Karakoç Sökmensüer,Sule Bulut,Fügen Tasman,Sevda Müftüo?lu BACKGROUND: Cyclosporin A (CsA) is an immunosuppressant widely used to treat transplant patients and various systemic diseases with immunological components. Gingival overgrowth (GO) is a common side effect of CsA administration; however, the pathogenesis of drug-induced GO is poorly understood. Th... ( view more )e aim of this study was to evaluate the expression of Ki-67, activation molecules (CD71, CD98), leukocytes activation antigens (CD45, CD45RA, CD50, CD11a, CD162, CD227, CD231), neurothelin (CD147), and novel endothelial cell antigens (B-F45, SCF87, B-D46, B-C44, VJ1/6) in gingival tissue in renal transplant recipients treated with CsA. METHODS: Tissues from 15 renal transplant patients with significant GO and 10 systemically healthy control subjects with gingivitis were studied. Frozen-section biopsies were stained with monoclonal antibodies specific for the above-mentioned antigens using an indirect immunoperoxidase technique. RESULTS: Comparison of the CsA-treated and control groups revealed no significant differences with respect to expression of Ki-67; CD50; activation molecules; neurothelin; or novel endothelial cell antigens B-D46, B-C44, and VJ1/6. However, expression patterns of CD45, CD45RA, CD11a, CD162, CD227, CD231, B-F45, and SCF87 were significantly different in CsA and control groups. CONCLUSION: Leukocyte activation antigens play an important role in CsA-induced gingival overgrowth. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Effect of Carisolv on the human dental pulp: a histological study. May 2004 Gulcin Bulut,Osman Zekioglu,Cemal Eronat,Hakan Bulut OBJECTIVES: The aim of this study was to investigate histopathologically after 1 week and 1 month the effect of Carisolv on exposed human pulp after a contact period of 10 min in comparison to sterile saline solution. METHODS: Class V cavities were prepared in 40 human first premolars, and the pulp... ( view more ) chambers were perforated. The pulp tissue was either exposed to Carisolv or sterile saline solution for 10 min, covered with Teflon and restored with compomer filling material. After observation periods of 1 week and 1 month, the teeth were extracted and examined by light microscopy. RESULTS: Histological evaluation revealed similar pulpal response which consisted of a slight inflammation in both groups after 1 week. The only difference was localized haemorrhage in controls while no haemorrhage was observed in the test group which may show the haemostatic effect of Carisolv. After 1 month the test teeth displayed a very mild inflammation adjacent to the perforation area while haemorrhage disappeared in the controls. In general, pulps showed structural integrity in both groups. Statistical analysis showed no difference between the test and the control groups in both test periods. CONCLUSIONS: The results suggest that Carisolv is biocompatible with human pulp tissue and may have a haemostatic effect. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Lipoma arborescens; successfully treated by yttrium-90 radiosynovectomy. Oct 2003 Taner Erselcan,Okay Bulut,Sema Bulut,Derya Dogan,Bulent Turgut,Semra Ozdemir,Fahrettin Goze Although radiosynovectomy (RS) applications have been carried out for many years, clinical indications of this non-invasive procedure is thought to be limited probably due to the lack of information of clinicians. Clinicians' preferential indication for RS is the treatment-resistant synovitis of in... ( view more )dividual joints, i.e. despite systemic pharmacotherapy and intra-articular steroid injections. We present here a case of "lipoma arborescens" treated by yttrium-90, which is a rare intra-articular lesion characterized by villous proliferation of the synovial membrane and hyperplasia of subsynovial fat. The results of clinical, biochemical and hematological examinations, magnetic resonance (MR) imaging, arthroscopy and histological analysis have shown that the etiology was lipoma arborescens in a female patient, aged 36 having swelling and sometimes associating pain at her right knee for 4 years. We have applied to our patient's right knee RS with 185 MBq yttrium-90 colloid together with 40 mg of methylprednisolone acetate, although in our literature survey we have not met any similar case being treated with such indication. Even a year after the application, the patient has absolutely benefited from the treatment clinically, and this was also confirmed by comparative MR images (pre- and post-treatment). Consequently, we consider that Y-90 treatment might be applicable in suitable cases with lipoma arborescens. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles The measurement of the rotational deformities with computed tomography in femoral shaft fractures of the children treated with early spica cast. Jul 2003 Sema Bulut,Okay Bulut,Fikret Ta?,Hulusi E?ilmez Twenty-eight children with femoral shaft fractures, treated with early spica cast, were evaluated with computed tomography (CT), for their femoral shaft rotational deformities. The femoral torsion angles were measured on both sides. If the torsion angle of the fractured side was more than the other... ( view more ) side, it was considered as an internal rotational deformity and if it was less, it was considered as an external rotational deformity. Internal rotational deformities were detected in nine cases and external rotational deformities were detected in 17 cases. Rotational deformity was not observed in two cases. Four cases, with a rotational deformity more than 10 degrees, were corrected with a gypsotomy through the level of the fracture. We concluded that a rotational deformity, which is an important complication in conservative treatment of the femoral shaft fractures in children, can be determined exactly with CT and corrections on the spica cast can be made with a gypsotomy. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles The value of routine antibiotic prophylaxis in mandibular third molar surgery: acute-phase protein levels as indicators of infection. Jun 2001 E Bulut,S Bulut,I Etikan,O Koseoglu Postoperative infections in the oral region are usually caused by anaerobic bacteria. While some authors claim that routine antibiotic prophylaxis is necessary after third molar surgery, others do not recommend this practice. The major subject of controversy is what constitutes postoperative infect... ( view more )ion. Previous studies that have examined the benefit of routine antibiotic prophylaxis have used several clinical symptoms (pain, swelling, and trismus) as indicators of infection; however, these clinical symptoms may be vague and unreliable, and cannot be evaluated scientifically. As a result, their use has only sparked more debate in this area of research. The present study assessed the value of routine antibiotic prophylaxis in impacted mandibular third molar surgery using acute-phase protein levels as potential indicators of early and late postoperative infection. Specifically, serum levels of C-reactive protein and alpha-1 antitrypsin were measured preoperatively and postoperatively in patients who received either prophylactic antibiotics or placebos. The results revealed no statistically significant difference between treated and control patients in terms of incidence of postoperative infection. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Equilibrium and kinetic data and process design for adsorption of Congo Red onto bentonite. Jun 15, 2008 Emrah Bulut,Mahmut Ozacar,I Ayhan Sengil The adsorption of Congo Red onto bentonite in a batch adsorber has been studied. Four kinetic models, the pseudo first- and second-order equations, the Elovich equation and the intraparticle diffusion equation, were selected to follow the adsorption process. Kinetic parameters; rate constants, equi... ( view more )librium adsorption capacities and correlation coefficients, for each kinetic equation were calculated and discussed. It was shown that the adsorption of Congo Red onto bentonite could be described by the pseudo second-order equation. The experimental isotherm data were analyzed using the Langmuir, Freundlich and Temkin equations. Adsorption of Congo Red onto bentonite followed the Langmuir isotherm. A single stage batch adsorber was designed for different adsorbent mass/treated effluent volume ratios using the Langmuir isotherm. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Synergistic apoptotic effects of taurolidine and TRAIL on squamous carcinoma cells of the esophagus. Jun 2008 Adrien Daigeler,Ansgar Michael Chromik,Anne Geisler,Daniel Bulut,Christoph Hilgert,Andreas Krieg,Ludger Klein-Hitpass,Marcus Lehnhardt,Waldemar Uhl,Ulrich Mittelkötter The treatment of choice for esophageal cancer is considered surgical resection, but a median survival of around 20 months after treatment is still discouraging. The value of adjuvant or neoadjuvant radiation or chemotherapy is limited and to date, benefits have only been described for certain tumor... ( view more ) stages. Therefore, new therapeutic options are required. As alternative chemotherapeutics, we tested the antibiotic taurolidine (TRD) on KYSE 270 human esophageal carcinoma cells alone and in combination with rhTRAIL (TNF related apoptosis-inducing ligand). Viability, apoptosis and necrosis were visualized by TUNEL assay and quantitated by FACS analysis. Gene expression was analysed by RNA microarray. The most effective concentration of TRD as single substance (250 micromol/l) induced apoptosis to a maximum of 40% after 12-h dose dependently, leaving 4% viable cells after 48 h; by comparison, rhTRAIL did not have a significant effect. The combination of both substances doubled the effect of TRD alone. Gene expression profiling revealed that TRD downregulated endogenous TRAIL, TNFRSF1A, TRADD, TNFRSF1B, TNFRSF21, FADD, as well as MAP2K4, JAK2 and Bcl2, Bcl2l1, APAF1 and caspase-3. TNFRSF25, cytochrome-c, caspase-1, -8, -9, JUN, GADD45A and NFKBIA were upregulated. TRAIL reduced endogenous TRAIL, Bcl2l1 and caspase-1 expression. BIRC2, BIRC3, TNFAIP3, and NFKBIA were upregulated. The combined substances upregulated endogenous TRAIL, NFKBIA and JUN, whereas DFFA and TRAF3 were downregulated compared to TRD as single substance. We conclude that TRD overcomes TRAIL resistance in KYSE 270 cells. Synergistic effects are dependent on the same and on distinct apoptotic pathways which, jointly triggered, result in an amplified response. Several apoptotic pathways, including the TNF-receptor associated and the mitochondrial pathway, were differentially regulated by the substances on gene expression level. Additionally transcription factors seem to be influenced, NFKB in particular. Endogenous TRAIL expression is increased by the combination of substances, whereas it is reduced by each single substance. Taking into consideration that the non-toxic TRD was able to reduce rhTRAIL toxicity and dose, combined therapy with TRD and rhTRAIL may offer new options for treatment in esophageal cancer. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles On the robustness of overall F0-only modifications to the perception of emotions in speech. Jun 2008 Murtaza Bulut,Shrikanth Narayanan Emotional information in speech is commonly described in terms of prosody features such as F0, duration, and energy. In this paper, the focus is on how F0 characteristics can be used to effectively parametrize emotional quality in speech signals. Using an analysis-by-synthesis approach, F0 mean, ra... ( view more )nge, and shape properties of emotional utterances are systematically modified. The results show the aspects of the F0 parameter that can be modified without causing any significant changes in the perception of emotions. To model this behavior the concept of emotional regions is introduced. Emotional regions represent the variability present in the emotional speech and provide a new procedure for studying speech cues for judgments of emotion. The method is applied to F0 but can be also used on other aspects of prosody such as duration or loudness. Statistical analysis of the factors affecting the emotional regions, and discussion of the effects of F0 modifications on the emotion and speech quality perception are also presented. The results show that F0 range is more important than F0 mean for emotion expression. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Determination of landscape beauties through visual quality assessment method: a case study for Kemaliye (Erzincan/Turkey). Jun 2008 Zohre Bulut,Hasan Yilmaz Kemaliye (Erzincan/Turkey) is the member of European Association of Historic Towns and Regions. The aim of this study was to reveal the visual richness of the town; to identify the relationship between landscape spatial pattern and visual quality of the landscape and to offer some suggestions for t... ( view more )he future planning in regarding to these visual beauties. The visual quality assessment method was used in this study. The results of the study revealed three landscape types that have the highest visual quality. Among those, the highest one is urban scenery 3 (US3; VQP = 5.9400), the second is geological structure scenery 5 (GSS 5; VQP = 5.9200) and the third natural scenery 3 (NS3; VQP = 5.9133). Visual quality assessment showed that urban pattern, geological structure and natural resources of the region also have visual value. The relationships between landscape spatial pattern and visual quality of landscape indicated that certain characteristics of landscape affected the quality. For instance, as the texture level decreased in natural landscapes and as the green areas increased in geological structure, visual preferences ratio increased. Some suggestions were also made regarding the visual resources use in the region. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Synthesis, spectroscopy, X-ray structure and redox behaviors of 4-(N-R-salicylideneimine)-2,6-diphenylphenols. Jun 2008 Veli T Kasumov,Hasan Türkmen,Ibrahim Uçar,Ahmet Bulut,Nurettin Yayli A series of sterically hindered 4-(N-R-salicylaldimine)-2,6-diphenylphenols (X), where R=H (1), 3-CH3 (2), 5-CH3 (3), 3-OCH3 (4), 4-OCH3 (5), 5-OCH3 (6), 3-tBu (7), 5-tBu (8), 3,5-tBu2(9) and 5,6-benzo(10), were synthesized and their structure as well as redox behavior studied by analytical, spectr... ( view more )oscopic [1H, (13C) NMR, IR, UV-vis and mass spectrometry] and cyclic voltammetric (CV) techniques. Single crystal X-ray diffraction studies of 7 evidenced its existence as non-planar enol-imine tautomer structure, in which the phenol ring of the molecule is twisted around C-N single bond by 21.5(2) degrees. The packing structure of 7 is stabilized by C-H...pi(Ph) and O...O and C...O intermolecular short contact interactions. The CV of X display rate is dependent on irreversible and quasi-reversible redox waves in the anodic and cathodic regions due to oxidation and reduction of phenolic and iminic groups, respectively. As evidenced by ESR and UV-vis study, chemical oxidation of X by PbO2 and (NH4)2Ce(NO3)6 in MeCN and CHCl3 generates stable phenoxyl radicals [(g approximately 2.005 and lambda approximately 450 nm (1600-8200 M(-1) cm(-1))]. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Effect of high-energy extracorporeal shock waves on the immature epiphysis in a rabbit model. Jun 2008 Hayati Ozturk,Okay Bulut,Zekeriya Oztemur,Celal Kaloglu,Iclal Ozdemir Kol INTRODUCTION: We investigated the effect of high-energy extracorporeal shock wave (ESW) on immature tibial epiphysis in a rabbit model. MATERIALS AND METHODS: Twenty New Zealand white immature rabbit were used in this study. Animals were divided into two groups and they received 14 kW, 0.6 mJ/mm(2)... ( view more ), 1,500 or 3,000 shots for three times with an interval of 7 days. After 6 weeks all rabbits were killed. The all tibia epiphysis were assessed by histology. The epiphyseal plaque thickness of right tibiae of the 3,000-shot ESW group was significantly higher than those of the 1,500-shot ESW group and the left tibia epiphyses of the 1,500- and 3,000-shot ESW groups as controls (P < 0.05). RESULTS: The epiphyseal plaque thickness of right tibiae of the 1,500-shot ESW group was significantly higher than that of the left tibia epiphyses of the 1,500- and 3,000-shot ESW groups as controls (P < 0.05). DISCUSSION: We demonstrated that high-energy ESW stimulated the growth of immature rabbit epiphysis. The long-term effect of shock wave on the immature rabbit epiphysis deserves further study. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Intradiscal electrothermal treatment for chronic discogenic low back pain: a prospective outcome study of 39 patients with the Oswestry disability index at 18 month follow-up. May 2008 Rüçhan Ergün,Zeki Sekerci,Hüsamettin Bulut,Habibullah Dolgun OBJECTIVE: The authors evaluate the efficacy of intradiscal electrothermal therapy (IDET) for discogenic pain on outcome of patients using the Oswestry disability index (ODI) after 18 month follow-up. METHODS: Thirty-nine patients with chronic discogenic low back pain who failed to improve followin... ( view more )g conservative treatment were considered for this study. Inclusion criteria included the presence of one- or two-level symptomatic disk degeneration without evidence of nerve root compression. Patients were excluded if there was severe disk degeneration together with loss of more than 50% disk height. We measured the outcome scores at minimum of 18 month period with the Turkish version of the ODI and compared them with pre-treatment scores. RESULTS: All procedures were considered technically successful and there were no device-related complications. Mean ODI scores of 39 patients pre-operatively and post-operatively 6, 12 and 18 months were 45.7436 +/- 11.6545, 24.7692 +/- 10.7861, 23.0256 +/- 10.6412 and 21.4872 +/- 10.0286, respectively. The effect of treatment was calculated as the difference between the scores before and after treatment. They were 20.9744 +/- 12.5394, 22.7179 +/- 12.5697 and 24.2564 +/- 12.5922 after the same follow-up periods. There was a significant difference (p<0.01) between all the mean scores after treatment (6, 12 and 18 months) compared with the pre-IDET mean ODI. DISCUSSION: Although various alterations in outcome scores have been reported in previous works, we found nearly four in five patients (79.48%) who clearly benefited from this therapy. This procedure may become a middle step for carefully selected group of patients who failed non-operative treatment before surgical intervention. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Circulating endothelial microparticles correlate inversely with endothelial function in patients with ischemic left ventricular dysfunction. May 2008 Daniel Bulut,Karin Maier,Nadine Bulut-Streich,Jan Börgel,Christoph Hanefeld,Andreas Mügge BACKGROUND: Bone-marrow derived endothelial progenitor cells (CD34+ and VEGFR2+ KDR+ EPC) and endothelial-derived microparticles (CD 31+Annexin V+, EMP; indicator for endothelial apoptosis) were examined in the peripheral blood of 35 male, clinically stable patients with 3-vessel coronary artery di... ( view more )sease (CAD). The patients were divided in 2 groups, those with preserved or normal function (n = 17; EF 65 +/- 6%) and those with reduced left ventricular (LV) function (n = 18; EF 36 +/- 11%). METHODS AND RESULTS: The number of circulating EPCs was decreased by 25% (P = .07) and the number of EMPs was increased by 109 % (P < .05) in patients with LV dysfunction compared with those with normal or preserved LV function. EPCs were positively correlated (r = 0.24 for patients with LV dysfunction and r = 0.28 for patients with preserved LV function) with endothelial function as assessed by flow-mediated vasodilatation. In contrast, EMPs were inversely correlated (r = -0.42 for patients with LV dysfunction and r = -0.49 for patients with preserved LV function). CONCLUSIONS: CAD patients with significant LV dysfunction show an increased index of endothelial cell damage. This decrease (or lack of compensatory elevation) of EPCs may result in a reduced potential for repair and thus contribute at least in part to the pathogenesis of endothelial dysfunction. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Sensory neuropeptides and epithelial cell restitution: the relevance of SP- and CGRP-stimulated mast cells. May 2008 Kerem Bulut,Peter Felderbauer,Susanne Deters,Karoline Hoeck,Anjona Schmidt-Choudhury,Wolfgang E Schmidt,Peter Hoffmann BACKGROUND: Calcitonin-gene-related peptide (CGRP) and substance P (SP) are neurotransmitters of extrinsic primary afferent neurons located within the dorsal root ganglia. In experimental models of colitis in rats and rabbits, a protective role of SP and CGRP on intestinal mucosa was presumed. The ... ( view more )mucosal protection partly depends on a CGRP-mediated modulation of mucosal blood flow. Limited data are available regarding CGRP- or SP-mediated effects on epithelial cell restitution. Having shown earlier that SP-stimulated fibroblasts but not CGRP-stimulated fibroblasts induce epithelial cell migration in vitro, the aim of this study was to explore whether mast cells mediate effects of SP and CGRP on epithelial cell restitution in vitro. METHODS: Mast cells (C57) were exposed to SP [10(-12)-10(-6 M)] and CGRP [10(-12)-10(-7 M)]. After a 24-h incubation period, the cell supernatants (conditioned media, CDM) were taken from mast cell cultures and directly applied to rat intestinal epithelial cell lines-18 or Caco-2 monolayers, which had been wounded with a razor blade 24 h prior to the experiments. Epithelial cell migration was assessed by counting cells across the wound edge and epithelial cell proliferation was measured using 3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyl-tetrazolium bromide test. RESULTS: CGRP significantly induced epithelial cell migration and proliferation via mast cells when supernatants were directly applied to epithelial cells in vitro. The effects on epithelial cell migration were abolished after neutralizing anti-transforming growth factor-beta (TGF-beta) had been added to the cell cultures. SP had no effects on epithelial cells following stimulation of mast cells. CONCLUSION: CGRP modulates epithelial cell restitution in vitro mediated by mast cells. The CGRP- and mast-cell-induced epithelial cell migration is TGF-beta dependent. This observation underlines an important role for extrinsic primary afferent neurons in mucosal defence and repair and in keeping the mucosal homeostasis. This knowledge leads to a better understanding of the interaction of the enteric nervous system and wound healing and may, in the future, lead to new therapeutic approaches to inflammatory diseases of the intestine. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Morphology of large ZSM-5 crystals unraveled by fluorescence microscopy. Apr 30, 2008 Maarten B J Roeffaers,Rob Ameloot,Mukulesh Baruah,Hiroshi Uji-I,Metin Bulut,Gert De Cremer,Ulrich Müller,Pierre A Jacobs,Johan Hofkens,Bert F Sels,Dirk E De Vos Understanding the internal structure of ZSM-5 crystallites is essential for improving catalyst performance. In this work, a combination of fluorescence microscopy, AFM, SEM, and optical observations is employed to study intergrowth phenomena and pore accessibility in a set of five ZSM-5 samples wit... ( view more )h different crystal morphologies. An amine-functionalized perylene dye is used to probe acid sites on the external crystal surface, while DAMPI (4-(4-diethylaminostyryl)- N-methylpyridinium iodide) is used to map access to the straight channels in MFI from the outer surface. The use of these dyes is validated by studying the well-understood rounded-boat type ZSM-5 crystals. Next coffin-shaped ZSM-5 crystals are considered; we critically evaluate the seemingly conflicting 2-component and 3-component models that have been proposed to account for the hourglass structure in these crystals. The data prove that observation of an hourglass structure is essentially unrelated to a 90 degree rotation of the pyramidal crystal components under the (010) face. Hence, in perfectly formed coffin-shaped crystals, the straight channels can be accessed from (010). However, in other crystal batches, sections with a 90 degrees rotation can be found; they are indeed located inside the crystal sections under (010) but often only partially occupy these pyramidal components. In such a case, both straight and sinusoidal pores surface at the hexagonal face. The results largely support the 3-component model, but with the added notion that 90 degree rotated sections (as proposed in the 2-component model) are most likely to be formed inside the defect-rich, pyramidal crystal sections under the (010) faces. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles The "reading man" procedure: a new technique for the closure of circular skin defects. Apr 2008 Mehmet Mutaf,Mahmut Sunay,Omer Bulut BACKGROUND: As most of the skin lesions tend to grow in a circular pattern, the resultant defects after surgical removal of these lesions are often circular. Although a number of local flap procedures have been described, alternative techniques are still needed for the closure of circular defects. ... ( view more )PURPOSE: Here, a new surgical technique for the closure of circular skin defects is presented. This technique basically uses the extra skin relaxation gained with an unequal Z-plasty maneuver in favor of the defect closure. The procedure is named as "the reading man" because its surgical design resembles the silhouette of a man who is reading a book held in his hand. MATERIAL AND METHODS: In this technique, 2 flaps designed in an unequal Z-plasty manner are used. The first flap is transposed to the defect area whereas the second flap is used for closure of the first flap's donor site. For 3 years, this technique has been used for closure of the circular skin defects in 27 patients (19 men and 8 women) aged from 2 months to 68 years. The defect size was ranging between 1.5 and 14 cm in diameter. RESULTS: A tension-free defect closure was obtained in all patients. All flaps healed with no complications. There was no patient with dog ear formation. A mean follow-up of 15 months (6 months-3 years) revealed an esthetically acceptable scar formation in all patients. CONCLUSION: The reading man procedure was found to be a useful and an easy going technique for the closure of circular skin defects located on various anatomic regions. It enables surgeon to obtain a tension-free closure of considerably large skin defects with minimal scarring and additional healthy skin excision. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Removal of cadmium from aqueous solution by Nordmann fir (Abies nordmanniana (Stev.) Spach. Subsp. nordmanniana) leaves. Apr 2008 H Serencam,A Gundogdu,Y Uygur,B Kemer,V N Bulut,C Duran,M Soylak,M Tufekci The utility of Nordmann fir (Abies nordmanniana (Stev.) Spach. Subsp. nordmanniana) leaves from Eastern Black Sea region for the removal (sorption) of metal ions from aqueous solutions was investigated. For this, the optimum values of pH, time, metal concentration, leaf concentration, leaf particle... ( view more ) size and adsorption capacity were determined. Also the recovery conditions of the metals from leaves were studied. Cd metal was selected because of its toxic properties. Freundlich isotherm model was used to describe the adsorption behaviour and the experimental results obtained for Cd(2+) adsorption, followed this model well. The utility of Nordmann fir leaves to remove toxic metals from aqueous solutions was proved. Hence, this study showed that the leaves of Nordmann fir can provide cheap source as biosorbents for toxic metal removal from natural or wastewaters. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Page 1 of 16 1 2 3 4 > Last >> (382 articles found)

      
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