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GST Primary GST Primary Best Strategies for Health Care Quality Im... Best Strategies for Health Care Quality Improvement - Diabetes Quality Improvement Strategies for Antibio... Kathryn McDonald, Stanford-UCSF Evidence-b... Systematic review assessing the effect of ... Quality Improvement Strategies for Antibiotics Management Kathryn McDonald, Stanford-UCSF Evidence-based Practice Center, 117 Encina Commons, Stanford, CA 94305-6019, Kathy.mcdonald@stanford.edu Systematic review assessing the effect of quality improvement strategies on appropriate prescribing of antibiotics and appropriate choice of antibiotics. Adherence Adherence Assistive Devices Assistive Devices Childhood Burn Hanson MacMillan Childhood Burn Hanson MacMillan CLSA_9 CLSA_9 Cyberabuse Cyberabuse Cognitive Behavioural Therapy for Violent ... This review included randomized trials abo... Cognitive Behavioural Therapy for Violent Men who Batter Their Partners This review included randomized trials about the effects of cognitive behavioral therapy on domestic violence. The intervention included programs based on the Duluth Model. The violence had to be committed by a male toward his female partner. The violence also had to be physical. The primary outcomes were new arrests and convictions, and new reports of violence. CABG vs PCI CABG vs PCI Quality Improvement Strategies for Prevent... Quality Improvement Strategies for Preventing Nosocomial Infections (Created 17-Feb-06) Quality Improvement Strategies for Asthma ... Quality Improvement Strategies for Asthma Control Erectile Dysfunction (Created 30-Jan-06) Erectile Dysfunction (Created 30-Jan-06) Inequality - Smoking Cessation to Reduce S... This review was the first part of a projec... Inequality - Smoking Cessation to Reduce Socio-Economic Differences This review was the first part of a project about inequality. It included randomized trials about the effect of smoking cessation interventions on reducing socio-economic differences. The studies had to report data either on persons with low socio-economic groups status or, preferably, on both low and high socio-economic groups. Diet and Physical Activity to Reduce Socio... This review was the second part in a proje... Diet and Physical Activity to Reduce Socio-Economic Differences This review was the second part in a project about inequality. It included randomized trials about the effect of interventions on reducing socio-economic differences in diet and physical activity. The studies had to report data either on persons with low socio-economic groups status or, preferably, on both low and high socio-economic groups. Workfare The data in SRS are not identical to the d... Workfare The data in SRS are not identical to the data in the published report. We used SRS only for an updated search. The review included randomized trials about the effect of welfare-to-work programs. Participants were welfare recipients. There were basically two types of programs. The educational type tried to build knowledge and skills in order to help the welfare recipients acquire jobs that could support them economically. The "work first" approach was more aimed at getting the participants quickly into a job. Exercise interventions for the management ... The objective of this systematic review wa... Exercise interventions for the management of frailty The objective of this systematic review was to examine the effectiveness of current exercise interventions on the management of frailty. A comprehensive search of Medline, Embase, Psycinfo, Cinahl, Scopus, Ageline, Eric, and SportDiscus databases was conducted and produced 1808 citations. So far we have completed 2 levels of “title and abstract” screening and we ended up with 262 articles. We have just started the full text screening. Eligibility criteria included original studies whose participants were identified as frail or prefrail with specific criteria and in which structured physical activity was included as at least one component of the intervention. Create a free account, build a dictionary with saved terms to re-use later! Public Domestic Violence - Using Cognitive Behavior Therapy Smoking Cessation to Reduce Socio-Economic Differences Diet and Physical Activity to Reduce Socio-Economic Differences Workfare Exercise Interventions for the Management of Frailty Search     Simple Advanced Refine (4 coded questions)  Any of these:   Exact Phrase: All of these: None of these: Author: Periodical: Projects: No restrictions   Libraries: Public   Select SRS Projects Show Saved Terms Select Library Show articles that do not have abstracts  Language English French German Italian Japanese Russian Spanish Afrikaans Albanian Unknown Arabic Armenian Azerbaijani Bosnian Bulgarian Catalan Chinese Croatian Czech Danish Dutch Esperanto Estonian Finnish Georgian Greek, Modern Hebrew Hindi Hungarian Icelandic Indonesian Kinyarwanda Korean Latin Latvian Lithuanian Macedonian Malay Malayalam Maori Multiple Languages Norwegian Persian Polish Portuguese Pushto Romanian Sanskrit Scottish gaelic Serbian Slovak Slovenian Swedish Thai Turkish Ukrainian Vietnamese Not English Not French Type of Article Clinical Trial Editorial Letter Meta-Analysis Practice Guideline Randomized Controlled Trial Review Addresses Bibliography Biography Case Reports Classical Article Clinical Conference Clinical Trial, Phase I Clinical Trial, Phase II Clinical Trial, Phase III Clinical Trial, Phase IV Comment Comparative Study Consensus Development Conference Consensus Development Conference, NIH Controlled Clinical Trial Corrected and Republished Article Dictionary Directory Duplicate Publication English Abstract Evaluation Studies Festschrift Government Publications Guideline Historical Article Interview In Vitro Journal Article Lectures Legal Cases Legislation Multicenter Study News Newspaper Article Overall Patient Education Handout Periodical Index Published Erratum Retracted Publication Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. 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Retraction of Publication Scientific Integrity Review Support of Research Technical Report Twin Study Validation Studies Not a Primary Study or Review Unknown Primary Study Case Series Case Control Cohort Study Observational Study Qualitative Research CBA or ITS Registry Double Blind Controlled before after study Quasi-randomized trial Simple before after study Cluster-RCT Non-Randomized Study Report Book Book chapter Dissertation Conference procedings Secondary Research Not RCT Humans or Animals Humans Animals Ages All Infant: birth-23 months All Child: 0-18 years All Adult: 19+ years Newborn: birth-1 month Infant: 1-23 months Preschool Child: 2-5 years Child: 6-12 years Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Middle Aged + Aged: 45+ years Aged: 65+ years 80 and over: 80+ years Undetermined Results(1-25 of 228) Sort By: Publication Date Relevance Took: 0.157 seconds to search 17,750,454  Action: Copy Results to new Clipboard Build Search Link Page 1 of 10 1 2 3 4 > Last >> (228 articles found) [The comparison between the efficiency of different anti-arrhythmic agents in preventing postoperative atrial fibrillation after open heart surgery] Jun 2008 Ebubekir Emre Men,Ozlem Yildirimtürk,Aylin Tu?cu,Vedat Aytekin,Saide Aytekin OBJECTIVE: Atrial fibrillation (AF) is one of the most frequent complications that may occur after open-heart surgery. Clinical reports regarding comparison of different anti-arrhythmic agent's usage to maintain sinus rhythm after open-heart surgery are not conclusive. We examined the effects of di... ( view more )fferent anti-arrhythmic agents administration before operation on postoperative AF incidence, duration of hospitalization and complications. METHODS: Overall, 180 patients (130 men and 50 women, mean age 58.13+/-11.71 years) who were candidates for open-heart surgery, were included in this prospective, single-blind study. All patients divided into five different groups. All anti-arrhythmic drugs were administered approximately 7 days before the operation. Propafenone was given to Group 1 (G1); sotalol to Group 2 (G2); amiodarone to Group 3 (G3) and diltiazem to Group 4 (G4) at doses of 300 mg/day, 80 mg/day, 400 mg/day and 180 mg/day orally respectively. The fifth group (G5) did not receive any of anti-arrhythmic drugs. The medication was continued for ten days postoperatively. Statistical analysis was performed using Chi-Square and one-way ANOVA tests. RESULTS: Atrial fibrillation developed during postoperative period in 18.1% patients in G1, 9.1% patients in G2, 16.2% patients in G3, 28.6% patients in G4 and 38.1% patients in G5. The prevalence of postoperative AF was significantly higher in G5 as compared with other groups (p=0.026). There were significant differences across groups in duration of hospitalization (p=0.033), with shortest mean duration of hospitalization in G2 (8.9+/-2.7 days). CONCLUSION: Any anti-arrhythmic agent started 7 days before the operation and continued for 10 days, may reduce the prevalence of postoperative AF, morbidity and duration of hospitalization. However, we found that sotalol and amiodarone were more effective than other anti-arrhythmic agents in our patient population. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Impact of anemia on nonfatal coronary events after percutaneous coronary interventions. Nov 2007 Alp Burak Catakoglu,Saide Aytekin,Murat Sener,Hilal Kurtoglu,Huseyin Celebi,I C Cemsid Demiroglu,Vedat Aytekin Anemia is associated with higher rates of cardiovascular events in patients with heart failure, acute myocardial infarction, and in patients undergoing coronary artery bypass graft surgery. Although studies have focused on fatal coronary events in anemic patients following percutaneous coronary int... ( view more )ervention (PCI), data is lacking regarding nonfatal coronary events. The aim of our study was to analyze the incidence of anemia in patients who developed nonfatal events after successful PCI, and to make a comparison with event-free patients. Forty-nine consecutive patients with and 51 without nonfatal coronary events (nonfatal myocardial infarction, coronary artery bypass grafting, or repeat PCI) during the 1-year follow-up after the index PCI procedure were included in the study. Anemia was defined using World Health Organization (WHO) criteria as a hematocrit value at initial presentation <39% for men and <36% for women. Baseline hematocrit levels were measured before the procedure. Baseline clinical, lesion, and procedural characteristics were comparable in both groups. Anemia was present in 33.8% of men and 30.4% of women. The incidence of anemia in patients with nonfatal coronary events was 46.9% and 15.7% in the event-free group, which was significantly different (P = 0.001). Anemia was found to be an independent risk factor for nonfatal coronary events in PCI patients (odds ratio: 2.24, 95% confidence interval: 1.05-4.79; P = 0.036). In conclusion, anemia is an important risk factor for predicting nonfatal coronary events after PCI. Although previous studies have shown its impact on fatal events, this study has demonstrated that anemia also has a role in nonfatal thrombotic coronary events and restenosis. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Clinico-epidemiologic study of cutaneous leishmaniasis in Diyarbakir Turkey. 2006 S Aytekin,M Ertem,O Ya?diran,N Aytekin Cutaneous leishmaniasis (CL) is a zoonotic disease, endemic and notifiable in southeastern Turkey. We investigated clinical features, individual characteristics, and environmental factors of affected patients, and identified additional patients with CL in Diyarbakir. In 2002 we studied the epidemio... ( view more )logy of CL in Dedeköy and Durabeyli towns in Diyarbakir Province. We evaluated patients with any skin lesions. A questionnaire including demographic details was completed by each patient. Clinical details of lesions and other dermatological findings were recorded. We walked around the town and surveyed it for environmental factors. CL was diagnosed in 78 individuals aged 1-85 years (mean age of 20). Although all age groups were affected, the majority of patients were under age 20. The lesions ranged from approximately 0.5 to 20 cm. They were located on the face (46.7 %), upper extremity (23.2 %), lower extremity (5.1 %), and other sites. Different types of lesions were observed such as nodule with crust, nodule with osseous crust, violaceous infiltrative plaque with vegetative nodule, erysipelas-like plaque verrucous annular plaque, and eczema-like plaques. The incidence of CL is increasing in Dicle and Durabeyli towns and the clinical appearance may vary greatly. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Determination of the width of the presacral space on magnetic resonance imaging. Jan 2004 Aytekin Oto,Bora Peynircioglu,Muzaffer Eryilmaz,Aytekin Besim,H Selçuk Sürücü,H Hamdi Celik Presacral space enlargement may be the first sign of certain diseases. The normal width of the presacral space has not been widely investigated and in all previous studies was calculated from lateral radiographs obtained at barium enema examination. Our study determined the normal width of the pres... ( view more )acral space on MRI and investigated a possible difference between men and women. The width of the presacral space was measured retrospectively from sagittal T2-weighted MR images of 193 patients (87 males; 106 females, aged 18-83 years). Presacral space width was measured separately for S1, S2, and S3 vertebral levels from the anterior surface of the vertebral bodies to the closest part of the posterior wall of the rectum. Differences between male and female subjects were analyzed by t-tests. Normal mean widths of the presacral space in men and women were 16.2 mm and 11.9 mm for S1, 14.9 mm and 11.2 mm for S2, and 13.0 mm and 10.6 mm for S3, respectively. Measurements of the presacral space width in men were significantly larger than in women at all three levels (P < 0.001 for S1, P < 0.001 for S2, P = 0.006 for S3). In summary, the presacral space width measured on MRI was found to be significantly larger in the male than in the female population. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles CT virtual bronchoscopy in the evaluation of children with suspected foreign body aspiration. Nov 2003 Mithat Haliloglu,Arbay O Ciftci,Aytekin Oto,Burcak Gumus,F Cahit Tanyel,Mehmet E Senocak,Nebil Buyukpamukcu,Aytekin Besim OBJECTIVE: Computed tomography (CT) virtual bronchoscopy is a noninvasive technique that provides an internal view of trachea and major bronchi by three-dimensional reconstruction. The aim of this study was to investigate the usefulness of virtual bronchoscopy in the evaluation of suspected foreign... ( view more ) body aspiration in children. MATERIALS AND METHODS: Twenty-three children (12 girls, 11 boys) with a mean age of 2.4 years (8 months-14 years) who were admitted to emergency room with a suspicion of foreign body aspiration were included in this study. Chest radiograms, spiral computed tomography scans and virtual bronchoscopy images were obtained. Then, rigid bronchoscopy was performed within 24 h. RESULTS: CT virtual bronchoscopy and conventional bronchoscopy revealed the location of the foreign body in seven patients. It was in the right main bronchus in four patients, in the right lower lobe bronchus in one patient, and in the left main bronchus in two patients. There was no discordance between two modalities. CT examination revealed hyperaeration of the ipsilateral lung in four patients, hyperaeration of the ipsilateral lung and mediastinal shift in one patient and bronchiectatic changes in one patient. CT detected no additional finding in one patient with a foreign body in the right main bronchus. In 10 of 16 patients without foreign body, CT examination demonstrated atelectasis, infiltration, peribronchial thickening, and paratracheal lymphadenpoathy. CONCLUSION: Helical CT scanning with virtual bronchoscopy should be performed in only selected cases with suspected foreign body aspiration. When the chest radiograph is normal and the clinical diagnosis suggests aspirated foreign body, helical CT and virtual bronchoscopy can be considered in order to avoid needless rigid bronchoscopy. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles [The role of spiral CT in the preoperative evaluation of malignant gastric neoplasms] Sep 2003 Hatice Lakadamyali,Aytekin Oto,Ilkay Akmangit,Osman Abbaso?lu,Bülent Sivri,Okan Akhan,Aytekin Besim PURPOSE: The purpose of this study was to evaluate the performance of spiral CT in preoperative staging in patients with gastric cancer. MATERIALS AND METHODS: A total of 28 patients with an established diagnosis of 24 gastric adenocarcinoma, 2 gastric lymphoma, 1 carcinoid tumor, 1 leiomyosarcoma ... ( view more )were evaluated with spiral CT for serosal invasion, pancreatic invasion, metastasis and peritoneal involvement. Results were compared with surgical and pathological staging. RESULTS: The accuracy of spiral CT in determining the depth of tumor invasion, pancreatic invasion, lymph node metastasis, peritoneal metastasis, liver metastasis and splenic metastasis were 82% (23/28), 96% (27/28), 82% (23/28), 96% (27/28), 100% (28/28) and 100% (28/28) respectively. The differentiation between T2-T3, T3-T4, N0-N1, N1-N2, N2-N3 were possible in 83% (15/18), 92% (23/25), 79% (15/19), 73% (8/11), and 89% (8/9). The accuracy of spiral CT in overall TNM staging of gastric adenocarcinomas was 67% (16/24). CONCLUSION: Spiral CT is an effective tool in the preoperative staging of gastric malignancies. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles CT attenuation of colorectal polypoid lesions: evaluation of contrast enhancement in CT colonography. Jul 2003 Aytekin Oto,Veli Gelebek,Berna Sayan Oguz,Bülent Sivri,Ahmet Deger,Okan Akhan,Aytekin Besim The aim of this study was to calculate pre- and postcontrast CT attenuation values of benign colorectal polyp and carcinoma lesions detected by virtual colonoscopy, and to investigate whether contrast enhancement of these lesions can be potentially used for differentiation from residual fluid in th... ( view more )e colon. Fifteen benign polyps and 21 colorectal carcinoma lesions detected by virtual colonoscopy in 18 patients were included in our study. All of the polyps and carcinoma lesions were confirmed by colonoscopic biopsy. Measurement of CT attenuation values was performed in precontrast (supine) and postcontrast (prone) scans for each polyp and carcinoma. The CT attenuation values of residual fluid in the colon was also measured from the same location before and after intravenous contrast administration. On unenhanced CT scan mean attenuation values of benign polyps and colorectal carcinomas were 32.4 and 42.6 HU, respectively. Following contrast enhancement, mean attenuation value increased to 78.9 HU for polyps and 90.7 HU for carcinomas. Increase in the CT attenuation values of these lesions was significant ( p<0.0001). Mean CT attenuation value of residual fluid before and after administration of IV contrast were 14.6 and 13.8 HU, respectively. The difference between CT attenuation value of residual fluid in the colon before and after contrast material was not significant ( p=0.29). Colorectal benign polyps and carcinomas demonstrate significant enhancement following contrast administration and use of intravenous contrast material during virtual colonoscopy may help in some cases in differentiating these solid lesions from residual colonic fluid that does not enhance. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Interdigitating fasciocutaneous gluteal V-Y advancement flaps for reconstruction of sacral defects. Jun 2003 Aydan Ay,Oygar Aytekin,Ahmet Aytekin The authors describe a modification of the classic gluteal bilateral V-Y advancement flap for sacral defect closure. After initial debridement, the V-Y design is marked on both sides of the defect. The incision is carried down to the fascia of the underlying gluteus maximus muscle. The upper and lo... ( view more )wer arms of the flaps are elevated and advanced on the gluteal muscle toward the midline, interdigitating each opposing arm. The overall result is a zigzag, broken midline suture. This procedure was carried out in 14 patients with sacral pressure sores and in 1 patient with a chronic pilonidal sinus. All flaps survived without major problems. There were no recurrences during the 6 to 16 months of follow-up. The interdigitating fasciocutaneous V-Y gluteal flap design is effective in breaking the midline vertical scar and preserving the gluteus maximus muscle. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles [Staging of urinary bladder tumors with CT and MRI] Mar 2003 Ilkay Akmangit,Hatice Lakadamyali,Aytekin Oto,Haluk Ozen,Okan Akhan,Aytekin Besim PURPOSE: The purpose of this study was to evaluate the performance of spiral CT and MRI in patients with bladder tumor. MATERIALS AND METHODS: In this study, patients with suspected urinary bladder tumor were evaluated by abdominal CT and MRI. This study included 32 patients. In 23 cases, transuret... ( view more )hral resection (TUR), and in 9 cases radical cystectomy was performed. Additionally, pelvic lymph node dissection was performed in 9 patients. RESULTS: According to the pathological results of TUR-performed patients; the accuracy of spiral CT and MRI in preoperative staging of bladder tumors was 41.6% and 83.3%, respectively. The accuracy of spiral CT and MRI in preoperative staging of bladder tumors were 66.6% and 77.7% in patients who underwent radical cystectomy. Pelvic lymph node involvement was evaluated properly with MRI and CT. CONCLUSION: In the preoperative staging of bladder tumors, MRI is superior to CT. The superiority is more definite especially in early stage tumors. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles The comparison of reproductive health data in a rural district in Turkey (1981-2001). Dec 2002 N T Aytekin,K Pala,N Aki?,S Nacarküçük,H Aytekin OBJECTIVES: The main objective was to compare new reproductive and family planning data with data from the 1981 survey. METHODS: All 15-49-year-old married women living in seven villages of Gemlik were interviewed and the data were compared with the 1981 data of the same villages. RESULTS: In 1981,... ( view more ) 66.8% used a family planning method, 6.8% used an intrauterine device, 10.2% used oral contraceptives and 10.0% used condoms. In 2001, these values were 93.0%, 36.5%, 6.0% and 14.8%, respectively. In 1981, 51.5% and in 2001 35.5% used coitus interruptus. CONCLUSION: In 20 years, users of both current family planning methods and modem methods have increased; users of traditional methods have decreased. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Distribution of blood pressures in Gemlik District, north-west Turkey. Sep 2002 Necla Tugay Aytekin,Kayihan Pala,Emel Irgil,Nalan Akis,Hamdi Aytekin The objectives of the present study were to evaluate the prevalence, awareness and control of hypertension among individuals over 30 years of age and to plan a follow-up programme for the same age group. A community-based sample of 1992 individuals (952 men and 1,040 women) was selected randomly. O... ( view more )ut of the total study population, 1,388 (69.7%) individuals had normal blood pressure according to World Health Organisation criteria (systolic blood pressure < 140 mmHg and diastolic blood pressure < 90 mmHg), and the rest (n = 604, 30.3%) had hypertension to varying degrees. Since 61 individuals with normal blood pressure were using antihypertensive medication, the overall hypertension prevalence was 33.4%. Among the study subjects with hypertension, 44.4% were aware of their condition, 37.7% were using medication and 9.2% had controlled hypertension. One out of five individuals (n = 399, 20.0%) had never had their blood pressure measured before. Females had a higher hypertension prevalence than males (36.7% and 29.7%, respectively). Hypertension prevalence increased with age and individuals with a body mass index > 25 were at greater risk. The present findings suggest that there is a need to implement an effective, community-based and low-cost management programme. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Family planning choices and some characteristics of coitus interruptus users in Gemlik, Turkey. 2001 Sep-Oct N T Aytekin,K Pala,E Irgil,H Aytekin The objectives of this study were to gain information about some fertility issues, contraceptive method choices, and the reasons for coitus interruptus (CI) use among married women aged 15-49, in Gemlik, Turkey. One thousand nine hundred ten women were interviewed for this cross-sectional study. Th... ( view more )e pregnancy rate per woman was 2.9. 716 women (37.5%) had at least one unwanted pregnancy. Of the study population, 79.6% were using a contraceptive method (45.1% were using a modern method, 34.5% a traditional method). CI was the most preferred method (33.7%). Fertility measures of women who had used CI continuously were compared with other women. It was found that most CI users were content with the method. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles A placebo-controlled study of extract of ginkgo biloba added to clozapine in patients with treatment-resistant schizophrenia. Jul 2008 Ali Doruk,Ozcan Uzun,Aytekin Oz?ahin The focus of this study was the systematic evaluation of the clinical effects of the extract of ginkgo biloba (EGb) as an adjunct to the atypical antipsychotic clozapine in the treatment of refractory schizophrenia. In a placebo-controlled study, 42 patients with chronic, treatment-resistant schizo... ( view more )phrenia, who were maintained on optimal doses of clozapine, were administered either 120 mg/day of EGb (N=20) or placebo (N=22) for 12 weeks. Clinical evaluations with the Brief Psychiatric Rating Scale, the Scale for the Assessment of Positive Symptoms, and the Scale for the Assessment of Negative Symptoms were completed biweekly. The use of EGb as an adjunct to clozapine was effective in decreasing negative symptoms, but not positive and overall psychopathology symptoms. EGb produced a mean 7.9+/-7.0 point reduction in the total Scale for the Assessment of Negative Symptoms score compared with a mean 1.8+/-3.5 point reduction in the placebo group (P=0.034). These preliminary data suggested that EGb was found useful for enhancing the effect of clozapine on negative symptoms in patients with treatment-resistant schizophrenia. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Efficacy of linezolid in the treatment of mediastinitis due to methicillin-resistant Staphylococcus aureus: an experimental study. Jul 2008 Mustafa Sacar,Suzan Sacar,Ilknur Kaleli,Nural Cevahir,Zafer Teke,Semra Toprak Kavas,Ali Asan,Faruk Onder Aytekin,Ahmet Baltalarli,Huseyin Turgut INTRODUCTION: The treatment of postoperative mediastinitis is very important because of its high morbidity, mortality, and increased hospital stay and hospital costs. The aims of our research were to investigate whether linezolid alone can be an effective treatment agent for methicillin-resistant S... ( view more )taphylococcus aureus (MRSA) mediastinitis, and to determine whether linezolid can provide synergistic activity when given in combination with rifampin. METHODS: A partial upper median sternotomy was performed on 70 rats. The animals were divided into seven groups: an uncontaminated control group; an untreated contaminated group; three contaminated groups that received antibiotic therapy with either 25 or 50mg/kg linezolid twice a day, or rifampin 5mg/kg twice a day; and two contaminated groups that received a combination therapy consisting of 25 or 50mg/kg linezolid and rifampin 5mg/kg twice a day. The antibiotic treatment lasted 7 days. Tissue samples from the upper ends of the sternum and swab specimens of the upper mediastinum were obtained and evaluated microbiologically. RESULTS: The 25-mg/kg dose of linezolid, either alone or combined with rifampin, was not effective in reducing the bacterial counts in mediastinum and sternum. Quantitative bacterial cultures of mediastinum and sternum were significantly lower in the groups receiving 50mg/kg linezolid alone or in combination with rifampin compared with the control. Adding of rifampin to linezolid therapy did not result in a significant change in bacterial counts versus linezolid alone. CONCLUSION: A high dose of linezolid should be considered as a possible therapeutic agent for the treatment of post-sternotomy infection caused by MRSA. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Dietary breads: myth or reality? Jul 2008 Banu Mesci,Aytekin Oguz,Hatice Gul Sagun,Mehmet Uzunlulu,Elmas Biberci Keskin,Damla Coksert AIMS: To assess the differences in acute effects of whole wheat bread, wheat bran bread and rye bread--perceived as dietary (Low caloric!) breads--on glucose and insulin levels in patients with type 2 diabetes, as compared to white wheat bread. METHODS: One hundred twenty one type 2 diabetic patien... ( view more )ts were randomized into three groups as whole wheat, wheat bran and rye bread groups. Each group ate 100 g of bread with water with in 10 min. Blood glucose measurements were made at every 30 min in 2 h. Insulin was measured at fasting and at the second hour in the patients who do not use insulin. The same processes were repeated on the following day, with white wheat bread for each group. RESULTS: No significant difference was found in either glycemic or insulinemic effects between four types of breads when compared to each other (p=0.093 for glycemic effect and p=0.297 for insulinemic effect). CONCLUSION: Three different bread types consumed as an alternative to white bread in Turkey, increase blood glucose levels of diabetic patients similar to white bread. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles An unconditioned bone marrow transplantation in a child with purine nucleoside phosphorylase deficiency and its unique complication. Jun 2008 Caner Aytekin,Mutlu Yuksek,Figen Dogu,Aydin Yagmurlu,Alisan Yildiran,Suat Fitoz,Meltem Kologlu,Emel Babacan,Michael S Hershfield,Aydan Ikinciogullari Purine nucleoside phosphorylase deficiency is a rare immunodeficiency syndrome characterized by recurrent infections, neurological dysfunction, and autoimmunity. Early diagnosis and hematopoietic stem cell transplantation may reverse the dismal prognosis in PNP deficiency. This report presents a ne... ( view more )w PNP deficiency case successfully transplanted without a conditioning regimen from an HLA-identical family donor, who developed a complication of disseminated BCG infection. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Mirtazapine augmentation in depressed patients with sexual dysfunction due to selective serotonin reuptake inhibitors. Jun 2008 Nahit Kamil Ozmenler,Tunay Karlidere,Ali Bozkurt,Sinan Yetkin,Ali Doruk,Levent Sutcigil,Adnan Cansever,Ozcan Uzun,Fuat Ozgen,Aytekin Ozsahin OBJECTIVE: To evaluate the effect of mirtazapine augmentation in patients with sexual dysfunction induced by current selective serotonin reuptake inhibitor (SSRI) treatment. METHODS: Forty-nine outpatients in remission from major depressive disorder with SSRI treatment and experiencing treatment-em... ( view more )ergent sexual dysfunction were invited to participate and 33 (25 women and 8 men) were included in this 8-week open-label study. All patients continued her/his current SSRI treatment (dosages unchanged) and started on mirtazapine augmentation of 15 mg/day during the first week and 30 mg/day throughout the rest of the study. The Hamilton rating scale for depression (HAM-D), the psychotropic-related sexual dysfunction questionnaire (PRSexDQ), and the Golombok and Rust Inventory of Sexual Satisfaction (GRISS) were given to all patients at baseline and at each follow-up (end of the first, second, fourth, sixth, and eight weeks). RESULTS: Mirtazapine augmentation led to significant reductions in HAM-D, PRSexDQ, and GRISS scores throughout the study especially after week 4 and 48.5% of patients (n = 16) reported that they had no overall sexual dysfunction at the end of the study. CONCLUSIONS: Mirtazapine augmentation is a good choice for the treatment of SSRI-induced sexual dysfunction, and the results are typically seen later after 4-8 weeks. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Portal vein hemodynamics in patients with non-alcoholic fatty liver disease. May 2008 Besir Erdogmus,Ali Tamer,Ramazan Buyukkaya,Burhan Yazici,Ayla Buyukkaya,Esin Korkut,Aytekin Alcelik,Ugur Korkmaz Paralleling the rise in the incidence of obesity and diabetes worldwide, nonalcoholic fatty liver disease (NAFLD) is being increasingly recognized as one of the major causes of chronic liver disease. Doppler sonography is used as a diagnostic method in the non-invasive assessment of the hemodynamic... ( view more )s of hepatic vascular flow in liver diseases. We investigated the effects of fatty infiltration in the liver on the Doppler flow hemodynamics of the portal vein. Doppler sonography of the liver and portal vein was performed in 60 subjects with NAFLD and 20 healthy volunteers (control). The patients were grouped into mild (grade 1), moderate (grade 2), and severe (grade 3) according to sonographic appearance of hepatosteatosis (n = 20 for each group). The vein pulsatility index (VPI), mean flow velocity (MFV), peak maximum velocity (V(max)), and peak minimum velocity (V(min)) of the portal vein were significantly lower in patients with NAFLD than those of the controls (p < 0.001). The VPI was 0.20 in the patients and 0.31 in the control. The MFV was 12.3 cm/sec in the patients and 16.5 cm/sec in the control group. The portal vein flow was found to be decreased as the grade of fatty infiltration increased for VPI (r = -0.946, p < 0.001), MFV (r = -0.951, p < 0.001). The alteration in Doppler waveform pattern of portal vein with fatty liver population suggests reduced vascular compliance in the liver. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Pathophysiology of anemia and nursing care implications. Apr 2008 Sharon M Coyer,Ayhan Aytekin Lash Anemia is a decrease in erythrocyte mass or amount of hemoglobin from impaired production of erythrocytes, blood loss, or increased erythocyte destruction. The pathophysiology, clinical manifestations, and selected pathologies of anemia and their implications for nursing practice are reviewed. View Full Abstract View Article Details View Coded Data Related Articles Gadolinium-based contrast exposure, nephrogenic systemic fibrosis, and gadolinium detection in tissue. Apr 2008 Clark D Wiginton,Brent Kelly,Aytekin Oto,Mary Jesse,Patricia Aristimuno,Randy Ernst,Gregory Chaljub OBJECTIVE: The objective of our study was to retrospectively review one institution's cases of nephrogenic systemic fibrosis (NSF), evaluate possible associated factors, determine the prevalence of NSF, and search for gadolinium in skin samples obtained from patients with NSF. MATERIALS AND METHODS... ( view more ): A retrospective review of our dermatopathology database from 1997 to 2007 was performed to search for patients with NSF. The records of patients with NSF were reviewed for factors suspected to be associated with NSF such as acidosis, low hemoglobin levels, low serum calcium levels, inflammatory conditions, serum antibodies, pharmaceutical erythropoietin, angiotensin-converting enzyme inhibitors, gadolinium-based contrast agents (GBCAs), renal failure, and dialysis. The biopsy samples from NSF patients and from control subjects were examined with energy-dispersive X-ray spectroscopy to detect gadolinium. Retrospective chart reviews of patients evaluated at our local dialysis center and our dermatology clinic were conducted to identify patients who underwent MRI, who had NSF managed exclusively by our tertiary referral centers, or both from 1997 to 2007. RESULTS: Seven cases of NSF were found in the dermatopathology database. Two of the seven patients were also followed up at our outpatient dialysis clinic. No other cases of NSF were discovered within the dialysis clinic's population exclusively followed within our institution. All seven dermatopathology database NSF patients developed symptoms of NSF after receiving GBCAs during renal failure and showed concomitant proinflammatory conditions. No other proposed risk factors were uniformly present in these NSF cases. All four NSF patients with chronic renal failure developed NSF after hemodialysis, with one patient dialyzed 12 hours after receiving a contrast dose. Gadodiamide was the only GBCA that all seven NSF patients received before symptom onset. Symptom onset was from 3 weeks to 18 months after GBCA exposure, with cumulative GBCA doses ranging from 0.16 to 0.43 mmol/kg. Gadolinium was detected in six of seven NSF patients' skin biopsies. Seven of eight random control specimens obtained from three healthy control subjects, three patients with renal insufficiency who had not been exposed to gadodiamide, and two patients without renal disease who had been exposed to gadodiamide were negative. Seventy-two dialysis clinic patients underwent 127 contrast-enhanced MR examinations from 1997 to 2007. Eighteen patients received gadopentetate, none of whom developed NSF. Sixty-three patients received gadodiamide, two of whom developed NSF (prevalence of NSF in patients exposed to GBCA, 2.8%; odds ratio, 0.82 [95% CI, 0.04-18.10]; likelihood ratio, 1.16 [95% CI, 1.06-1.26]). Nine patients received both contrast agents. CONCLUSION: An association with GBCAs in the development of NSF is suggested in the setting of renal insufficiency, but other factors seem to play a role. Dialysis did not prevent the development of NSF. Gadolinium was detected in skin samples from NSF patients. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Mucoepidermoid carcinoma of the parotid gland with ovarian and peritoneal metastasis. Apr 2008 Selim Buyukkurt,Aytekin Altintas,Derya Gumurdulu,Handan Zeren,Baris Guzel Metastatic ovarian carcinoma generally arises from the gastrointestinal tract. Mucoepidermoid carcinoma is the most common malignant tumor of the salivary gland. It typically disseminates to the regional lymph nodes and surrounding soft tissues. Distant metastasis of the parotid mucoepidermoid carc... ( view more )inoma is very rare, and it usually occurs to the lungs, bones and liver. A 28-year-old woman with a history of high grade mucoepidermoid carcinoma of the parotid gland was admitted with ascites and bilateral ovarian masses. Breast examination, endoscopic evaluation of the gastrointestinal tract, total bone scintigraphy, abdominopelvic and chest tomography and cytological analysis of the ascites did not detect a primary malignancy. Nevertheless, pathological examination of the ovaries revealed a metastasis from the mucoepidermoid carcinoma. Metastatic ovarian tumors usually originate from the gastrointestinal tract. Other sources of tumor metastasis should also be considered. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles A sensorimotor approach to sound localization. Mar 2008 Murat Aytekin,Cynthia F Moss,Jonathan Z Simon Sound localization is known to be a complex phenomenon, combining multisensory information processing, experience-dependent plasticity, and movement. Here we present a sensorimotor model that addresses the question of how an organism could learn to localize sound sources without any a priori neural... ( view more ) representation of its head-related transfer function or prior experience with auditory spatial information. We demonstrate quantitatively that the experience of the sensory consequences of its voluntary motor actions allows an organism to learn the spatial location of any sound source. Using examples from humans and echolocating bats, our model shows that a naive organism can learn the auditory space based solely on acoustic inputs and their relation to motor states. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Generating somatic mosaicism with a Cre recombinase-microsatellite sequence transgene. Mar 2008 Aytekin Akyol,Takao Hinoi,Ying Feng,Guido T Bommer,Thomas M Glaser,Eric R Fearon Strategies for altering constitutional or somatic genotype in mice are well established, but approaches to generate mosaic genotypes in mouse tissues are limited. We showed that a functionally inactive Cre recombinase transgene with a long mononucleotide tract altering the reading frame was stochas... ( view more )tically activated in the mouse intestinal tract. We demonstrated the utility of this approach by inducing colonic polyposis after Cre-mediated bi-allelic inactivation of the Apc gene. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles The neocartilaginous formation with hydroxyl-apatite in injection laryngoplasty: an experimental study on rabbit model. Feb 2008 Erkan Ozudogru,Hamdi Cakli,Esin Asan,Cemal Cingi,Kezban Gurbuz,Aytekin Yaz,Beklen Ure Adductor paralysis or the pathologies occurring after laryngeal surgery such as scarring or atrophy of the vocal cords cause glottic insufficiency during phonation. Injection laryngoplasty has been a widely accepted technique due to lower morbidity of the procedure and the applicability via endosco... ( view more )pe in the treatment of these pathologies. Various materials have been used in injection laryngoplasty. The primary expectations in these techniques are the persistence of injected material long enough, without resorbtion or any cause of serious tissue response and having beneficial effects in reinforcing the glottic tissue. In the present study, we used large molecular-sized calcium hydroxyl-apatite (CaHA) particles in injection laryngoplasty to observe the effects of the material in the laryngeal tissues under the light microscopic examination. The study was performed on 12 rabbits in four groups. After injecting Ca(10) (PO4)(6)(OH)(2) (Coaptite((R))) into their vocal folds, the rabbits were killed at certain intervals, in the 1st week (group 1) in the 1st month (group 2) in the 3rd month (group 3) and in the 6th month (group 4). Larynges were removed and processed for light microscopic observations. Our observations revealed that this material induced the new cartilage formation without a serious tissue response in the larynges. Formation of a new cartilage tissue was the most significant, but an unexpected outcome of the study. The injected material inducing a neocartilage formation without any tissue reaction persisted long enough in the laryngeal tissues. Although neocartilage formation may interfere the vocal fold vibrations, providing glottic closure in the phonation with a durable material will be an important gain. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Crohn's disease complicated by multiple stenoses and internal fistulas clinically mimicking small bowel endometriosis. Jan 7, 2008 Zafer Teke,Faruk Onder Aytekin,Ali Ozgur Atalay,Nese Calli Demirkan We report a 31-year-old woman with Crohn's disease complicated by multiple stenoses and internal fistulas clinically misdiagnosed as small bowel endometriosis, due to the patient's perimenstrual symptoms of mechanical subileus for 3 years; at first monthly, but later continuous, and gradually incre... ( view more )asing in severity. We performed an exploratory laparotomy for small bowel obstruction, and found multiple ileal strictures and internal enteric fistulas. Because intraoperative findings were thought to indicate Crohn's disease, a right hemicolectomy and partial distal ileum resection were performed for obstructive Crohn's ileitis. Histopathology of the resected specimen revealed Crohn's disease without endometrial tissue. The patient made an uneventful recovery from this procedure and was discharged home 10 d post-operatively. The differential diagnosis of Crohn's disease with intestinal endometriosis may be difficult pre-operatively. The two entities share many overlapping clinical, radiological and pathological features. Nevertheless, when it is difficult to identify the cause of intestinal obstruction in a woman of child-bearing age with cyclical symptoms suggestive of small bowel endometriosis, Crohn's disease should be included in the differential diagnosis. ( view less ) View Full Abstract View Article Details View Coded Data Related Articles Page 1 of 10 1 2 3 4 > Last >> (228 articles found)

      
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