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| | | Type of Article | | Clinical Trial Editorial Letter Meta-Analysis Practice Guideline Randomized Controlled Trial Review Addresses Bibliography Biography Case Reports Classical Article Clinical Conference Clinical Trial, Phase I Clinical Trial, Phase II Clinical Trial, Phase III Clinical Trial, Phase IV Comment Comparative Study Consensus Development Conference Consensus Development Conference, NIH Controlled Clinical Trial Corrected and Republished Article Dictionary Directory Duplicate Publication English Abstract Evaluation Studies Festschrift Government Publications Guideline Historical Article Interview In Vitro Journal Article Lectures Legal Cases Legislation Multicenter Study News Newspaper Article Overall Patient Education Handout Periodical Index Published Erratum Retracted Publication Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Retraction of Publication Scientific Integrity Review Support of Research Technical Report Twin Study Validation Studies Not a Primary Study or Review Unknown Primary Study Case Series Case Control Cohort Study Observational Study Qualitative Research CBA or ITS Registry Double Blind Controlled before after study Quasi-randomized trial Simple before after study Cluster-RCT Non-Randomized Study Report Book Book chapter Dissertation Conference procedings Secondary Research Not RCT
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| | | Intervention | | Patient education Communication and counselling Patient involvement through self-monitoring Reminders Reinforcement or rewards Other (e.g. combined education and reminders) Unknown Educational Materials Group threrapy Couples threrapy Individual threrapy Healthy eating Increased physical activity Not Diet or Exercise Welfare-to-work program
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N Hoffman Dr. Neal Hoffman, Medical Director of the Adolescent AIDS Program at Montefiore Hospital, discusses special care considerations for HIV-positive adolescents. General health maintenance and STD treatment encompass about 75 percent of the care provided through the clinic. The program has been expande... ( view more )d to serve people up to the age of 24, unlike many programs which end at 21. Dr. Hoffman believes that many in the program are just developing their sense of trust in the doctors and it is counterproductive to arbitrarily eliminate them from the program. Teenagers tend to be less compliant about taking their medications, and have great fears of disclosing their HIV status to partners and family members. Mandatory partner notification programs are not a viable alternative, as many of the clients have limited sexual experience and their confidentiality is compromised by telling their partners. The program is part of the AMHARN study, a five-year longitudinal study of disease progression in adolescent cohorts funded by the National Institutes of Health (NIH). ( view less ) Soo Hyun Rhee,John K Hewitt,Jeffrey M Lessem,Michael C Stallings,Robin P Corley,Michael C Neale Given that knowledge regarding the etiology of comorbidity between disorders can have a significant impact on research regarding the classification, treatment, and etiology of the disorders, the ability to reject incorrect hypotheses regarding the causes of comorbidity is very important. A simulati... ( view more )on study was conducted to assess the validity of the Neale and Kendler (1995) model-fitting approach in examining the etiology of comorbidity between two disorders. First, data were simulated under the assumptions of the 13 alternative comorbidity models described by Neale and Kendler. Second, model-fitting analyses testing the comorbidity models were conducted on the simulated datasets. Thirteen sets of data with varying model parameters were simulated to test Neale and Kendler's assertion that their model-fitting approach is appropriate across a range of potential prevalences and degrees of familiality. The validity of the model-fitting approach in examining unselected twin data and a combination of selected family data and unselected family data was explored. The model-fitting approach successfully discriminated several classes of comorbidity models, although discrimination between models within classes of related models was less accurate. Results suggest that the model-fitting approach can be a useful tool in examining the etiology of the comorbidity between disorders if the caveats of the present study's results are considered carefully. As predicted by Neale and Kendler, variations in the disorder prevalences and familial correlations did not affect the validity of their model-fitting approach, but affected the power to discriminate the correct model. As suggested by Neale and Kendler, the model-fitting approach can be applied to both unselected and selected data and to both twin and family data. ( view less ) Soo Hyun Rhee,Michael C Neale,Robin C Corley,John K HewittNeale and Kendler (1995, Am J Hum Genet 57:935-953) described 13 comorbidity models, providing the most comprehensive set of alternative hypotheses regarding the possible causes of comorbidity to date. This research note describes an extension of the Neale and Kendler model fitting approach that pe... ( view more )rmits the inclusion of measured covariates. An example of 13 models examining the comorbidity between alcohol dependence and illicit drug dependence is presented. ( view less ) Renee B Patrick,John C GibbsThe authors addressed whether parental expression of disappointment should be included as a distinct factor in M. L. Hoffman's well-established typology of parenting styles (induction, love withdrawal, power assertion). Hoffman's 3-factor model, along with a more inclusive 4-factor model (induction... ( view more ), love withdrawal, power assertion, and expressions of disappointment), were respectively evaluated in exploratory factor analyses. The analysis utilized extant data comprised of responses by children (N = 73) and their mothers (N = 67) to an adaptation of M. L. Hoffman and H. D. Saltzstein's parental discipline measure. The findings supported Hoffman's original model. Disappointment may be reducible to love withdrawal or induction, although disappointment may be a more appropriate induction for adolescents. ( view less ) V Freeman,C Mutatiri,M Pretorius,A Doubell OBJECTIVE: To evaluate left ventricular enlargement in the lateral projection of the chest using the Hoffman and Rigler sign. BACKGROUND: The Hoffman and Rigler sign for determining left ventricular enlargement was suggested as early as 1965 before the routine use of echocardiography. METHODS: We s... ( view more )tudied 136 patients who had had cardiac ultrasound and chest X-rays with lateral projections. We assessed left ventricular size on the lateral projection using the Hoffman and Rigler method (measurement A) and compared this measurement to the value obtained by cardiac ultrasound. The effect of right ventricular size on this measurement was also evaluated. RESULTS The average value of measurement A in all patients with echocardiographic evidence of left vetricular enlargement (LVED above 59 mm) was 19 mm (SD +/- 4.03) (95% CI 17.96 to 20.04). Of the 48 patients with a normal size left ventricle on echocardiography, 25.58% had measurement A 18 mm and above, and 13.95% had a value 19 mm and above. Of the 19 patients with right ventricular enlargement (normal left ventricle) on echocardiography, 36.84% had measurement A18 mm and above, whereas 21.05% had this value 19 mm and above. Measurement A in patients with left ventricular enlargement compared with those with right ventricular enlargement showed a significant difference (p < 0.05). CONCLUSIONS: When the crossing of the inferior vena cava and the left ventricle can be adequately visualised, the Hoffman and Rigler sign of evaluating left ventricular enlargement in the lateral projection of the chest is a valuable alternative where cardiac ultrasound is not readily available. ( view less ) Alice L R Spooner,Alan D Baddeley,Susan E Gathercole BACKGROUND: The Neale Analysis of Reading Ability (NARA) (Neale, 1997) is widely used in education and research. It provides measures of reading accuracy (decoding) and comprehension, which are frequently interpreted separately. AIMS: Three studies were conducted to investigate the degree to which ... ( view more )the NARA measures could be separated. SAMPLES: British 7- and 8-year-olds participated in Study 1 (N=114) and Study 2 (N=212). In Study 3, 16 skilled and less-skilled comprehenders were identified from the Study 2 sample. METHODS: Study 1: By investigating their contribution to silent reading comprehension, the independence of NARA decoding and comprehension scores was determined. Study 2: Decoding groups matched for listening comprehension were compared on the NARA comprehension measure, and population performance was compared across listening comprehension and NARA reading comprehension. Study 3: Comprehension groups were compared on ability to answer open-ended and forced-choice questions. RESULTS: Firstly, NARA comprehension performance depended on decoding, to the extent that children with high listening comprehension ability but low decoding ability attained low NARA comprehension scores. Secondly, 32% of children who attained low NARA comprehension scores exhibited high listening comprehension. Thirdly, comprehension groups differed when assessed with open-ended questions but not when assessed with forced-choice questions. CONCLUSIONS: The NARA can underestimate the comprehension ability of children with weak decoding skills and children who have some difficulty with open-ended questions. The decoding and comprehension measures of the NARA cannot be separated. These findings have important implications for the interpretation of the measures provided by the NARA, in education and research. ( view less ) J M Neiderhiser,D A Bussell,A Pike,R Plomin,S Simmens,G W Howe,E M Hetherington,D Reiss This article addresses concerns raised by M. C. Neale (1999) in his commentary on the D. A. Bussell et al. (1999) Nonshared Environment in Adolescent Development (NEAD) study. These concerns fall into two categories: (a) model assumptions and sample design and (b) testing of alternative models. The... ( view more ) validity of the assumptions of quantitative genetic models is a concern for all researchers in this area. Discussion of those assumptions in this reply is brief and focuses on those most relevant to the NEAD sample. The two alternative models proposed by Neale were designed to provide alternatives to the large shared environmental effect found in the original report of Bussell et al. Because these alternative models did not provide a better fit, the appropriateness of Bussell et al.'s basic model and the importance of shared environmental influences for explaining the association among family subsystems are supported. ( view less ) Adel Khorbi,Naoufel Haddad,Mounir Chebil,Med Lassaad Kanoun,Naoufel Ben Dali,Abdelhamid Hachem Treatment of extra-articular upper metaphyseal tibial fractures can be difficult. Orthopedic treatment is frequently complicated by second displacement These fractures are inappropriate for locked intra-medullary nailing because of the shorteness of the proximal extremity. Damages of soft tissues. ... ( view more )frequently associated with these factures, expose internal osteosynthesis to many risks. For these reasons, we opted for external fixation. Our study was a retrospective analysis of 46 extra-articular metaphyseal tibial fractures treated by external fixation with Hoffman material. The average follow-up was 24 months. Consolidation was obtained within 4 months in average. Septic complications. inherent to the method were uncommon or minor. Functional results were satisfactory in 84% of cases. So, external fixation with Hoffman material. with particular recommandations, is a promising method for the treatment of extra-articular of proximal metaphyseal tibial fractures. ( view less ) Arkadiusz Sagan,Slawomir Nowicki,Ryszard Buczynski,Marek Kowalczyk,Tomasz Szoplik Methods of imaging phase objects are considered. First the square-root filter is inferred from a definition of fractional-order derivatives given in terms of the integration of a fractional order called the Riemann-Liouville integral. Then we present a comparison of the performance of three frequen... ( view more )cy-domain real filters: square root, Foucault, and Hoffman. The phase-object imaging method is useful as a phase-shift measurement technique under the condition that the output image intensity is a known function of object phase. For the square-root filter it is the first derivative of the object phase function. The Foucault filter, in spite of its position, gives output image intensities expressed by Hilbert transforms. The output image intensity obtained with the Hoffman filter is not expressed by an analytical formula. The performance of the filters in a 4f imaging system with coherent illumination is simulated by use of VirtualLab 1.0 software. ( view less ) Adolfo M Bronstein In 1978, Hoffman and Brookler published an article in The Laryngoscope to challenge prevailing views on the lack of diagnostic power of certain symptoms often reported by patients to neuro-otologists. Some of these 'under-rated neuro-otological symptoms' include complaints of non-rotational dizzine... ( view more )ss, blurred and double vision, and the development of visual motion hypersensitivity in patients with balance disorders. In this review, I revisit these visual symptoms in the light of new findings from our laboratory. Double vision due to skew eye deviation can indeed occur in peripheral vestibular disease when there is a large, acute peripheral imbalance of vestibular function. It is more frequent and severe in brain stem disease. In both cases, it is explained by disruption of the torsional vestibular ocular reflex. It is usually assumed that damage to the otolith underlies the emergence of skew diplopia, but recent evidence shows that the vertical canal system is likely to be partly responsible as well. The other 'under-rated symptom' revisited here is what patients describe as dizziness when watching moving objects or whilst walking in visually busy surroundings such as supermarkets. Recent work has shown that this 'visual vertigo' emerges in patients who, in addition to suffering from a vestibular disorder, have increased visual dependence. Visual dependence denotes subjects who preferentially use vision, as opposed to vestibular or proprioceptive input, for spatial orientation and postural control. We do not know as yet what makes some vestibular patients become extremely visually dependent. However, we have provided evidence for Hoffman and Brookler's impression that visually triggered complaints should not be summarily dismissed, as they often point to an underlying vestibular disorder. ( view less ) C NgwenaSouth Africa is experiencing an HIV/AIDS epidemic of enormous proportions. The workplace, like all the other sectors, is adversely affected. The tendency of a significant proportion of employers has been to discriminate against employees and job applicants living with HIV/AIDS through the use of HI... ( view more )V testing to exclude those that are HIV-positive. In the case of Hoffman v South African Airways, the Constitutional Court was asked to determine the constitutionality of excluding a job applicant on account of an HIV-positive status. The Court ruled in favour of the applicant and ordered instatement. Through an analysis of Hoffman v South African Airways, the article examines how constitutional values are impacting on HIV/AIDS-related ethics in the workplace. ( view less ) E Lenoble,R Terracher,H Kessi,D Goutallier Thirty-nine patients treated with the Hoffman external fixator for a diaphyseal fracture of the humerus, were clinically and radiologically assessed with an average follow-up of 3.2 years. Open fractures, failure of a previous treatment, secondary displacement, and polytraumatisms were the usual in... ( view more )dications for external fixation. Clinical bone healing was obtained within an average delay of 10.5 weeks. One patient underwent a pseudarthrosis. Six patients with secondary displacement of the fracture were operated on again, and the fracture was easily reduced by simple manipulation of the device under general anesthesia. The enclosing of the fractured extremities statistically diminished the risk of secondary displacement. Twenty CT scan examinations were performed to assess the occurrence of rotational malunion. Fourteen patients were malunited in internal rotation of the distal fragment with an average diminution of the retrotorsion of 19.4 degrees. No iatrogenic vascular or neurological complication occurred. The Hoffman external fixation does not replace the orthopedic treatment of the diaphyseal fractures of the humerus. It is simple to use and ensure satisfactory contention of the fractures' extremities when they are enclosed. If a secondary displacement occurs, it is simple to modify the device to reduce the fracture. If necessary, an additional surgical procedure, such as cancellous bone grafting or radial nerve repair, can be performed without modification of the osteosynthesis. ( view less ) A W Beveridge,K BrownIn a recent paper (R. E. Hoffman, L. Kirstein, S. Stopek, & D. V. Cicchetti, 1982, Brain and Language, 15, 207-233), Hoffman et al. outlined a method of analyzing schizophrenic speech. This method is briefly described. When this method was applied to transcripts of psychotic speech in a subsequent ... ( view more )study, major flaws in the system became evident. Despite its claims to be a semiobjective method there are still a great deal of intuitive judgments involved and the analyst has to make numerous ad hoc decisions. This applies particularly to the determination of deviance in a transcript. ( view less ) M K DuttThe paper deals with staining of the chromosomes of animal testicular materials with two basic dyes, Hoffman's violet and dahlia of the triphenylmethane group, following iodine-dye procedure. The important finding, as presented herein, is that iodinated alcohol after staining can be substituted wit... ( view more )h various acids, both organic as well as inorganic, all of which act as trapping agent preventing leaching of the dye that binds with the chromosomal DNA. It is clear from this study that RNA is not involved by this process of staining, since treatment of stained sections with cold phosphoric acid at 5 degrees C for 20--25 min and then stained also reveals perfect colouration of the chromosomes without any cytoplasmic staining. The in vitro absorption properties of Hoffman's violet have also been presented herein. The probable mechanism of action of these dyes has been suggested. ( view less ) R L Jacobs Twelve diabetic patients with varying degrees of insensitivity of the foot presented with problems of forefoot ulceration beneath one or more metatarsal heads. This was associated with local abscess formation. Some of these patients had previously been subjected to surgical procedures such as ray r... ( view more )esection or single metatarsal head resection for earlier problems and were left with areas of increased pressure in the weightbearing surface of the forefoot. Appropriate antibiotic therapy was started by the Infectious Diseases service in each case. Blood flow to the extremity was evaluated by pulse volume recordings and measurement of Doppler pressures at various levels down the extremity. Vascular reconstruction was indicated in two of these patients. After this reconstruction, circulation was deemed adequate to perform the Clayton (Clayton, M.L.: Surgery of the forefoot in Rheumatoid Arthritis. Clin. Orthop. 16:136-140, 1960) modification of the Hoffman (Hoffman, P.: An operation for severe grades of contracted or clawed toes. Am. J. Orthop. 9:441-449, 1911) procedure. This procedure was also done on 10 other patients with more adequate circulation. Although the time of healing was prolonged in some instances, all feet healed and the patients were successfully graduated to full weightbearing with extra depth shoes with soft neoprene rubber insoles. This procedure should be considered instead of transmetatarsal amputation in some patients with problems of ulceration and abscess formation of the forefoot if circulation is adequate, or can be restored to adequate levels by vascular reconstruction. ( view less ) M M McQueen,D Simpson,C M Court-Brown The aim of this study was to examine the use of a new joint sparing external fixation device for unstable redisplaced fractures of the distal radius. Participants were twenty consecutive patients with unstable redisplaced fractures of the distal radius with sufficient space in the distal fragment t... ( view more )o allow use of a nonbridging technique. The patients had to be capable of cooperating with functional outcome measures. All patients underwent closed nonbridging external fixation of the distal radius using the Hoffman 2 compact external fixator. The main outcome measures were radiological determinations of dorsal angle, radial shortening, and carpal alignment; measurements of mass grip strength and range of movement; and rate of complications. Volar tilt was successfully regained and maintained (mean 4 degrees) at final review. Radial shortening was a mean of one millimeter at final review. Nineteen of twenty patients regained normal carpal alignment. Grip strength returned to a mean of 74 percent of the opposite (normal) side in the whole group and 88 percent in those who completed review for the longest periods. Ranges of movement were restored to around 80 percent, except flexion (66 percent). The rate of major complications was 15 percent. We conclude that nonbridging external fixation using the Hoffman 2 compact device reliably restores and maintains volar tilt and radial length after re-reduction of unstable fractures of the distal radius. Functional outcome and complications are comparable with findings in previous reports. ( view less ) L J NealNew research demonstrates that home health nurses proceed through a three-stage process to become successful and autonomous in their practice. It also indicates that they must be adaptable in order to function effectively and successfully in home care. This research has many implications for clinic... ( view more )ians, managers, and administrators. ( view less ) N BlewettThe National Campaign Against Drug Abuse (NCADA) was established in April 1985. Aiming to provide a national framework to minimize the harmful consequences of drug use, the original 3-year programme was extended to 1997. A key figure in the NCADA, Dr Neal Blewett, was interviewed to gain his perspe... ( view more )ctive on the development and implementation of the Campaign over its first 10 years. ( view less ) J B Jemmott,D C McClelland We examined recent assertions of Stone, Cox, Valdimarsdottir, and Neale regarding the use of S-IgA concentrations in whole saliva as a measure of mucosal immune competence. Our conclusions are markedly different from theirs. In this article, we report the results of a meta-analysis that reveals a s... ( view more )ignificant relation between psychosocial variables and salivary S-IgA concentrations. Second, we note that an inverse relation between salivary flow and S-IgA would not preclude studying salivary S-IgA concentration. Third, we present a different perspective on the assertion of Stone et al that IgA proteases in whole saliva potentially lead to erroneous results from the radial immunodiffusion assay. Fourth, we report a meta-analysis suggesting a statistically significant relation between S-IgA salivary concentrations and the incidence of acute upper respiratory illnesses. We conclude that there is no empirical or logical reason to prefer the measurement of another aspect of immunity to total S-IgA concentration in whole saliva. ( view less ) Hande Turker,Oytun Bayrak,Levent Gungor,Ahmet Yilmaz,Murat Terzi,Cuneyt M Turker,Musa K Onar,Hakki KahramanAlthough hypothyroid myopathy is seen frequently and the relationship with autoimmune hypothyroidism and myasthenia gravis is well known, specific forms of hypothyroid myopathy such as Hoffman's syndrome (HS) are rarely described. Here we describe a 40-year-old patient with Hashimoto thyroiditis sh... ( view more )owing symptoms and signs of two discrete forms of hypothyroid myopathy (HS and myasthenic syndrome) together. To our knowledge this is the first reported case with features of both of these syndromes. We discuss the diagnosis, speculate whether this patient may represent a unique form of hypothyroid myopathy, and report the 6-month follow-up of the patient both clinically and electrophysiologically. ( view less ) M M Nordlund,A Thorstensson,A G Cresswell Despite higher neural activation during active as compared to passive muscle shortening, Hoffman reflexes (H-reflexes) are similar. This may be explained by homosynaptic post-activation depression (HPAD) of Ia-afferents being present during active shortening. Accordingly, it was investigated whethe... ( view more )r conditioning electrical stimulation of the tibial nerve reduced the H-reflex less during active than passive shortening. The effects of two conditioning modes (0.2 and 1 Hz) were compared to a control mode without conditioning. H-reflexes and M-waves were elicited as the ankle passed 90 degrees with the soleus muscle undergoing passive or active (20% MVC) lengthening or shortening. Conditioning had no effect during active shortening. In contrast, during passive shortening, the H:M of the 1 Hz mode was significantly less than that of the 0.2 Hz and control modes. In lengthening, H:M was unaffected by conditioning. These findings support that HPAD reduces the synaptic efficacy of Ia-afferents during active shortening, active and passive lengthening, but not passive shortening. ( view less ) S Deepak, Harikrishnan,B JayakumarMuscle weakness, stiffness and delayed tendon jerk relaxation are usual features of hypothyroidism while muscle hypertrophy, myoedema and wasting are occasionally seen. A 60-year-old male, who presented with proximal muscle weakness and muscle hypertrophy has been reported here. Thyroid function te... ( view more )sts, electromyogram and muscle biopsy established the diagnosis of thyroid myopathy with Hoffman's syndrome. ( view less ) Luiz Felipe Rocha Vasconcellos,Maria Claudia Peixoto,Tatiana Nunes de Oliveira,Glória Penque,Ana Claudia Celestino LeiteThe frequency of myopathy in hypothyroidism ranges from 30 to 80%. The major symptoms related are weakness, muscular cramps and myalgia. The pseudohyperthrophic form is called Hoffman's syndrome. The electrophysiological study reveals myopathy, neuropathy or mixed pattern. Laboratorial investigatio... ( view more )n generally shows increased levels of muscle enzymes and low serum thyroid hormones, with thyrotrophic-stimulating hormone (TSH) elevated. The treatment consists in hormone replacement and the prognosis is good in most of the cases. We report an adult male who developed muscular cramps, myalgia, weakness, pseudohyperthrophy, associated with facial edema and alteration of his voice. The muscle enzymes were increased and T4 was undetectable with a raised level of TSH. The myopathy was the initial manifestation of hypothyroidism in this case. ( view less ) Noritaka Kawashima,Hirofumi Sekiguchi,Tasuku Miyoshi,Kimitaka Nakazawa,Masami AkaiThe purpose of the present study was to ascertain the contribution of peripheral sensory inputs to posture-related Hoffman reflex (H-reflex) modulation in the human soleus muscle. The soleus H-reflexes were elicited in the sitting (SI) and passive standing (ST) conditions in patients with clinicall... ( view more )y complete spinal cord injuries (SCI) and in neurologically normal subjects. The results clearly showed suppression of the H-reflex amplitude during the ST compared with the SI condition especially in the SCI group. Considering the lack of a descending neural command in the SCI patients, our findings suggest that peripheral sensory inputs primarily contribute to the reduction of the soleus H-reflex during the upright standing posture. ( view less ) Maria Mastropasqua,Gaetano Spagna,Valentina Baldini,Ilaria Tedesco,Anna PaggiPrimary hypothyroidism is a chronic and insidious disease caused by failure of thyroid hormone production. We observed a 38-year-old woman admitted to our hospital due to progressive proximal weakness, muscle pain and fatigue during mild exercise. Laboratory tests showed features of rhabdomyolysis ... ( view more )and hypothyroidism. After examination of the thyroid, we reached a diagnosis of Hashimoto's thyroiditis and hypothyroid myopathy. Hypothyroidism should be considered as a differential diagnosis of creatine kinase elevation; actually, neuromuscular symptoms and signs occur in most newly diagnosed patients with thyroid diseases. Hypothyroidism presenting as muscle stiffness and pseudohypertrophy is called 'Hoffman's syndrome'. ( view less )
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